naltrexone and Chronic Pain

naltrexone has been researched along with Chronic Pain in 59 studies

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	37 (62.71)	24.3611
2020's	22 (37.29)	2.80

Authors

Authors	Studies
Araya, EI; Baggio, DF; Barroso, AR; Chichorro, JG; Koren, LO; Turnes, JM; Zanoveli, JM	1
Israel, RJ; Mehta, N; Slatkin, NE; Stambler, N	1
Agarwal, A; Gautam, S; Khuba, S; Kumar, S; Shamshrey, C; Singh, A	1
Akbik, H; Atluri, S; Buenaventura, R; Dann, T; Ferguson, K; Italiano, J; Sachdeva, H; Soin, A; Soin, Y; Sudarshan, G	2
Choo, TH; Langleben, DD; Nunes, EV; Pavlicova, M; Rotrosen, J; Shulman, M; Wang, AL	1
Brenner, D; Israel, RJ; Slatkin, NE; Stambler, N; Webster, LR	1
Di Cerbo, A; Iannitti, T; Morales-Medina, JC; Pugliese, N; Zizzadoro, C	1
Aitcheson, N; Lin, Z; Tynan, K	1
Bacorro, E; Beaudette-Zlatanova, B; Branch-Elliman, W; Dubreuil, M; Eyvazzadeh, C; Kaur, M; Lazzari, AA; Lew, RA; Libbey, C; Monach, PA; Otis, JD	1
Chadwick, AL; Rupp, A; Young, E	1
Creech, ZA; Koushik, SS; Noss, B; Poliwoda, S; Truong, GTD; Urits, I; Viswanath, O	1
Bass, A; Pixton, GC; Rauck, RL; Wilson, JG; Wolfram, G	1
Hu, C; Luo, Z; Miao, J; Shen, Y; Shu, S; Wang, Y; Zhu, X	1
Hale, M; Webster, L; Wild, J; Yamada, T	1
Brenner, DM; Liu, JJ; Quinton, SE	1
Fishman, MA; Kim, PS	1
Ashman, L; Hatfield, E; Phillips, K; Swidan, S	1
Bendiks, S; Blokhina, E; Bryant, K; Cheng, DM; Gnatienko, N; Krupitsky, E; Samet, JH; Tsui, JI; Verbitskaya, E; Vetrova, M	1
Freeman, PR; Huang, Z; Oser, C; Sohn, M; Talbert, JC	1
Kim, SA; Kim, YJ; Lee, GJ; Oh, SB	1
Amaya, F; Ishikawa, T; Kanbayashi, Y; Tabuchi, Y; Taguchi, T; Takayama, K; Ueno, H	1
Wirz, S	1
Arjona Ferreira, JC; Webster, LR; Yamada, T	1
Markham, A	1
Arjona Ferreira, JC; Hale, M; Reddy, J; Wild, J; Yamada, T	1
Harper, JR; Israel, RJ; Khan, A; Michna, E; Webster, LR	1
Murphy, JA; Sheridan, EA	1
Berlau, DJ; Patten, DK; Schultz, BG	1
Arjona Ferreira, JC; Baba, Y; Morlion, B; Nalamachu, S; Reddy, J; Webster, LR; Yamada, T	1
Abdollahi, M; Mozaffari, S; Nikfar, S	1
Fukumura, K; Kubota, R; Wajima, T	1
Pixton, GC; Setnik, B; Sommerville, KW; Webster, L	1
Fanelli, A; Ghisi, D; Sorella, MC	1
Donahue, RR; Doolen, S; Grachen, CM; Morón, JA; Sinha, GP; Taylor, BK	1
Hein, M; Ji, G; Navratilova, E; Neugebauer, V; Phelps, C; Porreca, F; Qu, C; Yakhnitsa, V	1
Faraone, S; Johnson, B; Middleton, B; Oaks, Z; Stage, A	1
Benth, JŠ; Krajci, P; Kunoe, N; Latif, ZE; Opheim, A; Sharma-Haase, K; Solli, KK; Tanum, L	1
Bannister, K; Dickenson, AH; Navratilova, E; Phelps, CE; Porreca, F	1
Baumrucker, SJ; Trofimovitch, D	1
Arjona Ferreira, JC; Hale, M; Wild, J; Yamada, T	1
Blair, HA	1
Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK	1
Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS	1
McLain, D; Parkitny, L; Younger, J	1
Atayee, RS; Best, BM; Liu, JC; Ma, JD; Morello, CM	1
Bansal, D; Ghai, B; Hota, D; Shah, CS	1
Thompson, CA	1
Beaudry, H; Gendron, L; Morón, JA	1
Indovina, P; Raffaeli, W	1
Frohe, T; Kirouac, M; Maisto, SA; McCallion, E; Vowles, KE; Witkiewitz, K	1
Bass, A; Bramson, C; Hale, ME; Malhotra, BK; Meisner, P; Pixton, G; Rauck, RL; Setnik, B; Sommerville, KW; Wilson, JG; Wolfram, G	1
Weber, HC	1
Baqai, A; Diwan, S; Giambrone, GP; Mehta, N; O'Connell, K	1
Davis, MP	1
Harper, JR; Israel, RJ; Rauck, R; Slatkin, NE; Stambler, N	1
Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D	1
Lee, JM; Mooney, J	1
Pappagallo, M; Sokolowska, M	1

