naltrexone and Recrudescence

naltrexone has been researched along with Recrudescence in 137 studies

Research

Studies (137)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (6.57)	18.7374
1990's	29 (21.17)	18.2507
2000's	43 (31.39)	29.6817
2010's	38 (27.74)	24.3611
2020's	18 (13.14)	2.80

Authors

Authors	Studies
Bisaga, A; Carpenter, KM; Choi, CJ; Levin, FR; Mariani, JJ; Mishlen, K; Nunes, EV; Pavlicova, M; Sullivan, MA	1
Boney, TY; Bonnie, RJ; Chen, DT; Friedmann, PD; Gordon, M; Kinlock, TW; Lee, JD; Murphy, SM; Nunes, EV; O'Brien, CP; Polsky, D	1
Benth, JŠ; Fadnes, LT; Gaulen, Z; Kunøe, N; Latif, ZE; Opheim, A; Solli, KK; Tanum, L	1
Brenna, IH; Fadnes, LT; Gaulen, Z; Kunoe, N; Opheim, A; Šaltytė Benth, J; Solli, KK; Tanum, L	1
Bunting, AM; Choo, TH; Krawczyk, N; Lee, JD; McNeely, J; Nunes, E; Pavlicova, M; Rotrosen, J; Tofighi, B	1
Angermaier, G; Carswell, N; Castaneda, C; Delgado, F	1
Batty, E; Booty, M; Eddens, K; Knudsen, HK; Oser, CB; Perry, B; Rockett, M; Staton, M	1
Creech, ZA; Koushik, SS; Noss, B; Poliwoda, S; Truong, GTD; Urits, I; Viswanath, O	1
Benth, JŠ; Fadnes, LT; Gaulen, Z; Kloster, PS; Kunøe, N; Opheim, A; Solli, KK; Tanum, L	1
Chan, MH; Chen, HH; Chen, LC	1
Fogelman, N; Hermes, G; Hyman, SM; Kosten, TR; Sinha, R	1
Kreek, MJ; Zhou, Y	1
Bisaga, A; Levin, FR; Mariani, JJ; Mishlen, K; Nunes, EV; Sibai, M	1
Altomare, J; Bahji, A; Carlone, D	1
Anton, RF; Arias, AJ; Feinn, R; Gelernter, J; Gueorguieva, R; Hartwell, EE; Hoffman, M; Kranzler, HR; Krystal, J; Morris, PE; Oslin, D; Petrakis, I; Schacht, JP	1
Farrer, LA; Henderson, DC; Kranzler, HR; Lin, Y; Xu, H; Zhang, H	1
Kebir, O; Laqueille, X; Mouaffak, F	1
Adhikari, S; Chapagai, M; Dhungana, S; Ojha, SP; Pant, SB; Tulachan, P	1
Elman, I; Langleben, DD; Shi, Z; Wang, AL	1
Farnaghi, F; Gholami, N; Hassanian-Moghaddam, H; McDonald, R; Saberi, M; Zamani, N	1
Bach, P; Hermann, D; Hoffmann, S; Kiefer, F; Mann, K; Pompili, E; Sommer, WH; Vollstädt-Klein, S; Weil, G	1
Campbell, ANC; Choo, TH; Fishman, M; Greiner, MG; Lee, JD; Novo, P; Nunes, EV; Pavlicova, M; Rotrosen, J; Scodes, J; Shulman, M	1
Boney, TY; Chen, DT; Fishman, MJ; Friedmann, PD; Gordon, M; Hu, MC; Lee, JD; Nunes, EV; O'Brien, CP; Wilson, D	1
Clarke, JG; Friedmann, PD; Hoskinson, R; Poshkus, M; Wilson, D	1
Bonnet, U; Dembski, N; Niederhofer, A; Niederhofer, E; Nyhuis, PW; Scherbaum, N; Schifano, F; Specka, M; Tenbergen, M	1
Crowley, R; Kreek, MJ; Prisinzano, T; Zhou, Y	1
Baillie, A; Haber, PS; Kranzler, HR; Luquin, N; Morley, KC; Shanahan, M; Teesson, M; Trent, R	1
Bowden-Jones, H; Smith, N; Ward, S	1
Barocas, JA; Saitz, R	1
Acion, L; Arndt, S; Jorge, RE; Li, R; Liu, X; McGavin, JK; Shorter, DI	1
Briand, LA; Graziane, NM; Kauer, JA; Pierce, RC; Polter, AM	1
Hallgren, KA; Witkiewitz, K	1
Chenut, C; Papageorgiou, C; Streel, E; Verbanck, P	1
Hashemian, M; Kolahi, AA; Mohajerani, SA; Mottaghi, K; Safari, F; Salimi, A	1
Courchesne, S; Eigenmann, K; Gelinas, J; Schouela, N; Sedki, F; Shalev, U	1
Braciszewski, JM; Falk, D; Kranzler, HR; O'Malley, SS; Stout, RL; Subbaraman, MS	1
Grosshans, M; Kiefer, F; Mutschler, J	1
Donoghue, K; Drummond, C; Elzerbi, C; Pilling, S; Saunders, R; Whittington, C	1
Gourevitch, MN; Grossman, E; Laska, E; Lee, JD; McDonald, R; McNeely, J; Rotrosen, J	1
Saitz, R	1
Berrettini, W; Gordon, AJ; Leong, SH; Lynch, KG; O'Brien, CP; Oslin, DW; Rukstalis, M	1
Frohe, T; Kirouac, M; Maisto, SA; McCallion, E; Vowles, KE; Witkiewitz, K	1
Blokhina, EA; Burakov, AM; Bushara, EM; Grininko, AY; Kosten, T; Krupitsky, EM; Masalov, DV; Palatkin, VY; Romanova, TN; Sinha, R; Tiurina, AA; Verbitskaya, VE; Yaroslavtseva, TS; Zvartau, EE	1
Sushchyk, S; Wang, JB; Xi, ZX	1
Klein, JW	1
Mihalova, T; Salam, S; Siripurapu, R	1
Alagoz, E; Gustafson, DH; Johnson, RA; Kornfield, R; Landucci, G; Mares, ML; McTavish, F; Pe-Romashko, K; Quanbeck, A; Shah, D; Thomas, C; Westergaard, RP	1
Fitzgerald, TT; Gordon, MS; O'Brien, CP; O'Grady, KE; Vocci, FJ	1
Chawarski, MC; Mazlan, M; Schottenfeld, RS	1
O'Brien, CP	3
Choi, SW; Choi, YS; Jae, YM; Kim, CM; Kim, HO; Kim, JG; Kim, SG; Kim, SY; Lee, HG; Oslin, DW; Son, BK	1
Albanese, M; Herman, J; Khantzian, E; Kueppenbender, K	1
Akhtaruzzaman, M; Hoque, MM; Hossain, KJ; Kamal, MM	1
Arnold-Reed, D; Hulse, GK; Morris, N; Tait, RJ	1
Hulse, GK; Ngo, HT; Tait, RJ	1
Krupitsky, E; O'Brien, CP; Woody, GE; Zvartau, E	1
Lapham, SC; McMillan, GP	1
Alexander, M; Forman, R; Oslin, DW; Swift, R	1
Chamorro, AJ; González-Sarmiento, R; Laso, FJ; Marcos, M; Mirón-Canelo, JA; Pastor, I	1
Carroll, FI; Damaj, MI; Jackson, KJ; McLaughlin, JP	1
Jovanović, T; Lazarević, D; Nikolić, G	1
Bujarski, S; Lunny, K; O'Malley, SS; Ray, LA	1
Liu, X; Weiss, F	1
Arias, F; Casas, M; Caso, C; Gonzalvo, B; Gual, A; Guardia, J; Mengual, I; Ramírez, M; Sanahuja, J; Segura, L; Trujols, J	1
Böning, J; Bonnet, U; Croop, R; Gastpar, M; Kielstein, V; Labriola, D; Mann, K; Schmidt, LG; Soyka, M; Wetterling, T	1
Bertschy, G; Besson, J; Bochud Tornay, C; Daeppen, JB; Favrat, B; Monnat, M; Schnyder, C	1
Froehlich, JC; O'Malley, SS	1
Brewer, C; Foster, J; Steele, T	1
Grinenko, AIa; Krupitskiĭ, EM; Zvartau, EE	1
Littleton, J; Zieglgänsberger, W	1
Castellano, M; Cervera, G; Martínez-Raga, J; Perez-Galvez, B; Sabater, A	1
Gerrits, MA; Kuzmin, AV; van Ree, JM	1
Feinn, R; Kranzler, HR	1
Demiralay, C; Jahn, H; Kiefer, F; Otte, C; Wiedemann, K; Wolf, K	1
Besson, J; Broers, B; Dorogy, F; Favrat, B; Krenz, S; Muller, J; Zimmermann, G; Zullino, D; Zwahlen, A	1
Adinoff, B; Junghanns, K; Kiefer, F; Krishnan-Sarin, S	1
Chen, CC; Chen, CH; Huang, MC; Yu, JM	1
Burns, LH; Leri, F	1
Aicardi, G; Burattini, C; Gill, TM; Janak, PH	1
Jung, YC; Namkoong, K	1
Grant, JE	1
Cornish, JW; O'Brien, C	1
Dackis, CA; Kampman, KM; O'Brien, CP; Oslin, DW; Pettinati, HM; Rabinowitz, AR; Wortman, SP	1
Diehl, A; Jiménez-Arriero, MA; Kiefer, F; Klein, O; Rubio, G	1
Akerele, E; Anen, SJ; Bisaga, A; Brooks, AC; Carpenter, K; Comer, SD; Garawi, F; Jiang, H; Nunes, EV; Raby, WN; Sullivan, MA	1
Dannon, PN; Gonopolsky, Y; Kotler, M; Lowengrub, K; Musin, E	1
Tyndale, R	1
Childress, AR; Ehrman, RN; McLellan, AT; O'Brien, CP; Ternes, J	1
Arndt, R; Evans, B; Greenstein, RA; O'Brien, CP; Woody, GE	1
Rawson, RA; Tennant, FS	1
Azatian, A; Joseph, H; Papiasvilli, A	1
Buongiorno, G; Hsuing, H; Kuznetsov, O; Swift, RM; Whelihan, W	1
O'Mara, NB; Wesley, LC	1
Porat, S; Shufman, EN; Witztum, E	1
Gelkopf, M; Lerner, AG; Sigal, M	1
Ciervo, U; Coccoli, M; Giannini, P; Rocchi, R; Rugolo, AP	1
Buzan, RD; Dubovsky, SL; Thomas, M; Treadway, J	1
Jaffe, AJ; O'Malley, SS; Rode, S; Rounsaville, BJ	1
Hoffman, RE; Ostroff, RB; Roth, AS	1
O'Brien, CP; Volpicelli, JR; Volpicelli, LA	1
O'Malley, SS	2
Chang, G; Jaffe, AJ; Meyer, RE; O'Malley, SS; Rounsaville, B; Schottenfeld, RS	2
Ehrenreich, H; Poser, W	1
Spanagel, R; Zieglgänsberger, W	1
Compton, P; Pasero, CL	1
Farren, CK; O'Malley, S	1
Cohen, H; Kotler, M; Rabinowitz, J; Tarrasch, R	1
Kranzler, HR	1
O'Brien, CP; Weinrieb, RM	1
Krois, S; Liberto, JG; Norbeck, J; O'Brien, J; Oslin, D	1
Alvarez, M; Cabré, L; Carrasco, G; Costa, J; Hernández, E; Molina, R; Puiggrós, A; Seoane, A; Sobrepere, G	1
Cohen, H; Kotler, M; Rabinowitz, J	1
Malerich, JA	1
Anton, RF; Dias, JK; Latham, PK; Malcolm, RJ; Moak, DH; Waid, LR	1
Kranzler, HR; Modesto-Lowe, V; Van Kirk, J	1
