naltrexone has been researched along with Morphine Abuse in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (36.45) | 18.7374 |
| 1990's | 29 (27.10) | 18.2507 |
| 2000's | 29 (27.10) | 29.6817 |
| 2010's | 10 (9.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caruso, TP; Jiang, JB; Larson, DL; Portoghese, PS; Takemori, AE | 1 |
| Bousquet, AR; Howes, JF; Kotick, MP; Polazzi, JO | 1 |
| Dewey, WL; Kellogg, GE; Mosier, PD; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zaidi, SA; Zhang, Y | 1 |
| Chen, C; Johnson, T; Meng, J; Roy, S; Wang, F; Zhang, L | 1 |
| Kelsey, JE; Schierberl, KC; Verhaak, AM | 1 |
| Becker, GL; France, CP; Gerak, LR; Koek, W | 1 |
| Chefer, VI; Shippenberg, TS; Thompson, AC | 1 |
| Acquas, E; Ibba, F; Kasture, S; Lecca, D; Marongiu, M; Murali, B; Pisanu, A; Puddu, A; Vinci, S; Zernig, G | 1 |
| Barr, GA; McPhie, AA | 1 |
| Johnson, F; Katz, N; Stauffer, J; Sun, S | 1 |
| Gieryk, A; Kubik, J; Przewlocki, R; Solecki, W; Ziolkowska, B | 1 |
| Huang, W; Li, Q; Shu, H; Wu, G; Zhang, H; Zhou, J | 1 |
| Madia, PA; Navani, DM; Sirohi, S; Yoburn, BC | 1 |
| Hales, TG | 1 |
| Costantino, CM; Devi, LA; Gomes, I; Lim, MP; Stockton, SD | 1 |
| Dewey, WL; Gerk, PM; He, H; Kozak, P; Li, G; Mitra, P; Scoggins, KL; Selley, DE; Stevens, DL; Yuan, Y; Zhang, Y | 1 |
| Ho, IK; Rockhold, RW; Sinchaisuk, S | 1 |
| Holtzman, SG; Kalinichev, M | 1 |
| Besson, JM; Gestreau, C; Le Guen, S | 1 |
| France, CP; McMahon, LR; Sell, SL | 1 |
| Fürst, Z; Gyarmati, Z; Timár, J | 1 |
| Bonnet, U; Overlack, M; Schürks, M | 1 |
| Sterious, SN; Walker, EA | 1 |
| Burns, LH; Olmstead, MC | 1 |
| Divin, MF; Ko, MC; Lee, H; Traynor, JR; Woods, JH | 1 |
| Glick, SD; Maisonneuve, IM; Panchal, V; Taraschenko, OD | 1 |
| Aceto, MD; Bowman, ER; Cook, CD; Harris, LS; May, EL | 1 |
| Crain, SM; Shen, KF | 2 |
| Kreek, MJ; Novick, DM | 1 |
| France, CP; Li, JX; McMahon, LR | 1 |
| Fossum, EN; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Divin, MF; Holden Ko, MC; Traynor, JR | 1 |
| Page, ME; Qian, Y; Sterling, RC; Van Bockstaele, EJ | 1 |
| Becker, GL; France, CP; Gerak, LR; Li, JX; McMahon, LR | 1 |
| DeLander, GE; Portoghese, PS; Takemori, AE | 1 |
| Chavkin, C; Goldstein, A | 1 |
| Martin, WR | 1 |
| Oishi, R; Takemori, AE | 1 |
| Retz, KC; Steele, WJ | 1 |
| Eisenberg, RM | 1 |
| Bodor, N; Katovich, MJ; Simpkins, JW; Song, IC; Tuttle, R | 1 |
| Brown, DR; Chang, EB; Field, M; Miller, RJ | 1 |
| Herling, S; Valentino, RJ; Woods, JH | 2 |
| Krystal, JH; Redmond, DE | 1 |
| Burks, TF; Porreca, F | 1 |
| Delander, GE; Takemori, AE | 1 |
| Burks, TF; Schreier, WA | 1 |
| Bree, MP; Mello, NK; Mendelson, JH | 1 |
