naltrexone has been researched along with Ache in 409 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 76 (18.58) | 18.7374 |
| 1990's | 88 (21.52) | 18.2507 |
| 2000's | 112 (27.38) | 29.6817 |
| 2010's | 108 (26.41) | 24.3611 |
| 2020's | 25 (6.11) | 2.80 |
| Authors | Studies |
|---|---|
| Hebbel, RP; Lunzer, MM; Portoghese, PS; Yekkirala, A | 1 |
| Otte, A; Park, K | 1 |
| Komrowski, MD; Sekhri, NK | 1 |
| Amris, K; Blichfeldt-Eckhardt, MR; Bruun, KD; Christensen, R; Holsgaard-Larsen, A; Toft, P; Vaegter, HB | 1 |
| Becker, S; Fahey, E; Gandhi, W; Hoeppli, ME; Price, RC; Qu, A; Schweinhardt, P; Sirucek, L | 1 |
| Brooks, JC; Hartley-Davies, R; Moran, R; Oliva, V; Pickering, AE | 1 |
| Biondi, BE; Schlossberg, EF; Shaw, A; Springer, SA; Vander Wyk, B | 1 |
| Billeci, D; Candeletti, S; Coluzzi, F; Losapio, LM; Rocco, M; Romualdi, P; Rullo, L; Scerpa, MS | 1 |
| Miller, CS; Sangalli, L | 1 |
| Dieb, W; Durif, F; Hafidi, A; Hamdi, D; Lashin, M; Omara-Reda, H; Ouachikh, O | 1 |
| Acevedo, L; Belli, B; Cami-Kobeci, G; Flynn, P; France, CP; Gerak, LR; Husbands, SM; Maguire, DR; Olson, KM; Traynor, JR | 1 |
| Berg, KA; Chavera, TS; Clarke, WP; Jamshidi, RJ; Jennings, EM; Smith, HR; Wedemeyer, MJ | 1 |
| McKew, JC; Sadee, W | 1 |
| DeGrado, JR; Dube, KM; Goodberlet, MZ; Habeeb, EA; Lupi, KE; Tran, LK | 1 |
| Cadet, T; Jalali, A; Jeng, PJ; Murphy, SM; Poole, S; Woody, G | 1 |
| DeSanto, K; Huang, H; Lyon, C; Radi, R; Rivera, J | 1 |
| De Mattos, T; Fernandes, LSA; Melo, DF; Nunes, BEM; Tortelly, VD | 1 |
| Caliari, MV; de Almeida, DL; Duarte, IDG; Lima Romero, TR; Paiva-Lima, P; Petrocchi, JA; Queiroz-Junior, C | 1 |
| Capim, SL; Côrtes, WDS; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, PA; Vasconcellos, MLAA | 1 |
| Ding, H; Kiguchi, N; Ko, MC | 1 |
| Ding, H; Kiguchi, N; Kishioka, S; Ko, MC | 1 |
| Cunningham, CW; France, CP; Gerak, LR; Hu, Z; Mada, S; Maguire, DR; Minervini, V; Soyer, A | 1 |
| Oberdick, J; Sadee, W; Wang, Z | 1 |
| Lamm, C; Rütgen, M; Zhang, L; Zhao, Y | 1 |
| Murray-Brown, FL | 1 |
| Alazzani, M; Alhusban, AY; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ | 1 |
| Chadwick, AL; Neuman, DL | 1 |
| Bansal, D; Bhansali, AK; Chakrabarti, A; Dutta, P; Hota, D; Srinivasan, A | 1 |
| al'Absi, M; Bruehl, S; Nakajima, M | 1 |
| Malcolm-Smith, S; Stein, DJ; van Honk, J; van Steenbergen, H; Weissman, DH | 1 |
| Bícego, KC; Cristina-Silva, C; Gargaglioni, LH; Martins, V | 1 |
| Eisenegger, C; Gartus, A; Lamm, C; Pletti, C; Riečanský, I; Rütgen, M; Seidel, EM | 1 |
| Al-Azzani, M; Alhusban, A; Alzoubi, KH; Bawaane, A; Khabour, OF; Nuseir, KQ | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Filipović, B; Lacković, Z | 1 |
| Castor, MGME; Diniz, DA; Duarte, IDG; Navarro, LC; Petrocchi, JA; Romero, TRL; Souza, TC | 1 |
| De Felice, M; Dodick, DW; Hernandez, PI; Nation, KM; Navratilova, E; Neugebauer, V; Porreca, F | 1 |
| Graham, DP; Kosten, TR; Nielsen, DA | 1 |
| Baamonde, A; Cernuda-Cernuda, R; Fernández-García, MT; Folgueras, AR; García-Domínguez, M; Hidalgo, A; Lastra, A; Menéndez, L | 1 |
| Kokki, H; Kokki, M; Kuronen, M; Nyyssönen, T; Savolainen, S | 1 |
| Antoniolli, AR; Branco, A; Gama, KB; Quintans, JS; Quintans-Júnior, LJ; Santana, WA; Soares, MB; Villarreal, CF | 1 |
| Pergolizzi, JV; Porreca, F; Raffa, RB; Taylor, R | 1 |
| Armstrong, SR; Beattie, DT; Campbell, CB; Hegde, SS; Long, DD; Richardson, CL; Tsuruda, PR; Vickery, RG | 1 |
| Alexander, S; Dupuis, LL; Lau, E; Mattiussi, A; Rodrigues, A; Wong, C | 1 |
| Rauck, RL | 1 |
| Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC | 1 |
| Anisimova, VA; Grechko, OIu; Shtareva, DM; Spasov, AA | 1 |
| Cheema, MS; Kader, AA; Kek, TL; Mohd Sani, MH; Salleh, MZ; Zakaria, ZA | 1 |
| Bergman, J; Kangas, BD | 1 |
| Ise, Y; Itoh, T; Komiya, S; Masukawa, D; Mizuo, K; Mori, T; Saeki, T; Shibasaki, M; Suzuki, T; Yoshizawa, K | 1 |
| Majumdar, S; Marcovitz, J; Mogil, JS; Pan, YX; Pasternak, GW; Pidakala, J; Tuttle, AH; Wieskopf, JS | 1 |
| Gregg, M; Martinez, L; Samaritan, G | 1 |
| Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC | 1 |
| Herrero, JF; Herrero-Zorita, C; Ramos-Zepeda, GA | 1 |
| Dou, Y; Huang, W; Li, Q; Lin, Y; Shu, H; Wang, Z; Xiao, X; Ye, F | 1 |
| Hotta, H; Piché, M; Watanabe, N | 1 |
| Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A | 1 |
| King, T; Navratilova, E; Okun, A; Porreca, F; Remeniuk, B; Sukhtankar, D; Xie, JY | 1 |
| Lu, Z; Majumdar, S; Pan, YX; Pasternak, GW; Rossi, GC; Xu, J | 1 |
| Backstedt, D; Jones, R; Prommer, E | 1 |
| Hummer, A; Lamm, C; Petrovic, P; Riečanský, I; Rütgen, M; Seidel, EM; Silani, G; Windischberger, C | 1 |
| Handberg, G; Plesner, KB; Vægter, HB | 1 |
| Bridgeman, MB; Chokhavatia, S; Dixit, D; John, ES | 1 |
| Cosson, P; Kapanci, L; Langhart, J; Leiba, J; Lembo, AB; Shore, C; Steger, VJ; Studer, LB | 1 |
| Drummond, PD; Hood, S; Vo, L | 1 |
| Can, ÖD; Kasap, M | 1 |
| Colucci, S; Harris, SC; Morganroth, J; Ripa, SR; Thorn, MD | 1 |
| Alijanpour, S; Amini-Khoei, H; Amiri, S; Banafshe, HR; Dehpour, AR; Haj-Mirzaian, A; Mehr, SE; Mesdaghinia, A; Mohammadi-Asl, A; Poursaman, S; Rastegar, M; Sadeghi, E; Samiei, E | 1 |
| Brellenthin, AG; Cook, DB; Crombie, KM; Koltyn, KF; Sehgal, N | 1 |
| Drummond, PD; Vo, L | 1 |
| Drummond, PD; Frew, AK | 3 |
| Brown, K; Coats, BD; Crysdale, NY; Harrison, JA; Hutchinson, MR; Maier, SF; Patel, SJ; Rice, KC; Sholar, PW; Shridhar, M; Watkins, LR; Zhang, Y | 1 |
| Beck, P; Bonacorso, HG; Drewes, C; Ferreira, J; Machado, P; Martins, MA; Mello, CF; Milano, J; Oliveira, SM; Rossato, MF; Rubin, MA; Zanatta, N | 1 |
| Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM | 2 |
| Bear, AE; Folk, JE; Negus, SS; Rice, KC | 1 |
| Cornélio, AM; Nunes-de-Souza, RL | 1 |
| Booker, L; Cravatt, BF; Lichtman, AH; Naidu, PS | 1 |
| Bakhle, YS; de Francischi, JN; Dos Reis, WG; Duarte, ID; Lima, PP; Rezende, RM | 1 |
| Fantegrossi, WE; Galuska, CM; Ko, MC; Prinssen, EP; Wichmann, J; Woods, JH | 1 |
| Kitamura, T; Ogawa, M; Yamada, Y | 1 |
| Fuchs, PN; Uhelski, ML | 1 |
| Cowan, A; Dun, NJ; Inan, S | 1 |
| Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR | 1 |
| Frishtick, R; Pick, CG; Rubovitch, V; Schreiber, S; Volis, I; Weizman, R | 1 |
| Miranda, HF; Pinardi, G | 1 |
| Rhudy, JL | 1 |
| Bruehl, S; Burns, JW; Chont, M; Chung, OY; Gilliam, W; Goodlad, JK; Magid, E; Matsuura, J; Somar, K | 1 |
| Bessière, B; Chateauraynaud, J; Laboureyras, E; Laulin, JP; Simonnet, G | 1 |
| Al-Khrasani, M; Asim, MF; Friedmann, T; Furst, S; Király, KP; Riba, P; Schmidhammer, H; Sobor, M; Spetea, M | 1 |
| Axmann, R; Brune, K; Heindl-Erdmann, C; Hess, A; Kreitz, S; Penninger, J; Schett, G; Zwerina, J | 1 |
| Bartolini, A; Bergonzi, MC; Bilia, AR; Galeotti, N; Ghelardini, C; Vivoli, E | 1 |
| Cravezic, A; do-Rego, JC; Fichna, J; Janecka, A; Perlikowska, R; Toth, G; Wyrebska, A | 1 |
| Bruehl, S; Burns, JW; Cairl, H; Chont, M; Chung, OY; Gilliam, W; Goodlad, JK; Magid, E; Matsuura, J; Somar, K; Stone, K | 1 |
| Jin, WY; Liu, D; Liu, Z; Yu, LC | 1 |
| Cheng, K; Morrissey, EM; Negus, SS; Rice, KC; Rosenberg, M | 1 |
| Fukuda, K; Koyama, T | 1 |
| Bilsky, EJ; Giuvelis, D; Lowery, JJ; Osborn, MD; Skorput, AG | 1 |
| Ansonoff, MA; Pintar, JE; Portoghese, PS | 1 |
| Beardsley, PM; Carroll, FI; Howard, JL; Pollard, GT | 1 |
| Botelho, AP; de Arruda Veiga, MC; Gameiro, GH; Marcondes, FK; Tuma, CE | 1 |
| Aicher, SA; Arttamangkul, S; Bobeck, EN; Hegarty, DM; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Bagaeva, TR; Iarushkina, NI | 1 |
| Duggan, ST; Scott, LJ | 1 |
| Belavic, JM | 1 |
| Bakhle, YS; de Francischi, JN; dos Reis, WG; Ferreira-Alves, DL; Gassani, BC; Paiva-Lima, P; Rezende, RM | 1 |
| Hale, M; Katz, N; Morris, D; Stauffer, J | 1 |
| Baiula, M; Bedini, A; De Marco, R; Gentilucci, L; Spampinato, S; Tolomelli, A | 1 |
| Chapleo, CB; Hay, JL; La Vincente, SF; Somogyi, AA; White, JM | 1 |
| Pergolizzi, JV; Raffa, RB | 1 |
| Berbari, J; Farah, B; Iskedjian, M; Iyer, S; Librach, SL; Wang, M | 1 |
| Lawson, KP; Mokha, SS; Nag, S; Thompson, AD | 1 |
| Akiyama, T; Carstens, E; Carstens, MI | 1 |
| Brewer, R; Johnson, FK; Morris, D; Sekora, D; Stauffer, J; Wang, C; Webster, LR | 1 |
| Cabañero, D; Campillo, A; García-Nogales, P; Puig, MM; Romero, A | 1 |
| Guymer, EK; Littlejohn, GO; Ngian, GS | 1 |
| Hesselink, JM; Kopsky, DJ | 1 |
| Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P | 1 |
| Blonsky, ER; Iyer, S; Manley, A; Michna, E; Randazzo, B; Schulman, S; Tzanis, E; Zhang, H | 1 |
| Gear, RW; Levine, JD | 1 |
| Ruan, X | 1 |
| Smith, HS | 1 |
| France, CR; Rhudy, JL | 1 |
| Dodrill, CL; Helmer, DA; Kosten, TR | 1 |
| Beninger, RJ; Olmstead, MC; Paquette, JJ; Tuerke, KJ | 1 |
| Craft, RM; Wakley, AA | 1 |
| Bihel, F; Bockel, F; Bourguignon, JJ; Elhabazi, K; Maldonado, R; Meziane, H; Mollereau, C; Moulédous, L; Petit-demoulière, B; Schmitt, M; Simonin, F; Trigo, JM; Zajac, JM | 1 |
| Morgan, RW; Nicholson, KL | 1 |
| Ciric, S; Johnson, FK; Setnik, B; Stauffer, J; Webster, LR | 1 |
| Brewer, R; Cleveland, JM; Morris, D; Setnik, B; Webster, LR | 1 |
| Dicay, M; Fichna, J; Janecka, A; Lewellyn, K; MacNaughton, WK; Storr, MA; Zjawiony, JK | 1 |
| Hales, TG | 1 |
| Ballesta, JJ; Cremades, J; Faura, CC; Garzón, J; Rodríguez-Muñoz, M | 1 |
| Ansonoff, M; Burgman, M; Grinnell, S; Le Rouzic, V; Majumdar, S; Pan, YX; Pasternak, GW; Pintar, J; Polikar, L | 1 |
| Bath, B; Bilsky, E; Burkart, J; Dallaire, B; Magiera, D; Phelps, M; Sadee, W; Webster, L; Yancey-Wrona, J; Yang, X | 1 |
| Cayley, WE | 1 |
| Bagaeva, TR; Filaretova, LP; Iarushkina, NI | 1 |
| Gatti, A; Sabato, AF | 1 |
| Bakhle, YS; Camêlo, VM; Dos Reis, WG; Faraco, A; Francischi, JN; Paiva-Lima, P; Rezende, RM | 1 |
| Costantino, CM; Devi, LA; Gomes, I; Lim, MP; Stockton, SD | 1 |
| Carstens, E; Carstens, MI; Davoodi, A; Spradley, JM | 2 |
| Caudle, RM; Edwards, RR; Fillingim, RB; Goodin, B; Gravenstein, N; Kindler, LL; King, CD; Riley, JL | 1 |
| Holzer, P | 1 |
| Heintz, J; Kissling, KT; Mohassel, LR | 1 |
| Casais e Silva, LL; Leite dos Santos, GG; Pereira Soares, MB; Villarreal, CF | 1 |
| Bannwarth, B | 1 |
| Schaeffer, T | 1 |
| Bagetta, G; Katsuyama, S; Komatsu, T; Kuwahata, H; Mizoguchi, H; Nagaoka, K; Nakamura, H; Sakurada, S; Sakurada, T | 1 |
| Arduino, C; Benedetti, F; Blanchard, C; Thoen, W; Vighetti, S | 1 |
| Mackey, S; McCue, R; Noor, N; Younger, J | 1 |
| Gabriel, A; Grond, S; Huang, YH; Lu, JT; Meuser, T; Pierce Palmer, P; Pietruck, C; Yu, LC | 1 |
| Bastia, E; Bertorelli, R; Citterio, F; Corradini, L; Forlani, A; Ongini, E | 1 |
| Borghi, V; Ilona, O; Labuz, D; Maj, M; Pavone, F; Przewlocka, B | 1 |
| Gardell, LR; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW | 1 |
| Brandão, ML; Castilho, VM; Macedo, CE | 1 |
| Leitermann, R; Mizoguchi, H; Nagase, H; Spaulding, A; Tseng, LF; Wu, HE | 1 |
| Arbuck, DM; Cruciani, RA; Lussier, D; Miller-Saultz, D | 1 |
| Sacerdote, P | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Brandão, ML; de Luca, MC; Landeira-Fernandez, J; Motta, VA | 1 |
| Darpolar, M; Dunn, W; Sun, HS; Tseng, LF; Wu, HE | 1 |
| Lundeberg, T; Yu, LC; Yu, SQ | 1 |
| Folk, JE; Linsenmayer, DC; Negus, SS; Rice, KC; Stevenson, GW | 1 |
| Gebhart, GF; Hartwig, AC; Law, AS; Mathias, SI | 1 |
| Bhardwaj, A; Chen, TY; Hurn, PD; Kirsch, JR; Koehler, RC; Toung, TJK; Traystman, RJ; Zhang, Z | 1 |
| Bogdanov, AI; Yarushkina, NI | 1 |
| Greene, JL; McClean, JM; Smith, MA | 1 |
| Fujimoto, JM; Leitermann, RJ; Sun, HS; Thompson, J; Tseng, LF; Wu, HE | 1 |
| Cohen, E; Goodchild, CS; Nadeson, R | 1 |
| D'Anci, KE; Kanarek, RB | 1 |
