Page last updated: 2024-10-31

naratriptan and Abdominal Migraine

naratriptan has been researched along with Abdominal Migraine in 112 studies

naratriptan: structure given in first source

Research Excerpts

ExcerptRelevanceReference
"To compare the effects of oral rizatriptan, sumatriptan, naratriptan, and zolmitriptan on the relief and emergence of nausea during a migraine attack."7.71Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. ( Goadsby, PJ; Jiang, K; Lines, CR; Lipton, RB; Massiou, H; McCarroll, KA; Pascual, J; Vandormael, K, 2001)
"Using the Marketscan database, the risk of major birth defects was ascertained in live-born infants whose birth mothers were exposed to sumatriptan, naratriptan, or sumatriptan/naproxen during pregnancy."3.88Use of existing electronic health care databases to evaluate medication safety in pregnancy: Triptan exposure in pregnancy as a case study. ( Bollinger, L; Cangialose, C; Chia, V; Mikol, DD; Xue, F; Yusuf, A, 2018)
"Accumulated data suggest that exposure to sumatriptan during pregnancy does not increase the risk of birth defects above the baseline rate."3.76Safety of triptans for migraine headaches during pregnancy and breastfeeding. ( Bozzo, P; Duong, S; Einarson, A; Nordeng, H, 2010)
"This case report describes for the first time acute coronary syndrome in a 67-year old patient after oral intake of naratriptan for migraine."3.75Triptans and troponin: a case report. ( Schneemann, M; Weder, CR, 2009)
"To compare the effects of oral rizatriptan, sumatriptan, naratriptan, and zolmitriptan on the relief and emergence of nausea during a migraine attack."3.71Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis. ( Goadsby, PJ; Jiang, K; Lines, CR; Lipton, RB; Massiou, H; McCarroll, KA; Pascual, J; Vandormael, K, 2001)
"1997, sumatriptan-treated migraineurs had significantly higher depression PCRs (22."3.70Are triptans with enhanced lipophilicity used for the acute treatment of migraine associated with an increased consulting rate for depressive illness? ( Croft, P; Frischer, M; Goadsby, PJ; Millson, D, 2000)
"MRM was defined as any migraine beginning during the perimenstrual period (PMP)."2.73Open-label, long-term tolerability of naratriptan for short-term prevention of menstrually related migraine. ( Ames, MH; Brandes, JL; Diamond, M; Smith, T, 2007)
"Naratriptan was marketed for the treatment of migraine attacks as the "gentle triptan" in a low oral dose of 2."2.72Naratriptan is as effective as sumatriptan for the treatment of migraine attacks when used properly. A mini-review. ( Tfelt-Hansen, P, 2021)
"naratriptan in the acute treatment of migraine."2.71Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine. ( Bordini, CA; Garcia-Ramos, G; Hettiarachchi, J; Hilliard, B; Leston, J; MacGregor, EA, 2003)
"However, the incidence of withdrawal symptoms and consumption of rescue drugs was higher among the patients who did not take regular medications during the first 6 days (P = 0."2.71Out-patient detoxification in chronic migraine: comparison of strategies. ( Krymchantowski, AV; Moreira, PF, 2003)
"Menstrual migraines are particularly difficult-totreat."2.71Naratriptan in the short-term prophylaxis of pure menstrual migraine. ( Allais, G; Benedetto, C; Bussone, G; D'Amico, D; Grazzi, L; Moschiano, F; Roncolato, M; Usai, S, 2005)
"Naratriptan is a novel 5-HT1 agonist developed to treat acute migraine."2.70Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine. ( Christensen, ML; Eades, SK; Fuseau, E; Hak, LJ; Kempsford, RD; Phelps, SJ, 2001)
"Naratriptan, 2."2.70Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study. ( Batenhorst, A; Jöbsis, M; Landy, S; Lipton, RB; Mannix, LK; Newman, L; O'Quinn, S; Putnam, DG; Silberstein, S; Watson, C, 2001)
") In a subset of patients experiencing headache relief after 2 attacks, headache recurrence 4 to 24 hours after initial dosing was reported by 55 naratriptan- and 77 sumatriptan-treated patients (41% and 57%, respectively; P = 0."2.69Comparison of naratriptan and sumatriptan in recurrence-prone migraine patients. Naratriptan International Recurrence Study Group. ( Becker, W; Boswell, D; Crisp, A; Göbel, H; Hauge, T; Mihout, B; Niewold, J; Tørring, J; Winter, P, 2000)
"Naratriptan for first-line migraine therapy was preferred by most patients over previous nontriptan therapy."2.69Evaluation of migraineurs' preferences for naratriptan over conventional first-line agents. ( Bort, T; Cady, R; Cervi, M; Pangtay, D; Powers, C; Szeto, S, 2000)
"Rizatriptan was more effective than naratriptan."2.69Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine. ( Allen, C; Bomhof, M; Legg, N; Patel, K; Paz, J; Vandormael, K, 1999)
"Naratriptan was also more effective than placebo in reducing clinical disability and the incidences of nausea, photophobia, and phonophobia."2.68Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group. ( Asgharnejad, M; Laurenza, A; Mathew, NT; Peykamian, M, 1997)
"Naproxen is a non-steroidal anti-inflammatory drug (NSAID); its efficacy in acute migraine has not been established by systematic reviews."2.49Naproxen with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Law, S; Moore, RA, 2013)
"Naratriptan 1 mg b."2.47Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register. ( Tfelt-Hansen, PC, 2011)
"The annual cost of migraine is euro27 billion in Europe, $US1."2.44Over-the-counter triptans for migraine : what are the implications? ( Steiner, TJ; Tfelt-Hansen, P, 2007)
"The clinical efficacy in migraine was compared for oral and subcutaneous sumatriptan and naratriptan."2.44Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. a comment. ( Tfelt-Hansen, P, 2007)
"Naratriptan has also a therapeutic effect on the nausea of migraine, possibly exerting its action at the level of the nucleus tractus solitarius via the same mechanisms by which it inhibits trigeminovascular nociceptive input."2.43Preclinical neuropharmacology of naratriptan. ( Lambert, GA, 2005)
"Naratriptan 2."2.42Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials. ( Ashcroft, DM; Millson, D, 2004)
"Oral rizatriptan 10 mg was more effective than oral sumatriptan, naratriptan, and zolmitriptan on stringent outcome measures of pain-free response at 2 hours, symptom-free response at 2 hours, and 24-hour sustained pain-free response."2.41Comparison of rizatriptan and other triptans on stringent measures of efficacy. ( Adelman, JU; Diener, HC; Ferrari, MD; Lines, CR; Lipton, RB; McCarroll, KA; Vandormael, K, 2001)
"Migraine headaches are a common medical problem that physicians frequently encounter in their practice."2.41Treatment of acute migraine attacks. ( Weintraub, JR, 2000)
"Two new intranasal migraine medications, sumatriptan and dihydroergotamine mesylate, may offer specific advantages for patients who are seeking alternatives to various oral or parenteral migraine abortive therapies."2.41Newer intranasal migraine medications. ( Logemann, CD; Rankin, LM, 2000)
"Naratriptan is a selective 5-HT(1B/1D) receptor agonist, with a high affinity at the 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor subtypes."2.41Naratriptan. ( Massiou, H, 2001)
"There exist increasing options for migraine treatment that may further improve the clinical effects of the older and newer triptans through early treatment of migraine at the stages of mild migraine pain, or even during the prodromal phase of the attack."2.41Acute treatment of migraine and the role of triptans. ( Freitag, FG, 2001)
"Thus sumatriptan has become the de facto gold standard and will be thus employed here."2.40The scientific basis of medication choice in symptomatic migraine treatment. ( Goadsby, PJ, 1999)