Reviews

18 review(s) available for naltrexone and Chronic Pain

Article	Year
Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis. Pain medicine (Malden, Mass.), 2023, 03-01, Volume: 24, Issue:3 Topics: Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Retrospective Studies	2023
Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis. Australian journal of general practice, 2023, Volume: 52, Issue:4 Topics: Chronic Pain; Fibromyalgia; Humans; Naltrexone; Prospective Studies	2023
Low-dose naltrexone's utility for non-cancer centralized pain conditions: a scoping review. Pain medicine (Malden, Mass.), 2023, Nov-02, Volume: 24, Issue:11 Topics: Chronic Disease; Chronic Pain; Humans; Inflammation; Naltrexone; Quality of Life	2023
Naldemedine for the treatment of opioid-induced constipation in adults with chronic noncancer pain. Pain management, 2020, Volume: 10, Issue:5 Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Opioid-Induced Constipation	2020
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review. Current pain and headache reports, 2020, Aug-26, Volume: 24, Issue:10 Topics: Chronic Pain; Fibromyalgia; Humans; Multiple Sclerosis; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders	2020
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review. Journal of the American Dental Association (1939), 2020, Volume: 151, Issue:12 Topics: Chronic Pain; Fibromyalgia; Humans; Naltrexone; Pain Management; Quality of Life	2020
Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review. Pain physician, 2021, Volume: 24, Issue:4 Topics: Animals; Chronic Pain; Fibromyalgia; Humans; Naltrexone; Prospective Studies; Retrospective Studies; United States	2021
[Management of adverse effects of opioid therapy]. Zeitschrift fur Gastroenterologie, 2017, Volume: 55, Issue:4 Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Chronic Pain; Constipation; Drug-Related Side Effects and Adverse Reactions; Germany; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Treatment Outcome	2017
Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain. The Annals of pharmacotherapy, 2018, Volume: 52, Issue:4 Topics: Analgesics, Opioid; Chronic Pain; Constipation; Evidence-Based Practice; Humans; Laxatives; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Piperidines; Polyethylene Glycols; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic	2018
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders. Pharmacotherapy, 2018, Volume: 38, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Chronic Pain; Crohn Disease; Dose-Response Relationship, Drug; Fibromyalgia; Humans; Inflammation; Multiple Sclerosis; Naltrexone; Narcotic Antagonists; Quality of Life	2018
Methylnaltrexone bromide for the treatment of opioid-induced constipation. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:10 Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Government Regulation; Half-Life; Humans; Naltrexone; Quality of Life; Quaternary Ammonium Compounds; Treatment Outcome	2018
Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain. Expert review of clinical pharmacology, 2018, Volume: 11, Issue:12 Topics: Abuse-Deterrent Formulations; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prescription Drug Misuse	2018
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes. The American journal of hospice & palliative care, 2019, Volume: 36, Issue:10 Topics: Analgesics, Non-Narcotic; Cancer Pain; Chronic Pain; Complex Regional Pain Syndromes; Diabetic Neuropathies; Dose-Response Relationship, Drug; Fibromyalgia; Humans; Naltrexone; Pain Management; Palliative Care; Quality of Life	2019
Naldemedine: A Review in Opioid-Induced Constipation. Drugs, 2019, Volume: 79, Issue:11 Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Clinical Trials, Phase III as Topic; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quality of Life	2019
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical rheumatology, 2014, Volume: 33, Issue:4 Topics: Anti-Inflammatory Agents; Chronic Pain; Fibromyalgia; Humans; Naltrexone; Neuroglia	2014
Opioid-induced constipation in chronic noncancer pain. Current opinion in endocrinology, diabetes, and obesity, 2016, Volume: 23, Issue:1 Topics: Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu	2016
Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review. Postgraduate medicine, 2016, Volume: 128, Issue:3 Topics: Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome	2016
Pharmacokinetic and pharmacodynamic evaluation of oxycodone and naltrexone for the treatment of chronic lower back pain. Expert opinion on drug metabolism & toxicology, 2016, Volume: 12, Issue:7 Topics: Analgesics, Opioid; Animals; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Humans; Low Back Pain; Naltrexone; Opioid-Related Disorders; Oxycodone; Practice Guidelines as Topic	2016