| Chen, CM; Huang, EY; Tao, PL | 1 |
| Cox, ML; Welch, SP | 1 |
| Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y | 1 |
| Aloisi, AM; Ceccarelli, I; Fiorenzani, P; Grasso, G; Lariviere, WR; Massafra, C; Massai, L; Muscettola, M | 1 |
| Cândido, CR; Francischi, JN; Pereira, LS; Resende, MA; Sabino, GG | 1 |
| Sun, YG; Yu, LC | 1 |
| Crown, ED; Grau, JW; Meagher, MW | 1 |
| Arthuri, MT; de Arruda Veiga, MC; Gameiro, GH; Tambeli, CH | 1 |
| Ambo, A; Bryant, SD; Fujita, Y; Jinsmaa, Y; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Angers, P; Dalbó, S; Jürgensen, S; Ribeiro-do-Valle, RM; Santos, AR | 1 |
| Boulet, JM; Walker, K; Whiteside, GT | 1 |
| Burns, LH; Butera, PG; Chindalore, VL; Craven, RA; Friedmann, N; Yu, KP | 1 |
| Carstens, E; Carstens, MI; Cuellar, JM; Moore, JA; Pinkerton, KE; Simons, CT; Uyeminami, D | 1 |
| Kaneko, C; Kuzumaki, N; Matsuzawa, K; Miyoshi, K; Nagumo, Y; Nakajima, M; Nanjo, K; Narita, M; Suzuki, T; Yamazaki, M | 1 |
| Kamei, J; Nozaki, C; Saitoh, A; Tamura, N | 1 |
| Boulet, JM; Chaffer, SM; Garrison, AE; Gottshall, SL; Harrison, JE; Mark, L; Pearson, MS; Turchin, PI; Valenzano, KJ; Whiteside, GT | 1 |
| Fan, GX; Tang, JS; Wang, JY; Yuan, YK; Zeng, XY | 1 |
| Jolly, A; Vickers, AP | 1 |
| Brandão, ML; De Luca-Vinhas, MC; Macedo, CE | 1 |
| Mohan, S; Stevens, CW | 1 |
| Xiong, W; Yu, LC | 1 |
| Barrett, AC; Lomas, LM; Negus, SS; Picker, MJ; Terner, JM | 1 |
| Kamei, J; Nozaki, C; Saitoh, A | 1 |
| Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC | 1 |
| Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK | 1 |
| Beheshtian, A; Dehpour, AR; Ghahremani, MH; Kiumehr, S; Payabvash, S; Sabzevari, O; Salmasi, AH; Tavangar, SM | 1 |
| Ambo, A; Bryant, SD; Fujita, Y; Jinsmaa, Y; Lazarus, LH; Li, T; Marczak, E; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Cody, C; O'Brien, B | 1 |
| Hatori, Y; Horie, S; Kitajima, M; Matsumoto, K; Misawa, K; Murayama, T; Takayama, H; Tashima, K; Wongseripipatana, S | 1 |
| Thompson, CA | 1 |
| al'Absi, M; Beesley, L; Carroll, D; Edwards, L; France, CR; Martin, U; McIntyre, D; Ring, C | 1 |
| Stancliff, S | 1 |
| Daniels, DJ; Lenard, NR; Portoghese, PS; Roerig, SC | 1 |
| Aceto, MD; Bowman, ER; Cook, CD; Harris, LS; May, EL | 1 |
| Kang, HW; Kim, JH; Kim, MS; Koo, S; Lee, SJ; Lyu, YS; Park, BR; Sohn, IC; Song, JH | 1 |
| Abul-Husn, NS; Jhamandas, K; Milne, B; Sutak, M | 1 |
| Ditto, B; Ghosh, S; Lewkowski, MD; Young, SN | 1 |
| Andoh, T; Kuraishi, Y; Nakashima, Y; Sasaki, A; Shiraki, K; Takasaki, I | 1 |
| Labuz, D; Machelska, H; Mousa, SA; Schäfer, M; Stein, C | 1 |
| Gu, XL; Sun, YG; Yu, LC | 1 |
| Alloui, A; Baron, A; Blondeau, N; Cupo, A; Diochot, S; Eschalier, A; Escoubas, P; Gélot, A; Heurteaux, C; Lazdunski, M; Mazzuca, M; Voilley, N; Zimmer, A; Zimmer, AM | 1 |
| Hamabe, W; Mashida, E; Nagae, R; Tokuyama, S | 1 |
| Ahn, DK; Han, SR; Jeon, HJ; Ju, JS; Kim, SK; Lee, MK; Lim, KH; Yang, GY; Yoon, YW | 1 |
| Ambriz-Tututi, M; Araiza-Saldaña, CI; Arreola-Espino, R; Caram-Salas, NL; Granados-Soto, V; Mixcoatl-Zecuatl, T; Rocha-González, HI; Urquiza-Marín, H | 1 |
| Miranda, HF; Pinardi, G; Prieto, JC; Puig, MM | 1 |
| al'Absi, M; Carroll, D; Edwards, L; France, CR; Martin, U; McIntyre, D; Ring, C | 1 |
| Loscalzo, LM; Marder, M; Paladini, AC; Wasowski, C | 1 |
| Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM | 1 |
| Chen, Q; Dong, L; Fu, CY; Ni, JM; Wang, R; Zhao, YL | 1 |
| Arastu, MF; Dean, RL; Deaver, DR; Dong, N; Gastfriend, DR; Kriksciukaite, K; O'Driscoll, K; Reitano, K; Todtenkopf, MS | 1 |
| Azad, SC; Beyer, A; Huge, V; Rammes, G; Zieglgänsberger, W | 1 |
| Galasso, FL; Israel, RJ; Moehl Boatwright, ML; Portenoy, RK; Stambler, N; Thomas, J; Tran, D; Von Gunten, CF | 1 |
| Ko, MC; Traynor, JR; Woods, JH; Xie, H | 1 |
| Portoghese, PS; Takemori, AE; Ward, SJ | 1 |
| Takemori, AE; Ward, SJ | 1 |
| Herz, A; Millan, MH; Millan, MJ; Przewłocki, R | 1 |
| Goldstein, DJ; Keiser, HR | 1 |
| Chance, WT | 1 |
| Buchsbaum, MS; Davis, GC | 1 |
| Buchsbaum, MS; Cappelletti, J; Davis, GC; Holcomb, HH; Reus, VI; Silberman, E | 1 |
| Griffiths, EC; Slater, P; Webster, VA | 1 |
| Cannon, JT; Lewis, JW; Liebeskind, JC; Shavit, Y; Terman, GW | 1 |
| Guile, MN; McCutcheon, NB | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Frischknecht, HR; Riggio, G; Siegfried, B; Waser, PG | 1 |
| Drugan, R; Hyson, RL; Maier, SF; Mayer, DJ; Moye, TB; Ryan, SM; Watkins, LR | 1 |
| Cannon, JT; Lewis, JW; Liebeskind, JC | 1 |
| Gintzler, AR | 2 |
| Bianchi, G; Fiocchi, R; Manara, L; Tavani, A | 1 |
| Maes, RA; Plomp, GJ; van Ree, JM | 1 |
| Barchas, JD; Grau, JW; Hyson, RL; Madden, J; Maier, SF | 1 |
| Buchsbaum, MS; Bunney, WE; Davis, GC | 1 |
| Pilcher, CW | 1 |
| Kalso, EA; Kontinen, VK | 1 |
| Kamei, J; Kasuya, Y; Saitoh, A | 1 |
| Carr, DB; Dorociak, A; Gumulka, SW; Lipkowski, AW; Maszczynska, I; Misterek, K; Szyfelbein, SK | 1 |
| Goettl, VM; Larson, AA | 1 |
| Krause, JE; McCarson, KE | 1 |
| Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Fleshner, M; Maier, SF; Mazzeo, R; Sutton, LC; Watkins, LR | 1 |
| Almeida, OF; Shippenberg, TS; Spanagel, R | 1 |
| Connelly, CD; Martinez, RP; Porreca, F; Raffa, RB; Schupsky, JJ | 1 |
| Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF | 1 |
| Hitosugi, H; Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H | 1 |
| Fujimoto, JM; Portoghese, PS; Rady, JJ; Takemori, AE | 1 |
| Dassaud, M; Diop, L; Junien, JL; Pascaud, X; Rivière, PJ | 1 |
| Randich, A; Robertson, JD; Willingham, T | 1 |
| Hamann, SR; Martin, WR | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Cattaneo, I; Guilbaud, G; Kayser, V | 1 |
| Ellis, EF; Embrey, JP; Uphouse, LA; Ward, CR; Welch, SP | 1 |
| Portoghese, PS; Takemori, AE | 1 |
| Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H | 1 |
| DeHaven-Hudkins, DL; Komer, KM; Mavunkel, BJ; Peterson, JA; Rzeszotarski, WJ | 1 |
| Desmeules, JA; Gacel, G; Guilbaud, G; Kayser, V; Roques, BP | 1 |
| Andres-Trelles, F; Baamonde, A; Hidalgo, A; Menendez, L | 1 |
| Desmeules, JA; Guilbaud, G; Kayser, V | 1 |
| Inturrisi, CE; Jenab, S; Kest, B | 1 |
| Cowan, A; Hunter, JC; Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Wheeler-Aceto, H | 1 |
| Kamei, J; Morita, K; Nagase, H; Saitoh, A; Suzuki, T | 1 |
| Arntz, A; Janssen, SA | 2 |
| Fields, HL; Roychowdhury, SM | 1 |
| Bian, D; Malan, TP; Nichols, ML; Ossipov, MH; Porreca, F | 1 |
| Goldstein, BD; Zachariou, V | 2 |
| Adler, MW; Chen, XH; de Riel, JK; Geller, EB; Liu-Chen, LY; Tallarida, RJ | 1 |
| Angel, F; Chevalier, E; Dahl, SG; Friese, N; Junien, JL; Pascaud, X; Riviere, PJ | 1 |
| Compton, P; Pasero, CL | 1 |
| Brady, MJ; Bruehl, S; Carlson, CR; Colclough, G; McCubbin, JA; Norton, JA; Sherman, JJ; Wilson, JF | 1 |
| Aarnisalo, AA; Idänpään-Heikkilä, JJ; Kalso, E; Kontinen, VK; Panula, P | 1 |
| Dawson-Basoa, M; Gintzler, AR | 1 |
| Hytrek, SD; McLaughlin, PJ; Tobias, SW; Zagon, IS | 1 |
| Hao, JX; Xu, XJ; Yu, W | 1 |
| Arneric, SP; Bannon, AW; Buckley, MJ; Decker, MW; Holladay, MW; Kim, DJ; Lin, NH; Ryther, KB; Wasicak, JT; Williams, M | 1 |
| Hansson, P; Löfgren, O; Lundeberg, T; Theodorsson, E; Yu, LC | 1 |
| Butelman, ER; Ko, MC; Woods, JH | 1 |
| Compton, P | 1 |
| Antelo, MT; Fernández, B; Kitchen, I; Viveros, MP | 1 |
| Demuth, HU; Inoue, M; Kisara, K; Nylander, I; Ohshima, K; Sakurada, C; Sakurada, T; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L | 1 |
| Fujimoto, JM; Gorny, JM; Rady, JJ | 1 |
| Fan, XT; Kitamura, K; Oka, T; Taniguchi, T | 1 |
| Kishimoto, Y; Misawa, M; Nagase, H; Suzuki, T; Takeda, F | 1 |
| Hitosugi, H; Kamei, J; Kashiwazaki, T; Nagase, H; Taki, K | 1 |
| Goto, K; Ishige, A; Komatsu, Y; Omiya, Y; Suzuki, Y | 1 |
| Fujimura, T; Kastin, AJ; Katsuyama, S; Murayama, K; Sakurada, S; Sakurada, T; Ueda, H; Yuki, M; Zadina, JE | 1 |
| Benyas, SI; Dykstra, LA; Picker, MJ; Tiano, MJ; Walker, EA | 1 |
| Gumułka, SW; Kolaric, S; Makulska-Nowak, HE; Mizerska, K | 1 |
| Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM | 1 |
| Lowe, J; Mason, DJ; Welch, SP | 1 |
| Fujii, T; Goto, T; Motoyama, Y; Ochi, T | 1 |
| Alberti, I; Fernández, B; Kitchen, I; Viveros, MP | 1 |
| Lohmann, AB; Welch, SP | 1 |
| Rochford, J; Spreekmeester, E | 1 |
| Ko, MC; Naughton, NN | 1 |
| McNally, GP; Westbrook, RF | 1 |
| Helmstetter, FJ; Tershner, SA | 1 |
| Scholz, M | 1 |
| Arai, K; Furuta, S; Hayashi, T; Katsuyama, S; Kisara, K; Miyazaki, S; Onodera, K; Sakurada, S; Sato, T; Yonezawa, A | 1 |
| Cook, DB; O'Connor, PJ; Ray, CA | 1 |
| Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I | 1 |
| Inoue, M; Kisara, K; Nakagawasai, O; Niijima, F; Nylander, I; Ohshima, K; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L | 1 |
| Hammond, DL; Hurley, RW | 1 |
| Campbell, VC; Welch, SP | 1 |
| Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Fournié-Zaluski, MC; Méen, M; Roques, BP | 1 |
| Gumułka, SW; Lipkowski, AW; Makulska-Nowak, HE; Rawa, MA | 1 |
| Agashe, GS; Clark, JD; Davies, MF; Kingery, WS; Sawamura, S; Zimmer, A | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Narita, M; Orito, T; Sakurada, C; Sakurada, S; Sakurada, T; Suzuki, T; Tan-no, K; Tseng, LF; Yuhki, M; Zadina, JE | 1 |
| Alvarez-Fuentes, J; Fernández -Arévalo, M; Holgado, MA; Micó, JA; Rojas -Corrales, MO; Sánchez-Lafuente, C | 1 |
| Cao, CQ; Dray, A; Hong, YG; Perkins, MN | 1 |
| Fujimura, T; Hayashi, T; Kastin, AJ; Murayama, K; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Takeshita, M; Yonezawa, A; Yuhki, M; Zadina, JE | 1 |
| Bauman, J; Cho, D; Dornbush, R; James, B; Mallya, A; Pevnick, J; Reker, D; Volavka, J | 1 |
| Buchsbaum, MS; Bunney, WE; Davis, GC; van Kammen, DP | 1 |
| Kosterlitz, HW | 1 |
| Frenk, H; Rosen, JB | 1 |
| Freedman, AM; Kestenbaum, RS; Resnick, RB; Volavka, J | 1 |
| al-Rodhan, NR; Kelly, PJ; Yaksh, TL | 1 |
| Maier, SF; Watkins, LR; Wiertelak, EP | 2 |
| Kamei, J; Kasuya, Y; Kawashima, N; Ohhashi, Y | 1 |
| Le, AD; Poulos, CX; Walker, MJ | 1 |
| Melzack, R; Plamondon, H; Vaccarino, AL | 1 |
| Kavaliers, M; Teskey, GC | 1 |
| Collins, JG; Kitahata, LM; Nakatani, K; Omote, K | 1 |
| Patel, A; Sewell, RD; Smith, HJ | 1 |
| Song, ZH; Takemori, AE | 2 |
| Mueller, J; Quock, RM | 1 |
| Gold, MS; Liebeskind, JC; Morgan, MM; Stein, C | 1 |
| Jacoby, HI; Martinez, RP; Raffa, RB; Schupsky, JJ | 1 |
| Bossut, DF; Huang, ZS; Mayer, DJ; Sun, SL | 1 |
| Bossut, DF; Mayer, DJ | 2 |
| Carlsson, S; Hoffmann, P; Thorén, P | 1 |
| Helmstetter, FJ; Landeira-Fernandez, J | 1 |
| Abbott, FV | 1 |
| Lee, C; Rodgers, RJ | 1 |
| Fanselow, MS; Lichtman, AH | 1 |
| Dionne, RA; Flores, CM; Hargreaves, KM; Mueller, GP | 1 |
| Lutfy, K; Sierra, V; Yoburn, BC | 1 |
| Costello, A; Dubner, R; Hargreaves, KM; Joris, J | 1 |
| Bohan, MC; Gintzler, AR | 1 |
| Botros, S; Larson, DL; Lipkowski, AW; Portoghese, PS; Stark, PA; Takemori, AE | 1 |
| Gonzalez, JP; Sewell, RD; Smith, HJ; Williams, PS | 1 |
| Kavaliers, M | 2 |
| Jackson, HC; Nutt, DJ; Ripley, TL | 1 |
| Calcagnetti, DJ; Fanselow, MS; Helmstetter, FJ | 2 |
| Boja, JW; Crisp, T; Schechter, MD; Stafinsky, JL | 1 |
| Field, EA; Kuhn, CM | 1 |
| Bodnar, RJ; Inturrisi, CE; Kest, B; Truesdell, LS; Yoburn, BC | 1 |
| Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F | 1 |
| Garzón, J; Sánchez-Blázquez, P | 1 |
| Inturrisi, CE; Luke, MC; Pasternak, GW; Yoburn, BC | 1 |
| Ding, XZ; Fan, SG; Han, JS | 1 |
| Maier, SF | 2 |
| Carter, MV; Hoerman, WA; Kelsey, JE; Kimball, LD; Radack, LS | 1 |
| Cruz-Morales, SE; Noble, RG | 1 |
| Fujimoto, JM; Roerig, SC; Tseng, LF | 1 |
| Gardner, EL; Tempel, A; Zukin, RS | 1 |