"Naratriptan has been recently approved for acute oral migraine therapy."2.40Naratriptan: an alternative for migraine. ( Dulli, DA, 1999)
"The other new migraine drugs zolmitriptan, naratriptan, rizatriptan and eletriptan differ in their pharmacological profiles, which translates into minor differences in efficacy, headache recurrence and side-effects."2.40Acute management of migraine: triptans and beyond. ( Diener, HC; Limmroth, V, 1999)
"Imaging migraine premonitory studies show increased midbrain activation consistent with the ventral tegmental area, an area involved in pain modulation and hedonic feeding."1.72Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine. ( Akerman, S; Goadsby, PJ; Holland, PR; Martins-Oliveira, M; Tavares, I, 2022)
"Patients with episodic and chronic migraine who experienced continuous and prolonged attacks for more than 72 hours were treated with dexamethasone (4 mg orally twice daily for 3 days), ketorolac (60 mg intramuscularly), bilateral nerve blocks (1-2% lidocaine, 0."1.56Unrecognized challenges of treating status migrainosus: An observational study. ( Ashina, S; Burstein, R; Chua, A; Grosberg, B; Iljazi, A; Melo-Carrillo, A; Rich-Fiondella, R; Veronesi, M, 2020)
"Naratriptan was taken before the patient went to bed."1.46Naratriptan in the Prophylactic Treatment of Cluster Headache. ( Araki, N; Asano, Y; Ito, Y; Kato, Y; Maruki, Y; Mitsufuji, T; Sakai, F; Shimazu, T; Tanahashi, N; Yamamoto, T, 2017)
"Familial hemiplegic migraine type 1 (FHM-1) is a monogenic subtype of migraine with aura caused by missense mutations in the CACNA1A gene, which encodes the pore-forming α1 subunit of voltage-gated neuronal CaV2."1.40Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study. ( Akerman, S; Andreou, AP; Ferrari, MD; Goadsby, PJ; Holland, PR; Lasalandra, MP; Moon, H; Park, J; van den Maagdenberg, AM, 2014)
"Naratriptan hydrochloride was dissolved immediately after disintegration, hence facilitating buccal absorption of the active pharmaceutical ingredient."1.40Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride. ( Führling, C; Gieseler, H; Stange, U, 2014)
"He suffered from frequent attacks of migraine-like headache (3-7 per month), pulsating in nature associated with nausea."1.38Migraine-like headache in a patient with complement 1 inhibitor deficient hereditary angioedema. ( Chung, JY; Kim, M, 2012)
"Chronic migraine (CM) is a common disorder, affecting 2% to 3% of the general population."1.34Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine. ( Cavalheiro, EA; Naffah-Mazzacoratti, Mda G; Peres, MF; Senne Soares, CA; Vieira, DS; Zukerman, E, 2007)
"In this report, a case with vitamin B12 deficiency showing a temporary confusion depending on the usage of naratriptan during the migraine attack was presented."1.34Temporary confusion depending on the usage of naratriptan. ( Gokalp, O; Gultekin, F; Incekara, F; Koyuncuoglu, HR; Kutluhan, S; Sozen, A; Tak, R, 2007)
"Migraine is a prevalent neurological disorder that can be alleviated by specific treatment for acute headaches, in particular, the triptans, including naratriptan."1.34[The Vigimig study of naratriptan use in general practice]. ( Allaert, FA; Druais, PL; El Hasnaoui, A; Lanteri-Minet, M; Nachit-Ouinekh, F, 2007)
"The treatment of migraine consists of the acute treatment of the migraine attack and prophylactic measures for either pharmacological or non-pharmacological management."1.33[Prophylactic measures and acute treatment of migraine]. ( Göbel, H; Heinze, A; Heinze-Kuhn, K, 2006)
" The analysis was based on phase I pharmacokinetic naratriptan data, sumatriptan pharmacodynamic data, and naratriptan preclinical (animal) potency information, together with general knowledge as to how migraine affects oral absorption."1.33Uncertainty analysis in pharmacokinetics and pharmacodynamics: application to naratriptan. ( Aarons, L; Gueorguieva, I; Nestorov, IA; Rowland, M, 2005)
"Eletriptan 40 mg also was found to have the lowest total triptan cost to successfully treat 100 patients."1.33Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat. ( Healey, PJ; Mullins, CD; Perfetto, EM; Subedi, PR; Weis, KA, 2005)
"Ischemic colitis has not been reported in association with naratriptan therapy."1.33Ischemic colitis associated with naratriptan and oral contraceptive use. ( Charles, JA; Pullicino, PM; Shroff, Y; Stoopack, PM, 2005)
" Disease dynamics must be considered to evaluate treatment response adequately and optimise the dosing regimen in migraine."1.33A model-based approach to treatment comparison in acute migraine. ( Danhof, M; Della Pasqua, O; Maas, HJ, 2006)
"Physicians had to document the migraine history, and to report symptoms and health care in a structured case report form."1.32[A descriptive analysis of naratriptan use among migraineurs in ambulatory medicine]. ( Brudon-Mollard, F; Chemali-Hudry, J; Druais, PL; El Hasnaoui, A; Giacomino, A; Hinault, P; Lanteri-Minet, M; Zaïm, M, 2003)
"The treatment of chronic migraine often poses a major challenge to the clinician."1.32Naratriptan in the preventive treatment of refractory chronic migraine: a review of 27 cases. ( Bigal, ME; Feleppa, M; Rapoport, AM; Sheftell, FD; Tepper, SJ; Volcy, M, 2003)
"In direct head-to-head comparative clinical trials, oral rizatriptan 10 mg enabled more migraine sufferers to function normally at 2 h after dosing than oral sumatriptan, naratriptan, and zolmitriptan."1.31Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials. ( Bussone, G; D'Amico, D; Gerth, W; Lines, CR; McCarroll, KA, 2002)
"The overall incidence of headache recurrence is low after naratriptan, 2."1.31Low migraine headache recurrence with naratriptan: clinical parameters related to recurrence. ( O'Quinn, S; Pait, D; Sheftell, F; Watson, C; Winter, P, 2000)
"Four hundred and seventeen (417) migraine patients treated 15,301 migraine attacks over the course of the study."1.31Tolerability and efficacy of naratriptan tablets in the acute treatment of migraine attacks for 1 year. Naratriptan Long-Term Study Group. ( Bomhof, MA; Hassani, H; Heywood, J; Pradalier, A; Thaventhiran, L; Winter, P, 2000)
"Modulatory effects of the new antimigraine drug naratriptan, a 5-HT(1)-receptor-agonist, on neurons of the nucleus raphé magnus were examined in rat by extracellular recordings."1.31Modulation of neuronal activity in the nucleus raphé magnus by the 5-HT(1)-receptor agonist naratriptan in rat. ( Chiang, CY; Ellrich, J; Hu, JW; Messlinger, K, 2001)
"Naratriptan is a newly developed triptan shown to be effective in the treatment of migraine."1.31Treatment of migraine in Canada with naratriptan: a cost-effectiveness analysis. ( Black, L; Caro, G; Caro, JJ; Getsios, D; Raggio, G, 2001)
"Rizatriptan was associated with significantly lower triptan tablet use and additional medication use per attack than the other triptans."1.31Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain. ( Fité, B; López-Gil, A; Pascual, J, 2002)
"Of the prophylactic antimigraine drugs tested, methysergide and lisuride behaved as efficacious agonists (Emax > or = 90% relative to 5-HT) whereas pitozifen and (-)propranolol acted as a partial agonist (60%) and an antagonist, respectively."1.30Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. ( Audinot-Bouchez, V; Chaput, C; Conte, C; Lavielle, G; Lochon, S; Millan, MJ; Newman-Tancredi, A; Verrièle, L, 1997)
"The antimigraine drugs ergotamine and sumatriptan may cause angina-like symptoms, possibly resulting from coronary artery constriction."1.30Coronary side-effect potential of current and prospective antimigraine drugs. ( Bax, WA; Ferrari, MD; MaassenVanDenBrink, A; Reekers, M; Saxena, PR, 1998)

