naphthoquinones has been researched along with Ascites* in 7 studies
7 other study(ies) available for naphthoquinones and Ascites
| Article | Year |
|---|---|
Antitumor activity of liposomal naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ.
We previously observed that rhinacanthins-C, -N and -Q, three main naphthoquinone esters isolated from the roots of Thai medicinal plant; Rhinacanthus nasutus KURZ. (Acanthaceae) induced apoptosis of human cervical carcinoma HeLaS3 cells. Since these rhinacanthins showed limited solubility in aqueous medium, we attempted to entrap them into liposomal membrane: Liposomalization enabled injection of the drugs and the drugs were expected to transfer to lipoproteins in the bloodstream. Liposomal formulations of rhinacanthins-C, -N and -Q showed strong antiproliferative activity against HeLaS3 cells with the IC50 values of 32, 17, 70 microM; 19, 17, 52 microM and 2.7, 2.0 and 5.0 microM for the exposure time of 24, 48, and 72 h, respectively. These liposomes suppressed the tumor growth in Meth-A sarcoma-bearing BALB/c mice at the dose of 5.0 mg/kg/d for 10 d. Among rhinacanthins, liposomal rhinacanthin-N significantly suppressed solid tumor growth. Based on these results, our findings demonstrated that rhinacanthin-N suppressed tumor growth in vivo, and suggested that liposomes are useful for preparing injectable formulation of hydrophobic drugs. Topics: Acanthaceae; Animals; Antineoplastic Agents, Phytogenic; Ascites; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Esters; HeLa Cells; Humans; Lignans; Liposomes; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Naphthoquinones; Neoplasm Transplantation; Phytotherapy; Plant Extracts; Plant Roots; Plants, Medicinal; Sarcoma, Experimental; Survival Analysis; Thailand | 2006 |
Inhibition and stimulation of the biosynthesis of protein and nucleic acid. IV. Effect of 2-amino-1,4-naphthoquinone imine on the biosynthesis of nucleic acid and protein in Ehrlich mouse ascites tumor cells in vitro.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Cell-Free System; DNA, Neoplasm; Imines; In Vitro Techniques; Mice; Naphthoquinones; Neoplasm Proteins; Peptide Biosynthesis; RNA, Neoplasm; Time Factors | 1969 |
[Derivatives of dipheoro-acetic acid with antibacterial activity. 3].
Topics: Acetates; Amides; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Ascites; Bacillus megaterium; Bacillus subtilis; Bacteria; Carcinoma, Ehrlich Tumor; Esters; Male; Mice; Naphthoquinones; Proteus; Pseudomonas; Sarcina; Staphylococcus; Triazoles | 1968 |
[Further research on the effect of vitamin K on the respiration and glycolysis of ascites cells of NK lymphoma in white mice].
Topics: Animals; Ascites; Carbohydrate Metabolism; Cell Respiration; Glycolysis; Lymphoma; Metabolism; Mice; Naphthoquinones; Neoplasms, Experimental; Vitamin K | 1963 |
[The effect of vitamins K1, K3 and K4 on respiration, glycolysis and growth of ascites cells of Ehrlich carcinoma and NK-lymphoma in white mice].
Topics: Animals; Antifibrinolytic Agents; Ascites; Carcinoma; Glycolysis; Lymphoma; Metabolism; Mice; Naphthoquinones; Neoplasms, Experimental; Vitamin K; Vitamin K 1; Vitamins | 1962 |
Studies on the metabolism of rat-ascites-tumor with nitrogen mustard sensitive and resistant strains. VII. Effect of ubiquinone a vitamin K3 on succinate- and alpha-glyceropnosphate-neotetrazolium reductase.
Topics: Animals; Ascites; Carcinoma, Hepatocellular; Coenzymes; Electron Transport Complex II; Liver Neoplasms; Liver Neoplasms, Experimental; Mechlorethamine; Naphthoquinones; Neoplasms, Experimental; Oxidoreductases; Rats; Succinate Dehydrogenase; Succinates; Succinic Acid; Tetrazolium Salts; Ubiquinone; Vitamin K; Vitamin K 3 | 1962 |
Anti-cancer effects of naphthoquinone derivatives tested by a screening with Ehrlich ascites cells in mice.
Topics: Animals; Antineoplastic Agents; Ascites; Mice; Naphthoquinones; Neoplasms | 1959 |