naphthoquinones and Carcinoma--Endometrioid

Clinically, evidence shows that uterine corpus endometrial carcinoma (UCEC) patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have a higher death-rate. However, current anti-UCEC/coronavirus disease 2019 (COVID-19) treatment is lacking. Plumbagin (PLB), a pharmacologically active alkaloid, is an emerging anti-cancer inhibitor. Accordingly, the current report was designed to identify and characterize the anti-UCEC function and mechanism of PLB in the treatment of patients infected with SARS-CoV-2

Topics: Adult; Aged; Aged, 80 and over; Calcium-Binding Proteins; Carcinoma, Endometrioid; Computational Biology; COVID-19; COVID-19 Drug Treatment; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Association Studies; Host-Pathogen Interactions; Humans; Membrane Proteins; Middle Aged; Mitogen-Activated Protein Kinase 3; Molecular Docking Simulation; Naphthoquinones; Prognosis; SARS-CoV-2; Signal Transduction; Tumor Necrosis Factor-alpha; Uterus