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's18 (16.07)18.2507
2000's74 (66.07)29.6817
2010's16 (14.29)24.3611
2020's4 (3.57)2.80

Authors

AuthorsStudies
Newman-Tancredi, A1
Conte, C1
Chaput, C1
Verrièle, L1
Audinot-Bouchez, V1
Lochon, S1
Lavielle, G1
Millan, MJ1
Martins-Oliveira, M1
Akerman, S2
Holland, PR2
Tavares, I1
Goadsby, PJ8
Iljazi, A1
Chua, A1
Rich-Fiondella, R1
Veronesi, M1
Melo-Carrillo, A1
Ashina, S1
Burstein, R1
Grosberg, B1
Amundsen, S1
Nordeng, H2
Fuskevåg, OM1
Nordmo, E1
Sager, G1
Spigset, O1
Tfelt-Hansen, P5
Ito, Y1
Mitsufuji, T1
Asano, Y1
Shimazu, T1
Kato, Y1
Tanahashi, N1
Maruki, Y1
Sakai, F2
Yamamoto, T1
Araki, N1
Kikui, S1
Takeshima, T2
Yusuf, A1
Chia, V1
Xue, F1
Mikol, DD1
Bollinger, L1
Cangialose, C1
Schneemann, M2
Ruggieri, F1
Law, S1
Derry, S1
Moore, RA1
Park, J1
Moon, H1
Lasalandra, MP1
Andreou, AP1
Ferrari, MD3
van den Maagdenberg, AM1
Jacobs, HS1
Stange, U1
Führling, C1
Gieseler, H1
Kraya, T1
Schlitt, A1
Tokuoka, K1
Takayanagi, R1
Suzuki, Y1
Watanabe, M1
Kitagawa, Y1
Yamada, Y1
Macone, AE1
Perloff, MD1
Ravikumar, K1
Sridhar, B1
Krishnan, H1
Singh, AN1
Weder, CR1
Jamieson, DG1
Beau-Salinas, F1
Jonville-Béra, AP1
Cissoko, H1
Bensouda-Grimaldi, L1
Autret-Leca, E1
Westgeest, HM1
Akol, H1
Schreuder, TC1
Duong, S1
Bozzo, P1
Einarson, A1
Tfelt-Hansen, PC1
Chung, JY1
Kim, M1
Tepper, SJ2
Rapoport, AM2
Sheftell, FD2
Bussone, G2
D'Amico, D2
McCarroll, KA3
Gerth, W1
Lines, CR3
Massiou, H4
Macaigne, G1
Simon, P1
Auriault, ML1
Boivin, JF1
Froguel, E1
Chayette, C1
Cheaib, S1
Deplus, R1
Adelman, JU2
Lewit, EJ1
Bigal, ME1
Volcy, M1
Feleppa, M1
Brudon-Mollard, F1
Druais, PL2
Giacomino, A1
Hinault, P1
Lanteri-Minet, M2
Zaïm, M1
Chemali-Hudry, J1
El Hasnaoui, A2
Stronks, DL1
Tulen, JH1
Bussmann, HB1
Mulder, LJ1
Passchier, J1
Létienne, R1
Verscheure, Y1
John, GW1
Garcia-Ramos, G1
MacGregor, EA1
Hilliard, B1
Bordini, CA1
Leston, J1
Hettiarachchi, J1
Boers, PM1
Donaldson, C1
Zagami, AS2
Lambert, GA2
Krymchantowski, AV1
Moreira, PF1
Ashcroft, DM1
Millson, D2
Iizuka, T1
Barrows, C1
Saunders, W1
Austin, R1
Putnam, G1
Mansbach, H1
Nakashima, K1
Kowa, H1
Morillo, LE2
Pascual, J3
Muñoz, P1
Charles, JA1
Pullicino, PM1
Stoopack, PM1
Shroff, Y1
Moschiano, F1
Allais, G1
Grazzi, L1
Usai, S1
Benedetto, C1
Roncolato, M1
Mullins, CD1
Weis, KA1
Perfetto, EM1
Subedi, PR1
Healey, PJ1
Tietjen, GE1
Athanas, K1
Utley, C1
Herial, NA1
Khuder, SA1
Gueorguieva, I1
Nestorov, IA1
Aarons, L1
Rowland, M1
Jamin, C1
Hinzelin, G1
Bidaut-Mazel, C1
Cuvellier, JC1
Joriot, S1
Auvin, S1
Vallée, L1
Shields, KG1
Göbel, H2
Heinze, A1
Heinze-Kuhn, K1
Maas, HJ1
Danhof, M1
Della Pasqua, O1
Kunkel, M1
Vieira, DS1
Naffah-Mazzacoratti, Mda G1
Zukerman, E1
Senne Soares, CA1
Cavalheiro, EA1
Peres, MF1
Brandes, JL1
Smith, T1
Diamond, M1
Ames, MH1
Nachit-Ouinekh, F1
Allaert, FA1
Steiner, TJ1
Kutluhan, S1
Incekara, F1
Sozen, A1
Koyuncuoglu, HR1
Tak, R1
Gokalp, O1
Gultekin, F1
Mathew, NT1
Asgharnejad, M1
Peykamian, M1
Laurenza, A1
Bomhof, MA2
Heywood, J2
Pradalier, A2
Enahoro, H2
Winter, P5
Hassani, H3
MaassenVanDenBrink, A1
Reekers, M1
Bax, WA1
Saxena, PR1
Scholz, MJ1
Monseu, G1
Sternon, J1
Limmroth, V2
Kazarawa, Z1
Fritsche, G1
Diener, HC4
Scheen, AJ1
Goldstein, D1
Dulli, DA1
Deleu, D2
Hanssens, Y2
Bomhof, M1
Paz, J1
Legg, N2
Allen, C1
Vandormael, K3
Patel, K1
Vishwanathan, K1
Bartlett, MG1
Stewart, JT1
Logemann, CD1
Rankin, LM1
Sheftell, F1
O'Quinn, S2
Watson, C2
Pait, D1
Wheeler, SD1
Gnecchi-Ruscone, T1
Bernard, X1
Pierre, P1
Anderson, D1
Winter, PD1
Crisp, A2
Melin, JA1
Camici, PG1
Powers, C1
Szeto, S1
Pangtay, D1
Bort, T1
Cervi, M1
Cady, R2
Bartleson, JD1
Warner, JS1
Havanka, H1
Dahlöf, C1
Pop, PH1
Whitehouse, H1
Boswell, D1
Becker, W1
Hauge, T1
Mihout, B1
Niewold, J1
Tørring, J1
Thaventhiran, L1
Weintraub, JR1
Valette, C1
Potrebic, S1
Raskin, NH1
Frischer, M1
Croft, P1
Ellrich, J1
Messlinger, K1
Chiang, CY1
Hu, JW1
Christensen, ML1
Eades, SK1
Fuseau, E1
Kempsford, RD1
Phelps, SJ1
Hak, LJ1
Newman, L1
Mannix, LK1
Landy, S1
Silberstein, S1
Lipton, RB3
Putnam, DG1
Jöbsis, M1
Batenhorst, A1
Caro, JJ1
Getsios, D1
Raggio, G1
Caro, G1
Black, L1
Hashimoto, S1
Iwata, M1
Marcus, DA1
Jiang, K1
Welch, KM1
Connor, HE1
Freitag, FG1
Fité, B1
López-Gil, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TreximetTM in the Prevention and Modification of Disease Progression in Migraine[NCT01300546]Phase 440 participants (Actual)Interventional2010-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Compliance With Lifestyle Changes

