naloxone and Infant--Premature--Diseases

To give new insights into how an infant responded to naloxone, given after acquiring a maternal opiate by recording the breathing pattern directly after birth.. A respiratory recording is presented of an infant during resuscitation in the delivery room after receiving naloxone for respiratory depression, resulting from maternal remifentanyl use.. The infant was born apneic and bradycardic. Normal resuscitation manoeuvres had no effect on the respiratory drive. Directly after administration of naloxone, a tachypneic breathing pattern with sporadic expiratory breaking manoeuvres was observed.. The immediate tachypnoea is most likely a direct effect of the naloxone causing an immediate 'rebound response' after the release of the opiate-induced inhibition of the respiratory drive.

Topics: Analgesics, Opioid; Anesthetics, Intravenous; Apnea; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Naloxone; Narcotic Antagonists; Piperidines; Pregnancy; Remifentanil; Respiratory Rate

The inability to appropriately ventilate neonates shortly after their birth could be related in rare cases to chest-wall rigidity caused by the placental transfer of fentanyl. Although this adverse effect is recognized when fentanyl is administered to neonates after their birth, the prenatal phenomenon is less known. Treatment with either naloxone or muscle relaxants reverses the fentanyl effect and may prevent unnecessary excessive ventilatory settings.

Topics: Cesarean Section; Female; Fentanyl; Humans; Infant, Newborn; Infant, Premature, Diseases; Muscle Rigidity; Naloxone; Narcotic Antagonists; Narcotics; Pregnancy; Pregnancy Complications, Infectious; Pyelonephritis; Respiratory Distress Syndrome; Thoracic Wall

Topics: Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Naloxone; Shock, Septic

Topics: Anesthesia, Inhalation; Apnea; Bradycardia; Endorphins; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Naloxone; Postoperative Complications; Pyloric Stenosis