| Jasinski, DR | 1 |
| Bilsky, EJ; French, ED; Glick, SD; Menkens, KA; Porreca, F; Reid, LD | 1 |
| Bhargava, HN; House, RV; Thomas, PT; Thorat, SN | 1 |
| Barjavel, MJ; Bhargava, HN; Matwyshyn, GA; Thorat, SN | 1 |
| Bhargava, HN | 2 |
| Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T | 1 |
| Almeida, OF; Bartl, C; Shippenberg, TS; Spanagel, R | 1 |
| Brent, PJ; Cantarell, PA; Chahl, LA; Kavanagh, C | 1 |
| Bhargava, HN; Matwyshyn, GA; Reddy, PL; Thorat, SN | 1 |
| Miyamoto, Y; Takemori, AE | 1 |
| Miyamoto, Y; Portoghese, PS; Takemori, AE | 1 |
| Coderre, TJ; Fundytus, ME; Schiller, PW; Shapiro, M; Weltrowska, G | 1 |
| Barr, GA; Jones, KL | 1 |
| Diana, M; Gessa, GL; Muntoni, AL | 1 |
| Feng, YZ; Ho, IK; Rockhold, RW; Tokuyama, S; Zhang, T; Zhu, H | 1 |
| Bhargava, HN; Thorat, SN | 1 |
| Bristow, LJ; Hogg, JE; Hutson, PH | 1 |
| Bhargava, HN; Kumar, S | 1 |
| Feng, Y; Ho, IK; Rockhold, RW | 1 |
| Rasmussen, K; Vandergriff, J | 1 |
| Aston-Jones, G; Delfs, JM; Druhan, J; Zhu, Y | 1 |
| Hensel, M; Kox, WJ | 1 |
| Kishioka, S; Paronis, CA; Woods, JH | 1 |
| Aston-Jones, G; Druhan, JP; Walters, CL | 1 |
| Zhang, HT | 1 |
| Georges, F; Le Moine, C; Stinus, L | 1 |
| Barr, GA; Zhu, H | 1 |
| Bilsky, EJ; Raehal, KM; Sadée, W; Wang, D | 1 |
| Ladewig, D | 1 |
| Costa, E; Fratta, W; Hong, J; Yang, HY | 1 |
| Gellert, VF; Holtzman, SG | 1 |
| Colombel, MC; Jacob, J; Tremblay, E | 1 |
| Brocco, MJ; Killam, KF; Robinson, CA | 1 |
| Bläsig, J; Herz, A; Höllt, V; Paschelke, G | 1 |
| Eades, CG; Gilbert, PE; Huppler, RE; Martin, WR; Thompson, JA | 1 |
| Misawa, M; Nagase, H; Narita, M; Suzuki, T; Takahashi, Y | 1 |
| Aghajanian, GK; Krystal, JH; Rasmussen, K | 1 |
| Aghajanian, GK; Beitner-Johnson, DB; Krystal, JH; Nestler, EJ; Rasmussen, K | 1 |
| Misawa, M; Suzuki, T | 1 |
| Fukagawa, Y; Misawa, M; Nagase, H; Suzuki, T | 1 |
| Aranow, JS; Kelsey, JE; Matthews, RT | 1 |
| Adams, JU; Holtzman, SG | 1 |
| Bronson, ME; Sparber, SB | 1 |
| Falls, WA; Kelsey, JE | 1 |
| Fukagawa, Y; Katz, JL; Suzuki, T | 1 |
| Cone, EJ; Fudala, PJ; Heishman, SJ; Henningfield, JE; Johnson, RE | 1 |
| Mucha, RF | 1 |
| Bykov, V; Danks, JA; Holaday, JW; Jacobson, AE; Long, JB; Rice, KC; Rothman, RB; Tortella, FC | 1 |
| Holtzman, SG; Locke, KW | 1 |
| Gilbert, PE; Jasinski, DR; Martin, CD; Martin, WR | 1 |
| Calligaro, D; Khazan, N; Young, GA | 1 |
| Portoghese, PS; Takahashi, M; Takemori, AE | 1 |
| Aceto, MD; Dewey, WL; Portoghese, PS; Takemori, AE | 1 |
| de Feo, G; Mazzanti, G; Piccinelli, D | 1 |
| Holtzman, SG | 1 |
2 review(s) available for naltrexone and Morphine Abuse
| Article | Year |
|---|---|
Opioid receptor heteromers in analgesia.