Self-assessed grade of compliance with lifestyle modification changes (where A=1, B=2, C=3, D=4, and F=5; lower scores represent better outcomes) in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. (NCT01300546)
Timeframe: Day 121

Interventionscores on a scale (Mean)
Sumatriptan/Naproxen Sodium2.33
Naproxen Sodium2.43

Percent Change of Headache Days Compared to Baseline

Comparing the number of migraine headache days during Baseline Period Days 1-30 to number or migraine headache days reported in Treatment Period Days 91-120 in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. Percent change=[ (total headache days during Treatment Period Month 3 (Days 91-120)-total headache days during Baseline (Days 1-30)/total headache days during Baseline (Days 1-30)]*100%). (NCT01300546)
Timeframe: Day 121 (following 30 day Baseline Period and Treatment Period Days 91-120)

Interventionpercent change of headache days (Mean)
Sumatriptan/Naproxen Sodium-13.50
Naproxen Sodium-36.50

Doses of Study Medication

Total number of doses of study medication reported taken per participant in Treatment Period Months 1, 2, and 3 in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. (NCT01300546)
Timeframe: Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventiondoses of study medication (Mean)
Treatment Period Month 1Treatment Period Month 2Treatment Period Month 3
Naproxen Sodium9.368.868.50
Sumatriptan/Naproxen Sodium11.0010.2810.28

Headache Days With Greater Than 50% Reduction

Number of subjects with at least a 50% reduction in number of headache days reported in Baseline versus Treatment period Months 1, 2, and 3 in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionparticipants (Number)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium336
Sumatriptan/Naproxen Sodium123

Migraine Attacks

Comparing the number of migraine attacks reported from Baseline to the number of migraine attacks reported in Treatment Period Months 1(Days 31-60), 2(Days 61-90), and 3(Days 91-120) in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. Each treatment month percent change was individually compared to Baseline. The following formula was used for each treatment period calculation. e.g.,Percent change=[ (total migraine attacks days during Treatment Period Month 3 (Days 91-120)-total migraine attacks during Baseline (Days 1-30)/total migraine attacks during Baseline (Days 1-30)]*100%). (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of migraine attacks (Mean)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium-12.23-9.03-39.12
Sumatriptan/Naproxen Sodium-4.35-2.88-8.63

Migraine Attacks With 50% Reduction

Number of subjects with at least a 50% reduction in number of migraine attacks reported in Baseline versus Treatment period Months 1, 2, and 3 in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionparticipants (Number)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium106
Sumatriptan/Naproxen Sodium324

Migraine Disability Assessment Test (MIDAS)

"Change in MIDAS total score from end of Baseline (Day 31) to end Treatment Period month 3 (Day 121) in the Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm.~Total score of disability ranges:~0 to 5, MIDAS Grade I, Little or no disability~6 to 10, MIDAS Grade II, Mild disability~11 to 20, MIDAS Grade III, Moderate disability~21+, MIDAS Grade IV, Severe disability No subscales are present." (NCT01300546)
Timeframe: Baseline MIDAS collected at Day 31, Post final dose study medication MIDAS collected at Day 121.

,
Interventionscores on a scale (Mean)
Baseline Day 31Day 121
Naproxen Sodium22.624.1
Sumatriptan/Naproxen Sodium28.727.9

Migraine Duration From Onset to Pain Free

Comparing mean migraine duration from onset to painfree from Baseline(Days 1-30) to each month: Treatment Period Months 1 (Days 31-60), 2(Days 61-90), and 3(Days 91-120) in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. Percent change was calculated by determining percent change in each subject, from Treatment Period Month 3 and Baseline, then comparing the average change between each arm. The following formula was used for each treatment period calculation. e.g.,Percent change=[(mean duration from onset to painfree during Treatment Period Month 3 (Days 91-120)- mean duration from onset to painfree during Baseline (Days 1-30)/mean duration from onset to painfree during Baseline (Days 1-30)]*100%). (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of migraine duration (Mean)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium-14.92-26.3570.84
Sumatriptan/Naproxen Sodium72.0435.8661.96

Migraine Duration From Time of Treatment to Pain Free

"% change from Baseline in mean migraine duration from time of treatment to pain free reported in Treatment Period Months 1, 2, and 3 in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm.~Percent change=[(mean duration from treatment to painfree during Treatment Period Month 3 (Days 91-120)- mean duration from treatment to painfree during Baseline (Days 1-30)/mean duration from treatment to painfree during Baseline (Days 1-30)]*100%)." (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of migraine duration (Mean)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium-14.91-25.5273.42
Sumatriptan/Naproxen Sodium150.1092.73114.10

Migraine Severity

Comparing migraine severity 2 hours after treatment from Baseline(Days 1-30) to migraine severity reported 2 hours after treatment in Treatment Period Months 1 (Days 31-60), 2(Days 61-90), and 3(Days 91-120) in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. Percent change was calculated by determining percent change in each subject, from Treatment Period Month 3 and Baseline, then comparing the average change between each arm. The following formula was used for each treatment period calculation. e.g.,Percent change=[ (mean migraine severity during Treatment Period Month 3 (Days 91-120)- mean migraine severity during Baseline (Days 1-30)/mean migraine severity during Baseline (Days 1-30)]*100%). (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of migraine severity (Mean)
2 hours after treatment for Baseline to Month 12 hours after treatment for Baseline to Month 22 hours after treatment for Baseline to Month 3
Naproxen Sodium11.780.3332.62
Sumatriptan/Naproxen Sodium-17.84-36.71-55.60