| Cohen, AH; Goodman, RR; Inturrisi, CE; Pasternak, GW; Yoburn, BC | 1 |
| Mantegazza, P; Panerai, AE; Sacerdote, P | 1 |
| Kleber, HD | 1 |
| Hamm, RJ; Knisely, JS | 3 |
| Hayes, AG; Skingle, M; Tyers, MB | 1 |
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| Birch, PJ; Hayes, AG | 1 |
| Harty, GJ; Yaksh, TL | 1 |
| Bibic, L; Pomeranz, B | 1 |
| Pomeranz, B; Warma, N | 1 |
| Blass, E; Fitzgerald, E; Kehoe, P | 1 |
| Fanselow, MS; Helmstetter, FJ | 1 |
| Gintzler, AR; Sander, HW | 1 |
| Hamm, RJ; Knisely, JS; Watson, A | 1 |
| Liebeskind, JC; Morgan, MJ; Terman, GW | 1 |
| Baker, TB; Dahl, JL; Silva, BW; Tiffany, ST | 1 |
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| Ader, DN; Drugan, RC; Maier, SF | 1 |
| Girardot, MN; Holloway, FA | 2 |
| Fanselow, MS | 1 |
| Bersh, PJ; Blustein, JE; Margules, DL; Walker, J; Whitehouse, WG | 1 |
| Fanselow, MS; Lester, LS | 1 |
| DiFazio, CA; Gal, TJ | 1 |
| Pittock, F; Randall, J; Rodgers, RJ | 1 |
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| Grishkat, HL; Kristal, MB; Thompson, AC | 1 |
| Bossut, DF; Hamm, RJ; Knisely, JS; Lyeth, BG; Watson, A | 1 |
24 review(s) available for naltrexone and Ache
| Article | Year |
|---|---|
Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.
Topics: Abuse-Deterrent Formulations; Analgesics, Opioid; Device Approval; Dosage Forms; Drug Approval; Drug Compounding; Drug Delivery Systems; Drug Labeling; Humans; Naltrexone; Opioid-Related Disorders; Pain; Pain Management; Prescription Drug Misuse; Prescription Drugs; United States; United States Food and Drug Administration | 2019 |
Current and Future Therapeutic Options in Pain Management: Multi-mechanistic Opioids Involving Both MOR and NOP Receptor Activation.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Drug Tolerance; Humans; Isoquinolines; Naltrexone; Nociceptin; Opioid Peptides; Pain; Phenylpropionates; Receptors, Opioid, mu | 2022 |
Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction.
Topics: Analgesia; Analgesics, Opioid; Humans; Ligands; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Opioid, mu | 2022 |
Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
Topics: Analgesics, Opioid; Animals; Isoquinolines; Naltrexone; Opioid Peptides; Opioid-Related Disorders; Pain; Phenylpropionates; Receptors, Opioid | 2022 |
Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics.
Topics: Analgesics, Opioid; Humans; Isoquinolines; Ligands; Naltrexone; Pain; Phenylpropionates; Receptors, Opioid | 2020 |
Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Humans; Ligands; Macaca mulatta; Mice; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pain Management; Receptors, Opioid, mu; Signal Transduction; Substance Withdrawal Syndrome | 2020 |
Naltrexone for cholestatic itch: a systematic review.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cholestasis; End Stage Liver Disease; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Pilot Projects; Pruritus; Research Design; Retrospective Studies | 2021 |
Opioid antagonists for pain.
Topics: Animals; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Pain | 2013 |
Treatment of opioid-induced constipation: focus on the peripheral μ-opioid receptor antagonist methylnaltrexone.
Topics: Analgesics, Opioid; Clinical Trials as Topic; Constipation; Dietary Fiber; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2013 |
Naloxegol: A Novel Therapy in the Management of Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Constipation; Drug Interactions; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Polyethylene Glycols; Quality of Life; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2016 |
[Low dose naltrexone for treatment of pain].
Topics: Analgesics, Opioid; Crohn Disease; Fibromyalgia; Humans; Multiple Sclerosis; Naltrexone; Narcotic Antagonists; Pain | 2015 |
Constipation in Elderly Patients with Noncancer Pain: Focus on Opioid-Induced Constipation.
Topics: Aged; Analgesics, Opioid; Constipation; Health Personnel; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
A morphine/naltrexone combination (Embeda) for pain.
Topics: Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; Drug Approval; Drug Combinations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration | 2010 |
Morphine/naltrexone.
Topics: Adult; Delayed-Action Preparations; Drug Combinations; Drug Interactions; Humans; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Receptors, Opioid, mu | 2010 |
Opioid formulations designed to resist/deter abuse.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Humans; Morphine; Naltrexone; Niacin; Opioid-Related Disorders; Oxycodone; Pain; United States | 2010 |
The use of opioids in fibromyalgia.
Topics: Analgesics, Opioid; Evidence-Based Medicine; Fibromyalgia; Humans; Naltrexone; Pain; Practice Guidelines as Topic; Tramadol; Treatment Failure | 2011 |
Morphine sulfate and naltrexone hydrochloride extended release capsules for the management of chronic, moderate-to-severe pain, while reducing morphine-induced subjective effects upon tampering by crushing.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Combinations; Euphoria; Female; Humans; Male; Morphine; Naltrexone; Pain | 2011 |
Prescription pain medication dependence.
Topics: Analgesics; Buprenorphine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution Treatment; Pain; Prescription Drugs; Substance-Related Disorders | 2011 |
Management of opioid-induced constipation in cancer patients: focus on methylnaltrexone.
Topics: Analgesics, Opioid; Constipation; Humans; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Palliative Care; Quaternary Ammonium Compounds | 2012 |
Opioid receptor heteromers in analgesia.
Topics: Analgesia; Analgesics; Animals; Drug Antagonism; Drug Overdose; Humans; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Protein Multimerization; Protein Structure, Quaternary; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; United States | 2012 |
Will abuse-deterrent formulations of opioid analgesics be successful in achieving their purpose?
Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Combinations; Drug Discovery; Drug Overdose; Drug Prescriptions; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain | 2012 |
Abuse-deterrent formulations, an evolving technology against the abuse and misuse of opioid analgesics.
Topics: Analgesics, Opioid; Buprenorphine; Chemistry, Pharmaceutical; Dextroamphetamine; Humans; Lisdexamfetamine Dimesylate; Morphine; Naltrexone; Opioid-Related Disorders; Pain; Prescription Drug Misuse; United States; United States Food and Drug Administration | 2012 |
Autoanalgesia: opiate and non-opiate mechanisms.
Topics: Animals; Central Nervous System; Conditioning, Classical; Diazepam; Electroshock; Emotions; Endorphins; Fear; Hypophysectomy; Hypothalamus; Male; Mice; Naloxone; Naltrexone; Norepinephrine; Pain; Raphe Nuclei; Rats; Reaction Time; Receptors, Opioid; Serotonin; Spinal Cord | 1980 |
Stressor controllability and stress-induced analgesia.
Topics: Analgesia; Animals; Avoidance Learning; Electroshock; Injections, Spinal; Morphine; Naloxone; Naltrexone; Pain; Rats; Restraint, Physical; Sensory Thresholds; Stress, Physiological; Time Factors | 1986 |
36 trial(s) available for naltrexone and Ache
| Article | Year |
|---|---|
Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial.
Topics: Double-Blind Method; Female; Fibromyalgia; Humans; Naltrexone; Pain; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome | 2021 |
Determinants of health-related quality of life among individuals with opioid use disorder, recently released from incarceration.
Topics: Delayed-Action Preparations; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Quality of Life | 2023 |
Is low-dose naltrexone effective in chronic pain management?
Topics: Amitriptyline; Fibromyalgia; Humans; Naltrexone; Pain; Pain Management | 2023 |
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Pain; Pain Measurement | 2021 |
Stress and pain: modality-specific opioid mediation of stress-induced analgesia.
Topics: Analgesia; Analgesics, Opioid; Female; Humans; Naltrexone; Narcotic Antagonists; Pain | 2021 |
Life satisfaction and pain interference in spine surgery patients before and after surgery: comparison between on-opioid and opioid-naïve patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Opioid; Drug Combinations; Elective Surgical Procedures; Female; Humans; Ketoprofen; Male; Meloxicam; Middle Aged; Naltrexone; Oxycodone; Pain; Pain Measurement; Personal Satisfaction; Prospective Studies; Quality of Life; Spine; Surveys and Questionnaires; Tromethamine; Young Adult | 2018 |
Methylnaltrexone for opioid-induced constipation in pediatric oncology patients.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Constipation; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Quaternary Ammonium Compounds; Retrospective Studies | 2013 |
Placebo analgesia and its opioidergic regulation suggest that empathy for pain is grounded in self pain.
Topics: Adult; Analgesia; Brain; Empathy; Female; Humans; Magnetic Resonance Imaging; Male; Naltrexone; Narcotic Antagonists; Neuroimaging; Pain; Placebo Effect; Radiography | 2015 |
Involvement of Opioid Receptors and α
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adult; Blood Pressure; Central Nervous System Sensitization; Clonidine; Cross-Over Studies; Double-Blind Method; Drug Administration Routes; Electric Stimulation; Female; Healthy Volunteers; Heart Rate; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Psychophysics; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Yohimbine; Young Adult | 2016 |
Effects of buprenorphine on QT intervals in healthy subjects: results of 2 randomized positive- and placebo-controlled trials.
Topics: Administration, Cutaneous; Adult; Arrhythmias, Cardiac; Aza Compounds; Buprenorphine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fluoroquinolones; Healthy Volunteers; Heart Rate; Humans; Male; Middle Aged; Moxifloxacin; Naltrexone; Pain; United States; Young Adult | 2017 |
Psychosocial Influences on Exercise-Induced Hypoalgesia.
Topics: Exercise; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Psychology; Young Adult | 2017 |
Stress-evoked opioid release inhibits pain in major depressive disorder.
Topics: Adult; Analgesics, Opioid; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Placebo Effect; Stress, Psychological | 2008 |
Opposite effects of opioid blockade on the blood pressure-pain relationship in depressed and non-depressed participants.
Topics: Adolescent; Adult; Blood Pressure; Cold Temperature; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Time Factors; Young Adult | 2009 |
Endogenous opioids may buffer effects of anger arousal on sensitivity to subsequent pain.
Topics: Adult; Anger; Arousal; Data Interpretation, Statistical; Double-Blind Method; Endorphins; Executive Function; Hand Strength; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement | 2009 |
Hypoalgesia associated with elevated resting blood pressure: evidence for endogenous opioid involvement.
Topics: Adult; Anger; Attention; Blood Pressure; Female; Humans; Hypertension; Ischemia; Linear Models; Male; Maze Learning; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Threshold; Reference Values; Sex Factors | 2010 |
Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chronic Disease; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain; Pain Measurement; Placebos; Treatment Outcome | 2010 |
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects.
