naphthoquinones and Pulmonary-Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from

Topics: Animals; Bleomycin; Cell Line; Fibroblasts; Lung; Mice; Naphthoquinones; p300-CBP Transcription Factors; Plant Roots; Plumbaginaceae; Pulmonary Fibrosis

We studied the protective effect of antioxidant echinochrome A on bleomycin-induced pulmonary fibrosis in rats at the early stages of postnatal ontogeny. Administration of echinochrome A was shown to reduce the severity of bleomycin-induced oxidative stress in the lungs, prevented the development of hypertrophy of interalveolar connective tissue and peribronchial lymphoid infiltration, and normalized the ratio of volume densities of interalveolar septa and alveolar lumen.

Topics: Animals; Antioxidants; Bleomycin; Lung; Naphthoquinones; Pulmonary Fibrosis; Rats