Percent Change in Headache Days All Treatment Periods Compared to Baseline

Comparing the number of migraine headache days during Baseline Period Days 1-30 to number or migraine headache days reported in Treatment Period Month 1 (Days 31-60), Treatment Period Month 2 (Days 61-90), and Treatment Period Month 3 (Days 91-120) in Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. e.g., Percent change=[ (total headache days during Treatment Period Month 3 (Days 91-120)-total headache days during Baseline (Days 1-30)/total headache days during Baseline (Days 1-30)]*100%). (NCT01300546)
Timeframe: Baseline Period collected at Day 31, Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of migraine headache days (Mean)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium-26.86-21.44-36.50
Sumatriptan/Naproxen Sodium-1.70-4.39-13.50

Percent Change of Doses of Study Medication

% change in number of doses during Baseline of triptans (Group A) and non-steroidal anti-inflammatory drugs(NSAIDs) (Group B) vs. doses during Treatment Period Months 1, 2, and 3 of study medication in the Sumatriptan/Naproxen Sodium arm vs. Naproxen Sodium arm. e.g.,Percent change=[(number of doses during Treatment Period Month 3 (Days 91-120)- number of doses during Baseline (Days 1-30)/number of doses during Baseline (Days 1-30)]*100%). The total number of subjects used in this analysis is different than the total number of subjects as the analysis is only looking at those subjects that were taking one of the study medications during Baseline. (NCT01300546)
Timeframe: Treatment Period Months 1, 2, and 3 collected at Days 61, 91, and 121.

,
Interventionpercent change of study medication (Mean)
Baseline to Treatment Period Month 1Baseline to Treatment Period Month 2Baseline to Treatment Period Month 3
Naproxen Sodium160.876.4112.7
Sumatriptan/Naproxen Sodium130.8114.996.1

Reviews

29 reviews available for naratriptan and Abdominal Migraine

ArticleYear
Naratriptan is as effective as sumatriptan for the treatment of migraine attacks when used properly. A mini-review.
    Cephalalgia : an international journal of headache, 2021, Volume: 41, Issue:14

    Topics: Animals; Migraine Disorders; Piperidines; Randomized Controlled Trials as Topic; Serotonin Receptor

2021
Naproxen with or without an antiemetic for acute migraine headaches in adults.
    The Cochrane database of systematic reviews, 2013, Oct-20, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Drug Therapy, Combination; Humans; Migr

2013
Triptans and migraine: advances in use, administration, formulation, and development.
    Expert opinion on pharmacotherapy, 2017, Volume: 18, Issue:4

    Topics: Carbazoles; Humans; Migraine Disorders; Piperidines; Serotonin 5-HT1 Receptor Agonists; Serotonin Re

2017
Published and not fully published double-blind, randomised, controlled trials with oral naratriptan in the treatment of migraine: a review based on the GSK Trial Register.
    The journal of headache and pain, 2011, Volume: 12, Issue:4

    Topics: Double-Blind Method; Germany; Humans; Migraine Disorders; Piperidines; Randomized Controlled Trials

2011
Mechanisms of action of the 5-HT1B/1D receptor agonists.
    Archives of neurology, 2002, Volume: 59, Issue:7

    Topics: Carbazoles; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Receptor

2002
Naratriptan.
    Current medical research and opinion, 2001, Volume: 17 Suppl 1

    Topics: Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Tryptamines

2001
Comparative aspects of triptans in treating migraine.
    Clinical cornerstone, 2001, Volume: 4, Issue:3

    Topics: Carbazoles; Cardiovascular Diseases; Humans; Indoles; Migraine Disorders; Oxazolidinones; Patient Sa

2001
Naratriptan for the treatment of acute migraine: meta-analysis of randomised controlled trials.
    Pharmacoepidemiology and drug safety, 2004, Volume: 13, Issue:2

    Topics: Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines;

2004
[Recent progress in therapy for migraine headache].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2004, Feb-10, Volume: 93, Issue:2

    Topics: Anticonvulsants; Botulinum Toxins; Calcitonin Gene-Related Peptide; Central Nervous System; Clinical

2004
[Meta-analysis of triptan treatment in migraine].
    No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:9

    Topics: Carbazoles; Evidence-Based Medicine; Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidine

2004
Migraine headache.
    Clinical evidence, 2003, Issue:10

    Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Dicl

2003
Migraine headache.
    Clinical evidence, 2004, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ergotamine; Humans; Ibuprofen; Indoles; Migrain

2004
Preclinical neuropharmacology of naratriptan.
    CNS drug reviews, 2005,Autumn, Volume: 11, Issue:3

    Topics: Analgesia; Animals; Cardiovascular Diseases; Humans; Migraine Disorders; Piperidines; Serotonin Rece

2005
[Naratriptan. A new medical option for the pharmacist].
    Medizinische Monatsschrift fur Pharmazeuten, 2007, Volume: 30, Issue:5

    Topics: Humans; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Tryptamines

2007
Over-the-counter triptans for migraine : what are the implications?
    CNS drugs, 2007, Volume: 21, Issue:11

    Topics: Germany; Humans; Migraine Disorders; Nonprescription Drugs; Piperidines; Serotonin Receptor Agonists

2007
Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. a comment.
    The journal of headache and pain, 2007, Volume: 8, Issue:5

    Topics: Administration, Oral; Biological Availability; Humans; Infusions, Parenteral; Injections, Subcutaneo

2007
Naratriptan: an alternative for migraine.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:6

    Topics: Animals; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Recep

1999
Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.
    Acta neurologica Belgica, 1999, Volume: 99, Issue:2

    Topics: Acute Disease; Animals; Clinical Trials as Topic; Coronary Circulation; Coronary Vasospasm; Drug Des

1999
Acute management of migraine: triptans and beyond.
    Current opinion in neurology, 1999, Volume: 12, Issue:3

    Topics: Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agoni

1999
The scientific basis of medication choice in symptomatic migraine treatment.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1999, Volume: 26 Suppl 3

    Topics: Acute Disease; Choice Behavior; Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorder

1999
Newer intranasal migraine medications.
    American family physician, 2000, Jan-01, Volume: 61, Issue:1

    Topics: Administration, Intranasal; Administration, Oral; Analgesics, Non-Narcotic; Clinical Trials as Topic

2000
Current and emerging second-generation triptans in acute migraine therapy: a comparative review.
    Journal of clinical pharmacology, 2000, Volume: 40, Issue:7

    Topics: Acute Disease; Carbazoles; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidine

2000
Treatment of acute migraine attacks.
    The Journal of the American Osteopathic Association, 2000, Volume: 100, Issue:9 Suppl

    Topics: Analgesics; Ergotamine; Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor Agonist

2000
New abortive agents for the treatment of migraine.
    Advances in internal medicine, 2001, Volume: 46

    Topics: Clinical Trials as Topic; Female; Humans; Indoles; Male; Migraine Disorders; Oxazolidinones; Piperid

2001
[Current topics: expectation for new triptans].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2001, Apr-10, Volume: 90, Issue:4