Topics: Adolescent; Adult; Analgesia; Analgesics, Opioid; Buprenorphine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Treatment Outcome | 2011 |
Long-term safety and efficacy of morphine sulfate and naltrexone hydrochloride extended release capsules, a novel formulation containing morphine and sequestered naltrexone, in patients with chronic, moderate to severe pain.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Constipation; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Pain; Pain Measurement; Treatment Outcome | 2010 |
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study.
Topics: Adult; Aged; Analgesics, Opioid; Chi-Square Distribution; Constipation; Defecation; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds; Surveys and Questionnaires; Treatment Outcome | 2011 |
Reliability and validity of a brief method to assess nociceptive flexion reflex (NFR) threshold.
Topics: Adolescent; Double-Blind Method; Electric Stimulation; Electromyography; Female; Follow-Up Studies; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Psychiatric Status Rating Scales; Reflex; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Skin; Statistics as Topic; Sural Nerve; Surveys and Questionnaires; Young Adult | 2011 |
Impact of intravenous naltrexone on intravenous morphine-induced high, drug liking, and euphoric effects in experienced, nondependent male opioid users.
Topics: Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Drug Combinations; Drug Interactions; Euphoria; Humans; Injections, Intravenous; Male; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pain Measurement; Substance-Related Disorders; Young Adult | 2011 |
Opioid titration and conversion in patients receiving morphine sulfate and naltrexone hydrochloride extended release capsules.
Topics: Adolescent; Adult; Aged; Capsules; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Young Adult | 2011 |
6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study.
Topics: Adult; Animals; Breath Tests; Constipation; Cross-Over Studies; Double-Blind Method; Gastrointestinal Transit; Humans; Male; Miosis; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pilot Projects; Placebos; Young Adult | 2011 |
Reduction of conditioned pain modulation in humans by naltrexone: an exploratory study of the effects of pain catastrophizing.
Topics: Adult; Catastrophization; Conditioning, Classical; Cross-Over Studies; Diffuse Noxious Inhibitory Control; Double-Blind Method; Female; Humans; Individuality; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Threshold; Young Adult | 2013 |
Pain as a reward: changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems.
Topics: Adult; Arm; Attitude to Health; Cannabinoid Receptor Antagonists; Culture; Double-Blind Method; Female; Humans; Ischemia; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Persuasive Communication; Physical Endurance; Piperidines; Pyrazoles; Receptors, Cannabinoid; Reward; Rimonabant; Suggestion; Time Factors; Young Adult | 2013 |
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels.
Topics: Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fibromyalgia; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Placebos; Self Report; Treatment Outcome | 2013 |
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Osteoarthritis; Oxycodone; Pain; Pain Measurement; Patient Satisfaction; Treatment Outcome | 2005 |
Effects of opioid blockade with naltrexone and distraction on cold and ischemic pain in hypertension.
Topics: Adult; Attention; beta-Endorphin; Cold Temperature; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Myocardial Ischemia; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Touch | 2007 |
Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals.
Topics: Adult; Blood Pressure; Double-Blind Method; Electric Stimulation; Endorphins; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold | 2008 |
Subcutaneous methylnaltrexone for the treatment of opioid-induced constipation in patients with advanced illness: a double-blind, randomized, parallel group, dose-ranging study.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Diarrhea; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Pain; Pain Measurement; Quaternary Ammonium Compounds; Terminal Care | 2008 |
Anxiety and pain: attentional and endorphinergic influences.
Topics: Adolescent; Adult; Anxiety; Attention; Electric Stimulation; Endorphins; Female; Galvanic Skin Response; Humans; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Phobic Disorders | 1996 |
Psychological coping with acute pain: an examination of the role of endogenous opioid mechanisms.
Topics: Acute Disease; Adaptation, Psychological; Adolescent; Adult; Attention; Double-Blind Method; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid | 1996 |
Pain tolerance in opioid addicts on and off naltrexone pharmacotherapy: a pilot study.
Topics: Adolescent; Adult; Cold Temperature; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Pressure | 1998 |
No interactive effects of naltrexone and benzodiazepines on pain during phobic fear.
Topics: Adolescent; Adult; Alprazolam; Anxiety; Benzodiazepines; Drug Interactions; Electroshock; Female; Humans; Middle Aged; Naltrexone; Pain; Pain Measurement; Pain Threshold; Phobic Disorders | 1999 |
Muscle pain perception and sympathetic nerve activity to exercise during opioid modulation.
Topics: Adolescent; Adult; Blood Pressure; Codeine; Exercise; Hand Strength; Heart Rate; Humans; Male; Muscle, Skeletal; Naltrexone; Opioid Peptides; Pain; Pain Threshold; Perception; Placebos; Sympathetic Nervous System | 2000 |
Prolonged antagonism of opioid action with intravenous nalmefene in man.
Topics: Adult; Drug Interactions; Fentanyl; Humans; Male; Muscle Rigidity; Naltrexone; Pain; Respiration; Tidal Volume; Time Factors | 1986 |
349 other study(ies) available for naltrexone and Ache
| Article | Year |
|---|---|
Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.
Topics: Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chemokine CCL5; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Transgenic; Morphine; Naloxone; Pain; Pain Measurement; Receptors, CCR5 | 2007 |
A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain | 2021 |
Endogenous opioids contribute to the feeling of pain relief in humans.
Topics: Analgesics, Opioid; Humans; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain | 2021 |
Simultaneous brain, brainstem, and spinal cord pharmacological-fMRI reveals involvement of an endogenous opioid network in attentional analgesia.
Topics: Adolescent; Adult; Analgesics, Opioid; Brain; Brain Stem; Female; Hot Temperature; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Naltrexone; Pain; Pain Measurement; Pain Perception; Reboxetine; Spinal Cord; Young Adult | 2022 |
Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Naltrexone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Prospective Studies | 2022 |
Low-dose naltrexone for treatment of burning mouth syndrome.
Topics: Burning Mouth Syndrome; Clonazepam; Female; Fibromyalgia; Headache; Humans; Middle Aged; Naltrexone; Pain | 2023 |
Naltrexone promotes mechanical allodynia in humans and rats.
Topics: Animals; Humans; Hyperalgesia; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2022 |
OREX-1038: a potential new treatment for pain with low abuse liability and limited adverse effects.
Topics: Analgesics, Opioid; Animals; Isoquinolines; Naltrexone; Pain; Phenylpropionates; Rats; Receptors, Opioid; Receptors, Opioid, mu | 2022 |
14-3-3γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine.
Topics: 14-3-3 Proteins; Analgesics; Animals; Cricetinae; Cricetulus; JNK Mitogen-Activated Protein Kinases; Naltrexone; Pain; Rats; Receptors, Opioid, kappa; RNA, Small Interfering | 2022 |
Naloxone Versus Methylnaltrexone for Opioid-Induced Constipation in Critically Ill Patients.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Humans; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Pain; Prospective Studies; Quaternary Ammonium Compounds; Retrospective Studies | 2023 |
Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias?
Topics: Alopecia; Humans; Naltrexone; Narcotic Antagonists; Pain; Paresthesia; Pruritus; Scalp Dermatoses | 2019 |
Peripheral antinociception induced by ketamine is mediated by the endogenous opioid system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Ketamine; Male; Mice; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 2019 |
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Formaldehyde; Glyburide; Humans; Male; Mice; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2020 |
Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Pain Measurement; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reinforcement, Psychology; Self Administration | 2020 |
Pharmacological fMRI provides evidence for opioidergic modulation of discrimination of facial pain expressions.
Topics: Adult; Discrimination, Psychological; Disgust; Double-Blind Method; Facial Expression; Facial Recognition; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Naltrexone; Narcotic Antagonists; Pain; Social Perception; Temporal Lobe; Young Adult | 2021 |
Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.
Topics: Analgesics; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Enkephalins; Hippocampus; Male; Maze Learning; Memory, Long-Term; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Wistar; Saccharin | 2021 |
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report.
Topics: Analgesia; Burning Mouth Syndrome; Female; Humans; Naltrexone; Pain; Pain Management | 2021 |
More pain, more gain: Blocking the opioid system boosts adaptive cognitive control.
Topics: Adaptation, Psychological; Adolescent; Adult; Affect; Analgesics, Opioid; Arousal; Cognition; Double-Blind Method; Female; Humans; Naltrexone; Narcotic Antagonists; Pain; Placebo Effect; Receptors, Opioid, mu; Young Adult | 2017 |
Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats.
Topics: Animals; Body Temperature; Male; Naltrexone; Narcotic Antagonists; Oxygen Consumption; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid, kappa; Stress, Psychological; Thermogenesis | 2017 |
Psychopharmacological modulation of event-related potentials suggests that first-hand pain and empathy for pain rely on similar opioidergic processes.
Topics: Adult; Analysis of Variance; Brain; Electric Stimulation; Electroencephalography; Empathy; Evoked Potentials; Female; Hand; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Placebo Effect; Psychophysics; Reaction Time; Surveys and Questionnaires | 2018 |
Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: Role of BDNF and β-endorphin.
Topics: Animals; Animals, Newborn; beta-Endorphin; Brain-Derived Neurotrophic Factor; Dietary Sucrose; Hippocampus; Male; Maze Learning; Memory, Long-Term; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Pain Threshold; Random Allocation; Rats, Wistar; Spatial Memory | 2017 |
Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Botulinum Toxins, Type A; Dura Mater; Male; Migraine Disorders; Morphine; Naltrexone; Narcotic Antagonists; Neurogenic Inflammation; Neuromuscular Agents; Nociception; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sciatic Nerve; Trigeminal Caudal Nucleus; Trigeminal Nerve | 2018 |
Serotonin induces peripheral antinociception via the opioidergic system.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Disease Models, Animal; Male; Mice; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Receptors, Opioid; Serotonin | 2018 |
Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain.
Topics: Analgesics, Opioid; Animals; Capsaicin; Central Amygdaloid Nucleus; Dynorphins; Hypothalamus; Male; Medulla Oblongata; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Stress, Physiological | 2018 |
Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury.
Topics: Analgesics, Opioid; Brain Injuries, Traumatic; Buprenorphine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Pain; Receptors, Opioid, mu | 2018 |
The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4
Topics: Analgesics; Animals; CD4-Positive T-Lymphocytes; Chemokine CCL4; Enkephalin, Methionine; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement | 2019 |
Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate.
Topics: Agave; Analgesics; Animals; Glyburide; KATP Channels; Male; Mice; Molecular Structure; Naltrexone; Pain; Periaqueductal Gray; Plant Leaves; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Steroids | 2013 |
The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Benzamides; Central Nervous System; Dogs; Female; Gastrointestinal Tract; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tropanes | 2013 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene Expression Regulation; Ketoprofen; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation; Time Factors | 2014 |
[Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205].
Topics: Analgesics; Animals; Animals, Outbred Strains; Benzimidazoles; Butorphanol; Male; Mice; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Rats; Receptors, Opioid, kappa | 2013 |
Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Bradykinin; Elaeocarpaceae; Flavonoids; Magnoliopsida; Male; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Pain; Phytotherapy; Plant Extracts; Plant Leaves; Potassium Channel Blockers; Protein Kinase C; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Purinergic P1; Tetradecanoylphorbol Acetate | 2014 |
Operant nociception in nonhuman primates.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Hot Temperature; Male; Morphine; Naltrexone; Nociception; Pain; Pain Measurement; Pain Threshold; Saimiri | 2014 |
Involvement of μ- and δ-opioid receptor function in the rewarding effect of (±)-pentazocine.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Isomerism; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pentazocine; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Reward | 2015 |
Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene.
Topics: Analgesics, Opioid; Animals; Exons; Female; Hot Temperature; Male; Mice; Mice, Knockout; Naltrexone; Pain; Pain Threshold; Protein Isoforms; Receptors, Opioid, mu | 2014 |
Informed consent abandoned--patient given contraindicated drug.
Topics: Alcoholism; Contraindications; Depressive Disorder; Humans; Informed Consent; Male; Medication Reconciliation; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Risk Management; Treatment Outcome | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation | 2014 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fentanyl; Inflammation; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord | 2014 |
High-dose pentazocine antagonizes the antinociception induced by high-dose morphine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Pain; Pentazocine; Receptors, Opioid, kappa | 2015 |
Types of skin afferent fibers and spinal opioid receptors that contribute to touch-induced inhibition of heart rate changes evoked by noxious cutaneous heat stimulation.
Topics: Analgesics, Opioid; Animals; Heart Rate; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Rats, Wistar; Receptors, Opioid; Reflex; Skin; Spinal Cord; Touch | 2015 |
Rutin antinociception involves opioidergic mechanism and descending modulation of ventrolateral periaqueductal grey matter in rats.
Topics: Animals; Male; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Opioid; Rutin; Tramadol | 2016 |
Behavioral and neurochemical analysis of ongoing bone cancer pain in rats.
Topics: Adenocarcinoma; Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bone Neoplasms; Cell Line, Tumor; Diclofenac; Disease Models, Animal; Female; Gyrus Cinguli; Lidocaine; Morphine; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Rats; Rats, Inbred F344 | 2015 |
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Knockout; Morphine; Naltrexone; Pain; Peptide Fragments; Protein Structure, Tertiary; Receptors, Opioid, mu; Recombinant Proteins | 2015 |
[Not Available].
Topics: Analgesia; Brain; Empathy; Female; Humans; Magnetic Resonance Imaging; Male; Naltrexone; Narcotic Antagonists; Neuroimaging; Pain | 2016 |
Opioid system mediated anti-nociceptive effect of agomelatine in mice.
Topics: Acetamides; Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rotarod Performance Test | 2016 |
Experiencing neonatal maternal separation increased pain sensitivity in adult male mice: Involvement of oxytocinergic system.
Topics: Analgesics, Opioid; Animals; Female; Hormone Antagonists; Male; Maternal Deprivation; Mice; Naltrexone; Oxytocin; Pain; Pain Threshold; Stress, Psychological; Vasotocin | 2017 |
Effect of combined opioid receptor and α
Topics: Adolescent; Adrenergic alpha-2 Receptor Antagonists; Adult; Analgesics, Opioid; Anxiety; Blinking; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Pain; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Reflex, Startle; Yohimbine; Young Adult | 2017 |
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
Topics: Animals; Behavior, Animal; Biomarkers; Cell Line; Humans; Injections, Spinal; Male; Microglia; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4 | 2008 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Freund's Adjuvant; Indomethacin; Inflammation; Male; Mice; Morphine; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain, Postoperative; Postural Balance; Pyrazoles; Stomach Ulcer | 2008 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea | 2009 |
Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Fentanyl; Hot Temperature; Ligands; Macaca mulatta; Naltrexone; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2009 |
Open elevated plus maze-induced antinociception in rats: a non-opioid type of pain inhibition?
Topics: Adaptation, Physiological; Adrenalectomy; Analgesics, Opioid; Analysis of Variance; Animals; Drug Tolerance; Habituation, Psychophysiologic; Inhibition, Psychological; Male; Maze Learning; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Stress, Psychological | 2009 |
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception.
