naloxone and Trauma--Nervous-System

To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).. IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.. IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.. IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.

Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hyperalgesia; Interleukin-2; Male; Mice; Mice, Inbred BALB C; Naloxone; Trauma, Nervous System