naloxone and Pituitary-Diseases

naloxone has been researched along with Pituitary-Diseases* in 2 studies

Trials

1 trial(s) available for naloxone and Pituitary-Diseases

Article	Year
Failure of naloxone to alter growth hormone and prolactin levels in acromegalic and in hyperprolactinaemic patients. Clinical endocrinology, 1979, Volume: 11, Issue:5 We examined the effects of high-dose intravenous naloxone administration in four acromegalic patients (mean serum growth hormone level 72 ng/ml) and in seven hyperprolactinaemic women (mean serum prolactin level 59 ng/ml), in order to assess whether this opiate antagonist would be effective in lowering growth hormone and prolactin levels. No effect was observed. This lack of effect suggests that an opioid pathway is not involved in the maintenance of elevated growth hormone or prolactin secretion in these patients. However, conclusions regarding the possible role of endogenous opioids in regulation of pituitary function in normal individuals cannot be drawn from this study. Topics: Acromegaly; Adult; Clinical Trials as Topic; Female; Growth Hormone; Humans; Middle Aged; Naloxone; Pituitary Diseases; Prolactin	1979

Article

Year

Failure of naloxone to alter growth hormone and prolactin levels in acromegalic and in hyperprolactinaemic patients.

Clinical endocrinology, 1979, Volume: 11, Issue:5

We examined the effects of high-dose intravenous naloxone administration in four acromegalic patients (mean serum growth hormone level 72 ng/ml) and in seven hyperprolactinaemic women (mean serum prolactin level 59 ng/ml), in order to assess whether this opiate antagonist would be effective in lowering growth hormone and prolactin levels. No effect was observed. This lack of effect suggests that an opioid pathway is not involved in the maintenance of elevated growth hormone or prolactin secretion in these patients. However, conclusions regarding the possible role of endogenous opioids in regulation of pituitary function in normal individuals cannot be drawn from this study.

Topics: Acromegaly; Adult; Clinical Trials as Topic; Female; Growth Hormone; Humans; Middle Aged; Naloxone; Pituitary Diseases; Prolactin

1979

Other Studies

1 other study(ies) available for naloxone and Pituitary-Diseases

Article	Year
The effect of naloxone on the secretion of pituitary hormones in patients with acromegaly, microprolactinomas, Cushing's disease and Nelson's syndrome. Endokrynologia Polska, 1986, Volume: 37, Issue:5 Topics: Cushing Syndrome; Humans; Naloxone; Pituitary Diseases; Pituitary Function Tests; Pituitary Hormones, Anterior	1986