Topics: Acetic Acid; Amidohydrolases; Animals; Benzamides; Carbamates; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Protective Agents; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer | 2009 |
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunologic Factors; Inflammation; Injections, Intraventricular; Leucine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Reaction Time; Sulfonamides; Time Factors | 2009 |
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
Topics: Alfentanil; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Hot Temperature; Imidazoles; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Nociceptin Receptor; Pain; Piperidines; Pruritus; Receptors, Opioid; Receptors, Opioid, mu; Reinforcement, Psychology; Respiratory Insufficiency; Spiro Compounds | 2009 |
The individual and combined effects of U50,488, and flurbiprofen axetil on visceral pain in conscious rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Abdominal Muscles; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Dose-Response Relationship, Drug; Drug Synergism; Flurbiprofen; Male; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum | 2009 |
Naltrexone fails to increase pain affect in response to inflammatory pain in a novel escape/avoidance paradigm.
Topics: Animals; Avoidance Learning; Carrageenan; Dose-Response Relationship, Drug; Drug Interactions; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence.
Topics: Animals; Behavior, Animal; Formaldehyde; Gene Expression Regulation; Guanidines; Lidocaine; Male; Mice; Morphinans; Naltrexone; Neurons; Pain; Proto-Oncogene Proteins c-fos; Pruritus; Receptors, Opioid, kappa | 2009 |
Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2009 |
The antinociceptive properties of reboxetine in acute pain.
Topics: Adrenergic Antagonists; Analgesics; Animals; Antidepressive Agents; Clonidine; Disease Models, Animal; Drug Interactions; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Reboxetine; Receptors, Opioid, mu | 2009 |
Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 2009 |
The importance of emotional processes in the modulation of pain.
Topics: Anger; Emotions; Humans; Naltrexone; Narcotic Antagonists; Pain | 2009 |
A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Functional Laterality; Male; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Random Allocation; Rats; Rats, Sprague-Dawley; Temperature; Time Factors; Treatment Outcome | 2010 |
Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred Strains; Models, Biological; Morphine; Morphine Derivatives; Naltrexone; Oxymorphone; Pain; Rats; Rats, Wistar; Receptors, Opioid, mu; Vas Deferens | 2010 |
Combining functional magnetic resonance imaging with mouse genomics: new options in pain research.
Topics: Animals; Biomedical Research; Brain Mapping; Disease Models, Animal; Genomics; Hot Temperature; Image Processing, Computer-Assisted; Kv Channel-Interacting Proteins; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Oxygen; Pain; Physical Stimulation; Repressor Proteins | 2010 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Compounding; Hypericum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Perylene; Phorbol Esters; Phytotherapy; Protein Kinase C; Quercetin; Somatostatin; Spectrometry, Mass, Electrospray Ionization; Statistics, Nonparametric; Time Factors | 2010 |
Synthesis and biological evaluation of cyclic endomorphin-2 analogs.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Brain; Cell Membrane; Endorphins; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Tissue Extracts | 2010 |
PRODUCT: Embeda 20mg/0.8mg.
Topics: Analgesics, Opioid; Contraindications; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Osteoarthritis; Pain | 2009 |
Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors.
Topics: Amygdala; Animals; Galanin; Hindlimb; Hot Temperature; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2010 |
Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lactic Acid; Male; Medial Forebrain Bundle; Morphine; Naltrexone; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reinforcement, Psychology; Self Stimulation | 2010 |
Involvement of the kappa-opioid receptor in nitrous oxide-induced analgesia in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Animals; Benzamides; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Treatment Outcome | 2010 |
In vivo characterization of the opioid antagonist nalmefene in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Substance Withdrawal Syndrome; Time Factors | 2010 |
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands.
Topics: Amides; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Ligands; Male; Mice; Mice, Knockout; Naltrexone; Oligopeptides; Pain; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2010 |
Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diure
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine-Related Disorders; Diuresis; Dose-Response Relationship, Drug; Male; Naltrexone; Pain; Piperidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa; Self Administration; Tetrahydroisoquinolines | 2010 |
The effects of acute restraint stress on nociceptive responses evoked by the injection of formalin into the temporomandibular joint of female rats.
Topics: Acute Disease; Animals; Behavior, Animal; Estrus; Female; Formaldehyde; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Proestrus; Rats; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Stress, Physiological; Temporomandibular Joint; Temporomandibular Joint Disorders | 2010 |
Opioid receptor internalization contributes to dermorphin-mediated antinociception.
Topics: Analgesics, Opioid; Animals; Bicuculline; Concanavalin A; Dynamins; Fluorescent Dyes; GABA-A Receptor Antagonists; Male; Microinjections; Naltrexone; Neurons; Opioid Peptides; Pain; Pain Measurement; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2010 |
Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement | 2010 |
[Mechanisms of corticotropin-releasing factor-induced analgesic effect in conscious rats].
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Hormone Antagonists; Hormones; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Mifepristone; Naltrexone; Narcotic Antagonists; Pain; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 2010 |
New drug formulation treats chronic pain.
Topics: Analgesics, Opioid; Chemistry, Pharmaceutical; Chronic Disease; Drug Combinations; Drug Therapy; Humans; Morphine; Naltrexone; Pain; Receptors, Opioid; Severity of Illness Index | 2010 |
Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Topics: Acetazolamide; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2010 |
Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model.
Topics: Analgesics; Animals; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Peptides, Cyclic; Receptors, Opioid, mu | 2010 |
Methylnaltrexone in the treatment of opioid-induced constipation in cancer patients receiving palliative care: willingness-to-pay and cost-benefit analysis.
Topics: Adolescent; Adult; Age Distribution; Analgesics, Opioid; Constipation; Consumer Behavior; Cost of Illness; Cost-Benefit Analysis; Female; Health Care Costs; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Neoplasms; Ontario; Pain; Palliative Care; Patient Acceptance of Health Care; Quaternary Ammonium Compounds; Sex Distribution; Socioeconomic Factors; Treatment Outcome; Young Adult | 2011 |
Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Area Under Curve; Dose-Response Relationship, Drug; Estradiol; Estrous Cycle; Female; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Naltrexone; Orchiectomy; Ovariectomy; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reverse Transcriptase Polymerase Chain Reaction; Sex Characteristics; Spinal Cord; Testosterone | 2010 |
Differential itch- and pain-related behavioral responses and µ-opoid modulation in mice.
Topics: Analgesics, Opioid; Animals; Antigens, Plant; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Injections, Intradermal; Irritants; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Mucuna; Naltrexone; Narcotic Antagonists; Pain; Pruritus; Receptor, PAR-2; Receptors, Opioid, mu; Receptors, Thrombin; Time Factors | 2010 |
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.
Topics: Animals; Dizocilpine Maleate; Dynorphins; Hyperalgesia; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Piperidines; Postoperative Complications; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Remifentanil; Spinal Cord | 2011 |
Enhancing acupuncture by low dose naltrexone.
Topics: Acupuncture Therapy; Analgesics, Opioid; Cannabinoids; Chronic Disease; Combined Modality Therapy; Humans; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Receptor Cross-Talk; Receptors, Cannabinoid | 2011 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Pain; Pain Measurement; Pain Threshold; Prazosin; Pyrrolidines; Receptors, Adrenergic, alpha-1; Receptors, Opioid, kappa; Receptors, Serotonin, 5-HT2; Serotonin Antagonists | 2011 |
Nucleus accumbens facilitates nociception.
Topics: Analysis of Variance; Animals; Electrodes, Implanted; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Spinal; Lidocaine; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Pain; Pain Measurement; Pain Perception; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Spinal Cord | 2011 |
Sustained-release morphine sulfate with sequestered naltrexone for moderate to severe pain: a new opioid analgesic formulation and beyond.
Topics: Analgesics, Opioid; Delayed-Action Preparations; Dosage Forms; Drug Combinations; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Pain | 2011 |
Dissociable effects of ultralow-dose naltrexone on tolerance to the antinociceptive and cataleptic effects of morphine.
Topics: Analgesics, Opioid; Animals; Catalepsy; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Long-Evans; Time Factors | 2011 |
THC-methadone and THC-naltrexone interactions on discrimination, antinociception, and locomotion in rats.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Locomotion; Male; Methadone; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2011 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug Tolerance; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Neuropeptide; Substance Withdrawal Syndrome | 2012 |
Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Male; Methadone; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Stereoisomerism | 2011 |
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blotting, Western; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes, Clerodane; Gastrointestinal Motility; Male; Mice; Naltrexone; Pain; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Salvia; Trinitrobenzenesulfonic Acid | 2012 |
Arresting the development of morphine tolerance and dependence.
Topics: Analgesics; Animals; Drug Tolerance; Humans; Ketamine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Ondansetron; Pain; Polypharmacy; Quaternary Ammonium Compounds; Serotonin Antagonists | 2011 |
Sensitivity to μ-opioid receptor-mediated anti-nociception is determined by cross-regulation between μ- and δ-opioid receptors at supraspinal level.
Topics: Analgesics, Opioid; Animals; Brain; Cyclic AMP; Disease Models, Animal; Guanosine 5'-O-(3-Thiotriphosphate); Immunoprecipitation; Male; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Opioid, mu; Species Specificity; Spinal Cord | 2012 |
Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.
Topics: Alternative Splicing; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Naltrexone; Pain; Pain Measurement; Protein Isoforms; Protein Multimerization; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Time Factors | 2011 |
Management of constipation in patients receiving palliative care.
Topics: Analgesics, Opioid; Constipation; Humans; Laxatives; Naltrexone; Narcotic Antagonists; Pain; Palliative Care; Quaternary Ammonium Compounds | 2011 |
[Analgesic effect of corticotropin-releasing factor administered into midbrain periaqueductal grey matter].
Topics: Analgesics; Animals; Cerebellum; Corticotropin-Releasing Hormone; Hormones; Male; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley | 2011 |
Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system.
Topics: Analgesics; Animals; Carrageenan; Celecoxib; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Inflammation; Male; Naltrexone; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, mu; Sulfonamides | 2012 |
Opioid modulation of facial itch- and pain-related responses and grooming behavior in rats.
Topics: Analgesics, Opioid; Animals; Antipruritics; Disease Models, Animal; Face; Grooming; Injections, Intradermal; Male; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Pain; Plant Oils; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors | 2012 |
Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal?
Topics: Age Factors; Analgesics, Opioid; Constipation; Defecation; Drug Combinations; Gastrointestinal Tract; Humans; Laxatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Predictive Value of Tests; Prevalence; Quaternary Ammonium Compounds; Receptors, Opioid; Risk Factors | 2012 |
Methylnaltrexone for opioid-induced constipation in a pediatric oncology patient.
Topics: Analgesics, Opioid; Brain Neoplasms; Child; Constipation; Female; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neuroblastoma; Pain; Quaternary Ammonium Compounds | 2012 |
Effects of acute stressors on itch- and pain-related behaviors in rats.
Topics: Animals; Behavior, Animal; Grooming; Injections, Intradermal; Irritants; Isothiocyanates; Male; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pruritus; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Psychological | 2012 |
Antinociceptive properties of Micrurus lemniscatus venom.
Topics: Administration, Oral; Analgesics; Animals; Elapid Venoms; Elapidae; Male; Mice; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 2012 |
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
Topics: Animals; Cannabinoids; Endorphins; Mice; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociception; Pain; Pain Measurement; Polycyclic Sesquiterpenes; Receptor, Cannabinoid, CB2; Sesquiterpenes | 2013 |
Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.
Topics: Animals; Endorphins; Hindlimb; Hot Temperature; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptors; Opioid Peptides; Pain; Pain Measurement; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Male; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pain; Receptors, Opioid; Time Factors; Vas Deferens | 2002 |
Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice.
Topics: Adenosine; Animals; Autoradiography; Central Nervous System; Fixatives; Formaldehyde; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Opioid, mu; Receptors, Purinergic P1; Spinal Cord; Thalamus | 2002 |
Dynorphin-independent spinal cannabinoid antinociception.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Benzoxazines; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Injections, Spinal; Male; Mice; Mice, Knockout; Morpholines; Naltrexone; Naphthalenes; Pain; Pain Measurement; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Single-Blind Method; Species Specificity; Spinal Cord | 2002 |
Role of benzodiazepine and serotonergic mechanisms in conditioned freezing and antinociception using electrical stimulation of the dorsal periaqueductal gray as unconditioned stimulus in rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Conditioning, Classical; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Male; Methysergide; Microinjections; Midazolam; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serotonin; Serotonin Antagonists | 2002 |
Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2003 |
Ultra-low dose oral naltrexone decreases side effects and potentiates the effect of methadone.
Topics: Administration, Oral; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Pain | 2003 |
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-12; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Morphine; Naltrexone; Pain | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
Antinociception induced by stimulation of ventrolateral periaqueductal gray at the freezing threshold is regulated by opioid and 5-HT2A receptors as assessed by the tail-flick and formalin tests.
Topics: Algorithms; Animals; Electric Stimulation; Formaldehyde; Ketanserin; Male; Microinjections; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT2A; Receptors, Opioid; Serotonin Antagonists; Stereotaxic Techniques | 2003 |
Antinociceptive properties of oxymorphazole in the mouse.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Morpholines; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Time Factors | 2003 |
Involvement of oxytocin in spinal antinociception in rats with inflammation.
Topics: Analgesics; Animals; Carrageenan; Hot Temperature; Inflammation; Injections, Spinal; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oxytocin; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Spinal Cord; Vasotocin | 2003 |
Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Benzamides; Benzeneacetamides; Benzomorphans; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reinforcement Schedule | 2003 |
Characterization and opioid modulation of inflammatory temporomandibular joint pain in the rat.
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Grooming; Head Movements; Male; Mastication; Morphine; Mustard Plant; Naltrexone; Narcotic Antagonists; Neural Pathways; Nociceptors; Pain; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Temporomandibular Joint Disorders; Trigeminal Caudal Nucleus | 2003 |
Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cranial Nerves; Functional Laterality; Gait; Hemodynamics; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Middle Cerebral Artery; Muscle Tonus; Naltrexone; Neuroprotective Agents; Pain; Piperidines; Putamen; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Weight Loss | 2003 |
Mechanisms of the effects of adrenocorticotropic hormone on pain sensitivity in rats.
Topics: Adrenocorticotropic Hormone; Animals; Drug Interactions; Hydrocortisone; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effects.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pentazocine; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Opioid, kappa | 2003 |
Nonopioidergic mechanism mediating morphine-induced antianalgesia in the mouse spinal cord.
Topics: Analgesia; Animals; beta-Endorphin; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Dynorphins; Enkephalins; Male; Mice; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance P | 2004 |
Supraspinal and spinal cord opioid receptors are responsible for antinociception following intrathecal morphine injections.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Models, Animal; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Random Allocation; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid; Spinal Cord; Tail | 2004 |
Naltrexone antagonism of morphine antinociception in sucrose- and chow-fed rats.
Topics: Analgesics, Opioid; Animal Feed; Animals; Dietary Sucrose; Energy Intake; Male; Morphine; Naltrexone; Pain; Rats; Rats, Long-Evans; Reaction Time | 2004 |
Supraspinal anti-allodynic and rewarding effects of endomorphins in rats.
Topics: Analgesics, Opioid; Animals; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Compression Syndromes; Oligopeptides; Pain; Pain Management; Pain Measurement; Rats; Rats, Sprague-Dawley | 2004 |
The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat.
Topics: Animals; Arthritis, Experimental; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Dronabinol; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Freund's Adjuvant; Injections, Intradermal; Injections, Intraperitoneal; Male; Morphine; Mycobacterium; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Opioid; Rimonabant | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; Inflammation; Limbic System; Male; Microdialysis; Microinjections; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reward | 2005 |
Estrogen and mu-opioid receptor antagonists counteract the 17 beta-estradiol-induced licking increase and interferon-gamma reduction occurring during the formalin test in male rats.
