naloxone and Skin-Ulcer

naloxone has been researched along with Skin-Ulcer* in 2 studies

Other Studies

2 other study(ies) available for naloxone and Skin-Ulcer

ArticleYear
Effectiveness and safety of oxycodone/naloxone in the management of chronic pain in patients with systemic sclerosis with recurrent digital ulcers: two case reports.
    Clinical interventions in aging, 2016, Volume: 11

    Digital ulcers (DUs) are a severe and frequent clinical feature of patients with systemic sclerosis (SSc). The presence of DUs may cause severe pain and often lead to impairment of patient's functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due to pain may be associated with a negative outcome of DU healing. Therefore, pain management has a key role in patients with SSc. These two case reports describe the effectiveness and safety of oxycodone/naloxone in patients with SSc complicated by painful chronic DUs. Such a therapy has provided pain relief and consequently an increased compliance during redressing wounds.

    Topics: Administration, Oral; Aged; Analgesics, Opioid; Chronic Pain; Drug Therapy, Combination; Female; Fingers; Humans; Middle Aged; Naloxone; Oxycodone; Pain Management; Quality of Life; Scleroderma, Systemic; Skin Ulcer; Wound Healing

2016
Is oxycodone/naloxone effective and safe in managing chronic pain of a fragile elderly patient with multiple skin ulcers of the lower limbs? A case report.
    Clinical interventions in aging, 2015, Volume: 10

    Skin ulcers are a common issue in the elderly, as physiological loss of skin elasticity, alterations in microcirculation, and concomitant chronic diseases typically occur in advanced age, thereby predisposing to these painful lesions. Wound-related pain is often associated with skin ulcers and negatively impacts both the patient's quality of life and, indirectly, wound healing. Pain management is an ongoing issue in the elderly, and remains underestimated and under-treated in this fragile population. Recent guidelines suggest the use of opioids as the frontline treatment of moderate and severe pain in nononcological pain in the elderly. However, due to the concerns of adverse reactions, drug interactions, and addiction, clinicians frequently hesitate to prescribe opioids. This case report describes an elderly diabetic patient with multiple ulcers of the lower limbs suffering wound-related pain. In our report, oxycodone/naloxone has proved to be an effective and safe drug, providing pain relief as well as increased compliance when redressing wounds and faster healing compared to that in similar patients. Our case provides anecdotal evidence, supported by other studies, to justify future, larger studies on chronic pain using this therapy.

    Topics: Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Diabetes Complications; Drug Combinations; Female; Frail Elderly; Humans; Lower Extremity; Naloxone; Narcotic Antagonists; Oxycodone; Pain Management; Quality of Life; Skin Ulcer

2015