Topics: Analgesia; Analgesics; Animals; Drug Antagonism; Drug Overdose; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Protein Multimerization; Protein Structure, Quaternary; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; United States | 2012 |
[The treatment of drug-dependence (author's transl)].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Alcoholism; Amphetamines; Barbiturates; Communication; Drug Tolerance; Female; Halfway Houses; Humans; Male; Methadone; Middle Aged; Morphine Dependence; Motivation; Naltrexone; Personality Disorders; Psychotherapy; Social Control, Formal; Social Control, Informal; Substance-Related Disorders | 1978 |
1 trial(s) available for naltrexone and Morphine Abuse
| Article | Year |
|---|---|
ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Humans; Illicit Drugs; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Osteoarthritis, Hip; Osteoarthritis, Knee; Pain Measurement; Treatment Outcome | 2010 |
104 other study(ies) available for naltrexone and Morphine Abuse
| Article | Year |
|---|---|
Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.
Topics: Alkylating Agents; Analgesics; Animals; Humans; In Vitro Techniques; Male; Mice; Molecular Conformation; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nitrogen Mustard Compounds; Rats; Receptors, Opioid; Time Factors | 1979 |
Analgesic narcotic antagonists. 9. 6-Methylene-8 beta-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Haplorhini; Humans; Mice; Morphinans; Morphine Dependence; Narcotic Antagonists; Rats; Reaction Time; Substance Withdrawal Syndrome | 1981 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Topics: Animals; CHO Cells; Cricetulus; Drug Design; Humans; Isoquinolines; Ligands; Mice; Molecular Dynamics Simulation; Morphinans; Morphine Dependence; Narcotic Antagonists; Receptors, Opioid, mu; Structure-Activity Relationship | 2015 |
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Deoxycholic Acid; Disease Models, Animal; Drug Tolerance; Dysbiosis; Enterococcus faecalis; Female; Gastrointestinal Microbiome; Metabolome; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Phosphatidylethanolamines; Statistics, Nonparametric | 2018 |
The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats.
Topics: Animals; Conditioning, Psychological; Defecation; Dynorphins; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Neurotransmitter Agents; Random Allocation; Rats, Long-Evans; Receptors, Opioid, kappa; Spatial Behavior; Substance Withdrawal Syndrome | 2015 |
Antagonist-precipitated and discontinuation-induced withdrawal in morphine-dependent rhesus monkeys.
Topics: Animals; Behavior, Animal; Body Temperature; Circadian Rhythm; Conditioning, Operant; Discrimination Learning; Drug Administration Schedule; Female; Heart Rate; Humans; Injections, Subcutaneous; Macaca mulatta; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Sodium Chloride; Stereotyped Behavior; Substance Withdrawal Syndrome; Time Factors | 2008 |
Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine.
Topics: Analysis of Variance; Animals; Association Learning; Behavior, Animal; Benzylidene Compounds; Conditioning, Classical; Disease Models, Animal; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Statistics, Nonparametric | 2009 |
Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: a confocal laser scanning microscopy study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Dendritic Spines; Disease Models, Animal; Male; Microscopy, Confocal; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Neurons; Nucleus Accumbens; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Silver Staining; Substance Withdrawal Syndrome; Time Factors; Withania | 2009 |
Regional Fos expression induced by morphine withdrawal in the 7-day-old rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Count; Female; Immunohistochemistry; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Nucleus Accumbens; Periaqueductal Gray; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Spinal Cord; Substance Withdrawal Syndrome | 2009 |
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Cues; Enkephalins; Gene Expression Regulation; Genotype; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenotype; Protein Precursors; Receptors, Opioid, kappa; Reward; RNA, Messenger; Species Specificity | 2010 |
Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats.
