naloxone and Stomach-Neoplasms

Topics: Abdominal Pain; Analgesics, Opioid; Delayed-Action Preparations; Female; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxycodone; Portal Vein; Stomach Neoplasms; Substance Withdrawal Syndrome; Treatment Outcome; Venous Thrombosis

Sensitivity of blood lymphocytes to the stimulating effect of met-enkephalin and dopamine was shown to decrease at late stages of the gastric cancer (IIIB-IV) or in the case of metastases to other organs, while to the inhibitory effect of serotonin it increased as compared to early stages (I-IIA). Using specific blockers of opioid, dopamine and serotonin receptors it was shown that these effects were mediated through stimulation of respective type receptors.

Topics: Adult; Aged; Chemoreceptor Cells; Dopamine; Enkephalin, Methionine; Female; Haloperidol; Humans; Leukocyte Adherence Inhibition Test; Lymphocytes; Male; Methysergide; Middle Aged; Naloxone; Neoplasm Staging; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Serotonin; Stomach Neoplasms

The increased incidence of gallbladder diseases after gastrectomy is discussed with regard to contractile motility of the gallbladder. Ultrasonographic findings and contraction of the gallbladder in response to egg yolk or caerulein were studied before and after gastrectomy at intervals ranging from 2 weeks to 6 months. Enlargement of the gallbladder with accumulation of biliary sludge and hypomotility were frequently observed within a month of operation for gastric cancer, suggesting that biliary stasis is an important contributing factor in postoperative acute cholecystitis. Within 3 months of operation, contraction had recovered to close to preoperative levels and the incidence of biliary sludge formation gradually decreased. Daily administration of an opiate antagonist, naloxone (0.8 mg), significantly improved gallbladder dyskinesia and decreased the incidence of biliary sludge formation within 1 month of gastrectomy.

Topics: Acute Disease; Ceruletide; Cholecystitis; Egg Yolk; Gallbladder; Gastrectomy; Humans; Middle Aged; Muscle Contraction; Naloxone; Postoperative Complications; Stomach Neoplasms

Contractile motility of the gallbladder was compared using a real-time ultrasonography in 13 patients with gastric ulcer and 31 patients with gastric cancer who had undergone either subtotal or total gastrectomy within 1 month previously. Contractile motility of the gallbladder after oral administration of dried egg yolk (Daiyan, Maruishi, Osaka), which was slightly but not significantly reduced in patients with gastric ulcer, was remarkedly impaired in patients with gastric cancer who had either subtotal or total gastrectomy including radical lymph node dissection. Especially, maximum contractile rate after Daiyan in Billroth II patients was significantly reduced than that of Billroth I patients. Intramuscular injection of naloxone (0.4 mg), which had no effects on contractions after Daiyan in healthy subjects, significantly improved the hypomotility in response to Daiyan in these gastric cancer patients. It was suggested, therefore, that the possible roles of various anatomical and mechanical changes resulting from gastrectomy including vagotomy and sympathectomy, and in particular exclusion of duodenum from digestive circuits and relative or absolute excess of endogenous opioids, were involved in the control of the gallbladder motility within 1 month after gastrectomy including lymphadenectomy.

Topics: Colectomy; Egg Yolk; Gallbladder; Gastrectomy; Humans; Lymph Node Excision; Male; Middle Aged; Naloxone; Stomach Neoplasms; Stomach Ulcer; Sympathectomy; Ultrasonography; Vagotomy