    Topics: Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Serotonin Receptor A

2001
Establishing a standard of speed for assessing the efficacy of the serotonin(1B/1D) agonists (triptans).
    Archives of neurology, 2001, Volume: 58, Issue:7

    Topics: Analgesics, Non-Narcotic; Carbazoles; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders;

2001
Have the triptans fulfilled their promise?
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2001, Volume: 8, Issue:5

    Topics: Humans; Indoles; Migraine Disorders; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Sumat

2001
Comparison of rizatriptan and other triptans on stringent measures of efficacy.
    Neurology, 2001, Oct-23, Volume: 57, Issue:8

    Topics: Administration, Oral; Humans; Indoles; Migraine Disorders; Oxazolidinones; Patient Satisfaction; Pip

2001
Acute treatment of migraine and the role of triptans.
    Current neurology and neuroscience reports, 2001, Volume: 1, Issue:2

    Topics: Acute Disease; Blood Flow Velocity; Carbazoles; Clinical Trials as Topic; Drug Administration Routes

2001

Trials

17 trials available for naratriptan and Abdominal Migraine

ArticleYear
Theory-based analysis of clinical efficacy of triptans using receptor occupancy.
    The journal of headache and pain, 2014, Dec-08, Volume: 15

    Topics: Humans; Migraine Disorders; Oxazolidinones; Piperidines; Pyrrolidines; Serotonin 5-HT1 Receptor Agon

2014
Effects of naratriptan versus naproxen on daily functioning in the acute treatment of migraine: a randomized, double-blind, double-dummy, crossover study.
    Headache, 2003, Volume: 43, Issue:8

    Topics: Activities of Daily Living; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Ove

2003
Comparative efficacy of eletriptan vs. naratriptan in the acute treatment of migraine.
    Cephalalgia : an international journal of headache, 2003, Volume: 23, Issue:9

    Topics: Adult; Double-Blind Method; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Patient

2003
Out-patient detoxification in chronic migraine: comparison of strategies.
    Cephalalgia : an international journal of headache, 2003, Volume: 23, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Chi-Square Distribution; Female; Headac

2003
Naratriptan in the short-term prophylaxis of pure menstrual migraine.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2005, Volume: 26 Suppl 2

    Topics: Adolescent; Adult; Drug Evaluation; Dysmenorrhea; Female; Follow-Up Studies; Humans; Indoles; Middle

2005
The combination of naratriptan and prochlorperazine in migraine treatment.
    Headache, 2005, Volume: 45, Issue:6

    Topics: Adult; Dopamine Antagonists; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Migrai

2005
Efficacy of oral naratriptan in the treatment of menstrually related migraine.
    European journal of neurology, 2005, Volume: 12, Issue:10

    Topics: Administration, Oral; Double-Blind Method; Female; Humans; Menstruation; Migraine Disorders; Pain Me

2005
Open-label, long-term tolerability of naratriptan for short-term prevention of menstrually related migraine.
    Headache, 2007, Volume: 47, Issue:6

    Topics: Adult; Female; Humans; Menstruation; Middle Aged; Migraine Disorders; Piperidines; Serotonin Recepto

2007
Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo-controlled, crossover study. The Naratriptan S2WA3003 Study Group.
    Neurology, 1997, Volume: 49, Issue:6

    Topics: Adolescent; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Gastrointestinal Diseases;

1997
Comparison of rizatriptan 10 mg vs. naratriptan 2.5 mg in migraine.
    European neurology, 1999, Volume: 42, Issue:3

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indoles; Male; Middle

1999
Effect of naratriptan on myocardial blood flow and coronary vasodilator reserve in migraineurs.
    Neurology, 2000, Jul-12, Volume: 55, Issue:1

    Topics: Adult; Coronary Circulation; Female; Heart; Humans; Indoles; Male; Middle Aged; Migraine Disorders;

2000
Evaluation of migraineurs' preferences for naratriptan over conventional first-line agents.
    Archives of family medicine, 2000, Volume: 9, Issue:8

    Topics: Adult; Aged; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Patient Satisfaction; P

2000
Efficacy of naratriptan tablets in the acute treatment of migraine: a dose-ranging study. Naratriptan S2WB2004 Study Group.
    Clinical therapeutics, 2000, Volume: 22, Issue:8

    Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indoles; Migraine Disorders; Patient

2000
Comparison of naratriptan and sumatriptan in recurrence-prone migraine patients. Naratriptan International Recurrence Study Group.
    Clinical therapeutics, 2000, Volume: 22, Issue:8

    Topics: Adolescent; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Humans; Indoles; Middle Ag

2000
[Quality of life of migraine patients after treatment with 2.5 mg oral naratriptan].
    Presse medicale (Paris, France : 1983), 2000, Dec-09, Volume: 29, Issue:38

    Topics: Administration, Oral; Adult; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Piperid

2000
Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine.
    Journal of clinical pharmacology, 2001, Volume: 41, Issue:2

    Topics: Adolescent; Area Under Curve; Child; Female; Humans; Indoles; Male; Migraine Disorders; Piperidines;

2001
Naratriptan as short-term prophylaxis of menstrually associated migraine: a randomized, double-blind, placebo-controlled study.
    Headache, 2001, Volume: 41, Issue:3

    Topics: Adult; Double-Blind Method; Female; Humans; Indoles; Menstruation; Migraine Disorders; Piperidines;

2001

Other Studies

66 other studies available for naratriptan and Abdominal Migraine

ArticleYear
Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Cell Membrane; C

1997
Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine.
    Cephalalgia : an international journal of headache, 2022, Volume: 42, Issue:13

    Topics: Animals; Blood Glucose; Male; Migraine Disorders; Neurons; Perception; Pituitary Adenylate Cyclase-A

2022
Unrecognized challenges of treating status migrainosus: An observational study.
    Cephalalgia : an international journal of headache, 2020, Volume: 40, Issue:8

    Topics: Adult; Dexamethasone; Female; Humans; Ketorolac; Male; Middle Aged; Migraine Disorders; Nerve Block;

2020
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 128, Issue:6

    Topics: Adult; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Migraine Disorders; Milk, Human; Oxa

2021
Naratriptan in the Prophylactic Treatment of Cluster Headache.
    Internal medicine (Tokyo, Japan), 2017, Oct-01, Volume: 56, Issue:19

    Topics: Adult; Aged; Cluster Headache; Female; Humans; Japan; Male; Middle Aged; Migraine Disorders; Piperid

2017
Naratriptan May Become an Alternative Prophylactic Option for Patients with Cluster Headache.
    Internal medicine (Tokyo, Japan), 2017, 10-01, Volume: 56, Issue:19

    Topics: Cluster Headache; Humans; Indoles; Migraine Disorders; Piperidines; Tryptamines

2017
Use of existing electronic health care databases to evaluate medication safety in pregnancy: Triptan exposure in pregnancy as a case study.
    Pharmacoepidemiology and drug safety, 2018, Volume: 27, Issue:12

    Topics: Abnormalities, Drug-Induced; Administrative Claims, Healthcare; Adolescent; Adult; Databases, Factua

2018
[Publish your case report].
    Praxis, 2013, Feb-27, Volume: 102, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Editorial Policies; Female; Humans; Medical Records, Problem-Oriented

