naloxone and Mitral-Valve-Insufficiency

naloxone has been researched along with Mitral-Valve-Insufficiency* in 2 studies

Other Studies

2 other study(ies) available for naloxone and Mitral-Valve-Insufficiency

ArticleYear
Prolonged recovery and respiratory depression after fentanyl infusion in a sheep undergoing mitral valve reconstruction.
    Laboratory animals, 2005, Volume: 39, Issue:4

    A sheep was anaesthetized for implantation of a novel device (MitroFast) to replace the posterior leaflet of the mitral valve. Anaesthetic management included a balanced anaesthetic protocol and consisted of propofol or isoflurane combined with fentanyl infusion (0.15-0.4 microg/kg/min). Deliberate hypothermia during cardiopulmonary bypass was set at 34.5-35.5 degrees C. Surgery proceeded uneventfully. Total time of aortic cross-clamping was 35 min and total time on extracorporeal circulation was 60 min. Visual inspection, intracardiac pressure testing and transesophageal echocardiography indicated proper functioning of the device. The anaesthetic period was uneventful, but recovery was prolonged with central nervous and respiratory depression and marked hypoxaemia. Administration of naloxone (1.5 microg/kg, repeated twice at 15-20 min intervals) reversed the central nervous and attenuated the respiratory depressions. An initially low rate of urine production normalized after rewarming and a single intravenous administration of furosemide.

    Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Animals; Female; Fentanyl; Mitral Valve Insufficiency; Naloxone; Narcotic Antagonists; Respiratory Insufficiency; Sheep; Sheep Diseases

2005
Effects of morphine on atrial preparations obtained from nonfailing and failing human hearts.
    British journal of anaesthesia, 1996, Volume: 76, Issue:1

    We have examined the effects of morphine in auricular myocardium from non-failing and failing human hearts. In both preparations morphine induced inhibition. These responses were not antagonized by naloxone. Comparison of mean IC30 values obtained in non-failing (3.9 (SEM 0.2) x 10(-8) mol litre-1) and failing (5010 (200) x 10(-8) mol litre-1) hearts indicated that the morphine concentration-response curves were significantly (P < 0.001) shifted to the right in preparations from failing hearts. In addition, a decrease in the maximal response was observed. These data indicate that opioid receptors are not involved in the cardiac effects induced by morphine and that there is a decrease in responses to morphine in the failing heart.

    Topics: Adult; Aged; Atrial Function, Right; Cardiac Output, Low; Dose-Response Relationship, Drug; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Mitral Valve Insufficiency; Morphine; Myocardial Contraction; Naloxone; Narcotic Antagonists; Narcotics

1996