Topics: Aconitum; Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Drugs, Chinese Herbal; Dynorphins; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phytotherapy; Plant Tubers; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa | 2011 |
The role of opioid antagonist efficacy and constitutive opioid receptor activity in the opioid withdrawal syndrome in mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Mice; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Substance Withdrawal Syndrome | 2011 |
Arresting the development of morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Ondansetron; Pain; Polypharmacy; Quaternary Ammonium Compounds; Serotonin Antagonists | 2011 |
Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
Topics: Animals; Caco-2 Cells; CHO Cells; Cricetinae; Cricetulus; Drug Implants; Guanosine 5'-O-(3-Thiotriphosphate); Heterocyclic Compounds; Humans; Male; Membranes; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Thalamus | 2011 |
Focal kappa-opioid receptor-mediated dependence and withdrawal in the nucleus paragigantocellularis.
Topics: Animals; Basal Ganglia; Butorphanol; Diffusion; Electric Stimulation; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stereotaxic Techniques; Stereotyped Behavior; Substance Withdrawal Syndrome | 2002 |
Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependence.
Topics: Acoustic Stimulation; Animals; Defecation; Male; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Ultrasonics; Urination; Vocalization, Animal | 2003 |
Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system.
Topics: Animals; Behavior, Animal; Cell Count; Central Nervous System; Gene Expression Regulation; Immunohistochemistry; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2003 |
Cocaine and other indirect-acting monoamine agonists differentially attenuate a naltrexone discriminative stimulus in morphine-treated rhesus monkeys.
Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Discrimination Learning; Disease Models, Animal; Dopamine Agents; Dopamine Uptake Inhibitors; Drug Interactions; Imipramine; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 2004 |
The development of tolerance to locomotor effects of morphine and the effect of various opioid receptor antagonists in rats chronically treated with morphine.
Topics: Animals; Behavior, Animal; Drug Interactions; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Wistar; Time Factors | 2005 |
Naltrexone treatment of combined alcohol and opioid dependence: deterioration of co-morbid major depression.
Topics: Alcoholism; Amitriptyline; Depressive Disorder, Major; Ethanol; Humans; Male; Middle Aged; Morphine; Morphine Dependence; Naltrexone; Narcotics; Severity of Illness Index; Substance Withdrawal Syndrome | 2005 |
Opioid antagonists differ according to negative intrinsic efficacy in a mouse model of acute dependence.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Diprenorphine; Dose-Response Relationship, Drug; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Substance Withdrawal Syndrome; Tremor | 2005 |
Ultra-low-dose naltrexone suppresses rewarding effects of opiates and aversive effects of opiate withdrawal in rats.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Female; Injections, Subcutaneous; Morphine Dependence; Motivation; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Orientation; Oxycodone; Rats; Rats, Sprague-Dawley; Reward; Substance Withdrawal Syndrome | 2005 |
Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey.
Topics: Animals; Binding Sites; Female; In Vitro Techniques; Ligands; Macaca mulatta; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Thalamus | 2006 |
Attenuation of morphine withdrawal signs by intracerebral administration of 18-methoxycoronaridine.
Topics: Animals; Brain; Drug Administration Routes; Female; Ibogaine; Locus Coeruleus; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2005 |
Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Benzomorphans; Female; Hot Temperature; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Stereoisomerism; Substance Withdrawal Syndrome | 2007 |
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2007 |
Hepatitis C treatment, subcutaneous naltrexone implants, and methadone maintenance treatment.
Topics: Antiviral Agents; Drug Implants; Hepatitis C; Humans; Methadone; Morphine Dependence; Naltrexone; Narcotics | 2007 |
Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.
Topics: Animals; Appetitive Behavior; Discrimination Learning; Dose-Response Relationship, Drug; Drug Inverse Agonism; Female; Macaca mulatta; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu | 2008 |
Tolerance to repeated morphine administration is associated with increased potency of opioid agonists.
Topics: Analgesics, Opioid; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Methionine; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu | 2008 |
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
Topics: Animals; Binding, Competitive; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Pain Measurement; Pyrroles; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
Low dose naltrexone administration in morphine dependent rats attenuates withdrawal-induced norepinephrine efflux in forebrain.