Eichmiller, PR; Gorelick, DA; Heishman, SJ; Hill, BH; Liberto, JG; Norbeck, J; Rothman, RB	1
Abels, I; Albanese, AP; Eustace, JC; Field, JM; Gevirtz, C; Oppenheim, B	1
Lawental, E	1
Henniger, MS; Hölter, SM; Lipkowski, AW; Spanagel, R	1
Alho, H; Heinälä, P; Kiianmaa, K; Kuoppasalmi, K; Lönnqvist, J; Sinclair, JD	1
Yarborough, WH	1
Cramer, JA; Kirk, GF; Krol, WF; Krystal, JH; Rosenheck, RA	1
Atias, S; Cohen, H; Rabinowitz, J	1
Manzanares, J; Ponce, G; Rubio, G	1
Hunt, RR	1
Kestenbaum, RS; Resnick, RB; Thomas, MA; Washton, AM	1
Greenstein, R; O'Brien, CP; Ternes, J; Woody, GE	1
Goldstein, A	1
Alterman, AI; Hayashida, M; O'Brien, CP; Volpicelli, JR	1
White, SD	1
Meyer, RE	1
Kleber, HD; Kosten, TR; Rounsaville, BJ	1
Jalali, B; Kleber, HD; Kosten, TR; Steidl, JH	1

Reviews

27 review(s) available for naltrexone and Recrudescence

Article	Year
Management of opioid withdrawal and initiation of medications for opioid use disorder in the hospital setting. Hospital practice (1995), 2022, Volume: 50, Issue:4 Topics: Analgesics, Opioid; Antiemetics; Benzodiazepines; Buprenorphine; Hospitals; Humans; Methadone; Naltrexone; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; Substance Withdrawal Syndrome; United States	2022
Acceptability and efficacy of naltrexone for criminal justice-involved individuals with opioid use disorder: a systematic review and meta-analysis. Addiction (Abingdon, England), 2020, Volume: 115, Issue:8 Topics: Adult; Criminals; Delayed-Action Preparations; Drug Overdose; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; Secondary Prevention; Treatment Outcome	2020
Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder. Addiction (Abingdon, England), 2020, Volume: 115, Issue:8 Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Female; Genotype; Humans; Male; Naltrexone; Narcotic Antagonists; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Receptors, Opioid, mu; Recurrence	2020
The efficacy of acamprosate and naltrexone in the treatment of alcohol dependence, Europe versus the rest of the world: a meta-analysis. Addiction (Abingdon, England), 2015, Volume: 110, Issue:6 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcoholism; Europe; Female; Global Health; Humans; Male; Middle Aged; Naltrexone; Randomized Controlled Trials as Topic; Recurrence; Taurine; Treatment Outcome	2015
Pharmacotherapy for Substance Use Disorders. The Medical clinics of North America, 2016, Volume: 100, Issue:4 Topics: Age Factors; Alcohol Deterrents; Alcoholism; Antidepressive Agents; Buprenorphine; Bupropion; Drug Therapy, Combination; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders; Tobacco Use Cessation Devices; Tobacco Use Disorder; Varenicline	2016
Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. Journal of studies on alcohol and drugs, 2011, Volume: 72, Issue:6 Topics: Alcoholism; Humans; Medication Adherence; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Recurrence; Statistics, Nonparametric; Treatment Outcome	2011
Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis. Addiction biology, 2012, Volume: 17, Issue:3 Topics: Alcoholism; Genotype; Heterozygote; Homozygote; Humans; Naltrexone; Narcotic Antagonists; Polymorphism, Genetic; Prospective Studies; Receptors, Opioid, mu; Recurrence; Temperance	2012
Advances in the use of naltrexone: an integration of preclinical and clinical findings. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism, 2003, Volume: 16 Topics: Alcohol Deterrents; Alcoholism; Genetic Predisposition to Disease; Humans; Motivation; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Recurrence	2003
Research advances in the understanding and treatment of addiction. The American journal on addictions, 2003, Volume: 12, Issue:s2 Topics: Acamprosate; Alcohol Deterrents; Brain; Chronic Disease; Disease Progression; Humans; Naltrexone; Narcotics; Prognosis; Recurrence; Risk Factors; Substance-Related Disorders; Taurine	2003
Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. The American journal on addictions, 2003, Volume: 12, Issue:s1 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Behavior, Animal; Brain; Humans; Naltrexone; Narcotic Antagonists; Receptors, Glutamate; Recurrence; Taurine	2003
Does effect size in naltrexone trials for alcohol dependence differ for single-site vs. multi-center studies? Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:6 Topics: Alcohol Drinking; Alcoholism; Humans; Models, Statistical; Multicenter Studies as Topic; Naltrexone; Narcotic Antagonists; Outcome Assessment, Health Care; Placebos; Publishing; Randomized Controlled Trials as Topic; Recurrence; Regression Analysis; Research Design	2005
Pharmacotherapy for alcohol dependence: anticraving medications for relapse prevention. Yonsei medical journal, 2006, Apr-30, Volume: 47, Issue:2 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Disulfiram; gamma-Aminobutyric Acid; Glutamine; Humans; Models, Biological; Models, Neurological; N-Methylaspartate; Naltrexone; Narcotic Antagonists; Neurons; Polymorphism, Genetic; Receptors, Opioid, mu; Recurrence; Taurine	2006
Understanding and treating kleptomania: new models and new treatments. The Israel journal of psychiatry and related sciences, 2006, Volume: 43, Issue:2 Topics: Algorithms; Cognitive Behavioral Therapy; Combined Modality Therapy; Disruptive, Impulse Control, and Conduct Disorders; Humans; Naltrexone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Recurrence	2006
The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking. Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:6 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Double-Blind Method; History, 20th Century; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Recurrence; Research Design; Severity of Illness Index; Time Factors; Treatment Outcome	2006
Treatment of alcoholism as a chronic disorder. EXS, 1994, Volume: 71 Topics: Adult; Alcoholism; Animals; Chronic Disease; Clinical Trials as Topic; Endorphins; Humans; Naltrexone; Patient Compliance; Recurrence	1994
Naltrexone in the treatment of alcohol dependence. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:2 Topics: Alcoholism; Animals; Breath Tests; Humans; Naltrexone; Randomized Controlled Trials as Topic; Recurrence; Surveys and Questionnaires	1994
[Prevention of heroin reabuse--value of naltrexone]. Harefuah, 1993, Volume: 125, Issue:3-4 Topics: Heroin Dependence; Humans; Israel; Naltrexone; Recurrence	1993
The use of opiate antagonists for recurrent self-injurious behavior. The Journal of neuropsychiatry and clinical neurosciences, 1995,Fall, Volume: 7, Issue:4 Topics: Adolescent; Adult; Behavior Therapy; Child; Combined Modality Therapy; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Recurrence; Self-Injurious Behavior	1995
Medical management of alcohol dependence: clinical use and limitations of naltrexone treatment. Alcohol and alcoholism (Oxford, Oxfordshire), 1995, Volume: 30, Issue:6 Topics: Alcoholism; Combined Modality Therapy; Humans; Naltrexone; Narcotic Antagonists; Psychotherapy; Randomized Controlled Trials as Topic; Recurrence; Time Factors	1995
