naphthoquinones has been researched along with Seizures* in 1 studies
1 other study(ies) available for naphthoquinones and Seizures
| Article | Year |
|---|---|
Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of Naphthoquinone Derivatives Containing Pyrazole and Pyrimidine Fragments.
Novel heterocyclic dichloronaphthoquinone derivatives have been synthesized by chlorine atom substitution in 2,3-dichloro-1,4-naphthoquinone to pyrazole or pyrimidine fragments. The structures of these compounds have been confirmed by FT-IR, ESI-MS, 1H?NMR, 13C-NMR and elementary analysis. Synthesized compounds were evaluated for their anticonvulsant action in a pentylenetetrazole (PTZ)-convulsion model and antidepressant activity in the forced swimming test (FST). All naphthoquinone derivatives at a dose 100 mg/kg indicated anticonvulsant effect in PTZ-induced test at 3 h and 24 h after oral administration. In addition, these compounds possessed prolonged antidepressant properties significantly reducing the duration of immobility time when compared to the reference drug amitriptyline. Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Antidepressive Agents; Depression; Male; Mice; Naphthoquinones; Pentylenetetrazole; Pyrazoles; Pyrimidines; Seizures | 2020 |