naphthoquinones and Hemorrhage

Topics: Aged; Clinical Trials as Topic; Hemorrhage; Hemostatics; Humans; Male; Middle Aged; Naphthoquinones; Placebos; Preoperative Care; Prostatectomy; Semicarbazides; Semicarbazones; Statistics as Topic

Arnebia euchroma (Royle) I.M.Johnst (AE) has been reported to be a potentially useful medicinal herb for the treatment of several circulatory diseases in traditional Chinese medicine. It shows effects such as "cooling of the blood," promotion of blood circulation, detoxification, and rash clearance.. To explore the hemostatic effect of the ethyl acetate extract of AE in mice.. In this study, we explored the effects of AE on bleeding time, blood coagulation time, platelet count, and blood coagulation parameters in normal Kunming mice. Different doses of the AE extract (5, 10, and 20 g kg. Bleeding and blood coagulation time were significantly lower and TT was shorter in the AE extract-treated groups than in the control groups. Furthermore, FIB levels and platelet count were higher, whereas blood platelet aggregation, blood platelet adhesion to fibrinogen, and PF-4 secretion from blood platelets were more obvious in the AE extract-treated groups than in the control group. However, no significant differences were detected for PT and aPTT between the extract-treated and control groups.. The ethyl acetate extract of AE showed potential hemostasis effects in mice by shortening the bleeding and coagulation time. In addition, the extract increased platelet count and induced blood platelet aggregation, blood platelet adhesion to fibrinogen, PF-4 secretion from blood platelets, and FIB level, while it shortened TT.

Topics: Animals; Blood Platelets; Boraginaceae; Fibrinogen; Hemorrhage; Hemostatics; Male; Mice; Molecular Structure; Naphthoquinones; Phytotherapy; Plant Extracts; Platelet Adhesiveness

The role of erythrocytes in realization of interrelation of the immunomodulating effects of lysozyme and naphthoquinones in normal and under conditions of acute hemorrhage was studied. Interaction of lysozyme and menadione at the level of intact erythrocytes and their stroma resulted in formation of highly efficient immunomodulating factors. The effect of such factors under conditions of acute hemorrhage was mediated by cytokines of the spleen macrophagael cells.

Topics: Acute Disease; Adjuvants, Immunologic; Animals; Drug Synergism; Erythrocytes; Hemorrhage; Leukocytes; Muramidase; Naphthoquinones; Rats; Rats, Wistar; Spleen; Vitamin K 1; Vitamin K 3

Topics: Animals; Blood Coagulation; Breast Feeding; Chickens; Female; Fish Products; Hemorrhage; History, 20th Century; Humans; Infant; Medicago sativa; Mycobacterium tuberculosis; Naphthoquinones; Plant Extracts; Pregnancy; Sterols; United States; Vitamin K; Vitamin K 1; Vitamins

Topics: Administration, Oral; Anemia; Animals; Dogs; Erythrocytes; Female; Haplorhini; Heinz Bodies; Hemoglobinometry; Hemorrhage; Liver; Male; Mice; Naphthoquinones; Prothrombin Time; Rats; Reticulocytes; Sex Factors; Species Specificity; Vitamin K

Topics: Adult; Child; Eye Diseases; Female; Hemorrhage; Hemostatics; Humans; Male; Naphthoquinones; Perfusion; Preoperative Care; Semicarbazides

Topics: Animals; Blood Pressure; Blood Pressure Determination; Capillary Resistance; Dogs; Hemorrhage; Hemostatics; Lagomorpha; Naphthoquinones; Pharmacology; Rabbits; Research

Topics: Antifibrinolytic Agents; Coumarins; Hemorrhage; Humans; Naphthoquinones; Phenprocoumon; Retinoids; Vitamin K; Vitamin K 1

Topics: Antifibrinolytic Agents; Coumarins; Dicumarol; Hemorrhage; Naphthoquinones; Poisoning; Retinoids; Vitamin K; Vitamin K 1

Topics: Anticoagulants; Antifibrinolytic Agents; Dicumarol; Hemorrhage; Hemostatics; Humans; Naphthoquinones; Vitamin K

Topics: Blood Coagulation; Hemorrhage; Humans; Naphthoquinones

Topics: Hemorrhage; Humans; Naphthoquinones

Topics: Antifibrinolytic Agents; Hemorrhage; Humans; Naphthoquinones; Retina; Retinal Hemorrhage; Retinoids; Vitamin K; Vitamins