naltrexone and Weight Gain

naltrexone has been researched along with Weight Gain in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (11.11)18.2507
2000's8 (22.22)29.6817
2010's15 (41.67)24.3611
2020's9 (25.00)2.80

Authors

AuthorsStudies
Akerman, S; Citrome, L; Cummings, H; McIntyre, RS; Tan, LA; Todtenkopf, MS; White, M1
Citrome, L; Faden, J; Serdenes, R1
Corrao, MM; Nelson, LA1
Gao, J; Li, J; Lu, X; Yang, J1
Graham, C; Sun, L; von Moltke, L; Yagoda, S; Yao, B1
Correll, CU; DiPetrillo, L; Du, Y; Graham, C; Hopkinson, C; Jiang, Y; Kahn, RS; McDonnell, D; Newcomer, JW; Silverman, B; Simmons, A1
Buchanan, RW1
Likhitsathian, S; Maneeton, B; Maneeton, N; Srisurapanont, M; Suttajit, S1
Paik, J1
Correll, CU; DiPetrillo, L; Kane, JM; Martin, W; Memisoglu, A; Silverman, BL1
McDonnell, D; Sun, L; von Moltke, L1
Correll, CU; DiPetrillo, L; Ehrich, EW; Jiang, Y; Martin, WF; Pathak, S; Silverman, BL; Weiden, PJ1
Kumar, V; McDonnell, D; Sun, L; von Moltke, L; Yu, M1
Cunningham, JI; Dean, RL; Deaver, DR; Eyerman, DJ; Namchuk, M; Sanchez, C; Todtenkopf, MS1
Guloksuz, S; Reutenauer, EL; Srihari, VH; Tek, C1
Ganguli, R; O'Malley, SS; Ratliff, J; Reutenauer, E; Tek, C1
Howland, RH1
Aronne, LJ; Igel, LI; Kumar, RB; Saunders, KH1
Burnand, B; Nanchen, D; Peytremann-Bridevaux, I; Walther, MR; Willi, C1
Billes, SK; Dunayevich, E; Erickson, JS; Katz, BB; Oskooilar, N; Tollefson, G; Wilcox, CS1
Kaplan, LM1
Jatlow, P; Makuch, R; Meandzija, B; O'Malley, SS; Toll, BA; White, M; Wu, R1
Borsook, D; Currie, PJ; Elman, I; Kurbanov, DB; Simonson, DC1
Cai, X; Cao, D; deWit, H; King, AC; Kranzler, HR; Matthews, AK; O'Malley, SS; Stachoviak, RJ1
Cao, D; King, AC; O'Malley, SS; Zhang, L1
Corp, ES; Jones, JE1
Chen, RZ; Fong, TM; Huang, RR; MacNeil, DJ; Shen, CP1
Blakeslee, A; Cooney, JL; Cooney, NL; Dubin, JA; Jatlow, P; Krishnan-Sarin, S; Makuch, R; McKee, SA; Meandzija, B; O'Malley, SS; Romano-Dahlgard, D; Wu, R1
McKee, SA; O'malley, SS; White, MA1
Katulak, NA; O'Malley, S; Toll, BA; Williams-Piehota, P1
Leary, V; Meandzija, B; O'Malley, SS; Salovey, P; Toll, BA; Wu, R1
Shaw, WN1
Alam, MY; Becker, JA; Goldman, MB; Luchins, DJ1
Barocka, A; Kaschka, WP; Plaskacewicz, GJ; Rechlin, T; Wildt, L; Zimmermann, U1
Lang, CM; McLaughlin, PJ; Tobias, SW; Zagon, IS1
Acosta, A; Baptista, T; Colasante, C; de Mendoza, S; de Quijada, M; Hernández, L; Lacruz, A; Mendoza, JM1

Reviews

8 review(s) available for naltrexone and Weight Gain

ArticleYear
Opioid antagonism mitigates antipsychotic-associated weight gain: focus on olanzapine.
    CNS spectrums, 2023, Volume: 28, Issue:3

    Topics: Analgesics, Opioid; Antipsychotic Agents; Humans; Naltrexone; Narcotic Antagonists; Olanzapine; Receptors, Opioid, kappa; Weight Gain

2023
Olanzapine-samidorphan combination tablets for the treatment of schizophrenia and bipolar I disorder - what is it, and will it be used?
    Expert review of neurotherapeutics, 2022, Volume: 22, Issue:5

