naloxone and Muscular-Diseases

To determine the effects of low-intensity exercise on chronic muscle pain and potential activation of the endogenous opioid system.. Randomized placebo-controlled trial.. Animal laboratory.. Sixty-three male Sprague-Dawley rats.. Rats performed a low-intensity exercise protocol for 5 consecutive days after the induction of chronic muscle pain. In a separate experiment, naloxone or saline was administered systemically before 5 low-intensity exercise sessions.. Mechanical hyperalgesia was measured using von Frey filaments to determine the mechanical withdrawal threshold.. Low-intensity exercise increased mechanical withdrawal threshold in the chronic muscle pain model. Naloxone attenuated the antihyperalgesic effects of low-intensity exercise.. Low-intensity exercise reversed mechanical hyperalgesia in the chronic muscle pain model through activation of the endogenous opioid system.

Topics: Analysis of Variance; Animals; Area Under Curve; Disease Models, Animal; Male; Muscular Diseases; Naloxone; Pain; Pain Measurement; Physical Conditioning, Animal; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity

In the present study 66 patients suffering from chronic myalgia were given vibratory stimulation as a pain relieving measure. Several of these patients had previously undergone treatments of various kinds without any significant relief. Forty-one patients reported a significant (20%) reduction of pain during vibratory stimulation. The best pain reducing site was found to be either the area of pain, a trigger or acupuncture point outside the painful area. The best pain reducing effect was obtained when the vibratory stimulation was applied with moderate pressure (1.0 kg) over the underlying structures. To obtain a maximal duration of pain relief the stimulation had to be applied for about 30 minutes.

Topics: Adult; Chronic Disease; Female; Humans; Male; Middle Aged; Muscular Diseases; Naloxone; Palliative Care; Vibration