Topics: Animals; Area Under Curve; Brain Chemistry; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dopamine beta-Hydroxylase; Electrochemistry; Extracellular Space; Immunoenzyme Techniques; Male; Microdialysis; Morphine Dependence; Naltrexone; Narcotic Antagonists; Norepinephrine; Prosencephalon; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2008 |
Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception.
Topics: Analgesics; Analgesics, Opioid; Animals; Data Interpretation, Statistical; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Heroin; Hot Temperature; Hypnotics and Sedatives; Macaca mulatta; Male; Midazolam; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Measurement; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2008 |
Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.
Topics: Analgesia; Animals; Body Weight; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord | 1984 |
Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.
Topics: Animals; Guinea Pigs; Humans; Male; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naltrexone; Receptors, Opioid | 1984 |
Emerging concepts concerning drug abuse.
Topics: Adolescent; Adult; Animals; Cats; Conditioning, Psychological; Cyclazocine; Dogs; Euphoria; Guinea Pigs; Homeostasis; Humans; Models, Biological; Mood Disorders; Morphine Dependence; Naltrexone; Rats; Receptors, Opioid; Substance-Related Disorders | 1980 |
Stereospecific accumulation of dihydromorphine and naltrexone by corpus striatal slices of morphine-dependent mice.
Topics: Animals; Binding, Competitive; Corpus Striatum; Dihydromorphine; Humans; In Vitro Techniques; Male; Mice; Morphine Dependence; Morphine Derivatives; Naloxone; Naltrexone; Receptors, Opioid; Stereoisomerism; Substance Withdrawal Syndrome | 1982 |
Blockade of morphine dependence-related enhancement of secretory protein synthesis in the pons-medulla and striatum-septum by naltrexone.
Topics: Animals; Body Temperature; Body Weight; Brain; Corpus Striatum; Humans; Male; Medulla Oblongata; Morphine Dependence; Naloxone; Naltrexone; Nerve Tissue Proteins; Pons; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Effects of naltrexone on plasma corticosterone in opiate-naive rats: a central action.
Topics: Animals; Corticosterone; Dose-Response Relationship, Drug; Humans; Hypothalamo-Hypophyseal System; Male; Morphine Dependence; Naloxone; Naltrexone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains | 1984 |
A rapid, quantitative in vivo assay for narcotic antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Female; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Skin Temperature; Tail; Time Factors | 1984 |
An antiabsorptive basis for precipitated withdrawal diarrhea in morphine-dependent rats.
Topics: Animals; Atropine; Biological Transport; Diarrhea; Gastrointestinal Motility; Hexamethonium Compounds; Humans; Intestinal Absorption; Male; Morphine; Morphine Dependence; Naltrexone; Quaternary Ammonium Compounds; Rats; Rats, Inbred Lew; Substance Withdrawal Syndrome; Water-Electrolyte Balance | 1984 |
Discriminative stimulus effects of naltrexone in narcotic-naive and morphine-treated pigeons.
Topics: Animals; Columbidae; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Humans; Morphine Dependence; Naloxone; Naltrexone | 1983 |
A preliminary description of acute physical dependence on morphine in the vervet monkey.
Topics: Animals; Behavior, Animal; Catheterization; Chlorocebus aethiops; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1983 |
Use of the novel irreversible opiate antagonist, beta-chlornaltrexamine, in the estimation of the normorphine affinity constant in naive and morphine tolerant guinea-pig ilea.
Topics: Animals; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Morphine Dependence; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists | 1983 |
Spinal antagonism of tolerance and dependence induced by systemically administered morphine.
Topics: Animals; Drug Tolerance; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Spinal Cord | 1983 |
Central regulation of intestinal function: morphine withdrawal diarrhea.
Topics: Animals; Body Weight; Diarrhea; Female; Humans; Intestines; Morphine Dependence; Nalorphine; Naltrexone; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1982 |
The relationship between the acute behavioral effects of narcotic antagonists and the narcotic-dependent state [proceedings].