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Humans; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Tablets; Weight Gain

2022
Olanzapine/Samidorphan: A New Combination Treatment for Schizophrenia and Bipolar I Disorder Intended to Reduce Weight Gain.
    CNS drugs, 2022, Volume: 36, Issue:6

    Topics: Analgesics, Opioid; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Humans; Naltrexone; Olanzapine; Schizophrenia; Weight Gain

2022
A meta-analysis comparing short-term weight and cardiometabolic changes between olanzapine/samidorphan and olanzapine.
    Scientific reports, 2021, 04-07, Volume: 11, Issue:1

    Topics: Antipsychotic Agents; Cardiometabolic Risk Factors; Drug Therapy, Combination; Female; Humans; Male; Metabolic Syndrome; Naltrexone; Olanzapine; Schizophrenia; Weight Gain

2021
Olanzapine/Samidorphan: First Approval.
    Drugs, 2021, Volume: 81, Issue:12

    Topics: Antipsychotic Agents; Bipolar Disorder; Drug Combinations; Humans; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Weight Gain

2021
Melatonin, Liraglutide, and Naltrexone/Bupropion for the Treatment of Obesity and Medication-Related Weight Gain.
    Journal of psychosocial nursing and mental health services, 2015, Volume: 53, Issue:6

    Topics: Anti-Obesity Agents; Bupropion; Drug Combinations; Humans; Liraglutide; Melatonin; Naltrexone; Obesity; Psychotropic Drugs; Weight Gain

2015
Practical Use of Pharmacotherapy for Obesity.
    Gastroenterology, 2017, Volume: 152, Issue:7

    Topics: Androgens; Anti-Obesity Agents; Antidepressive Agents; Antihypertensive Agents; Antipsychotic Agents; Appetite Depressants; Benzazepines; Bupropion; Drug Combinations; Fructose; Humans; Hypoglycemic Agents; Hypogonadism; Lactones; Liraglutide; Naltrexone; Obesity; Orlistat; Phentermine; Testosterone; Topiramate; Weight Gain

2017
Pharmacologic therapies for obesity.
    Gastroenterology clinics of North America, 2010, Volume: 39, Issue:1

    Topics: Anti-Obesity Agents; Appetite Depressants; Bariatric Surgery; Benzazepines; Bupropion; Cyclobutanes; Ephedrine; Fenfluramine; Humans; Lactones; Naltrexone; Obesity; Orlistat; Phentermine; Weight Gain; Weight Loss

2010

Trials

15 trial(s) available for naltrexone and Weight Gain

ArticleYear
Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study.
    The American journal of psychiatry, 2020, 12-01, Volume: 177, Issue:12

    Topics: Adolescent; Adult; Antipsychotic Agents; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Weight Gain; Young Adult

2020
A randomized, double-blind, placebo-controlled proof of concept study to evaluate samidorphan in the prevention of olanzapine-induced weight gain in healthy volunteers.
    Schizophrenia research, 2018, Volume: 195

    Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Naltrexone; Narcotic Antagonists; Olanzapine; Time Factors; Weight Gain; Young Adult

2018
Pharmacokinetics and Short-term Safety of ALKS 3831, a Fixed-dose Combination of Olanzapine and Samidorphan, in Adult Subjects with Schizophrenia.
    Clinical therapeutics, 2018, Volume: 40, Issue:11

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Chromatography, Liquid; Drug Combinations; Female; Humans; Male; Middle Aged; Naltrexone; Olanzapine; Schizophrenia; Tandem Mass Spectrometry; Weight Gain

2018
Mitigation of Olanzapine-Induced Weight Gain With Samidorphan, an Opioid Antagonist: A Randomized Double-Blind Phase 2 Study in Patients With Schizophrenia.
    The American journal of psychiatry, 2019, 06-01, Volume: 176, Issue:6

    Topics: Adult; Antipsychotic Agents; Constipation; Dizziness; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Sleepiness; Weight Gain

2019
A Phase I Open-Label Study to Evaluate the Effects of Rifampin on the Pharmacokinetics of Olanzapine and Samidorphan Administered in Combination in Healthy Human Subjects.
    Clinical drug investigation, 2019, Volume: 39, Issue:5

    Topics: Adult; Antipsychotic Agents; Cytochrome P-450 CYP3A Inducers; Drug Interactions; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Olanzapine; Rifampin; Weight Gain; Young Adult