Opioid antagonists in the treatment of alcohol dependence: clinical efficacy and prevention of relapse. Alcohol and alcoholism (Oxford, Oxfordshire), 1996, Volume: 31 Suppl 1 Topics: Alcoholism; Biomarkers; Humans; Motivation; Naltrexone; Narcotic Antagonists; Neurologic Examination; Opioid Peptides; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome	1996
[Naltrexone--prevention of recurrence in narcotic dependence and in alcoholism]. Der Internist, 1996, Volume: 37, Issue:10 Topics: Alcoholism; Delayed-Action Preparations; Follow-Up Studies; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Treatment Outcome	1996
Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends in pharmacological sciences, 1997, Volume: 18, Issue:2 Topics: Acamprosate; Alcoholism; Animals; Behavior, Animal; Calcium Channels; Disease Models, Animal; Humans; Naltrexone; Narcotic Antagonists; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Recurrence; Substance Withdrawal Syndrome; Synaptic Transmission; Taurine	1997
Compliance to naltrexone treatment after ultra-rapid opiate detoxification: an open label naturalistic study. Drug and alcohol dependence, 1997, Aug-25, Volume: 47, Issue:2 Topics: Anesthesia, General; Clonidine; Follow-Up Studies; Humans; Israel; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Recurrence; Substance Withdrawal Syndrome; Treatment Outcome	1997
Treatment of alcohol dependence. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1997, Volume: 3, Issue:3 Topics: Alcohol Deterrents; Alcoholics Anonymous; Alcoholism; Ethanol; Humans; Naltrexone; Narcotic Antagonists; Recurrence; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome	1997
Opioid antagonists in the treatment of alcohol dependence: clinical efficacy and prevention of relapse. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1996, Volume: 31, Issue:1 Topics: Alcoholism; Controlled Clinical Trials as Topic; Humans; Naltrexone; Narcotic Antagonists; Recurrence	1996
Clinical inquiries. How effective are pharmacologic agents for alcoholism? The Journal of family practice, 2002, Volume: 51, Issue:6 Topics: Alcoholism; Clinical Trials as Topic; Counseling; Evidence-Based Medicine; Humans; Naltrexone; Narcotic Antagonists; Practice Guidelines as Topic; Recurrence	2002
Clinical pharmacology of narcotic antagonists. Annals of the New York Academy of Sciences, 1978, Volume: 311 Topics: Animals; Conditioning, Psychological; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders	1978

Trials

48 trial(s) available for naltrexone and Recrudescence

Article	Year
A Randomized Trial Comparing Extended-Release Injectable Suspension and Oral Naltrexone, Both Combined With Behavioral Therapy, for the Treatment of Opioid Use Disorder. The American journal of psychiatry, 2019, 02-01, Volume: 176, Issue:2 Topics: Administration, Oral; Adult; Behavior Therapy; Delayed-Action Preparations; Female; Humans; Injections, Intramuscular; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Treatment Outcome	2019
Cost-effectiveness of extended release naltrexone to prevent relapse among criminal justice-involved individuals with a history of opioid use disorder. Addiction (Abingdon, England), 2017, Volume: 112, Issue:8 Topics: Adult; Cost-Benefit Analysis; Criminal Law; Criminals; Female; Humans; Male; Naltrexone; Narcotic Antagonists; New England; Opioid-Related Disorders; Recurrence; Secondary Prevention; Treatment Outcome	2017
Risk of Relapse Among Opioid-Dependent Patients Treated With Extended-Release Naltrexone or Buprenorphine-Naloxone: A Randomized Clinical Trial. The American journal on addictions, 2021, Volume: 30, Issue:5 Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Delayed-Action Preparations; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence	2021
The Predictive Value of Degree of Preference for Extended-Release Naltrexone for Treatment Adherence, Opioid Use, and Relapse. European addiction research, 2022, Volume: 28, Issue:1 Topics: Adult; Analgesics, Opioid; Delayed-Action Preparations; Humans; Injections, Intramuscular; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Treatment Adherence and Compliance	2022
Polysubstance use before and during treatment with medication for opioid use disorder: Prevalence and association with treatment outcomes. Journal of substance abuse treatment, 2022, Volume: 143 Topics: Analgesics, Opioid; Delayed-Action Preparations; Humans; Hypnotics and Sedatives; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prevalence; Recurrence; Treatment Outcome	2022
Risk of relapse to non-opioid addictive substances among opioid dependent patients treated with an opioid receptor antagonist or a partial agonist: A randomized clinical trial. Contemporary clinical trials, 2023, Volume: 135 Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Chronic Disease; Delayed-Action Preparations; Female; Humans; Injections, Intramuscular; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence	2023
Lofexidine in Combination With Oral Naltrexone for Opioid Use Disorder Relapse Prevention: A Pilot Randomized, Double-Blind, Placebo-Controlled Study. The American journal on addictions, 2019, Volume: 28, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Chemoprevention; Clonidine; Craving; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Intention to Treat Analysis; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Pilot Projects; Recurrence; Secondary Prevention; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult	2019
An analysis of the effect of mu-opioid receptor gene (OPRM1) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence. The pharmacogenomics journal, 2020, Volume: 20, Issue:5 Topics: Adult; Age Factors; Alcohol Abstinence; Alcohol Drinking; Alcoholism; DNA Methylation; Double-Blind Method; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Pharmacogenetics; Pharmacogenomic Variants; Promoter Regions, Genetic; Receptors, Opioid, mu; Recurrence; Time Factors; Treatment Outcome; United States	2020
Reduced cigarette smoking during injectable extended-release naltrexone treatment for opioid use disorder. The American journal of drug and alcohol abuse, 2020, 07-03, Volume: 46, Issue:4 Topics: Adult; Analgesics, Opioid; Cigarette Smoking; Craving; Delayed-Action Preparations; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Retrospective Studies; Tobacco Products; Young Adult	2020
Naturalistic follow-up after a trial of medications for opioid use disorder: Medication status, opioid use, and relapse. Journal of substance abuse treatment, 2021, Volume: 131 Topics: Adult; Analgesics, Opioid; Delayed-Action Preparations; Follow-Up Studies; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; United States	2021
Initiation of extended release naltrexone (XR-NTX) for opioid use disorder prior to release from prison. Journal of substance abuse treatment, 2018, Volume: 85 Topics: Adult; Delayed-Action Preparations; Female; Humans; Injections, Intramuscular; Male; Medication Adherence; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pilot Projects; Prisoners; Recurrence	2018
Effectiveness of Psychoanalytic-Interactional Group Therapy vs. Behavioral Group Therapy in Routine Outpatient Treatment of Alcohol-Dependent Patients. Substance use & misuse, 2018, 02-23, Volume: 53, Issue:3 Topics: Acamprosate; Alcoholism; Cognitive Behavioral Therapy; Combined Modality Therapy; Disulfiram; Female; Humans; Male; Middle Aged; Naltrexone; Outpatients; Psychoanalytic Therapy; Psychotherapy, Group; Recurrence; Secondary Prevention; Taurine; Treatment Outcome	2018
