nandrolone-phenpropionate and Body-Weight

The purpose of the present investigation was to study the effects of testosterone and anabolic steroids on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic steroids on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and HDL2 cholesterol concentrations of the androgen users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL cholesterol concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The HDL2 cholesterol concentration decreased by about 80% (P less than 0.01) and HDL3 cholesterol by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL cholesterol to total cholesterol and in HDL2 cholesterol to HDL3 cholesterol ratios were also noticed under the influence of exogenous androgens. The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes.

Topics: Adult; Anabolic Agents; Body Composition; Body Weight; Cholesterol, HDL; Doping in Sports; Follow-Up Studies; Humans; Lipids; Lipoproteins, HDL; Male; Methandrostenolone; Nandrolone; Physical Education and Training; Risk; Self Medication; Stanozolol; Testosterone; Time Factors

Respiratory failure in patients with COPD may be caused by insufficient force production or insufficient endurance capacity of the respiratory muscles. Anabolic steroids may improve respiratory muscle function in COPD. The effect of anabolic steroids on mitochondrial function in the diaphragm in emphysema is unknown. In an emphysematous male hamster model, we investigated whether administration of the anabolic steroid nandrolone decanoate (ND) altered the activity of mitochondrial respiratory chain complexes in the diaphragm. The bodyweight of hamsters treated with ND was decreased after treatment compared with initial values, and serum testosterone levels were significantly lower in hamsters treated with ND than in control hamsters. No difference in the activity of mitochondrial respiratory chain complexes in the diaphragm between normal and emphysematous hamsters was observed. Treatment with ND did not change the activity of mitochondrial respiratory chain complexes in the diaphragm of both normal and emphysematous hamsters. In emphysematous hamsters, administration of ND decreased the activity of succinate:cytochrome c oxidoreductase compared with ND treatment in normal hamsters. We conclude that anabolic steroids have negative effects on the activity of succinate:cytochrome c oxidoreductase and anabolic status in this emphysematous hamster model.

Topics: Anabolic Agents; Analysis of Variance; Animals; Body Weight; Cricetinae; Cytochrome-c Peroxidase; Data Interpretation, Statistical; Diaphragm; Disease Models, Animal; Injections, Intramuscular; Male; Mitochondria, Muscle; Nandrolone; Pulmonary Emphysema; Testosterone; Time Factors

The effects of three doses (1, 4 and 10 mg/kg body weight) of an anabolic steroid, nandrolone phenylpropionate (NPP), on body weight and composition, and muscle protein metabolism were investigated in female rats. Daily injections of 1 mg/kg of NPP for 10 days caused a significant increase in weight gain which was associated with an increase in body protein (9%) without affecting body fat. At higher doses this effect on body weight was attenuated, resulting in no change in body weight at 10 mg/kg. However body protein content was still increased (9%) whereas body fat content was significantly reduced (32%). NPP did not affect metabolizable energy intake at any dose tested. Body energy gain and gross energetic efficiency were both significantly reduced in animals treated with a dose of 10 mg/kg. The mass and protein content of gastrocnemius muscle were significantly increased in animals injected with NPP at all doses. Muscle protein synthesis measured in vivo was also significantly stimulated at 1 and 4 mg/kg but was not affected at 10 mg/kg. These data confirm an anabolic action of NPP and suggest highly dose-dependent effects on other parameters such as body weight, fat deposition and muscle protein synthesis.

Topics: Anabolic Agents; Animals; Body Composition; Body Weight; Dose-Response Relationship, Drug; Energy Metabolism; Female; Muscle Proteins; Nandrolone; Rats; Rats, Inbred Strains

An adult male bodybuilder of international level, who had decided to complement his training by self-administering the androgenic hormones (actually 53 mg/day), volunteered as a subject for investigation of his physical health and fitness over a training period of 1 year including only a 4-week abstinence from drugs in the middle of the year. The subject was able to gain greatly in fat-free weight (from 83 to 90 kg), in mean fiber area of the VL muscle (enlargement of 11.4% after a half year's training), and in maximal strength (from 5145 to 5948 N). The high level of serum testosterone and low level of serum SHBG observed tend to strengthen suggestions of the anabolic effects of androgenic steroids during training. The subject's health status was affected. A high serum E2 level during the use of androgens, atrophic testicles, and low LH, FSH, and T levels after drug withdrawal indicate that sustained testosterone/anabolic steroid administration affects the function of the pituitary and leads to long-lasting impairment of testicular endocrine function, and consequently to azoospermia and cynegomastia. The observed decrease in serum HDL-cholesterol (from 1.59 to 0.44 mmol/l) and in HDL2-cholesterol (from 0.42 to 0.01 mmol/l) may indicate a higher risk for atherogenesis.

