naringenin-chalcone has been researched along with Hypersensitivity* in 1 studies
1 other study(ies) available for naringenin-chalcone and Hypersensitivity
| Article | Year |
|---|---|
Anti-allergic activity of naringenin chalcone from a tomato skin extract.
The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. The tomato skin extract exerted the strongest inhibition of histamine release. Chlorogenic acid, rutin and naringenin were identified in the 60% ethanol extract of tomato skin. However, the extract contained an unknown compound which strongly inhibited histamine release. This active compound in tomato skin was identified as naringenin chalcone (trans-2'4'6'4-tetrahydroxychalcone). Naringenin chalcone inhibited histamine release with an IC(50) value of 68 microg/ml. The anti-allergic activity of the tomato skin extract was next investigated by the in vivo mouse ear-swelling response. We found that naringenin chalcone showed the strongest inhibitory effect of the polyphenols of the tomato skin extract. These results indicate that a tomato skin extract could inhibit allergic reactions. Topics: Animals; Anti-Allergic Agents; Chalcone; Chalcones; Flavonoids; Histamine Release; Hypersensitivity; Mice; Phenols; Polyphenols; Solanum lycopersicum | 2004 |