Topiramate versus naltrexone for alcohol use disorder: study protocol for a genotype-stratified, double-blind randomised controlled trial (TOP study). Trials, 2018, Aug-16, Volume: 19, Issue:1 Topics: Adolescent; Adult; Aged; Alcohol Abstinence; Alcohol Drinking; Alcoholism; Clinical Protocols; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Gene Frequency; Homozygote; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; New South Wales; Pharmacogenomic Variants; Prospective Studies; Receptors, Kainic Acid; Receptors, Opioid, mu; Recurrence; Research Design; Time Factors; Topiramate; Treatment Outcome; Young Adult	2018
Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury. The Journal of neuropsychiatry and clinical neurosciences, 2019,Fall, Volume: 31, Issue:4 Topics: Adult; Alcohol Deterrents; Alcoholism; Brain Injuries, Traumatic; Comorbidity; Double-Blind Method; GABA Agents; Humans; Male; Middle Aged; Naltrexone; Recurrence; Stress Disorders, Post-Traumatic; United States; Valproic Acid; Veterans	2019
What happens when people discontinue taking medications? Lessons from COMBINE. Addiction (Abingdon, England), 2014, Volume: 109, Issue:12 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Behavior Therapy; Combined Modality Therapy; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Naltrexone; Patient Dropouts; Recurrence; Taurine	2014
Opioid treatment at release from jail using extended-release naltrexone: a pilot proof-of-concept randomized effectiveness trial. Addiction (Abingdon, England), 2015, Volume: 110, Issue:6 Topics: Adult; Delayed-Action Preparations; Humans; Injections, Intramuscular; Male; Naltrexone; Narcotic Antagonists; New York City; Opioid-Related Disorders; Pilot Projects; Prisoners; Recurrence; Treatment Outcome	2015
Naltrexone vs Placebo for the Treatment of Alcohol Dependence: A Randomized Clinical Trial. JAMA psychiatry, 2015, Volume: 72, Issue:5 Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Asparagine; Aspartic Acid; Double-Blind Method; Drug Administration Schedule; Female; Genotype; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Odds Ratio; Polymorphism, Single Nucleotide; Recurrence; Treatment Outcome	2015
Pain as a predictor of heavy drinking and any drinking lapses in the COMBINE study and the UK Alcohol Treatment Trial. Addiction (Abingdon, England), 2015, Volume: 110, Issue:8 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Behavior Therapy; Chronic Pain; Combined Modality Therapy; Female; Humans; Male; Naltrexone; Pain Measurement; Recurrence; Taurine; Treatment Outcome	2015
[A double-blind randomized placebo-controlled study of the efficacy of the combined treatment with naltrexone and guanfacine for relapse prevention in opiate dependence]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:10 Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combination; Female; Guanfacine; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Secondary Prevention; Treatment Outcome; Young Adult	2015
The effect of bundling medication-assisted treatment for opioid addiction with mHealth: study protocol for a randomized clinical trial. Trials, 2016, 12-12, Volume: 17, Issue:1 Topics: Adaptation, Psychological; Analgesics, Opioid; Buprenorphine; Clinical Protocols; Combined Modality Therapy; Drug Users; Health Services Accessibility; Humans; Methadone; Mobile Applications; Naltrexone; Opiate Substitution Treatment; Opioid-Related Disorders; Quality of Life; Recurrence; Research Design; Smartphone; Telemedicine; Time Factors; Treatment Outcome; Wisconsin	2016
Extended-release naltrexone for pre-release prisoners: A randomized trial of medical mobile treatment. Contemporary clinical trials, 2017, Volume: 53 Topics: Crime; Delayed-Action Preparations; Delivery of Health Care; Female; HIV Infections; Humans; Injections, Intramuscular; Male; Medication Adherence; Mobile Health Units; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prisoners; Prisons; Recurrence; Risk-Taking; Substance Abuse Treatment Centers; United States	2017
Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial. Lancet (London, England), 2008, Jun-28, Volume: 371, Issue:9631 Topics: Adult; Buprenorphine; Counseling; Double-Blind Method; Heroin Dependence; HIV Infections; Humans; Malaysia; Naltrexone; Narcotic Antagonists; Recurrence; Risk-Taking; Treatment Outcome	2008
A micro opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients. Psychopharmacology, 2009, Volume: 201, Issue:4 Topics: Adult; Alcoholism; Alleles; Asian People; Cognitive Behavioral Therapy; Female; Humans; Korea; Male; Medication Adherence; Middle Aged; Naltrexone; Narcotic Antagonists; Polymorphism, Genetic; Prospective Studies; Receptors, Opioid, mu; Recurrence; Temperance	2009
Improving clinical outcomes in treating heroin dependence: randomized, controlled trial of oral or implant naltrexone. Archives of general psychiatry, 2009, Volume: 66, Issue:10 Topics: Administration, Oral; Adult; Drug Implants; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Recurrence; Substance Abuse Detection; Tablets; Treatment Outcome	2009
Risk factors for craving and relapse in heroin users treated with oral or implant naltrexone. Biological psychiatry, 2010, Aug-01, Volume: 68, Issue:3 Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Drug Implants; Drug-Seeking Behavior; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Patient Compliance; Recurrence; Risk Factors; Tablets; Treatment Outcome	2010
The effects of drinking goal on treatment outcome for alcoholism. Journal of consulting and clinical psychology, 2013, Volume: 81, Issue:1 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol Drinking; Alcoholism; Cognitive Behavioral Therapy; Female; Goals; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Recurrence; Taurine; Treatment Outcome	2013
A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol-dependence disorder: results from a multicenter clinical trial. Alcoholism, clinical and experimental research, 2002, Volume: 26, Issue:9 Topics: Adult; Alcoholism; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Patient Compliance; Recurrence; Survival Analysis	2002
Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study. Journal of clinical psychopharmacology, 2002, Volume: 22, Issue:6 Topics: Adult; Alanine Transaminase; Alcoholism; Aspartate Aminotransferases; Double-Blind Method; Female; gamma-Glutamyltransferase; Germany; Humans; Male; Naltrexone; Narcotic Antagonists; Recurrence; Surveys and Questionnaires; Temperance; Treatment Outcome	2002
[Pharmacotherapy in heroin addiction: pharmacological approaches to remission stabilization and recurrence prevention]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2003, Issue:10 Topics: Adult; Amitriptyline; Analysis of Variance; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Double-Blind Method; Drug Therapy, Combination; Heroin Dependence; Humans; Mood Disorders; Naltrexone; Narcotic Antagonists; Patient Compliance; Placebos; Recurrence; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome	2003
