naphthoquinones and Intestinal-Diseases

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays a crucial role in protection of cells from electrophile-induced toxicity through up-regulating phase II detoxifying enzymes and phase III transporters. We previously reported that oxidative stress induces up-regulation of interleukin-11 (IL-11), a member of the IL-6 family that ameliorates acetaminophen-induced liver toxicity. However, a role for IL-11 in protection of cells from electrophile-induced toxicity remains unclear. Here we show that an environmental electrophile, 1,2-naphthoquinone (1,2-NQ), but not 15d-prostaglandin J

Topics: Animals; Antineoplastic Agents; Cells, Cultured; Gene Expression Regulation; HEK293 Cells; Hep G2 Cells; Humans; Hydrogen Peroxide; Interleukin-11; Interleukin-11 Receptor alpha Subunit; Intestinal Diseases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Naphthoquinones; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Peritonitis; Prostaglandin D2; Reactive Oxygen Species