naloxone has been researched along with Sexual-Dysfunction--Physiological* in 2 studies
2 other study(ies) available for naloxone and Sexual-Dysfunction--Physiological
| Article | Year |
|---|---|
Ethopharmacology of copulatory disorder induced by chronic social conflict in male mice.
The present study was designed to investigate how the experience of fighting affects copulatory behavior in male mice and also to determine the effect of naloxone on the interaction between social conflict and copulatory disorder. To generate intraspecific fighting a resident-intruder paradigm was employed. Agonistic confrontations were terminated after 10 or 20 attack bites, and were repeated for 5 consecutive days. Twenty-four hours after the last confrontation test, both resident and intruder mice were tested with estrus females for 10 min. Compared to the control group without agonistic confrontation, intruder mice that had been attacked repeatedly showed a significant reduction of copulatory behavior. In contrast, attacking resident mice showed a significant increase in copulatory behavior. Pretreatment with naloxone (1 and 3 mg/kg, IP) prior to daily fighting failed to antagonize defeat-induced copulatory disorder. It would, therefore, appear that endogenous opioid mechanism may not participate in this phenomenon. Topics: Aggression; Animals; Conflict, Psychological; Copulation; Estrus; Female; Male; Mice; Mice, Inbred ICR; Naloxone; Sexual Behavior, Animal; Sexual Dysfunction, Physiological; Social Behavior | 1991 |
Endogenous opiate systems and primate reproduction: inability of naloxone to induce sexual activity in rhesus males.
The opiate antagonist naloxone was tested for its effectiveness in inducing sexual behavior in sexually inactive male rhesus macaques (Macaca mulatta). Naloxone was administered to males directly into the carotid artery via a T-tube implant. Naloxone-treated males and sexually receptive females were pair tested for sexual behavior. Despite the positive behavioral cues of the females, the males failed to initiate heterosexual interactions at any level of naloxone therapy. The implications of this finding for the role of the endogenous opiate system in primate reproduction are discussed in relation to the homeostatic nature of the system. Topics: Animals; Endorphins; Female; Humans; Macaca; Macaca mulatta; Male; Masturbation; Naloxone; Sexual Behavior; Sexual Dysfunction, Physiological | 1982 |