Add-on gabapentin in the treatment of opiate withdrawal. Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:3 Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Gabapentin; gamma-Aminobutyric Acid; Heroin; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Recurrence; Substance Withdrawal Syndrome	2004
Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism. Journal of psychiatric research, 2005, Volume: 39, Issue:5 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcoholism; Double-Blind Method; Female; Humans; Leptin; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Placebos; Recurrence; Taurine	2005
Opioid antagonist detoxification under anaesthesia versus traditional clonidine detoxification combined with an additional week of psychosocial support: a randomised clinical trial. Drug and alcohol dependence, 2006, Feb-01, Volume: 81, Issue:2 Topics: Adult; Algorithms; Analgesics; Anesthesia, General; Clonidine; Drug Administration Schedule; Female; Heroin Dependence; Hospitals, Psychiatric; Hospitals, Teaching; Humans; Inactivation, Metabolic; Male; Naltrexone; Narcotic Antagonists; Prospective Studies; Recurrence; Substance Withdrawal Syndrome; Time Factors; Treatment Outcome	2006
A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol dependence in Taiwan. Addiction biology, 2005, Volume: 10, Issue:3 Topics: Adult; Alcoholism; Double-Blind Method; Humans; Male; Middle Aged; Naltrexone; Recurrence; Taiwan	2005
Naltrexone-induced alterations in human ethanol intoxication. The American journal of psychiatry, 1994, Volume: 151, Issue:10 Topics: Administration, Oral; Adult; Affect; Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Ambulatory Care; Animals; Cognition; Double-Blind Method; Ethanol; Female; Humans; Male; Middle Aged; Naltrexone; Placebos; Psychomotor Performance; Recurrence; Sensation	1994
Experience of a "slip" among alcoholics treated with naltrexone or placebo. The American journal of psychiatry, 1996, Volume: 153, Issue:2 Topics: Alcohol Drinking; Alcoholic Intoxication; Alcoholism; Emotions; Humans; Naltrexone; Placebos; Recurrence	1996
Naltrexone as a treatment for repetitive self-injurious behaviour:an open-label trial. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:6 Topics: Adolescent; Adult; Borderline Personality Disorder; Dose-Response Relationship, Drug; Emotions; Female; Follow-Up Studies; Humans; Mental Disorders; Middle Aged; Naltrexone; Narcotic Antagonists; Pain Measurement; Recurrence; Self-Injurious Behavior; Treatment Outcome	1996
Naltrexone, relapse prevention, and supportive therapy with alcoholics: an analysis of patient treatment matching. Journal of consulting and clinical psychology, 1996, Volume: 64, Issue:5 Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Personality Assessment; Recurrence; Treatment Outcome; Verbal Learning	1996
Naltrexone as an adjunctive treatment for older patients with alcohol dependence. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 1997,Fall, Volume: 5, Issue:4 Topics: Aged; Alcoholism; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Patient Compliance; Recurrence; Severity of Illness Index	1997
Efficacy and safety of two new methods of rapid intravenous detoxification in heroin addicts previously treated without success. The British journal of psychiatry : the journal of mental science, 1997, Volume: 171 Topics: Adult; Conscious Sedation; Critical Care; Heroin Dependence; Humans; Inactivation, Metabolic; Infusions, Intravenous; Length of Stay; Middle Aged; Naloxone; Naltrexone; Narcotic Antagonists; Recurrence; Substance Withdrawal Syndrome; Treatment Failure	1997
Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. The American journal of psychiatry, 1999, Volume: 156, Issue:11 Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Patient Compliance; Patient Selection; Placebos; Recurrence; Reproducibility of Results; Treatment Outcome	1999
Naltrexone vs. nefazodone for treatment of alcohol dependence. A placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 22, Issue:5 Topics: Adult; Alcoholism; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Patient Compliance; Piperazines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Recurrence; Selective Serotonin Reuptake Inhibitors; Time Factors; Triazoles	2000
An open-label study of a functional opioid kappa antagonist in the treatment of opioid dependence. Journal of substance abuse treatment, 2000, Volume: 18, Issue:3 Topics: Administration, Sublingual; Adult; Affect; Buprenorphine; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Patient Dropouts; Psychiatric Status Rating Scales; Pupil; Receptors, Opioid, kappa; Recurrence; Substance Abuse Detection; Treatment Outcome	2000
Outcome and six month follow up of patients after Ultra Rapid Opiate Detoxification (UROD). Journal of addictive diseases, 2000, Volume: 19, Issue:2 Topics: Adolescent; Adult; Aftercare; Anesthesia, General; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; Recurrence; Retreatment; Substance Withdrawal Syndrome	2000
Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: a factorial double-blind, placebo-controlled trial. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:3 Topics: Adaptation, Psychological; Adult; Alcoholism; Cognitive Behavioral Therapy; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Placebos; Prospective Studies; Recurrence; Survival Analysis	2001
Naltrexone in the treatment of alcohol dependence. The New England journal of medicine, 2001, Dec-13, Volume: 345, Issue:24 Topics: Alcoholics Anonymous; Alcoholism; Combined Modality Therapy; Counseling; Double-Blind Method; Female; Humans; Male; Middle Aged; Multivariate Analysis; Naltrexone; Narcotic Antagonists; Patient Compliance; Recurrence; Treatment Failure	2001
Naltrexone in the treatment of alcohol dependence. Archives of general psychiatry, 1992, Volume: 49, Issue:11 Topics: Adult; Alcohol Drinking; Alcoholism; Ambulatory Care; Combined Modality Therapy; Double-Blind Method; Humans; Male; Naltrexone; Nausea; Patient Dropouts; Placebos; Psychiatric Status Rating Scales; Psychotherapy; Recurrence; Severity of Illness Index; Treatment Outcome	1992
Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Archives of general psychiatry, 1992, Volume: 49, Issue:11 Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Alcoholism; Combined Modality Therapy; Double-Blind Method; Female; Humans; Male; Naltrexone; Person-Centered Psychotherapy; Placebos; Psychiatric Status Rating Scales; Psychotherapy; Recurrence; Severity of Illness Index; Temperance	1992
Conditioning phenomena and the problem of relapse in opioid addicts and alcoholics. NIDA research monograph, 1988, Volume: 84 Topics: Alcoholism; Clinical Trials as Topic; Conditioning, Psychological; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Naltrexone; Recurrence	1988

Other Studies

62 other study(ies) available for naltrexone and Recrudescence

Article	Year
Social ecological factors and medication treatment for opioid use disorder among justice-involved rural and urban persons: the BMJ open, 2023, 03-20, Volume: 13, Issue:3 Topics: Analgesics, Opioid; Buprenorphine; Delayed-Action Preparations; Drug Overdose; Humans; Longitudinal Studies; Naltrexone; Narcotic Antagonists; Observational Studies as Topic; Opioid-Related Disorders; Recurrence; Reproducibility of Results	2023
