naloxone and Neutropenia

naloxone has been researched along with Neutropenia* in 2 studies

Other Studies

2 other study(ies) available for naloxone and Neutropenia

ArticleYear
Co-administration of morphine and levamisole increases death risk, produces neutropenia and modifies antinociception in mice.
    Addiction biology, 2022, Volume: 27, Issue:3

    Topics: Analgesics; Animals; Levamisole; Male; Mecamylamine; Mice; Morphine; Naloxone; Neutropenia

2022
Regulation of the estrous cycle by neutrophils via opioid peptides.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Jul-15, Volume: 187, Issue:2

    We found previously that neutrophil-depleted mice exhibited significant blockading of both the regular estrous cycle and cyclic changes of steroid hormone levels. In this study, we aimed at elucidation of the underlying mechanism. To examine the possibility that an increase in bacteria in the vaginal vault of neutrophil-depleted mice causes blockading of the estrous cycle, we treated neutrophil-depleted mice with antibiotics but failed to restore the estrous cycle. We then examined another possibility that neutrophils regulate the estrous cycle via opioid peptides, because opioid peptides regulate steroidogenesis in theca and granulosa cells in the ovaries, and because neutrophils contain opioid peptides. In support of this possibility, naloxone, an opioid antagonist, blocked the estrous cycle and a μ opioid receptor agonist restored the estrous cycle in neutrophil-depleted mice. Pro-opiomelanocortin was immunohistochemically detected in peripheral blood neutrophils but not in ones that had infiltrated into the ovaries. i.v. injection of anti-MIP-2 polyclonal Ab caused blockading of the estrous cycle, whereas MIP-2 was detected in the ovaries, suggesting a role of MIP-2 in the regulation of the estrous cycle. Moreover, i.v. injection of MIP-2 decreased the pro-opiomelanocortin signal in peripheral blood neutrophils and caused blockading of the estrous cycle. Together, these results suggest that neutrophils maintain the estrous cycle via opioid peptides.

    Topics: Animals; beta-Endorphin; Chemokine CXCL2; Estrous Cycle; Female; Mice; Mice, Inbred ICR; Naloxone; Neutropenia; Neutrophils; Opioid Peptides; Ovary; Receptors, Opioid, mu

2011