naphthofluorescein has been researched along with Hypoxia* in 1 studies
1 other study(ies) available for naphthofluorescein and Hypoxia
| Article | Year |
|---|---|
Furin inhibition prevents hypoxic and TGFβ-mediated blood-brain barrier disruption.
Hypoxic blood-brain barrier (BBB) dysfunction is a common feature of CNS diseases however mechanisms underlying barrier disturbance are still largely unknown. This study investigated the role of transforming growth factor β (TGFβ), a cytokine known to induce expression of the proprotein convertase Furin, in hypoxia-mediated barrier compromise. We show that exposure of brain endothelial cells (ECs) to hypoxia (1% O Topics: Amino Acid Chloromethyl Ketones; Animals; Benzamides; Blood-Brain Barrier; Capillary Permeability; Cell Membrane Permeability; Cell Movement; Cells, Cultured; Dioxoles; Endothelial Cells; Enzyme Inhibitors; Fluoresceins; Furin; Hypoxia; Male; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type I; Signal Transduction; Transforming Growth Factor beta | 2019 |