2019
Investigating the safety and efficacy of naltrexone for anti-psychotic induced weight gain in severe mental illness: study protocol of a double-blind, randomized, placebo-controlled trial.
    BMC psychiatry, 2013, Jun-27, Volume: 13

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Clinical Protocols; Double-Blind Method; Female; Humans; Male; Mental Disorders; Middle Aged; Naltrexone; Narcotic Antagonists; Overweight; Psychotic Disorders; Research Design; Schizophrenia; Weight Gain; Weight Loss

2013
A randomized, double-blind, placebo-controlled pilot study of naltrexone to counteract antipsychotic-associated weight gain: proof of concept.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Cholesterol; Double-Blind Method; Female; Glycated Hemoglobin; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Psychotic Disorders; Quality of Life; Schizophrenia; Triglycerides; Weight Gain; Young Adult

2014
An open-label study of naltrexone and bupropion combination therapy for smoking cessation in overweight and obese subjects.
    Addictive behaviors, 2010, Volume: 35, Issue:3

    Topics: Adult; Bupropion; Cotinine; Counseling; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Obesity; Overweight; Smoking; Smoking Cessation; Substance Withdrawal Syndrome; Treatment Outcome; Weight Gain

2010
Low-dose naltrexone augmentation of nicotine replacement for smoking cessation with reduced weight gain: a randomized trial.
    Drug and alcohol dependence, 2010, Oct-01, Volume: 111, Issue:3

    Topics: Administration, Cutaneous; Adult; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Naltrexone; Nicotine; Prospective Studies; Smoking; Smoking Cessation; Weight Gain

2010
Effects of naltrexone on smoking cessation outcomes and weight gain in nicotine-dependent men and women.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:5

    Topics: Administration, Oral; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Sex Factors; Smoking Cessation; Time Factors; Tobacco Use Cessation Devices; Tobacco Use Disorder; Treatment Outcome; Weight Gain

2012
Naltrexone reduction of long-term smoking cessation weight gain in women but not men: a randomized controlled trial.
    Biological psychiatry, 2013, May-01, Volume: 73, Issue:9

    Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Sex Factors; Smoking Cessation; Treatment Outcome; Weight Gain

2013
A controlled trial of naltrexone augmentation of nicotine replacement therapy for smoking cessation.
    Archives of internal medicine, 2006, Mar-27, Volume: 166, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Ambulatory Care; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Linear Models; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Smoking Cessation; Substance Withdrawal Syndrome; Surveys and Questionnaires; Treatment Outcome; Weight Gain

2006
Smoke and mirrors: magnified beliefs that cigarette smoking suppresses weight.
    Addictive behaviors, 2007, Volume: 32, Issue:10

    Topics: Adult; Culture; Feeding Behavior; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Overweight; Psychiatric Status Rating Scales; Self Concept; Smoking; Smoking Cessation; Weight Gain

2007
Validation of a scale for the assessment of food cravings among smokers.
    Appetite, 2008, Volume: 50, Issue:1

    Topics: Administration, Cutaneous; Appetite; Dietary Fats; Dietary Sucrose; Female; Food Preferences; Humans; Male; Naltrexone; Nicotine; Placebos; Reproducibility of Results; Smoking; Smoking Cessation; Surveys and Questionnaires; Taste; Weight Gain

2008
Effect of naltrexone on weight gain and food craving induced by tricyclic antidepressants and lithium: an open study.
    Biological psychiatry, 1997, Mar-15, Volume: 41, Issue:6

    Topics: Adult; Antidepressive Agents, Tricyclic; Appetite; Depressive Disorder; Female; Humans; Lithium; Middle Aged; Naltrexone; Narcotic Antagonists; Psychiatric Status Rating Scales; Weight Gain

1997

Other Studies

13 other study(ies) available for naltrexone and Weight Gain

ArticleYear
Samidorphan for the treatment of weight gain associated with olanzapine in patients with schizophrenia and bipolar disorder.
    Expert review of clinical pharmacology, 2022, Volume: 15, Issue:9

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Humans; Naltrexone; Narcotic Antagonists; Olanzapine; Schizophrenia; Weight Gain

2022
Combination of Olanzapine and Samidorphan Has No Clinically Significant Effect on the Pharmacokinetics of Lithium or Valproate.
    Clinical drug investigation, 2020, Volume: 40, Issue:1