The Utilization of Low Dose Naltrexone for Chronic Pain. CNS drugs, 2023, Volume: 37, Issue:8 Topics: Analgesics, Opioid; Chronic Disease; Chronic Pain; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence	2023
Extinction and reinstatement of methamphetamine-induced conditioned place preference in zebrafish. Addiction biology, 2023, Volume: 28, Issue:12 Topics: Animals; Clonidine; Extinction, Psychological; Methamphetamine; Morphine; Naltrexone; Recurrence; Zebrafish	2023
Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice. Brain research, 2019, 12-01, Volume: 1724 Topics: Alcohol Drinking; Alcoholism; Analgesics, Opioid; Animals; Drinking; Ethanol; Female; Male; Mice; Mice, Inbred C57BL; Morphinans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recurrence; Secondary Prevention; Spiro Compounds	2019
A week-long outpatient induction onto XR-naltrexone in patients with opioid use disorder. The American journal of drug and alcohol abuse, 2020, 05-03, Volume: 46, Issue:3 Topics: Adult; Buprenorphine; Delayed-Action Preparations; Feasibility Studies; Female; Heroin Dependence; Humans; Injections, Intramuscular; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Outpatients; Recurrence; Substance Withdrawal Syndrome; Young Adult	2020
Mu-opioid antagonism in the treatment of cannabis use disorder Journal of psychiatry & neuroscience : JPN, 2020, 03-01, Volume: 45, Issue:2 Topics: Craving; Dose-Response Relationship, Drug; Humans; Male; Marijuana Abuse; Middle Aged; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Recurrence; Substance Withdrawal Syndrome	2020
Comparison of Disulfiram and Naltrexone in Cases of Alcohol Dependence Syndrome. Journal of Nepal Health Research Council, 2020, Apr-20, Volume: 18, Issue:1 Topics: Adult; Alcohol Deterrents; Alcoholism; Cross-Sectional Studies; Disulfiram; Female; Humans; Male; Middle Aged; Naltrexone; Nepal; Prospective Studies; Recurrence; Treatment Outcome	2020
A study of the effectiveness of naltrexone in preventing recurrence of methadone poisoning in opioid-naive children. Drug and alcohol dependence, 2021, 02-01, Volume: 219 Topics: Adolescent; Aftercare; Analgesics, Opioid; Child; Child, Preschool; Female; Hospitalization; Humans; Infant; Intensive Care Units; Iran; Male; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neoplasms; Patient Discharge; Poisoning; Recurrence; Retrospective Studies	2021
FMRI-based prediction of naltrexone response in alcohol use disorder: a replication study. European archives of psychiatry and clinical neuroscience, 2021, Volume: 271, Issue:5 Topics: Alcoholism; Humans; Magnetic Resonance Imaging; Naltrexone; Recurrence; Reproducibility of Results; Treatment Outcome	2021
Relapse to opioid use disorder after inpatient treatment: Protective effect of injection naltrexone. Journal of substance abuse treatment, 2018, Volume: 85 Topics: Adult; Female; Humans; Injections, Intramuscular; Inpatients; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Outpatients; Randomized Controlled Trials as Topic; Recurrence; Substance Withdrawal Syndrome	2018
Effects of mesyl salvinorin B alone and in combination with naltrexone on alcohol deprivation effect in male and female mice. Neuroscience letters, 2018, 04-23, Volume: 673 Topics: Alcohol Drinking; Animals; Diterpenes; Diterpenes, Clerodane; Ethanol; Female; Male; Mesylates; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Recurrence	2018
The use of naltrexone in pathological and problem gambling: A UK case series. Journal of behavioral addictions, 2018, Sep-01, Volume: 7, Issue:3 Topics: Adult; Craving; Female; Follow-Up Studies; Gambling; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Problem Behavior; Recurrence; Retrospective Studies; Severity of Illness Index; Treatment Outcome; United Kingdom	2018
Being Explicit About Decisions: Prescribe Medications for Opioid Use Disorder on the Basis of Proven Effectiveness, Not Beliefs. Annals of internal medicine, 2019, 01-15, Volume: 170, Issue:2 Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Cost-Benefit Analysis; Humans; Naltrexone; Opioid-Related Disorders; Recurrence	2019
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity. Neuron, 2013, Mar-06, Volume: 77, Issue:5 Topics: Animals; Cocaine-Related Disorders; Dopaminergic Neurons; Drug-Seeking Behavior; Extinction, Psychological; In Vitro Techniques; Long-Term Potentiation; Microinjections; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid, kappa; Recurrence; Self Administration; Stress, Psychological; Swimming; Synapses; Ventral Tegmental Area	2013
Missing data in alcohol clinical trials: a comparison of methods. Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:12 Topics: Alcohol-Related Disorders; Bias; Data Collection; Humans; Naltrexone; Narcotic Antagonists; Patient Dropouts; Randomized Controlled Trials as Topic; Recurrence	2013
DSM IV axis II traits can influence compliance to treatment with oral naltrexone: a preliminary study on 30 opiate dependent patients. Addictive behaviors, 2014, Volume: 39, Issue:1 Topics: Administration, Oral; Adult; Female; Humans; Male; Medication Adherence; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Personality; Personality Assessment; Personality Disorders; Recurrence	2014
Long-term relapse of ultra-rapid opioid detoxification. Journal of addictive diseases, 2014, Volume: 33, Issue:1 Topics: Adolescent; Adult; Anesthesia, General; Employment; Female; Follow-Up Studies; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Prospective Studies; Recurrence; Regression Analysis; Substance Withdrawal Syndrome; Treatment Outcome; Young Adult	2014
A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats. Addiction biology, 2015, Volume: 20, Issue:3 Topics: Animals; Conditioning, Operant; Drug-Seeking Behavior; Extinction, Psychological; Food Deprivation; Heroin; Male; Naltrexone; Narcotic Antagonists; Narcotics; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recurrence; Self Administration; Stress, Psychological	2015
Treatment of cocaine craving with as-needed nalmefene, a partial κ opioid receptor agonist: first clinical experience. International clinical psychopharmacology, 2015, Volume: 30, Issue:4 Topics: Adult; Behavior, Addictive; Cocaine-Related Disorders; Craving; Drug Partial Agonism; Female; Humans; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa; Recurrence; Time Factors; Treatment Outcome	2015
[Acamprosate and naltrexone: similar efficacy for relapse]. Revue medicale suisse, 2014, Dec-17, Volume: 10, Issue:455 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Humans; Naltrexone; Narcotic Antagonists; Recurrence; Taurine	2014
Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2 Topics: Animals; Berberine Alkaloids; beta-Endorphin; Cocaine-Related Disorders; Drug Therapy, Combination; Drug-Seeking Behavior; Hypothalamus; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Pro-Opiomelanocortin; Rats; Rats, Wistar; Recurrence; Self Administration; Substance Withdrawal Syndrome	2016