Trials

14 trial(s) available for naltrexone and Chronic Pain

Article	Year
Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials. F1000Research, 2021, Volume: 10 Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome	2021
Baseline- and treatment-associated pain in the X:BOT comparative effectiveness study of extended-release naltrexone versus buprenorphine-naloxone for OUD. Addiction biology, 2022, Volume: 27, Issue:2 Topics: Buprenorphine, Naloxone Drug Combination; Chronic Pain; Delayed-Action Preparations; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prospective Studies	2022
Pilot Study of Low-dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: A Randomized, Double-blind, Placebo-controlled, Crossover Clinical Trial. Clinical therapeutics, 2023, Volume: 45, Issue:5 Topics: Arthritis; Chronic Pain; Double-Blind Method; Fatigue; Humans; Naltrexone; Peripheral Nervous System Diseases; Pilot Projects; Quality of Life; Treatment Outcome	2023
Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain. Clinical drug investigation, 2020, Volume: 40, Issue:2 Topics: Adult; Analgesics, Opioid; Chronic Pain; Cross-Over Studies; Delayed-Action Preparations; Fasting; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Oxycodone; Tablets; Therapeutic Equivalency	2020
Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial. AIDS care, 2023, Volume: 35, Issue:8 Topics: Alcoholism; Chronic Pain; HIV Infections; Humans; Naltrexone; Narcotic Antagonists; Pilot Projects; Treatment Outcome	2023
A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain. Pain medicine (Malden, Mass.), 2017, Dec-01, Volume: 18, Issue:12 Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists	2017
Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials. The lancet. Gastroenterology & hepatology, 2017, Volume: 2, Issue:8 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Double-Blind Method; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Young Adult	2017
Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial. Pain medicine (Malden, Mass.), 2017, Aug-01, Volume: 18, Issue:8 Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Time	2017
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study. Pain, 2018, Volume: 159, Issue:5 Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quality of Life; Treatment Outcome	2018
No increased pain among opioid-dependent individuals treated with extended-release naltrexone or buprenorphine-naloxone: A 3-month randomized study and 9-month open-treatment follow-up study. The American journal on addictions, 2019, Volume: 28, Issue:2 Topics: Adult; Buprenorphine, Naloxone Drug Combination; Chronic Pain; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Norway; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Measurement	2019
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials. Pain, 2019, Volume: 160, Issue:10 Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Time Factors; Treatment Outcome	2019
Pain as a predictor of heavy drinking and any drinking lapses in the COMBINE study and the UK Alcohol Treatment Trial. Addiction (Abingdon, England), 2015, Volume: 110, Issue:8 Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Behavior Therapy; Chronic Pain; Combined Modality Therapy; Female; Humans; Male; Naltrexone; Pain Measurement; Recurrence; Taurine; Treatment Outcome	2015
A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment. Pain, 2015, Volume: 156, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Analysis of Variance; Chronic Pain; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Humans; Low Back Pain; Middle Aged; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Treatment Outcome; Young Adult	2015
Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain. Pain practice : the official journal of World Institute of Pain, 2017, Volume: 17, Issue:6 Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome	2017