Topics: Adipose Tissue; Adult; Anabolic Agents; Body Weight; Cholesterol, HDL; Diet; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Isometric Contraction; Luteinizing Hormone; Male; Methandrostenolone; Nandrolone; Physical Education and Training; Self Medication; Semen; Skin Diseases; Stanozolol; Testis; Testosterone

Topics: Animals; Body Weight; Female; Muscle Proteins; Nandrolone; Rats

Topics: Animals; Body Height; Body Weight; Epididymis; Genitalia, Male; Male; Nandrolone; Nandrolone Decanoate; Penis; Rats; Seminal Vesicles; Testis; Testosterone

The effect of 11 weekly injections of nandrolone phenylpropionate (400 mg) was investigated by a crossover trial (2 training periods) in 6 Thoroughbred geldings undergoing training. A decrease in body weight and flank measurement occurred only during the first training period and was not modified by the anabolic steroid. Urinary nitrogen excretion was lower in the anabolic treated animals only in the first training period. Neither training nor training plus nandrolone phenylpropionate administration caused any marked alteration in blood biochemistry or haematology. A significant decrease in plasma chloride and increase in haematocrit occurred independent of treatment in the latter, more extensive anaerobic training of both parts of the crossover. No change in urinary pH or specific gravity was found throughout the study. No evidence of improved racing performance due to nandrolone phenylpropionate administration was observed. Behavioural changes attributed to the drug could be detected for at least 6 weeks after the cessation of treatment.

Topics: Anabolic Agents; Animals; Body Weight; Creatinine; Horses; Male; Nandrolone; Nitrogen; Physical Conditioning, Animal

The age dependency of changes in food intake and body weight in Wistar rats after androgen and estrogen treatment was followed. The 5 age categories of female rats were treated by androgen and the 6 age categories of male rats were treated by estrogen. The androgen treatment induced an expressive increase in weight gains in all age categories of female rats, except the 1st (after birth), during 25 days from the beginning of the experiments. The increase of weight gains resulted in significantly higher body weight on the 25th day of experiments in the experimental rats. The differences in weight gains among the individual experimental groups after androgen treatment show a rising effect with the age of the animals. There was only a slight increase of food intake in the older experimental groups during the androgen treatment. The estrogen treatment in male rats induced an expressive decrease in weight gains in the 2nd age category (after weaning) and losses of body weight in older experimental groups during 20 days from the beginning of the treatment. The body weight of experimental animals on the 20th day was significantly lower than in the control ones. The losses of the body weight after the estrogen treatment rose with the age of the rats. The food intake was also considerably decreased by estrogen treatments, approximately equally in all experimental groups. The comparison of magnitude of the changes in food intake and body weight after androgen and estrogen treatments indicates that the primary effect of these hormones is their anabolic or catabolic activity which secondarily induces the changes in food intake and its utilization.

Topics: Aging; Androgens; Animals; Body Weight; Eating; Estradiol; Estrogens; Female; Male; Nandrolone; Rats; Rats, Inbred Strains

Topics: Antineoplastic Agents; Blood Platelets; Body Weight; Erythrocyte Count; Genital Neoplasms, Female; Hemoglobinometry; Humans; Leukocyte Count; Leukopenia; Nandrolone; Nandrolone Decanoate; Neoplasm Recurrence, Local; Neoplasms; Surgical Procedures, Operative; Triaziquone

Topics: Blood Cell Count; Blood Sedimentation; Body Weight; Colitis; Colitis, Ulcerative; Crohn Disease; Dumping Syndrome; Duodenal Ulcer; Enteritis; Gastrointestinal Diseases; Humans; Liver Cirrhosis; Liver Function Tests; Nandrolone; Nutrition Disorders

Topics: Body Weight; Child; Dehydroepiandrosterone; Humans; Infant; Infant Nutrition Disorders; Nandrolone; Phenylpropionates; Testosterone; Weight Gain

Topics: Body Weight; Child; Humans; Infant; Nandrolone; Testosterone; Weight Gain