Topics: Animals; Behavior, Animal; Drug Interactions; Estradiol; Estrogen Antagonists; Fulvestrant; Injections, Intraventricular; Interferon-gamma; Male; Naltrexone; Narcotic Antagonists; Neuroimmunomodulation; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu | 2004 |
Local transcutaneous electrical stimulation (TENS) effects in experimental inflammatory edema and pain.
Topics: Animals; Carrageenan; Edema; Female; Foot; Hyperalgesia; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation | 2004 |
Interactions of galanin and opioids in nociceptive modulation in the arcuate nucleus of hypothalamus in rats.
Topics: Analgesics, Opioid; Animals; Arcuate Nucleus of Hypothalamus; Dose-Response Relationship, Drug; Galanin; Hindlimb; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Rats; Rats, Wistar; Receptors, Opioid | 2005 |
Pain in a balance: noxious events engage opposing processes that concurrently modulate nociceptive reactivity.
Topics: Afferent Pathways; Analysis of Variance; Animals; Behavior, Animal; Electroshock; Male; Naltrexone; Narcotic Antagonists; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Vocalization, Animal | 2004 |
Peripheral effect of a kappa opioid receptor antagonist on nociception evoked by formalin injected in TMJ of pregnant rats.
Topics: Animals; Female; Formaldehyde; Naltrexone; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; Receptors, Opioid, kappa; Temporomandibular Joint | 2005 |
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Tail; Time Factors | 2005 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-Response Relationship, Drug; Formaldehyde; Ketanserin; Male; Mice; Motor Activity; Naltrexone; Pain; Pain Measurement; Phytotherapy; Plant Preparations; Prazosin; Receptors, Serotonin, 5-HT2; Reserpine; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Yohimbine | 2005 |
The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid).
Topics: Acetates; Animals; Aza Compounds; Brain; Carrageenan; Edema; Injections, Intraventricular; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spiro Compounds | 2005 |
Nicotinic receptor involvement in antinociception induced by exposure to cigarette smoke.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mecamylamine; Naltrexone; Narcotic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Opioid, mu; Smoking | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; Chronic Disease; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Piperazines; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Somatostatin; Sulfur Isotopes; Time Factors; Tranquilizing Agents | 2006 |
Antinociceptive effect of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Time Factors | 2005 |
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Opioid; Sciatic Nerve | 2005 |
mu- but not delta- and kappa-opioid receptor mediates the nucleus submedius interferon-alpha-evoked antinociception in the rat.
Topics: Animals; Escape Reaction; Interferon-alpha; Male; Mediodorsal Thalamic Nucleus; Microinjections; Naloxone; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Naltrexone and problems in pain management.
Topics: Administration, Oral; Analgesics, Opioid; Contraindications; Drug Resistance; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Patient Selection; Risk Factors | 2006 |
Pharmacological assessment of the freezing, antinociception, and exploratory behavior organized in the ventrolateral periaqueductal gray.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Exploratory Behavior; Freezing Reaction, Cataleptic; Ketanserin; Male; Microinjections; Midazolam; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serotonin Antagonists | 2006 |
Systemic and spinal administration of the mu opioid, remifentanil, produces antinociception in amphibians.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Injections, Subcutaneous; Models, Animal; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Piperidines; Rana pipiens; Receptors, Opioid, mu; Remifentanil; Time Factors | 2006 |
Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats.
Topics: Analgesics, Opioid; Animals; Male; Morphine; Naloxone; Naltrexone; Nucleus Accumbens; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2006 |
Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Tolerance; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley; Sex Factors; Species Specificity | 2006 |
Characterization of the antinociceptive effects of oxycodone in diabetic mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oxycodone; Pain; Pain Measurement; Streptozocin | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Tolerance; Edema; Endorphins; Foot; Hyperalgesia; Indomethacin; Injections; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Species Specificity | 2006 |
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldehyde; Mice; Motor Activity; Naloxone; Naltrexone; Narcotic Antagonists; Nimodipine; Oxytocin; Pain; Random Allocation; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2006 |
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Survival; Chronic Disease; Glutathione; Liver; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oxidative Stress; Pain; Signal Transduction | 2006 |
Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.
Topics: Analgesia; Animals; Brain; Guinea Pigs; Ileum; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Tail; Vas Deferens | 2006 |
Analgesia and sedation in the presence of a naltrexone implant: a novel pharmacological challenge.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Drug Implants; Drug Resistance; Humans; Male; Naltrexone; Narcotic Antagonists; Pain; Wounds and Injuries | 2006 |
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Gastrointestinal Transit; Guinea Pigs; Herbal Medicine; Ileum; Male; Mice; Mitragyna; Molecular Structure; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Thailand; Vas Deferens | 2006 |
Pain management research goes beyond the obvious.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Constipation; Humans; Naltrexone; Narcotic Antagonists; Pain; Piperidines; Pyridines; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2006 |
Regarding naltrexone for probationers and parolees.
Topics: Buprenorphine; Heroin Dependence; Humans; Injections; Long-Term Care; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Prisoners; Treatment Outcome | 2007 |
Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Psychological; Ligands; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu | 2007 |
Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).
Topics: Analgesics, Opioid; Animals; Arthritis, Experimental; Benzomorphans; Female; Hot Temperature; Macaca mulatta; Male; Mice; Mice, Inbred ICR; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Stereoisomerism; Substance Withdrawal Syndrome | 2007 |
Antinociception of heterotopic electro-acupuncture mediated by the dorsolateral funiculus.
Topics: Acupuncture Points; Animals; Behavior, Animal; Electroacupuncture; Formaldehyde; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Neurons; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 2007 |
Negative affect, pain and sex: the role of endogenous opioids.
Topics: Adolescent; Adult; Affect; Anger; Anxiety; Central Nervous System; Cold Temperature; Depression; Double-Blind Method; Electroshock; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Neuropsychological Tests; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Sex Characteristics; Stress, Psychological | 2007 |
Effects of opioid blockade on the modulation of pain and mood by sweet taste and blood pressure in young adults.
Topics: Adult; Affect; Analgesia; Cold Temperature; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Management; Pain Measurement; Pain Threshold; Taste; Time Factors | 2008 |
Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Female; Foot; Herpes Simplex; Herpesvirus 1, Human; Injections; Injections, Subcutaneous; Loperamide; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation | 2007 |
Relative contribution of peripheral versus central opioid receptors to antinociception.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Gene Expression; Loperamide; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 2007 |
The neural pathway of galanin in the hypothalamic arcuate nucleus of rats: activation of beta-endorphinergic neurons projecting to periaqueductal gray matter.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Fluorescent Antibody Technique; Galanin; Hindlimb; Hot Temperature; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Physical Stimulation; Rats; Rats, Wistar | 2007 |
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Topics: Acid Sensing Ion Channels; Analgesics; Animals; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Membrane Proteins; Mice; Mice, Knockout; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Tissue Proteins; Neurons; Pain; Pain Measurement; Peptides; Protein Precursors; Reaction Time; Sodium Channels; Spider Venoms; Spinal Cord; Time Factors | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Chronic Disease; Drug Tolerance; Formaldehyde; Male; Mice; Morphine; Naltrexone; Oligonucleotides, Antisense; Pain; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Receptors, Opioid, kappa; Tail | 2007 |
Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
Topics: Analgesics; Anesthesia, General; Animals; Inflammation; Injections; Injections, Intramuscular; Male; Masseter Muscle; Morphine; Mustard Plant; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Plant Oils; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Single-Blind Method; Somatostatin | 2008 |
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Female; Formaldehyde; Guanidines; Indoles; Melatonin; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Postural Balance; Rats; Rats, Wistar; Receptor, Melatonin, MT2 | 2007 |
Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain.
Topics: Acetaminophen; Acute Disease; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Ketoprofen; Male; Mice; Morphine; Muscarinic Antagonists; Naltrexone; Narcotic Antagonists; Pain; Prazosin | 2008 |
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Topics: Acetic Acid; Alprazolam; Analgesics; Animals; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; Hesperidin; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid | 2008 |
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intralesional; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Rats, Wistar; Research Design; Time Factors | 2008 |
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice.
Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes | 2008 |
Overriding the blockade of antinociceptive actions of opioids in rats treated with extended-release naltrexone.
Topics: Alcoholism; Analgesics, Opioid; Animals; Delayed-Action Preparations; Drug Interactions; Fentanyl; Humans; Hydrocodone; Male; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Plethysmography, Whole Body; Rats; Rats, Sprague-Dawley; Respiration | 2008 |
Activation of kappa opioid receptors decreases synaptic transmission and inhibits long-term potentiation in the basolateral amygdala of the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics, Non-Narcotic; Animals; Chronic Disease; Electric Stimulation; Electrophysiology; Emotions; Extinction, Psychological; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Pain; Receptors, Opioid, kappa; Synaptic Transmission | 2009 |
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Thalamus; Time Factors | 2008 |
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Drug Interactions; Female; Male; Mice; Morphine; Nalorphine; Naloxone; Naltrexone; Narcotics; Pain; Reaction Time | 1982 |
Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.
Topics: Acetates; Acetic Acid; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Hot Temperature; Male; Mice; Naloxone; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1983 |
Evidence for a role of the ventro-medial posterior hypothalamus in nociceptive processes in the rat.
Topics: Animals; beta-Endorphin; Dynorphins; Electroshock; Endorphins; Enkephalin, Methionine; Hypothalamus; Hypothalamus, Posterior; Male; Morphine; Naltrexone; Nociceptors; Pain; Protein Precursors; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1983 |
A case of episodic flushing and organic psychosis: reversal by opiate antagonists.
Topics: Adult; Anxiety Disorders; Female; Histamine Release; Humans; Mast Cells; Naloxone; Naltrexone; Neurocognitive Disorders; Pain; Skin; Vasodilator Agents | 1983 |
Pain sensitivity and endorphins in functional psychoses.
Topics: Bipolar Disorder; Depressive Disorder; Endorphins; Evoked Potentials, Somatosensory; Female; Humans; Male; Naltrexone; Nociceptors; Pain; Psychotic Disorders; Receptors, Opioid; Schizophrenic Psychology; Sensory Thresholds | 1981 |
Role of opioid peptides in disorders of attention in psychopathology.
Topics: Adrenocorticotropic Hormone; Adult; Attention; Brain Mapping; Endorphins; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Evoked Potentials, Visual; Female; Humans; Male; Naltrexone; Pain; Peptide Fragments; Schizophrenia; Schizophrenic Psychology | 1982 |
Antinociceptive effects of thyrotrophin-releasing hormone and its analogues in the rat periaqueductal grey region.
Topics: Analgesics; Animals; Naltrexone; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reaction Time; Thyrotropin-Releasing Hormone | 1983 |
Intrinsic mechanisms of pain inhibition: activation by stress.
Topics: Adaptation, Physiological; Adrenalectomy; Anesthesia; Animals; Brain Stem; Conditioning, Psychological; Electroshock; Endorphins; Histamine; Humans; Hypophysectomy; Immunosuppression Therapy; Naltrexone; Neoplasms; Nociceptors; Pain; Pentobarbital; Rats; Stress, Physiological | 1984 |
Effects of naltrexone and signaling inescapable electric shock on nociception and gastric lesions in rats.
Topics: Animals; Brain; Endorphins; Humans; Male; Naltrexone; Pain; Psychophysiologic Disorders; Rats; Stomach Ulcer | 1984 |
The effects of intrathecal morphine and naltrexone on autotomy in sciatic nerve sectioned rats.
Topics: Animals; Behavior, Animal; Differential Threshold; Disease Models, Animal; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Sciatic Nerve; Time Factors | 1984 |
Inhibition of morphine-induced analgesia and locomotor activity in strains of mice: a comparison of long-acting opiate antagonists.
Topics: Animals; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Naloxone; Naltrexone; Pain; Species Specificity | 1983 |
Opiate and non-opiate analgesia induced by inescapable tail-shock: effects of dorsolateral funiculus lesions and decerebration.
Topics: Animals; Brain; Decerebrate State; Electroshock; Endorphins; Male; Naltrexone; Neural Pathways; Pain; Rats; Spinal Cord; Time Factors | 1984 |
Involvement of central muscarinic cholinergic mechanisms in opioid stress analgesia.
Topics: Animals; Electroshock; Endorphins; Male; Morphine; Naltrexone; Oxotremorine; Pain; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Stress, Physiological | 1983 |
Activation of opioid-containing systems during gestation.
Topics: Animals; Endorphins; Female; Labor, Obstetric; Naltrexone; Pain; Pregnancy; Pregnancy, Animal; Rats; Sensory Thresholds | 1982 |
Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Gastrointestinal Motility; Male; Morphine; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Structure-Activity Relationship | 1982 |
Disposition of morphine in rat brain: relationship to biological activity.
Topics: Animals; Brain; Chromatography, Gas; Male; Morphine; Naltrexone; Pain; Radioimmunoassay; Rats | 1981 |
Long-term stress-induced analgesia and activation of the opiate system.
Topics: Analgesia; Animals; Electroshock; Endorphins; Naltrexone; Pain; Rats; Stress, Physiological; Tail; Time Factors | 1981 |
Alterations of evoked potentials link research in attention dysfunction to peptide response symptoms of schizophrenia.
Topics: Acoustic Stimulation; Attention; Endorphins; Evoked Potentials; Humans; Morphine; Naltrexone; Pain; Peptides; Schizophrenia; Schizophrenic Psychology | 1980 |
Endorphin-mediated increases in pain threshold during pregnancy.
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Female; Naltrexone; Pain; Pregnancy; Pregnancy, Animal; Rats; Time Factors | 1980 |
Repeated administration of naltrexone produces tolerance to naloxone-induced hyperalgesia.
Topics: Animals; Drug Tolerance; Male; Mice; Naloxone; Naltrexone; Pain | 1980 |
Differential modulation of alpha 2-adrenergic and mu-opioid spinal antinociception by neuropeptide FF.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Male; Medetomidine; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1995 |
Involvement of delta 1-opioid receptors in the antinociceptive effects of mexiletine in mice.
Topics: Animals; Diabetic Neuropathies; Male; Mexiletine; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reference Values | 1995 |
Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.
Topics: Analgesics; Animals; Drug Synergism; Enkephalins; Injections, Spinal; Male; Naltrexone; Pain; Pain Measurement; Rats; Rats, Wistar; Substance P | 1994 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neurokinin B; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-3; RNA, Messenger; Spinal Cord; Substance P; Time Factors | 1995 |
Naltrexone for alcohol dependence.
Topics: Alcoholism; Clinical Trials as Topic; Costs and Cost Analysis; Dose-Response Relationship, Drug; Drug Interactions; Humans; Naltrexone; Pain; Randomized Controlled Trials as Topic; Thioridazine | 1995 |
Peripheral kappa-opioid receptors mediate the antinociceptive effect of fedotozine (correction of fetodozine) on the duodenal pain reflex inrat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Duodenum; Injections, Intravenous; Injections, Intraventricular; Male; Morphine; Naloxone; Naltrexone; Pain; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Reflex | 1994 |
A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
Topics: Adrenal Medulla; Adrenalectomy; Analgesia; Analysis of Variance; Animals; Chlorisondamine; Corticosterone; Electroshock; Epinephrine; Male; Naltrexone; Norepinephrine; Pain; Rats; Rats, Sprague-Dawley; Stress, Psychological; Time Factors | 1994 |
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin | 1994 |
Etonitazene-induced antinociception in mu1 opioid receptor deficient CXBK mice: evidence for a role for mu2 receptors in supraspinal antinociception.