Other Studies

27 other study(ies) available for naltrexone and Chronic Pain

Article	Year
Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain. Behavioural brain research, 2022, 01-24, Volume: 417 Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trigeminal Neuralgia	2022
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review". Pain physician, 2021, Volume: 24, Issue:8 Topics: Chronic Pain; Humans; Naltrexone	2021
In Response Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review". Pain physician, 2021, Volume: 24, Issue:8 Topics: Chronic Pain; Humans; Naltrexone	2021
Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain. International journal of molecular sciences, 2023, Feb-01, Volume: 24, Issue:3 Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Inverse Agonism; Hyperalgesia; Inflammation; Mice; Naltrexone; Opioid Peptides; Opioid-Related Disorders; Rats; Rats, Wistar	2023
The Utilization of Low Dose Naltrexone for Chronic Pain. CNS drugs, 2023, Volume: 37, Issue:8 Topics: Analgesics, Opioid; Chronic Disease; Chronic Pain; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence	2023
Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride) extended-release capsules in older patients: a pooled analysis of two clinical trials. Current medical research and opinion, 2020, Volume: 36, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Low Back Pain; Male; Middle Aged; Naltrexone; Oxycodone; Randomized Controlled Trials as Topic; Young Adult	2020
Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age. Drugs & aging, 2020, Volume: 37, Issue:4 Topics: Aged; Aged, 80 and over; Chronic Pain; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Safety	2020
Trends in Urine Drug Monitoring Among Persons Receiving Long-Term Opioids and Persons with Opioid Use Disorder in the United States. Pain physician, 2021, Volume: 24, Issue:2 Topics: Adult; Analgesics, Opioid; Buprenorphine; Chronic Pain; Cross-Sectional Studies; Drug Monitoring; Female; Humans; Male; Methadone; Middle Aged; Naltrexone; Opioid-Related Disorders; United States; Young Adult	2021
Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain. Brain research, 2021, 07-01, Volume: 1762 Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa	2021
Factors affecting the effect of naldemedine for opioid-induced constipation: a single-institution, retrospective analysis. Die Pharmazie, 2021, 04-01, Volume: 76, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cholinergic Antagonists; Chronic Pain; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Retrospective Studies; Time Factors; Tramadol; Treatment Outcome; Young Adult	2021
Naldemedine: First Global Approval. Drugs, 2017, Volume: 77, Issue:8 Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Drug Approval; Humans; Japan; Laxatives; Naltrexone; United States	2017
Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine. Pharmaceutical research, 2018, Oct-02, Volume: 35, Issue:11 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Body Weight; Cancer Pain; Chronic Pain; Constipation; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Naltrexone	2018
Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users. Current medical research and opinion, 2019, Volume: 35, Issue:3 Topics: Adult; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome	2019
Opioid receptors inhibit the spinal AMPA receptor Ca Experimental neurology, 2019, Volume: 314 Topics: Adamantane; Animals; Calcium; Chronic Pain; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Nociception; Posterior Horn Cells; Receptors, AMPA; Receptors, Glutamate; Receptors, Opioid; Spinal Cord; Synapses	2019
Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain. Pain, 2019, Volume: 160, Issue:4 Topics: Animals; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neuralgia; Neurons; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Synaptic Transmission	2019
Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone. Discovery medicine, 2018, Volume: 26, Issue:144 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Female; Fibromyalgia; Humans; Hyperalgesia; Male; Middle Aged; Naltrexone; Opioid-Related Disorders; Pain Management; Pain Measurement; Pain Threshold; Predictive Value of Tests; Retrospective Studies; Young Adult	2018
Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain. Pain, 2019, Volume: 160, Issue:7 Topics: Amygdala; Animals; Chronic Pain; Diffuse Noxious Inhibitory Control; Electrophysiological Phenomena; Functional Laterality; Hindlimb; Hyperalgesia; Ligation; Male; Naltrexone; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Spinal Nerves	2019
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science (New York, N.Y.), 2013, Sep-20, Volume: 341, Issue:6152 Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Isoflurane; Male; Mice; Naltrexone; Nociceptive Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome	2013
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life sciences, 2013, Dec-18, Volume: 93, Issue:25-26 Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	2013
Naltrexone metabolism and concomitant drug concentrations in chronic pain patients. Journal of analytical toxicology, 2014, Volume: 38, Issue:4 Topics: Age Factors; Analgesics, Opioid; Chronic Pain; Creatinine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Humans; Limit of Detection; Male; Medication Adherence; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Retrospective Studies; Sex Factors	2014
Off-label, low-dose naltrexone for refractory chronic low back pain. Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:5 Topics: Adult; Chronic Pain; Humans; Low Back Pain; Male; Naltrexone; Narcotic Antagonists; Off-Label Use; Pain Measurement; Treatment Outcome	2014
GI relief may come sooner than later for patients with chronic noncancer pain. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2014, Jul-15, Volume: 71, Issue:14 Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Drug Approval; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration	2014
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain. The European journal of neuroscience, 2015, Volume: 41, Issue:7 Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta	2015
Low-dose naltrexone to prevent intolerable morphine adverse events: a forgotten remedy for a neglected, global clinical need. Pain medicine (Malden, Mass.), 2015, Volume: 16, Issue:6 Topics: Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neoplasms	2015
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nature medicine, 2017, Volume: 23, Issue:2 Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord	2017
Methylnaltrexone in treatment of opioid-induced constipation in a pediatric patient. The Clinical journal of pain, 2012, Volume: 28, Issue:4 Topics: Analgesics, Opioid; Child, Preschool; Chronic Pain; Constipation; Humans; Male; Naltrexone; Narcotic Antagonists; Pediatrics; Quaternary Ammonium Compounds	2012
The implications of tamper-resistant formulations for opioid rotation. Postgraduate medicine, 2012, Volume: 124, Issue:5 Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Tolerance; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Patient Selection	2012