Topics: Animals; Behavior, Animal; Columbidae; Cyclazocine; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists | 1981 |
Naltrexone effects on morphine and food self-administration in morphine-dependent rhesus monkeys.
Topics: Animals; Conditioning, Operant; Food; Humans; Macaca mulatta; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Self Administration; Substance Withdrawal Syndrome | 1981 |
Clinical pharmacology of mixed agonist-antagonist drugs [proceedings].
Topics: Buprenorphine; Cyclazocine; Humans; Methadone; Morphinans; Morphine Dependence; Naltrexone | 1981 |
Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
Topics: Animals; Cocaine; Conditioning, Operant; Drug Implants; Female; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Opioid, delta; Self Administration | 1995 |
Effects of naltrexone on morphine-induced tolerance and physical dependence and changes in cellular immune function in mice.
Topics: Animals; B-Lymphocytes; Body Weight; Cell Division; Drug Implants; Drug Tolerance; Female; Immunity, Cellular; Killer Cells, Natural; Mice; Morphine; Morphine Dependence; Naltrexone; Substance Withdrawal Syndrome; T-Lymphocytes | 1995 |
Comparative effects of NG-monomethyl-L-arginine and MK-801 on the abstinence syndrome in morphine-dependent mice.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Dizocilpine Maleate; Male; Mice; Morphine Dependence; Naltrexone; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, N-Methyl-D-Aspartate | 1994 |
Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase.
Topics: Animals; Arginine; Drug Implants; Drug Tolerance; Enzyme Inhibitors; Male; Morphine; Morphine Dependence; Naltrexone; Nitric Oxide Synthase; omega-N-Methylarginine; Pain Measurement; Rats; Rats, Sprague-Dawley | 1995 |
Effect of naltrindole on the development of physical dependence on morphine in mice: a behavioral and biochemical study.
Topics: Animals; Behavior, Animal; Body Weight; Male; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid; Sodium Chloride; Time Factors | 1995 |
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin | 1995 |
Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Conditioning, Operant; Dopamine; Injections, Intraventricular; Limbic System; Male; Microdialysis; Morphine Dependence; Naloxone; Naltrexone; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Substance Withdrawal Syndrome | 1994 |
The kappa-opioid receptor agonist U50,488H induces acute physical dependence in guinea-pigs.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Behavior, Animal; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Dependence; Motor Activity; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Pyrrolidines; Receptors, Opioid, kappa; Substance Withdrawal Syndrome; Substance-Related Disorders | 1993 |
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat.
Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice.
Topics: Animals; Brain; Cerebral Ventricles; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Mice; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 1993 |
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice.
Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates | 1993 |
Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi].
Topics: Animals; Behavior, Animal; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Tetrahydroisoquinolines | 1995 |
Ontogeny of morphine withdrawal in the rat.
Topics: Age Factors; Animals; Arousal; Female; Humans; Infant, Newborn; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Neonatal Abstinence Syndrome; Neurologic Examination; Rats; Substance Withdrawal Syndrome | 1995 |
Repeated naltrexone administration accelerates resolution of morphine somatic withdrawal signs in morphine-dependent rats.
Topics: Animals; Behavior, Animal; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1996 |
Mu- and delta-opioid receptor antagonists precipitate similar withdrawal phenomena in butorphanol and morphine dependence.
Topics: Animals; Butorphanol; Drug Evaluation, Preclinical; Injections, Intraventricular; Locus Coeruleus; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Substance Withdrawal Syndrome | 1996 |
Evidence for a role of nitric oxide of the central nervous system in morphine abstinence syndrome.
Topics: Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intraventricular; Male; Mice; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Substance Withdrawal Syndrome | 1996 |
Competitive and glycine/NMDA receptor antagonists attenuate withdrawal-induced behaviours and increased hippocampal acetylcholine efflux in morphine-dependent rats.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Binding, Competitive; Clonidine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Microdialysis; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pipecolic Acids; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1997 |
Time course of the changes in central nitric oxide synthase activity following chronic treatment with morphine in the mouse: reversal by naltrexone.