    Topics: Adult; Antipsychotic Agents; Cohort Studies; Drug Combinations; Drug Interactions; Female; Humans; Lithium Carbonate; Male; Naltrexone; Narcotic Antagonists; Olanzapine; Valproic Acid; Weight Gain; Young Adult

2020
How Much of an Advance Is the Addition of Samidorphan to Olanzapine?
    The American journal of psychiatry, 2020, 12-01, Volume: 177, Issue:12

    Topics: Antipsychotic Agents; Humans; Naltrexone; Olanzapine; Schizophrenia; Weight Gain

2020
Samidorphan mitigates olanzapine-induced weight gain and metabolic dysfunction in rats and non-human primates.
    Journal of psychopharmacology (Oxford, England), 2019, Volume: 33, Issue:10

    Topics: Adipose Tissue; Animals; Antipsychotic Agents; Drug Combinations; Female; Glucose Metabolism Disorders; Macaca fascicularis; Male; Naltrexone; Narcotic Antagonists; Olanzapine; Rats; Rats, Sprague-Dawley; Sex Factors; Weight Gain

2019
[Preventing weight gain in smoking cessation: there is no miracle solution].
    Revue medicale suisse, 2009, Aug-05, Volume: 5, Issue:212

    Topics: Adult; Bupropion; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Female; Fluoxetine; Humans; Naltrexone; Narcotic Antagonists; Patient Education as Topic; Risk; Selective Serotonin Reuptake Inhibitors; Smoking Cessation; Substance Withdrawal Syndrome; Weight Gain

2009
Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:9

    Topics: Animals; Antipsychotic Agents; Appetite Depressants; Appetite Regulation; Behavior, Animal; Benzodiazepines; Delayed-Action Preparations; Drug Interactions; Energy Intake; Feeding Behavior; Female; Injections, Intramuscular; Injections, Intraperitoneal; Leptin; Naltrexone; Narcotic Antagonists; Olanzapine; Random Allocation; Rats; Rats, Wistar; Weight Gain

2012
Effect of naltrexone on food intake and body weight in Syrian hamsters depends on metabolic status.
    Physiology & behavior, 2003, Volume: 78, Issue:1

    Topics: Animals; Body Weight; Cricetinae; Drinking; Eating; Female; Male; Mesocricetus; Metabolism; Naltrexone; Narcotic Antagonists; Weight Gain

2003
Chronic administration of nalmefene leads to increased food intake and body weight gain in mice.
    European journal of pharmacology, 2004, Jul-08, Volume: 495, Issue:1

    Topics: Administration, Oral; Animals; Diet; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Eating; Energy Intake; Intubation, Gastrointestinal; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Time Factors; Weight Gain

2004
A preliminary investigation of naltrexone augmentation of bupropion to stop smoking with less weight gain.
    Addictive behaviors, 2008, Volume: 33, Issue:1

    Topics: Adult; Bupropion; Case-Control Studies; Combined Modality Therapy; Dopamine Uptake Inhibitors; Drug Therapy, Combination; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Smoking Cessation; Treatment Outcome; Weight Gain

2008
Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:3

    Topics: Albuterol; Animals; Appetite Depressants; Cyclohexanes; Dextroamphetamine; Drug Tolerance; Eating; Endorphins; Female; Fenfluramine; Injections, Subcutaneous; Male; Naltrexone; Obesity; Piperidines; Rats; Rats, Zucker; Weight Gain

1993
Effects of naltrexone on mannerisms and water imbalance in polydipsic schizophrenics: a pilot study.
    Schizophrenia research, 1995, Volume: 17, Issue:3

    Topics: Adult; Antipsychotic Agents; Drinking; Drug Therapy, Combination; Humans; Hyponatremia; Male; Naltrexone; Narcotic Antagonists; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Stereotyped Behavior; Treatment Outcome; Water-Electrolyte Balance; Weight Gain

1995
Opioid receptor blockade during prenatal life modifies postnatal behavioral development.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Female; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reflex; Weight Gain

1997
Naltrexone does not prevent the weight gain and hyperphagia induced by the antipsychotic drug sulpiride in rats.
    Appetite, 2000, Volume: 34, Issue:1

    Topics: Animals; Antipsychotic Agents; Diestrus; Eating; Female; Hyperphagia; Naltrexone; Narcotic Antagonists; Obesity; Rats; Rats, Wistar; Sulpiride; Weight Gain

2000