Topics: Animals; Benzimidazoles; Cerebral Ventricles; Dose-Response Relationship, Drug; Enkephalin, Leucine; Hot Temperature; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, mu; Spinal Cord | 1994 |
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse.
Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord | 1994 |
Streptozotocin-induced diabetes selectively reduces antinociception mediated by mu 1-opioid receptors, but not that mediated by mu 2-opioid receptors.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid, mu; Spinal Cord | 1994 |
Supraspinal delta receptor subtype activity of heroin and 6-monoacetylmorphine in Swiss Webster mice.
Topics: Animals; Benzylidene Compounds; Heroin; Male; Mice; Morphine Derivatives; Naltrexone; Pain; Receptors, Opioid, delta | 1994 |
Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Blood Pressure; Colon; Injections, Intraventricular; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Neurons, Afferent; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Vagotomy; Vagus Nerve | 1994 |
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve | 1993 |
Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Lobeline; Microinjections; Morphine; Naltrexone; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tegmentum Mesencephali | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Differential effects of specific delta and kappa opioid receptor antagonists on the bidirectional dose-dependent effect of systemic naloxone in arthritic rats, an experimental model of persistent pain.
Topics: Analysis of Variance; Animals; Arthritis; Benzomorphans; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vocalization, Animal | 1993 |
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Receptors, Opioid, kappa; Tolmetin | 1993 |
Enkephalin antinociception in mice is mediated by delta 1- and delta 2-opioid receptors in the brain and spinal cord, respectively.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naltrexone; Pain; Receptors, Opioid, delta; Spinal Cord | 1993 |
Effect of diabetes on the antinociceptive effect of beta-endorphin.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values | 1993 |
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetates; Analgesics; Animals; Binding, Competitive; Bombesin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Naltrexone; Oximes; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa | 1993 |
The highly selective delta agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine.
Topics: Analgesics; Animals; Arthritis, Experimental; Drug Administration Schedule; Drug Interactions; Enkephalins; Male; Morphine; Naloxone; Naltrexone; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Reference Values; Vocalization, Animal | 1993 |
Involvement of spinal kappa opioid receptors in a type of footshock induced analgesia in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Electroshock; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, kappa; Spinal Cord; Stress, Psychological | 1993 |
Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain.
Topics: Analgesics; Animals; Benzeneacetamides; Benzomorphans; Disease Models, Animal; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vocalization, Animal | 1993 |
Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment.
Topics: Animals; Blotting, Northern; Evaluation Studies as Topic; Male; Mice; Naltrexone; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; RNA, Messenger; Time Factors | 1995 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1996 |
Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.
Topics: Analgesics, Opioid; Animals; Capsaicin; Cough; Female; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Species Specificity | 1996 |
Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; Male; Medulla Oblongata; Mesencephalon; Microinjections; Models, Neurological; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Time Factors | 1996 |
Antiallodynic effects of a CCKB antagonist in rats with nerve ligation injury: role of endogenous enkephalins.
Topics: Animals; Male; Naltrexone; Narcotic Antagonists; Pain; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Thiorphan | 1996 |
Delta-Opioid receptor modulation of the release of substance P-like immunoreactivity in the dorsal horn of the rat following mechanical or thermal noxious stimulation.
Topics: Animals; Decerebrate State; Enkephalin, Methionine; Functional Laterality; Hindlimb; Hot Temperature; Male; Naltrexone; Narcotic Antagonists; Pain; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid, delta; Spinal Cord; Substance P; Time Factors | 1996 |
Use of a mu-antisense oligodeoxynucleotide as a mu opioid receptor noncompetitive antagonist in vivo.
Topics: Animals; Base Sequence; Cerebral Ventricles; Injections, Intraventricular; Injections, Subcutaneous; Male; Molecular Sequence Data; Morphine; Naltrexone; Narcotic Antagonists; Oligonucleotides, Antisense; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu | 1996 |
Cancer pain remedy wins orphan drug status.
Topics: Blood-Brain Barrier; Constipation; Drug Therapy, Combination; Humans; Morphine; Naltrexone; Narcotic Antagonists; Nausea; Neoplasms; Orphan Drug Production; Pain; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 1996 |
Reversal by kappa-agonists of peritoneal irritation-induced ileus and visceral pain in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetic Acid; Analgesics; Animals; Benzofurans; Benzomorphans; Cyclazocine; Fentanyl; Gastric Emptying; Intestinal Pseudo-Obstruction; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peritoneum; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Thiophenes | 1997 |
Managing pain in addicted patients.
Topics: Alcoholism; Analgesics; Heroin Dependence; Humans; Naltrexone; Narcotic Antagonists; Pain; Recurrence; Substance-Related Disorders | 1997 |
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus.
Topics: Animals; Decerebrate State; Dynorphins; Hindlimb; Male; Naltrexone; Pain; Peptide Fragments; Physical Stimulation; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P | 1997 |
Neuropeptide FF in the rat spinal cord during carrageenan inflammation.
Topics: Animals; Carrageenan; Hot Temperature; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Neuropeptides; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Involvement of spinal cord delta opiate receptors in the antinociception of gestation and its hormonal simulation.
Topics: Animals; Benzylidene Compounds; Female; Humans; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sensory Thresholds; Sex Characteristics; Spinal Cord; Time Factors | 1997 |
Opioid receptor blockade throughout prenatal life confers long-term insensitivity to morphine and alters mu opioid receptors.
Topics: Analgesics, Opioid; Animals; Body Weight; Female; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 1998 |
Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.
Topics: Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Female; Hyperalgesia; Injections, Spinal; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Self Mutilation; Somatostatin; Spinal Cord Injuries; Stress, Mechanical | 1998 |
Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice.
Topics: Analgesics, Non-Narcotic; Animals; Azetidines; Hexamethonium; Lethal Dose 50; Male; Maze Learning; Mecamylamine; Mice; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines | 1998 |
Opioids modulate the calcitonin gene-related peptide8-37-mediated hindpaw withdrawal latency increase in thermally injured rats.
Topics: Animals; Brain Chemistry; Burns; Calcitonin Gene-Related Peptide; Hindlimb; Injections, Spinal; Male; Mitogens; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Peptide Fragments; Pressure; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1998 |
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
Topics: Animals; Azocines; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hot Temperature; Macaca mulatta; Male; Naltrexone; Pain; Receptors, Opioid, mu | 1998 |
Effects of preweanling chronic naltrindole administration on stress-induced antinociceptive responses in rats.
Topics: Aging; Alfentanil; Analgesics, Opioid; Animals; Animals, Newborn; Drug Administration Schedule; Female; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stress, Psychological; Swimming | 1998 |
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors | 1998 |
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice.
Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors | 1998 |
Effects of peptidase inhibitors on the enkephalin-induced anti-nociception in rats.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Captopril; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enkephalin, Methionine; Glycopeptides; Injections, Intraventricular; Injections, Subcutaneous; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Peptides; Protease Inhibitors; Rats; Rats, Wistar | 1998 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Reward; Time Factors | 1999 |
Algogenic mediator-induced nociceptive response in diabetic mice.
Topics: Animals; Benzylidene Compounds; Bradykinin; Diabetes Mellitus, Experimental; Dinoprost; Dose-Response Relationship, Drug; Formaldehyde; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid, delta; Somatostatin | 1999 |
Analgesia-producing mechanism of processed Aconiti tuber: role of dynorphin, an endogenous kappa-opioid ligand, in the rodent spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Administration, Topical; Analgesics; Animals; Arcuate Nucleus of Hypothalamus; Cold Temperature; Dexamethasone; Dopamine Antagonists; Drugs, Chinese Herbal; Dynorphins; Glucocorticoids; Hypothalamus; Immune Sera; Ligands; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salicylamides; Spinal Cord; Sulpiride | 1999 |
Differential involvement of mu-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Oligopeptides; Pain; Receptors, Opioid, mu; Time Factors | 1999 |
Naltrexone and beta-funaltrexamine antagonism of the antinociceptive and response rate-decreasing effects of morphine, dezocine, and d-propoxyphene.
Topics: Animals; Dose-Response Relationship, Drug; Male; Naltrexone; Nociceptors; Pain; Rats | 1999 |
Paradoxical effects of intracerebroventricular low-dose opioid antagonists in SHR with chronic pain.
Topics: Analgesia; Animals; Arteries; Blood Pressure; Body Temperature; Body Weight; Brain; Chronic Disease; Hypertension; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Quaternary Ammonium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1999 |
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Vocalization, Animal | 1999 |
Cannabinoid modulation of dynorphin A: correlation to cannabinoid-induced antinociception.
Topics: Analgesics; Animals; Cannabinoids; Cyclohexanols; Dimethyl Sulfoxide; Dronabinol; Dynorphins; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant | 1999 |
Antinociceptive properties of FR140423 mediated through spinal delta-, but not mu- and kappa-, opioid receptors.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Binding, Competitive; Diarrhea; Injections, Intraventricular; Injections, Spinal; Male; Membranes; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfoxides | 1999 |
Neonatal naltrindole and handling differently affect morphine antinociception in male and female rats.
Topics: Analgesics; Animals; Female; Handling, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Sex Characteristics; Stress, Physiological | 1999 |
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1999 |
Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2000 |
An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
Topics: Analgesics, Opioid; Animals; Antipruritics; Dose-Response Relationship, Drug; Female; Hot Temperature; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pruritus; Receptors, Opioid | 2000 |
Acute exposure to saccharin reduces morphine analgesia in the the rat: evidence for involvement of N-methyl-D-aspartate and peripheral opioid receptors.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Saccharin; Sweetening Agents | 2000 |
Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray.
Topics: Amygdala; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Naltrexone; Narcotic Antagonists; Neural Pathways; Neurons; Neurotensin; Nociceptors; Pain; Peptides; Periaqueductal Gray; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotensin; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Valine | 2000 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Constipation; Female; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Quaternary Ammonium Compounds | 2000 |
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Receptors, Opioid; Stress, Physiological; Walking | 2000 |
Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Drug Tolerance; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Motor Activity; Naltrexone; Narcotic Antagonists; Pain | 2001 |
Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.
Topics: Animals; Brain; Cell Extracts; Drug Interactions; Dynorphins; Glycopeptides; Hydroxymercuribenzoates; Injections, Intraventricular; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Pain Measurement; Protease Inhibitors; Rats | 2001 |
Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Male; Microinjections; Naltrexone; Pain; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2001 |
The role of minoxidil on endogenous opioid peptides in the spinal cord: a putative co-agonist relationship between K-ATP openers and opioids.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Male; Minoxidil; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Vasodilator Agents | 2001 |
Enhancement of the effects of a complete inhibitor of enkephalin-catabolizing enzymes, RB 101, by a cholecystokinin-B receptor antagonist in diabetic rats.
Topics: Aminopeptidases; Animals; Diabetes Mellitus, Experimental; Disulfides; Drug Synergism; Indoles; Male; Meglumine; Naloxone; Naltrexone; Neprilysin; Pain; Pain Measurement; Phenylalanine; Pressure; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Time Factors; Vocalization, Animal; Weight Loss | 2001 |
Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Drug Interactions; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Threshold; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalins; Genotype; Hypnotics and Sedatives; Immunohistochemistry; Male; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Neurons; Nitrous Oxide; Pain; Pain Measurement; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, Opioid | 2001 |
Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse.
Topics: Analgesics; Animals; Benzylidene Compounds; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Immune Sera; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Pain Threshold; Peptide Fragments; Time Factors | 2001 |
Effectiveness of repeated administration of a new oral naltrexone controlled-release system on morphine analgesia.
Topics: Administration, Oral; Animals; Delayed-Action Preparations; Drug Administration Schedule; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pain | 2001 |
Selective depression of nociceptive responses of dorsal horn neurones by SNC 80 in a perfused hindquarter preparation of adult mouse.
Topics: Action Potentials; Animals; Benzamides; In Vitro Techniques; Male; Mice; Naltrexone; Narcotic Antagonists; Pain; Piperazines; Posterior Horn Cells; Receptors, Opioid, delta | 2001 |
Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Naloxone; Naltrexone; Oligopeptides; Pain; Pain Measurement; Quaternary Ammonium Compounds; Reflex; Time Factors | 2002 |
Hormonal and other effects of naltrexone in normal men.
Topics: Adrenocorticotropic Hormone; Adult; Body Temperature; Humans; Hydrocortisone; Luteinizing Hormone; Male; Naloxone; Naltrexone; Pain; Prolactin; Respiration; Testosterone | 1979 |
Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone.
Topics: Adult; Electric Stimulation; Evoked Potentials; Female; Humans; Male; Naloxone; Naltrexone; Pain; Schizophrenia | 1979 |
Endogenous opioid peptides and the control of pain.
Topics: Analgesia; Animals; Cats; Central Nervous System; Endorphins; Humans; Naloxone; Naltrexone; Pain; Spinal Cord; Substance P; Swine | 1979 |
Suppressant effects of naltrexone on water intake in rats.
Topics: Animals; Body Weight; Depression, Chemical; Drinking Behavior; Female; Naloxone; Naltrexone; Pain; Quinine; Rats; Self Administration; Sensory Thresholds; Time Factors; Water Deprivation | 1979 |
Short-term effects of naltrexone in 155 heroin ex-addicts.
Topics: Abdomen; Administration, Oral; Blood Pressure; Brain; Dose-Response Relationship, Drug; Drug Evaluation; Heart; Heroin Dependence; Humans; Naloxone; Naltrexone; Pain; Respiration; Substance-Related Disorders; Time Factors | 1976 |
Comparison of the neurochemistry of the endogenous opioid systems in two brainstem pain-processing centers.
Topics: Animals; Brain Stem; Dipeptides; Dose-Response Relationship, Drug; Medulla Oblongata; Microinjections; Naloxone; Naltrexone; Neprilysin; Pain; Periaqueductal Gray; Rats | 1992 |
Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Topics: Analysis of Variance; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Intraventricular; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1992 |
Effects of diabetes on stress-induced analgesia in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Physical Exertion; Receptors, Opioid, mu; Sensory Thresholds; Stress, Physiological | 1992 |
Effects of naltrindole and nor-binaltorphimine treatment on antinociception induced by sub-acute selective mu opioid receptor blockade.
Topics: Animals; Indoles; Male; Morphinans; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity | 1992 |
Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electroshock; Indoles; Injections, Spinal; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Somatostatin; Spinal Cord | 1992 |
Analgesic and aversive effects of naloxone in BALB/c mice.
Topics: Analgesia; Animals; Choice Behavior; Dose-Response Relationship, Drug; Formaldehyde; Mice; Mice, Inbred BALB C; Naloxone; Naltrexone; Pain | 1992 |
Modifications of social conflict-induced analgesic and activity responses in male mice receiving chronic opioid agonist and antagonist treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Conflict, Psychological; Enkephalin, Leucine; Infusion Pumps, Implantable; Levorphanol; Male; Mice; Motor Activity; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Receptors, Opioid; Social Behavior; Sodium Chloride | 1991 |
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats.
Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1991 |
Novel inhibitors of enkephalin-degrading enzymes. III: 4-Carboxymethylamino-4-oxo-3 (phenylamino) butanoic acids as enkephalinase inhibitors.