Topics: Animals; Brain; Kinetics; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nitric Oxide Synthase; Spinal Cord | 1997 |
Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol--but not morphine-dependent rats.
Topics: Animals; Butorphanol; Excitatory Amino Acids; Locus Coeruleus; Male; Microdialysis; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1997 |
The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Electrophysiology; Excitatory Amino Acid Agonists; Locus Coeruleus; Male; Membrane Potentials; Morphine; Morphine Dependence; Naltrexone; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substance Withdrawal Syndrome | 1999 |
The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal.
Topics: Amygdala; Animals; Axonal Transport; Caudate Nucleus; Male; Microinjections; Morphine Dependence; Naloxone; Naltrexone; Neurons; Norepinephrine; Oxidopamine; Propranolol; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Thalamus; Tyrosine 3-Monooxygenase | 1999 |
Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: a prospective study in methadone, heroin, codeine and morphine addicts.
Topics: Adult; Anesthesia, General; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Morphine Dependence; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prospective Studies; Substance Withdrawal Syndrome | 2000 |
Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Drug Tolerance; Heroin; Heroin Dependence; Macaca mulatta; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Respiration; Time Factors | 2000 |
Behavioral activation induced by D(2)-like receptor stimulation during opiate withdrawal.
Topics: Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Locomotion; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior; Substance Withdrawal Syndrome | 2000 |
[Regulation of the central opioidergic nervous system on the emotional state of anxiety and its possible mechanisms].
Topics: Animals; Anxiety; Brain; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Serotonin; Substance Withdrawal Syndrome | 1997 |
Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved.
Topics: Animals; Brain; Corpus Striatum; Drug Implants; Gene Expression Regulation; Genes, fos; Male; Morphine; Morphine Dependence; Naltrexone; Neurons; Organ Specificity; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome; Transcription, Genetic | 2000 |
Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid | 2001 |
Inhibition of morphine withdrawal by the NMDA receptor antagonist MK-801 in rat is age-dependent.
Topics: Age Factors; Animals; Body Temperature; Body Weight; Central Nervous System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Male; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Narcotics; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2001 |
Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Cell Line; Cell Membrane; Cyclic AMP; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Magnesium; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome; Sulfur Radioisotopes; Transfection; Tritium | 2001 |
Stability of Met-enkephalin content in brain structures of morphine-dependent or foot shock-stressed rats.
Topics: Animals; Brain; Corpus Striatum; Enkephalins; Humans; Hypothalamus; Male; Morphine Dependence; Naltrexone; Oligopeptides; Rats; Stress, Psychological; Substance Withdrawal Syndrome | 1977 |
The effects of naltrexone on the development of physical dependence on morphine.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Drug Implants; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Time Factors | 1978 |
Discriminative stimulus effects of naltrexone in the morphine-dependent rat.
Topics: Animals; Generalization, Stimulus; Humans; Male; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Prejudice; Rats; Substance Withdrawal Syndrome; Time Factors | 1979 |
[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].
Topics: Animals; Diprenorphine; Humans; Male; Mice; Morphinans; Morphine; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome; Time Factors | 1976 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methadyl Acetate; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Phenytoin; Secobarbital; Self Administration | 1976 |
Comparison of withdrawal precipitating properties of various morphine antagonists and partial agonists in relation to their stereospecific binding to brain homogenates.
Topics: Benzomorphans; Binding Sites; Brain; Humans; Levallorphan; Morphine Dependence; Nalorphine; Naloxone; Naltrexone; Narcotic Antagonists; Pentazocine; Receptors, Drug; Sodium; Stereoisomerism; Subcellular Fractions; Substance Withdrawal Syndrome | 1976 |
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Topics: Animals; Apomorphine; Cyclazocine; Cyclopropanes; Dextropropoxyphene; Dogs; Ethylketocyclazocine; Humans; Morphinans; Morphine; Morphine Dependence; Nalorphine; Naltrexone; Phenazocine; Spinal Cord | 1976 |
Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Pyrrolidines; Rats | 1992 |
Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration.
Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Injections, Intraventricular; Kynurenic Acid; Locus Coeruleus; Male; Morphine Dependence; Naltrexone; Neurons; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1991 |
Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; GTP-Binding Proteins; Locus Coeruleus; Male; Morphine Dependence; Naltrexone; Neurons; Protein Kinases; Rats; Rats, Inbred Strains; Reference Values; Substance Withdrawal Syndrome | 1990 |
Physical dependence on morphine using the mu receptor deficient CXBK mouse.
Topics: Animals; Mice; Mice, Inbred C57BL; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Species Specificity; Substance Withdrawal Syndrome | 1990 |
Effects of chronic treatment with specific antagonists on analgesia and physical dependence on morphine in rats.
Topics: Analgesics; Animals; Indoles; Male; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Weight Loss | 1990 |
Context-specific morphine withdrawal in rats: duration and effects of clonidine.
Topics: Animals; Arousal; Association Learning; Clonidine; Male; Morphine; Morphine Dependence; Motor Activity; Naltrexone; Rats; Social Environment; Substance Withdrawal Syndrome; Weight Loss | 1990 |
Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats.
Topics: Analgesics; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Tolerance; Food; Infusion Pumps; Male; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Reaction Time; Reinforcement Schedule; Substance Withdrawal Syndrome | 1990 |
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Chick Embryo; Methadone; Morphine Dependence; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pyrrolidines; Receptors, Opioid; Substance Withdrawal Syndrome | 1989 |
Procedures that produce context-specific tolerance to morphine in rats also produce context-specific withdrawal.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Social Environment; Substance Withdrawal Syndrome; Thermosensing | 1989 |
Effects of a selective kappa-opioid agonist, U-50,488H, on morphine dependence in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Male; Morphine Dependence; Naltrexone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 1989 |
A dose run-up and safety evaluation of nalmefene HCl in human volunteers.
Topics: Adult; Arousal; Dose-Response Relationship, Drug; Humans; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists | 1989 |
Taste aversion involving central opioid antagonism is potentiated in morphine-dependent rats.
Topics: Animals; Blood-Brain Barrier; Dose-Response Relationship, Drug; Drug Synergism; Infusions, Parenteral; Injections, Subcutaneous; Male; Morphine Dependence; Nalorphine; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Rats; Rats, Inbred Strains; Taste | 1989 |
Chronic administration of morphine and naltrexone up-regulate[3H][D-Ala2,D-leu5]enkephalin binding sites by different mechanisms.
Topics: Animals; Drug Tolerance; Male; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium Chloride | 1988 |
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats.
Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
An analysis of naltrexone precipitated abstinence in morphine-dependent chronic spinal dogs.
Topics: Animals; Behavior, Animal; Cordotomy; Dogs; Dose-Response Relationship, Drug; Female; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid; Substance Withdrawal Syndrome | 1987 |
Dissociation of the opioid and nonopioid effects of cyclazocine.
Topics: Animals; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Female; Hallucinogens; Morphine; Morphine Dependence; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism | 1988 |
Irreversible binding of [3H]beta-funaltrexamine to brain slices of morphine-tolerant and -dependent mice.
Topics: Animals; Brain Chemistry; Corpus Striatum; Drug Tolerance; In Vitro Techniques; Male; Mesencephalon; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Stereoisomerism | 1988 |
Effects of beta-funaltrexamine (beta-FNA) on morphine dependence in rats and monkeys.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Macaca mulatta; Male; Morphine Dependence; Naltrexone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Species Specificity; Substance Withdrawal Syndrome; Time Factors | 1986 |
[Activity of naloxone and naltrexone on the development of the morphine withdrawal syndrome].
Topics: Animals; Behavior, Animal; Female; Male; Mice; Morphine Dependence; Naloxone; Naltrexone; Rats; Substance Withdrawal Syndrome | 1986 |
Discriminative stimulus effects of morphine withdrawal in the dependent rat: suppression by opiate and nonopiate drugs.
Topics: Animals; Body Weight; Clonidine; Haloperidol; Humans; Male; Morphine Dependence; Naloxone; Naltrexone; Narcotics; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome | 1985 |