2013
Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse: a Fos protein study.
    Neurobiology of disease, 2014, Volume: 64

    Topics: Animals; Calcium Channels; Cerebellar Ataxia; Electric Stimulation; Gene Knock-In Techniques; Mice;

2014
Long-acting triptans and weather-related migraines.
    Headache, 2014, Volume: 54, Issue:1

    Topics: Adolescent; Carbazoles; Delayed-Action Preparations; Female; Follow-Up Studies; Humans; Male; Migrai

2014
Formulation, preparation, and evaluation of novel orally disintegrating tablets containing taste-masked naproxen sodium granules and naratriptan hydrochloride.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:4

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Drug Storage; Excip

2014
[Myocardial ischemia caused by overuse of headache medications].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2014, Volume: 109, Issue:7

    Topics: Combined Modality Therapy; Drug Substitution; Female; Humans; Middle Aged; Migraine Disorders; Myoca

2014
Maximum effect of triptans in migraine? A comment.
    Cephalalgia : an international journal of headache, 2008, Volume: 28, Issue:7

    Topics: Dose-Response Relationship, Drug; Humans; Injections, Subcutaneous; Migraine Disorders; Pain Measure

2008
Halide salts of antimigraine agents eletriptan and naratriptan.
    Acta crystallographica. Section C, Crystal structure communications, 2008, Volume: 64, Issue:Pt 12

    Topics: Analgesics; Crystallography, X-Ray; Halogens; Humans; Hydrogen Bonding; Migraine Disorders; Molecula

2008
Triptans and troponin: a case report.
    Orphanet journal of rare diseases, 2009, Jun-18, Volume: 4

    Topics: Acute Coronary Syndrome; Aged; Electrocardiography; Female; Humans; Migraine Disorders; Piperidines;

2009
Rizatriptan. Comparative trial results.
    Postgraduate medicine, 2000, Volume: 108, Issue:3 Suppl

    Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Migraine Disorders; Oxazolidinones; Pipe

2000
Drug dependence associated with triptans and ergot derivatives: a case/non-case study.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:4

    Topics: Claviceps; Dihydroergotamine; Ergotamine; Humans; Migraine Disorders; Oxazolidinones; Piperidines; P

2010
Pure naratriptan-induced ischemic colitis: a case report.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2010, Volume: 21, Issue:1

    Topics: Colitis, Ischemic; Female; Humans; Middle Aged; Migraine Disorders; Piperidines; Tryptamines; Vasoco

2010
Safety of triptans for migraine headaches during pregnancy and breastfeeding.
    Canadian family physician Medecin de famille canadien, 2010, Volume: 56, Issue:6

    Topics: Breast Feeding; Female; Humans; Migraine Disorders; Piperidines; Pregnancy; Pregnancy Complications;

2010
Migraine-like headache in a patient with complement 1 inhibitor deficient hereditary angioedema.
    Journal of Korean medical science, 2012, Volume: 27, Issue:1

    Topics: Adult; Angioedemas, Hereditary; Brain; Complement C1 Inhibitor Protein; Danazol; Estrogen Antagonist

2012
Restoring migraine sufferers' ability to function normally: a comparison of rizatriptan and other triptans in randomized trials.
    European neurology, 2002, Volume: 48, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Female; Humans; Indoles; Male; Middle Aged; Migraine

2002
[Ischemic colitis associated with naratriptan administration].
    Gastroenterologie clinique et biologique, 2002, Volume: 26, Issue:11

    Topics: Colitis, Ischemic; Female; Humans; Indoles; Middle Aged; Migraine Disorders; Piperidines; Serotonin

2002
[Early, but not unnecessarily frequent administration. What is proper timing for triptan drugs?].
    MMW Fortschritte der Medizin, 2003, Jan-16, Volume: 145, Issue:1-2

    Topics: Drug Administration Schedule; Humans; Indoles; Migraine Disorders; Pain Measurement; Piperidines; Se

2003
Naratriptan in the preventive treatment of refractory chronic migraine: a review of 27 cases.
    Headache, 2003, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Pain, Intractable

2003
[A descriptive analysis of naratriptan use among migraineurs in ambulatory medicine].
    Revue neurologique, 2003, Volume: 159, Issue:5 Pt 1

    Topics: Acute Disease; Adult; Ambulatory Care; Female; Follow-Up Studies; Humans; Indoles; Male; Migraine Di

2003
Investigation of the effects of naratriptan, rizatriptan, and sumatriptan on jugular venous oxygen saturation in anesthetized pigs: implications for their mechanism of acute antimigraine action.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:1

    Topics: Anesthesia; Animals; Blood Gas Analysis; Hemodynamics; Indoles; Jugular Veins; Male; Migraine Disord

2003
[Improved pharmacokinetics. Fast tryptan with sustained response].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Administration, Oral; Controlled Clinical Trials as Topic; Delayed-Action Preparations; Female; Head

2003
[Highly selective beginning. Associated symptoms and side effects in retrospect].
    MMW Fortschritte der Medizin, 2003, May-26, Volume: 145 Suppl 2

    Topics: Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Indoles; Migraine D

2003
Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy.
    Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:2

    Topics: Action Potentials; Animals; Cats; Cerebrovascular Circulation; Electric Stimulation; Indoles; Microe

2004
The sumatriptan/naratriptan aggregated patient (SNAP) database: aggregation, validation and application.
    Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:7

    Topics: Clinical Trials as Topic; Data Collection; Databases, Factual; Humans; Indoles; Logistic Models; Mig

2004
Correlation between lipophilicity and triptan outcomes.
    Headache, 2005, Volume: 45, Issue:1

    Topics: Central Nervous System Diseases; Chemical Phenomena; Chemistry, Physical; Humans; Indoles; Migraine

2005
Ischemic colitis associated with naratriptan and oral contraceptive use.
    Headache, 2005, Volume: 45, Issue:4

    Topics: Adult; Colitis, Ischemic; Contraceptives, Oral; Drug Interactions; Female; Humans; Indoles; Migraine

2005
Triptans for migraine therapy: a comparison based on number needed to treat and doses needed to treat.
    Journal of managed care pharmacy : JMCP, 2005, Volume: 11, Issue:5

    Topics: Algorithms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Costs; Humans; Mana

2005
Uncertainty analysis in pharmacokinetics and pharmacodynamics: application to naratriptan.
    Pharmaceutical research, 2005, Volume: 22, Issue:10

    Topics: Algorithms; Analgesics; Female; Humans; Male; Migraine Disorders; Models, Biological; Piperidines; S

2005
[Medical treatment of migraine attacks in the child].
    Revue de l'infirmiere, 2006, Issue:117

    Topics: Acetaminophen; Age Factors; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Ergot Alkalo

2006
Serotonin receptors modulate trigeminovascular responses in ventroposteromedial nucleus of thalamus: a migraine target?
    Neurobiology of disease, 2006, Volume: 23, Issue:3

    Topics: Afferent Pathways; Animals; Cerebral Arteries; Drug Interactions; Glutamic Acid; Male; Migraine Diso

2006
[Prophylactic measures and acute treatment of migraine].
    Schmerz (Berlin, Germany), 2006, Volume: 20, Issue:6

