naphthoquinones and Myocardial-Infarction

Necrosis plays vital roles in living organisms which is related closely with various diseases. Non-invasively necrotic imaging can be of great values in clinical decision-making, evaluation of individualized treatment responses, and prediction of patient prognosis. This narrative review will demonstrate how the evolution of quinones for necrotic imaging has been promoted by searching for their active centers. In this review, we summarized the recent developments of various quinones with the continuous simplified π-conjugated cores in necrotic imaging and speculated their possible molecular mechanisms might be attributed to their intercalations with exposed DNA in necrotic tissues. We discussed their clinical challenges of necrotic imaging with quinones and their future translation studies deserved to be explored in personalized patient treatment.

Topics: Animals; Anthraquinones; Cells; DNA; Humans; Molecular Probes; Myocardial Infarction; Naphthoquinones; Necrosis; Quinones; Rats

To evaluate effects of histochrome on severity of reperfusion damage in opening of the coronary artery in patients with acute myocardial infarction (MI).. 86 acute MI patients were randomized into three groups. 26 patients of group 1 A received 100 mg histochrome 10 min before and 1 hour after intravenous bolus administration of thrombolytic streptokinase; 20 patients of group 1 B received histochrome by the same scheme on the disease day 1 followed by 100 mg/day for 10 days; 40 control patients have undergone thrombolysis without prophylactic histochrome.. In the control group ventricular extrasystoles (VES) arose in 100% patients, in groups 1A and 1B--in 27%. The same picture was observed in relation to episodes of accelerated idioventricular rhythm. Coronary reperfusion was accompanied by fast dynamics of ST segment and ORS complex in the control group. MI focus measured by the Selvester ECG method was less in histochrome groups. After myocardial reperfusion malonic dialdehyde in the serum rose 6 times in the control groups and was slightly elevated in groups 1A and 1B.. Preventive administration of histochrome before thrombolytic therapy to reperfuse myocardium diminishes reperfusion damage: inhibits activity of lipid peroxidation and development of necrosis focus in acute period of MI.

Topics: Antioxidants; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Naphthoquinones

Shikonin is widely acknowledged as a bioactive substance extracted from the root of lithospermum erythrorhizon with multifunction. It alleviates ischemic/reperfusion (I/R) injury in liver and brain. Due to the similar pathogenesis of I/R and hypoxia/reoxygenation (H/R)-stimulated injury, we aimed to explore the potential pharmacological effects of Shikonin on the myocardial injury. The rats with myocardial I/R injury and the primary cardiomyocytes with H/R-stimulated injury were taken as in vivo and in vitro models. 2,3,5-Triphenyltetrazolium chloride staining and ELISA kits were used for detection of myocardial infarction and cardiac injury. Hematoxylin and eosin and immunohistochemistry staining were used to analyze the effect of Shikonin on autophagy histology. Western blot was performed to detect the proteins related to autophagy and Hippo pathway. The results showed that SHK reduces the size of myocardial infarction, improved cardiac function, suppressed the expression of autophagy-related proteins, and reduced the amount of autophagosomes. The underlying mechanism is to activate Hippo pathway. In vitro assay also suggested that SHK enhanced the cell viability, reduced the apoptotic rates in rat primary cardiomyocytes. Collectively, our results demonstrated that SHK protects against myocardial I/R injury by inhibiting autophagy, of which the underlying molecular mechanism is to activate the Hippo signaling pathway.

Topics: Animals; Apoptosis; Autophagy; Hippo Signaling Pathway; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Naphthoquinones; Rats; Signal Transduction

A series of hydroxynaphthazarins has been synthesized. Some of them were found in in vivo experiments to be protectors of myocardium under ischemia-reperfusion and to reduce the infarction zone by 50% without any adverse effect. All compounds exhibit a moderate or small toxicity and are active in low doses.

Topics: Animals; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Chemical; Myocardial Infarction; Naphthoquinones; Nitroglycerin; Rabbits; Vasodilator Agents; Verapamil

Topics: Antioxidants; Humans; Myocardial Infarction; Myocardial Reperfusion Injury; Naphthoquinones; Spectrophotometry, Ultraviolet