naphthoquinones and Hand-Dermatoses

Topics: Adult; Burns, Chemical; Female; Hand Dermatoses; Hand Injuries; Humans; Naphthoquinones; Tattooing

Topics: Aged; Blister; Dermatitis, Irritant; Hand Dermatoses; Humans; Hyperpigmentation; Juglans; Male; Naphthoquinones

Topics: Adolescent; Coloring Agents; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Hand Dermatoses; Humans; Naphthoquinones; Neck

Topics: Adult; Coloring Agents; Dermatitis, Allergic Contact; Female; Hand Dermatoses; Humans; Naphthoquinones; Phenylenediamines; Tattooing

Capecitabine is a chemotherapeutic drug for use in cancers. Hand-foot syndrome (HFS) is side effect of capecitabine which can lead the cessation of the therapy or dose reduction. Henna (Lawsonia inermis) is a traditionally used plant of Middle-East that is applied on hands and feet. Some of cancer patients in capecitabine treatment who developed HFS, we recommended to apply henna. In these patients, six patients were grade 3 HFS and four were grade 2 HFS. Complete response (CR) were seen in four of grade 3 HFS and all of grade 2; two grade 3 HFS improved to grade 1. So far, in the chemotherapy, there was no need of dose reduction and also no side effect of henna seen. Clinical improvement in these patients may relate to anti-inflammatory, antipyretic and analgesic effects of henna. Prospective studies are needed to show this therapeutic effect of henna.

Topics: Administration, Cutaneous; Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Middle Aged; Naphthoquinones; Neoplasms; Paresthesia; Severity of Illness Index; Syndrome; Treatment Outcome

The use of temporary natural henna painting for body adornment and hair dyeing is very common in several countries of the Indian subcontinent, Middle East, and North Africa, and the fad is spreading in other parts of the world. Several cases of para-phenylenediamine (PPD) contaminated, temporary traditional/natural henna induced sensitization and acute allergic reaction have been reported, along with occasional serious long term and rare fatal consequences. We report here a 17-year-old girl with blisters over her hands of five-days duration that appeared within 72 hours of applying a temporary henna paint to her hands during a social occasion. Similar lesions were noted on her face. She had previously applied black henna only once, a year earlier without developing any lesions. Clinical diagnosis of acute allergic contact dermatitis (ACD) was made. After a short course of oral corticosteroids, topical mometasone furaote 1.0% cream, and oral antihistamines, the lesions healed completely over the next four weeks leaving post-inflammatory hypopigmentation. Patch testing done with standard European battery, PPD 1% in petrolatum, and commercially available natural henna powder revealed a 3+ reaction to PPD at 48 hours. No reaction was seen at the natural henna site. Awareness of the condition among physicians and the public and regulation regarding warnings of the risks of using such products is urgently warranted.

Topics: Adolescent; Allergens; Dermatitis, Allergic Contact; Diagnosis, Differential; Facial Dermatoses; Female; Hand Dermatoses; Humans; Naphthoquinones; Patch Tests; Phenylenediamines

Topics: Adult; Coloring Agents; Cosmetics; Dermatitis, Contact; Drug Eruptions; Female; Hand Dermatoses; Humans; Middle Aged; Naphthoquinones