Severe tumefactive rebound of multiple sclerosis following fingolimod cessation. BMJ case reports, 2016, Jun-03, Volume: 2016 Topics: Adult; Brain; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Multiple Sclerosis, Relapsing-Remitting; Naltrexone; Narcotic Antagonists; Recurrence; Withholding Treatment	2016
A 50-year-old woman addicted to heroin: review of treatment of heroin addiction. JAMA, 2008, Jul-16, Volume: 300, Issue:3 Topics: Buprenorphine; Drug Therapy, Combination; Female; Heroin Dependence; History, 19th Century; History, 20th Century; Humans; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Recurrence; Self-Help Groups; United States	2008
"Narcotics helped, I thought." Recurrent traumatization and recovery from drug dependence. Harvard review of psychiatry, 2008, Volume: 16, Issue:5 Topics: Adaptation, Psychological; Adult; Alcoholism; Anxiety Disorders; Behavior Therapy; Child; Child Abuse; Child Abuse, Sexual; Combined Modality Therapy; Comorbidity; Countertransference; Diagnosis, Dual (Psychiatry); Family Therapy; Female; Humans; Life Change Events; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Physician-Patient Relations; Psychotherapy; Psychotherapy, Group; Reactive Attachment Disorder; Recurrence; Spouse Abuse	2008
Naltrexone in drug addiction: significance in the prevention of relapse. Mymensingh medical journal : MMJ, 2009, Volume: 18, Issue:1 Suppl Topics: Adolescent; Adult; Child; Female; Health Surveys; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Surveys and Questionnaires; Treatment Outcome; Young Adult	2009
Addiction treatment in Russia. Lancet (London, England), 2010, Oct-02, Volume: 376, Issue:9747 Topics: Behavior, Addictive; Buprenorphine; Delayed-Action Preparations; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Russia; Substance Abuse, Intravenous; Suicide Prevention	2010
Open-label pilot study of extended-release naltrexone to reduce drinking and driving among repeat offenders. Journal of addiction medicine, 2011, Volume: 5, Issue:3 Topics: Adult; Alcohol Drinking; Alcoholism; Automobile Driving; Biomarkers; Breath Tests; Criminals; Delayed-Action Preparations; Feasibility Studies; Female; Humans; Injections, Intravenous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Protective Devices; Recurrence; Treatment Outcome; Young Adult	2011
Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology, 2013, Volume: 226, Issue:4 Topics: Animals; Conditioning, Psychological; Disease Models, Animal; Extinction, Psychological; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nicotine; Receptors, Opioid, kappa; Recurrence; Risk Factors; Self Administration; Smoking; Stress, Psychological	2013
[Differences in depression severity and frequency of relapses in opiate addicts treated with methadone or opiate blocker after detoxification]. Vojnosanitetski pregled, 2012, Volume: 69, Issue:4 Topics: Adult; Depression; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Opioid-Related Disorders; Recurrence; Young Adult	2012
Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Sep-15, Volume: 22, Issue:18 Topics: Administration, Inhalation; Alcoholism; Animals; Appetitive Behavior; Behavior, Animal; Conditioning, Psychological; Corticotropin-Releasing Hormone; Cues; Disease Models, Animal; Drug Synergism; Electroshock; Ethanol; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Opioid; Recurrence; Self Administration; Stress, Physiological	2002
Ultra-rapid opiate detoxification using deep sedation and prior oral buprenorphine preparation: long-term results. Drug and alcohol dependence, 2003, Apr-01, Volume: 69, Issue:3 Topics: Adult; Buprenorphine; Conscious Sedation; Family Practice; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Outcome and Process Assessment, Health Care; Premedication; Recurrence; Substance Withdrawal Syndrome; Time Factors; Vomiting	2003
Naltrexone implants can completely prevent early (1-month) relapse after opiate detoxification: a pilot study of two cohorts totalling 101 patients with a note on naltrexone blood levels. Addiction biology, 2003, Volume: 8, Issue:2 Topics: Adult; Cohort Studies; Drug Administration Routes; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Inactivation, Metabolic; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pilot Projects; Prevalence; Prostheses and Implants; Recurrence	2003
Reinstatement of cocaine-seeking behavior in rats is attenuated following repeated treatment with the opioid receptor antagonist naltrexone. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:3 Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, mu; Recurrence; Substance Abuse, Intravenous	2005
Suppression of the HPA axis stress-response: implications for relapse. Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:7 Topics: Adrenocorticotropic Hormone; Alcoholism; Arousal; Drive; Genetic Predisposition to Disease; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Naltrexone; Pituitary-Adrenal System; Recurrence; Risk	2005
Ultra-low-dose naltrexone reduces the rewarding potency of oxycodone and relapse vulnerability in rats. Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:2 Topics: Animals; Avoidance Learning; Conditioning, Operant; Cues; Electroshock; Extinction, Psychological; Male; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Oxycodone; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement Schedule; Reward; Self Administration	2005
The ethanol self-administration context as a reinstatement cue: acute effects of naltrexone. Neuroscience, 2006, Volume: 139, Issue:3 Topics: Alcohol Drinking; Animals; Association Learning; Central Nervous System Depressants; Ethanol; Extinction, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Recurrence; Self Administration; Sweetening Agents	2006
Naltrexone for probationers and parolees. Journal of substance abuse treatment, 2006, Volume: 31, Issue:2 Topics: Commitment of Mentally Ill; Counseling; Crime; Forensic Psychiatry; Heroin Dependence; Humans; Illicit Drugs; Naltrexone; Narcotic Antagonists; Patient Compliance; Prisoners; Recurrence; United States	2006
Cloninger's typology and treatment outcome in alcohol-dependent subjects during pharmacotherapy with naltrexone. Addiction biology, 2008, Volume: 13, Issue:1 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcoholism; Combined Modality Therapy; Double-Blind Method; Female; Follow-Up Studies; Genetic Predisposition to Disease; Germany; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Patient Compliance; Psychotherapy; Randomized Controlled Trials as Topic; Recurrence; Spain; Taurine; Treatment Outcome	2008
Management of relapse in naltrexone maintenance for heroin dependence. Drug and alcohol dependence, 2007, Dec-01, Volume: 91, Issue:2-3 Topics: Adult; Behavior Therapy; Combined Modality Therapy; Diagnostic and Statistical Manual of Mental Disorders; Female; Follow-Up Studies; Heroin Dependence; Humans; Inpatients; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Outpatients; Recurrence; Time Factors	2007
12-month follow-up study of drug treatment in pathological gamblers: a primary outcome study. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6 Topics: Adolescent; Adult; Analysis of Variance; Bupropion; Delayed-Action Preparations; Drug Therapy; Fluvoxamine; Follow-Up Studies; Fructose; Gambling; Humans; Israel; Male; Middle Aged; Naltrexone; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Psychopharmacology; Recurrence; Reproducibility of Results; Surveys and Questionnaires; Time Factors; Topiramate	2007