Topics: Abdomen; Aminopeptidases; Analgesics; Animals; Butyrates; Indicators and Reagents; Kinetics; Male; Mice; Mice, Inbred Strains; Molecular Structure; Naltrexone; Neprilysin; Pain; Pain Measurement; Structure-Activity Relationship | 1991 |
Involvement of spinal kappa opioid receptors in the antagonistic effect of dynorphins on morphine antinociception.
Topics: Animals; Dynorphins; Indoles; Male; Mice; Morphinans; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Spine; Stereoisomerism | 1991 |
Protection by U-50,488H against beta-chlornaltrexamine antagonism of nitrous oxide antinociception in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Animals; Fentanyl; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nitrous Oxide; Pain; Pyrrolidines; Sufentanil | 1991 |
Periaqueductal gray stimulation produces a spinally mediated, opioid antinociception for the inflamed hindpaw of the rat.
Topics: Analysis of Variance; Animals; Electric Stimulation; Freund's Adjuvant; Hindlimb; Inflammation; Male; Mycobacterium; Naloxone; Naltrexone; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; Spinal Cord | 1991 |
Endothelin-1-induced nociception.
Topics: Animals; Endothelins; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Pain Measurement | 1991 |
Electroacupuncture in rats: evidence for naloxone and naltrexone potentiation of analgesia.
Topics: Aging; Analgesia; Analysis of Variance; Animals; China; Electroacupuncture; Female; Male; Naloxone; Naltrexone; Pain; Pain Management; Rats; Rats, Inbred Strains; Sensory Thresholds; Sex Characteristics; Species Specificity; United States | 1991 |
Electroacupuncture analgesia in rats: naltrexone antagonism is dependent on previous exposure.
Topics: Analgesia; Analysis of Variance; Animals; China; Electroacupuncture; Male; Naloxone; Naltrexone; Pain; Pain Management; Rats; Rats, Inbred Strains; Species Specificity; Time Factors; United States | 1991 |
Electroacupuncture analgesia in naive rats: effects of brainstem and spinal cord lesions, and role of pituitary-adrenal axis.
Topics: Adrenalectomy; Analgesia; Animals; Brain Stem; Electroacupuncture; Hypophysectomy; Male; Naltrexone; Pain; Pain Management; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Spinal Cord; Time Factors | 1991 |
The effects of mu, delta- and kappa-opioid receptor antagonists on the pain threshold increase following muscle stimulation in the rat.
Topics: Analgesia; Animals; Electric Stimulation; Male; Muscles; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred SHR; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Conditional hypoalgesia is attenuated by naltrexone applied to the periaqueductal gray.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Electroshock; Female; Formaldehyde; Microinjections; Naltrexone; Pain; Periaqueductal Gray; Rats; Receptors, Opioid | 1990 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Ethylketocyclazocine; Formaldehyde; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urination | 1990 |
Antinociceptive effects of elevated plus-maze exposure: influence of opiate receptor manipulations.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred DBA; Morphine; Naltrexone; Pain; Pain Measurement; Receptors, Opioid | 1990 |
Cats produce analgesia in rats on the tail-flick test: naltrexone sensitivity is determined by the nociceptive test stimulus.
Topics: Animals; Cats; Electroshock; Fear; Hot Temperature; Male; Naltrexone; Pain; Pain Measurement; Rats | 1990 |
The role of pituitary beta-endorphin in mediating corticotropin-releasing factor-induced antinociception.
Topics: Analgesics; Animals; beta-Endorphin; Corticotropin-Releasing Hormone; Dexamethasone; Male; Morphine; Naltrexone; Pain; Pituitary Gland; Radioimmunoassay; Rats; Rats, Inbred Strains; Reference Values; Time Factors | 1990 |
Involvement of spinal kappa opioid receptors in the antinociception produced by intrathecally administered corticotropin-releasing factor in mice.
Topics: Animals; Corticotropin-Releasing Hormone; Drug Interactions; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid; Receptors, Opioid, kappa | 1990 |
Simultaneous development of opioid tolerance and opioid antagonist-induced receptor upregulation.
Topics: Analgesia; Animals; Brain; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Male; Mice; Morphine; Naloxone; Naltrexone; Pain; Receptors, Opioid; Reference Values; Up-Regulation | 1990 |
Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia.
Topics: Analgesics; Animals; Body Temperature; Carrageenan; Dextrorphan; Dose-Response Relationship, Drug; Edema; Levorphanol; Male; Morphine; Naltrexone; Narcotics; Pain; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Pain thresholds are elevated during pseudopregnancy.
Topics: Animals; Female; Gonadal Steroid Hormones; Naltrexone; Pain; Pseudopregnancy; Rats; Sensory Thresholds | 1990 |
Opioid agonist and antagonist activities of peripherally selective derivatives of naltrexamine and oxymorphamine.
Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Hydromorphone; Male; Mice; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Oxymorphone; Pain; Structure-Activity Relationship | 1989 |
Novel inhibitors of enkephalin-degrading enzymes. I: Inhibitors of enkephalinase by penicillins.
Topics: Analgesics; Animals; Brain; Enkephalin, Leucine-2-Alanine; Isoenzymes; Male; Mice; Mice, Inbred Strains; Naltrexone; Neprilysin; Pain; Penicillins; Thiorphan; Time Factors | 1989 |
Beta-funaltrexamine disrupts the day-night rhythm of nociception in mice.
Topics: Animals; Circadian Rhythm; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, mu | 1989 |
Exploring delta-receptor function using the selective opioid antagonist naltrindole.
Topics: Animals; Behavior, Animal; Indoles; Male; Morphinans; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stress, Psychological | 1989 |
Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Fear; Female; Formaldehyde; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 1989 |
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
Topics: 3,4-Methylenedioxyamphetamine; Amphetamines; Analgesics; Animals; Dose-Response Relationship, Drug; Male; Methysergide; Morphine; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1989 |
Delayed suppression of serum luteinizing hormone after naloxone treatment in neonatal female rats.
Topics: Animals; Animals, Newborn; Female; Luteinizing Hormone; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Secretory Rate; Time Factors | 1989 |
Chronic opioid antagonist treatment facilitates nonopioid, stress-induced analgesia.
Topics: Animals; Cold Temperature; Drug Implants; Male; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Stress, Physiological; Swimming | 1987 |
Quaternary naltrexone reveals the central mediation of conditional opioid analgesia.
Topics: Animals; Brain; Conditioning, Classical; Female; Injections, Intraventricular; Naltrexone; Pain; Quaternary Ammonium Compounds; Rats; Receptors, Opioid | 1987 |
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord | 1987 |
Opioid analgesia in the mouse: evidence for multiple receptors using beta-FNA.
Topics: Analgesia; Animals; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Pain; Receptors, Opioid | 1986 |
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Morphine; Naltrexone; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1988 |
[Frequency as the cardinal determinant for electroacupuncture analgesia to be reversed by opioid antagonists].
Topics: Acupuncture Therapy; Animals; beta-Endorphin; Dynorphins; Electric Stimulation Therapy; Endorphins; Enkephalins; Naloxone; Naltrexone; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Determinants of the nature of environmentally induced hypoalgesia.
Topics: Analgesia; Animals; Electroshock; Endorphins; Male; Naltrexone; Pain; Pentobarbital; Rats; Rats, Inbred Strains; Stress, Psychological | 1989 |
Arcuate nucleus lesions reduce opioid stress-induced analgesia (SIA) and enhance non-opioid SIA in rats.
Topics: Analgesia; Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Biotin; Body Weight; Drinking Behavior; Electroshock; Endorphins; Feeding Behavior; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Stress, Psychological; Wheat Germ Agglutinins | 1986 |
Mating produced analgesia in the Syrian hamster.
Topics: Animals; beta-Endorphin; Copulation; Cricetinae; Electroshock; Endorphins; Female; Male; Mesocricetus; Naltrexone; Pain; Reaction Time; Sex Characteristics | 1986 |
Comparisons of descending pain inhibitory pathways activated by beta-endorphin and morphine as characterized by supraspinal and spinal antinociceptive interactions in mice.
Topics: Analgesia; Animals; beta-Endorphin; Drug Tolerance; Efferent Pathways; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Pain; Spinal Cord | 1988 |
Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.
Topics: Animals; Brain Chemistry; Guanosine Triphosphate; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Time Factors | 1985 |
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment.
Topics: Animals; Binding, Competitive; Brain; Drug Implants; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Morphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Time Factors | 1985 |
Analgesic effects of mu antagonists after naloxone non-reversible stress-induced analgesia.
Topics: Analgesics; Animals; Diprenorphine; Electroshock; Male; Nalorphine; Naloxone; Naltrexone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Stress, Physiological | 1985 |
Naltrexone.
Topics: Humans; Methadone; Naltrexone; Opioid-Related Disorders; Pain; Pituitary Gland; Receptors, Opioid; Substance Withdrawal Syndrome | 1985 |
Environmentally induced analgesia: ontogeny of a nonopioid system.
Topics: Analgesia; Animals; Cholinergic Fibers; Electroshock; Environment; Male; Naltrexone; Nervous System; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Scopolamine | 1986 |
Reversal by beta-funaltrexamine of the antinociceptive effect of opioid agonists in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzodiazepines; Buprenorphine; Cyclazocine; Ethylketocyclazocine; Fentanyl; Male; Naltrexone; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats.
Topics: Animals; Animals, Newborn; Cholecystokinin; Drug Interactions; Morphine; Motor Activity; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reference Values; Sincalide; Stress, Psychological; Vocalization, Animal | 1988 |
Reversal by beta-funaltrexamine and 16-methyl cyprenorphine of the antinociceptive effects of opioid agonists in the mouse and guinea-pig.
Topics: Abdomen; Animals; Guinea Pigs; Male; Mice; Morphinans; Muscle Contraction; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain | 1988 |
Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Spinal; Morphine; Naltrexone; Pain; Rats; Spinal Cord; Structure-Activity Relationship; Strychnine | 1988 |
Electroacupuncture suppresses a nociceptive reflex: naltrexone prevents but does not reverse this effect.
Topics: Acupuncture Therapy; Analgesia; Animals; Injections, Intravenous; Injections, Spinal; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reflex | 1988 |
Electroacupuncture suppression of a nociceptive reflex is potentiated by two repeated electroacupuncture treatments: the first opioid effect potentiates a second non-opioid effect.
Topics: Acupuncture Therapy; Animals; Injections, Intravenous; Injections, Spinal; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reflex | 1988 |
Interactions between sucrose, pain and isolation distress.
Topics: Animals; Female; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Social Isolation; Sucrose; Taste; Vocalization, Animal | 1987 |
Effects of naltrexone on learning and performance of conditional fear-induced freezing and opioid analgesia.
Topics: Animals; Conditioning, Classical; Fear; Female; Learning; Naltrexone; Pain; Rats | 1987 |
Evidence for opioid and non-opioid forms of stress-induced analgesia in the snail, Cepaea nemoralis.
Topics: Animals; Cold Temperature; Endorphins; Enkephalin, Leucine; Hot Temperature; Naloxone; Naltrexone; Pain; Reaction Time; Snails; Stress, Physiological | 1987 |
Spinal cord mediation of the opioid analgesia of pregnancy.
Topics: Animals; Electroshock; Endorphins; Female; Gestational Age; Injections, Spinal; Naltrexone; Pain; Pregnancy; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord | 1987 |
Ontogeny of an endogenous, nonopioid and hormonally mediated analgesic system.
Topics: Aging; Analgesia; Animals; Cold Temperature; Dexamethasone; Endorphins; Hormones; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Stress, Physiological | 1987 |
Environmentally-induced analgesia: age-related differences in a hormonally-mediated, nonopioid system.
Topics: Adrenal Glands; Aging; Analgesia; Analysis of Variance; Animals; Cold Temperature; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains | 1986 |
Opioid and non-opioid stress analgesia from cold water swim: importance of stress severity.
Topics: Analgesia; Animals; Cold Temperature; Electroshock; Endorphins; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Stress, Physiological; Swimming | 1986 |
Endogenous analgesia in the pregnant rat: an artifact of weight-dependent measures?
Topics: Animals; Body Weight; Endorphins; Female; Naloxone; Naltrexone; Pain; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Sensory Thresholds | 1986 |
Opioid-mediation of separation distress in 10-day-old rats: reversal of stress with maternal stimuli.
Topics: Animals; Animals, Newborn; Brain; Endorphins; Female; Maternal Deprivation; Morphine; Naltrexone; Pain; Rats; Rats, Inbred Strains; Social Isolation; Vocalization, Animal | 1986 |
The analgesia produced by food deprivation in 4-month old, 14-month old, and 24-month old rats.
Topics: Aging; Analgesia; Animals; Dexamethasone; Endorphins; Food Deprivation; Hormones; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains | 1986 |
Shock controllability and the nature of stress-induced analgesia.
Topics: Animals; Electroshock; Escape Reaction; Hot Temperature; Male; Naltrexone; Pain; Rats; Reaction Time; Stress, Physiological | 1985 |
Effect of age and long-term stress experience on adaptation to stress analgesia in mature rats: role of opioids.
Topics: Aging; Animals; Cold Temperature; Endorphins; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reaction Time; Stress, Physiological | 1985 |
Odors released by stressed rats produce opioid analgesia in unstressed rats.
Topics: Animals; Female; Naltrexone; Pain; Pheromones; Rats; Rats, Inbred Strains; Reaction Time; Stress, Physiological | 1985 |
Shock controllability and opioid substrates of escape performance and nociception: differential effects of peripherally and centrally acting naltrexone.
Topics: Animals; Brain; Endorphins; Escape Reaction; gamma-Aminobutyric Acid; Male; Naltrexone; Nervous System; Pain; Peripheral Nerves; Pituitary Gland; Rats; Reaction Time; Stress, Physiological | 1985 |
Exposure to a cat produces opioid analgesia in rats.
Topics: Animals; Endorphins; Fear; Female; Naloxone; Naltrexone; Nervous System; Pain; Rats; Rats, Inbred Strains; Reaction Time | 1985 |
Hot-plate learning in mice is unaltered by immediate post-training administration of naloxone, naltrexone or morphine.
Topics: Animals; Endorphins; Hot Temperature; Learning; Male; Memory; Mice; Morphine; Naloxone; Naltrexone; Pain | 1985 |
Evidence of a supraspinal opioid analgesic mechanism engaged by lateral hypothalamic electrical stimulation.
Topics: Animals; Brain Mapping; Electric Stimulation; Endorphins; Hypothalamic Area, Lateral; Male; Naltrexone; Pain; Rats; Rats, Inbred Strains; Reward; Sensory Thresholds | 1985 |
Naltrexone antagonizes the biobehavioral adaptation to cold water stress in rats.
Topics: Adaptation, Physiological; Animals; Body Temperature; Central Nervous System; Cold Temperature; Endorphins; Male; Naloxone; Naltrexone; Neuronal Plasticity; Pain; Rats; Rats, Inbred Strains; Reaction Time; Stress, Physiological | 1985 |
Placenta ingestion enhances opiate analgesia in rats.
Topics: Analgesia; Animals; Diet; Electroshock; Female; Maternal Behavior; Morphine; Naltrexone; Pain; Placenta; Pregnancy; Rats; Sensory Thresholds | 1985 |
Hormonal mediation of the analgesia produced by food deprivation.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Dexamethasone; Endorphins; Food Deprivation; Hormones; Male; Naltrexone; Pain; Pituitary Hormones; Rats; Rats, Inbred Strains; Sensory Thresholds | 1985 |