naphthoquinones and Scalp-Dermatoses

A previous analysis of undesirable events (UEvs), reported to four major companies following the use of hair-colouring products in Europe, showed that the reporting rates were stable for both oxidative and direct hair-colouring products over the period 2003-2006.. In order to verify the impact of risk management measures implemented since 2006, as well as the impact of a new Commission Regulation (No 1223/2009), the same four companies analysed cosmetovigilance data collected over an additional four-year period (2014-2017). The objective was to determine whether there was any time effect, country effect, or product type effect, as well as identify risk factors.. Each company collected reports of alleged UEvs, undesirable effects (UEfs) and serious undesirable effects (SUEs) for their products in their key European markets, and calculated the respective reporting rates (number of events/million units sold). A detailed analysis was performed on allergic contact dermatitis-type events.. The reporting rates for alleged UEvs and allergic-type UEfs associated with hair-colouring products remained stable over the four-year period, although a statistically significant decrease was observed for some companies. No time effect on SUEs was observed for three companies but a statistically significant decrease in SUEs was observed for one company. Black henna tattoos remained a major risk factor regarding SUEs due to hair dyes.. The reporting rates of undesirable events, including contact allergy-type events, were stable over time. This was true for oxidative and direct hair dyes, for both home use and professional exposure scenarios.

Topics: Dermatitis, Allergic Contact; Europe; Follow-Up Studies; Hair Dyes; Humans; Naphthoquinones; Product Surveillance, Postmarketing; Risk Factors; Scalp Dermatoses; Tattooing

Allergic contact dermatitis related to para-phenylendiamine (PPD) from temporary black henna tattoos and hair dyes has become an epidemic in recent years. Several cases of adverse skin reactions to PPD have been reported in the literature. Herein, we present a case of angioedema-like allergic contact dermatitis related to hair coloring with henna.

Topics: Adult; Angioedema; Dermatitis, Allergic Contact; Face; Hair Dyes; Humans; Male; Naphthoquinones; Scalp Dermatoses; Tongue

Temporary tattooing with black henna is known to cause contact dermatitis; however, this adverse effect is not considered to be life threatening. We report a female adolescent who used black henna as a hair dye and developed severe contact dermatitis with scalp, facial, and neck swelling causing hoarseness and stridor. A flexible bronchoscopy showed a normal epiglottis, and the patient was intubated, ventilated, and eventually recovered. We conclude that the use of black henna hair dye in sensitized patients can be life threatening.

Topics: Adolescent; Dermatitis, Allergic Contact; Edema; Female; Hair Dyes; Hoarseness; Humans; Naphthoquinones; Respiratory Sounds; Scalp Dermatoses

Topics: Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Hair Dyes; Humans; Middle Aged; Naphthoquinones; Patch Tests; Scalp Dermatoses

Topics: Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Eczema; Female; Hair Dyes; Humans; Middle Aged; Naphthoquinones; Patch Tests; Scalp Dermatoses