    Topics: Anticonvulsants; Humans; Migraine Disorders; Piperidines; Serotonin Agents; Tryptamines

2006
A model-based approach to treatment comparison in acute migraine.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:5

    Topics: Dose-Response Relationship, Drug; Humans; Markov Chains; Migraine Disorders; Models, Biological; Pip

2006
Glutamate levels in cerebrospinal fluid and triptans overuse in chronic migraine.
    Headache, 2007, Volume: 47, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Glutamic Acid; Headache Disorders; Headache D

2007
[The Vigimig study of naratriptan use in general practice].
    Presse medicale (Paris, France : 1983), 2007, Volume: 36, Issue:11 Pt 1

    Topics: Adult; Drug Prescriptions; Drug Utilization; Family Practice; Female; France; Humans; Male; Migraine

2007
Temporary confusion depending on the usage of naratriptan.
    The journal of headache and pain, 2007, Volume: 8, Issue:6

    Topics: Confusion; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Migraine Disorders; Piperidines;

2007
A triptan too far?
    Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:2

    Topics: Acute Disease; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinon

1998
Oral naratriptan approved for migraine attacks.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Apr-01, Volume: 55, Issue:7

    Topics: Drug Approval; Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Trypta

1998
Tolerability and efficacy of naratriptan tablets with long-term treatment (6 months). Naratriptan Long-term Study Group.
    Cephalalgia : an international journal of headache, 1998, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hum

1998
Coronary side-effect potential of current and prospective antimigraine drugs.
    Circulation, 1998, Jul-07, Volume: 98, Issue:1

    Topics: Adolescent; Adult; Aged; Angina Pectoris; Child; Coronary Vessels; Dihydroergotamine; Ergotamine; Fe

1998
When the migraine rx isn't working.
    RN, 1998, Volume: 61, Issue:8

    Topics: Administration, Oral; Adult; Contraindications; Female; Humans; Indoles; Migraine Disorders; Patient

1998
New "triptans" and other drugs for migraine.
    The Medical letter on drugs and therapeutics, 1998, Oct-09, Volume: 40, Issue:1037

    Topics: Adrenergic beta-Antagonists; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive

1998
[Zolmitriptan].
    Revue medicale de Bruxelles, 1998, Volume: 19, Issue:6

    Topics: Chemistry, Pharmaceutical; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidine

1998
Headache after frequent use of serotonin agonists zolmitriptan and naratriptan.
    Lancet (London, England), 1999, Jan-30, Volume: 353, Issue:9150

    Topics: Adult; Female; Headache; Humans; Indoles; Middle Aged; Migraine Disorders; Oxazoles; Oxazolidinones;

1999
Naratriptan is effective and well tolerated in the acute treatment of migraine.
    Neurology, 1999, Apr-12, Volume: 52, Issue:6

    Topics: Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Piperidines; Tryptamines; Vasoconstri

1999
[Pharmacy-clinic medication of the month. Naratriptan (naramig)].
    Revue medicale de Liege, 1999, Volume: 54, Issue:3

    Topics: Drug Administration Schedule; Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor A

1999
Vasoconstrictive properties of the 5HT1B/1D agonists: response to Dahlöf and Mathew.
    Cephalalgia : an international journal of headache, 1999, Volume: 19, Issue:5

    Topics: Humans; Indoles; Migraine Disorders; Piperidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin,

1999
Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2000, Volume: 14, Issue:3

    Topics: Bufotenin; Chromatography, High Pressure Liquid; Humans; Indoles; Mass Spectrometry; Migraine Disord

2000
Low migraine headache recurrence with naratriptan: clinical parameters related to recurrence.
    Headache, 2000, Volume: 40, Issue:2

    Topics: Acute Disease; Adult; Aged; Female; Humans; Indoles; Male; Middle Aged; Migraine Disorders; Piperidi

2000
Naratriptan prophylaxis of transformed migraine or hemicrania continua?
    Headache, 2000, Volume: 40, Issue:6

    Topics: Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Tryptamines; Vasocons

2000
Triptans to the rescue: effective therapy for migraine headaches in the workplace.
    Mayo Clinic proceedings, 2000, Volume: 75, Issue:8

    Topics: Absenteeism; Adult; Cost-Benefit Analysis; Efficiency; Female; Humans; Indoles; Injections, Subcutan

2000
Re: "Naratriptan in the prophylaxis of transformed migraine" (Sheftell FD Rapoport AM, Coddon DR. Headache.1999,39:506-510).
    Headache, 2000, Volume: 40, Issue:3

    Topics: Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor Agonists; Tryptamines; Vasocons

2000
Tolerability and efficacy of naratriptan tablets in the acute treatment of migraine attacks for 1 year. Naratriptan Long-Term Study Group.
    Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:5

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Indoles; Male; Middle Aged; Migraine Disord

2000
Are triptans with enhanced lipophilicity used for the acute treatment of migraine associated with an increased consulting rate for depressive illness?
    Cephalalgia : an international journal of headache, 2000, Volume: 20, Issue:8

    Topics: Cohort Studies; Depression; Female; Humans; Indoles; Male; Migraine Disorders; Oxazolidinones; Piper

2000
Modulation of neuronal activity in the nucleus raphé magnus by the 5-HT(1)-receptor agonist naratriptan in rat.
    Pain, 2001, Feb-15, Volume: 90, Issue:3

    Topics: Animals; Indoles; Male; Migraine Disorders; Neurons; Piperidines; Raphe Nuclei; Rats; Rats, Wistar;

2001
Treatment of migraine in Canada with naratriptan: a cost-effectiveness analysis.
    Headache, 2001, Volume: 41, Issue:5

    Topics: Canada; Cost-Benefit Analysis; Humans; Indoles; Migraine Disorders; Piperidines; Serotonin Receptor

2001
Effect of rizatriptan and other triptans on the nausea symptom of migraine: a post hoc analysis.
    Headache, 2001, Volume: 41, Issue:8

    Topics: Administration, Oral; Adult; Double-Blind Method; Humans; Indoles; Migraine Disorders; Nausea; Oxazo

2001
Sumatriptan and naratriptan tolerability and safety: an update of post-marketing experience.
    Cephalalgia : an international journal of headache, 2001, Volume: 21 Suppl 1

    Topics: Contraindications; Coronary Circulation; Dose-Response Relationship, Drug; Humans; Indoles; Injectio

2001
Looking forward: the expanding utility of sumatriptan and naratriptan.
    Cephalalgia : an international journal of headache, 2001, Volume: 21 Suppl 1

    Topics: Headache Disorders; Humans; Indoles; Migraine Disorders; Piperidines; Primary Health Care; Serotonin

2001
Building on the sumatriptan experience: the development of naratriptan.
    Cephalalgia : an international journal of headache, 2001, Volume: 21 Suppl 1

    Topics: Administration, Oral; Biological Availability; Clinical Trials as Topic; Dose-Response Relationship,

2001
Comparison of triptan tablet consumption per attack: a prospective study of migraineurs in Spain.
    Headache, 2002, Volume: 42, Issue:2

    Topics: Female; Humans; Indoles; Male; Migraine Disorders; Oxazolidinones; Piperidines; Prospective Studies;

2002