Drug addiction: a critical problem calling for novel solutions. Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:4 Topics: Benzazepines; Buprenorphine; Bupropion; Chronic Disease; Financing, Government; Genetic Testing; Harm Reduction; Humans; Marijuana Smoking; Naltrexone; Narcotic Antagonists; Prevalence; Privacy; Quinoxalines; Receptors, Nicotinic; Recurrence; Risk-Taking; Smoking; Smoking Cessation; Smoking Prevention; Social Environment; Substance-Related Disorders; Varenicline	2008
Use of naltrexone to extinguish opioid-conditioned responses. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:9 Pt 2 Topics: Adult; Combined Modality Therapy; Conditioning, Classical; Extinction, Psychological; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Opioid-Related Disorders; Recurrence; Relaxation Therapy	1984
Opioid antagonists: do they have a role in treatment programs? NIDA research monograph, 1983, Volume: 43 Topics: Buprenorphine; Drug Tolerance; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence	1983
Five-year follow-up of opiate addicts with naltrexone and behavior therapy. NIDA research monograph, 1984, Volume: 49 Topics: Adult; Behavior Therapy; Combined Modality Therapy; Follow-Up Studies; Heroin Dependence; Humans; Male; Naloxone; Naltrexone; Recurrence	1984
A study of the use of clonidine and naltrexone in the treatment of opioid addiction in the former USSR. Journal of addictive diseases, 1994, Volume: 13, Issue:1 Topics: Adult; Clonidine; Cross-Cultural Comparison; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Naltrexone; Neurologic Examination; Opioid-Related Disorders; Patient Dropouts; Recurrence; Treatment Outcome; USSR	1994
Naltrexone abuse and risk of suicide. The Journal of nervous and mental disease, 1993, Volume: 181, Issue:11 Topics: Ambulatory Care; Humans; Naltrexone; Opioid-Related Disorders; Recurrence; Risk Factors; Self Medication; Suicide	1993
[Naltrexone therapy. Experience with "Telephone Assistance" in Rome]. Minerva psichiatrica, 1993, Volume: 34, Issue:1 Topics: Adult; Hotlines; Humans; Italy; Naltrexone; Opioid-Related Disorders; Recurrence	1993
Managing pain in addicted patients. The American journal of nursing, 1997, Volume: 97, Issue:4 Topics: Alcoholism; Analgesics; Heroin Dependence; Humans; Naltrexone; Narcotic Antagonists; Pain; Recurrence; Substance-Related Disorders	1997
Sequential use of naltrexone in the treatment of relapsing alcoholism. The American journal of psychiatry, 1997, Volume: 154, Issue:5 Topics: Adult; Alcohol Drinking; Alcoholism; Drug Administration Schedule; Humans; Male; Naltrexone; Recurrence	1997
Current research in the treatment of alcoholism in liver transplant recipients. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1997, Volume: 3, Issue:3 Topics: Alcohol Drinking; Alcoholism; Double-Blind Method; Female; Humans; Liver Diseases, Alcoholic; Liver Transplantation; Male; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Recurrence; Research Design	1997
Outcomes of ultrarapid opiate detoxification combined with naltrexone maintenance and counseling. Psychiatric services (Washington, D.C.), 1998, Volume: 49, Issue:6 Topics: Adult; Anesthesia, General; Clonidine; Combined Modality Therapy; Counseling; Follow-Up Studies; Humans; Intensive Care Units; Israel; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence; Sympatholytics; Time Factors; Treatment Outcome	1998
Prevention of relapse in alcohol dependence. American family physician, 1999, Apr-01, Volume: 59, Issue:7 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Behavior Therapy; Disulfiram; Family; Humans; Naltrexone; Narcotic Antagonists; Recurrence; Self-Help Groups; Taurine	1999
Ultra rapid opiate detoxification as compared to 30-day inpatient detoxification program--a retrospective follow-up study. Journal of substance abuse, 2000, Volume: 11, Issue:2 Topics: Adult; Female; Follow-Up Studies; Heroin Dependence; Humans; Israel; Length of Stay; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Outcome and Process Assessment, Health Care; Patient Admission; Pilot Projects; Recurrence	2000
Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology, 2000, Volume: 153, Issue:1 Topics: Alcohol Drinking; Animals; Benzofurans; Conditioning, Operant; Drinking; Eating; Male; Naltrexone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Recurrence; Self Administration	2000
Addiction medicine for the primary care physician. The Journal of the Oklahoma State Medical Association, 2001, Volume: 94, Issue:11 Topics: Acamprosate; Alcohol Deterrents; Alcoholics Anonymous; Alcoholism; Antidepressive Agents, Tricyclic; Disulfiram; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Primary Health Care; Recurrence; Risk Factors; Severity of Illness Index; Substance-Related Disorders; Taurine; Treatment Outcome	2001
Outcomes of naltrexone maintenance following ultra rapid opiate detoxification versus intensive inpatient detoxification. The American journal on addictions, 2002,Winter, Volume: 11, Issue:1 Topics: Adult; Analgesics; Clonidine; Humans; Inactivation, Metabolic; Israel; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Patient Compliance; Recurrence; Retrospective Studies; Substance Withdrawal Syndrome; Treatment Outcome	2002
Naltrexone for alcohol dependence. The New England journal of medicine, 2002, Apr-25, Volume: 346, Issue:17 Topics: Alcoholism; Humans; Naltrexone; Narcotic Antagonists; Patient Selection; Recurrence; Time Factors	2002
Naltrexone in the treatment of opiate dependence. NIDA research monograph, 1978, Issue:19 Topics: Adolescent; Adult; Follow-Up Studies; Forecasting; Heroin Dependence; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics; New York City; Psychotherapy; Receptors, Opioid; Recurrence; Substance Withdrawal Syndrome; Substance-Related Disorders	1978
Heroin addiction. Sequential treatment employing pharmacologic supports. Archives of general psychiatry, 1976, Volume: 33, Issue:3 Topics: Heroin Dependence; Humans; Methadone; Morphine; Naltrexone; Prognosis; Recurrence	1976
Naltrexone for treatment of acral lick dermatitis in dogs. Journal of the American Veterinary Medical Association, 1990, Apr-01, Volume: 196, Issue:7 Topics: Animals; Dermatitis; Dog Diseases; Dogs; Drug Evaluation; Erythromycin; Female; Male; Naltrexone; Parakeratosis; Recurrence	1990
The antecedents and benefits of achieving abstinence in opioid addicts: a 2.5-year follow-up study. The American journal of drug and alcohol abuse, 1987, Volume: 13, Issue:3 Topics: Adult; Combined Modality Therapy; Female; Follow-Up Studies; Hospitals, University; Humans; Male; Methadone; Naltrexone; Opioid-Related Disorders; Psychiatric Department, Hospital; Recurrence; Social Adjustment	1987
Relationship of marital structure and interactions to opiate abuse relapse. The American journal of drug and alcohol abuse, 1987, Volume: 13, Issue:4 Topics: Adult; Family; Female; Humans; Male; Marriage; Naltrexone; Opioid-Related Disorders; Recurrence	1987