naloxone and Immunologic-Deficiency-Syndromes

naloxone has been researched along with Immunologic-Deficiency-Syndromes* in 2 studies

Reviews

1 review(s) available for naloxone and Immunologic-Deficiency-Syndromes

ArticleYear
In vivo and in vitro studies of opiates and cellular immunity in narcotic addicts.
    Advances in experimental medicine and biology, 1991, Volume: 288

    Topics: Adult; Antibody Formation; Cells, Cultured; Cytotoxicity, Immunologic; Disease Susceptibility; Endorphins; Heroin Dependence; HIV Infections; Humans; Immunologic Deficiency Syndromes; Killer Cells, Natural; Life Style; Male; Methadone; Middle Aged; Naloxone; Narcotics; Neurosecretory Systems; Opioid-Related Disorders; Stereoisomerism; T-Lymphocyte Subsets

1991

Other Studies

1 other study(ies) available for naloxone and Immunologic-Deficiency-Syndromes

ArticleYear
Effects of acute and subchronic delta 9-tetrahydrocannabinol administration on the plasma catecholamine, beta-endorphin, and corticosterone levels and splenic natural killer cell activity in rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 180, Issue:2

    The effect of acute (1 day) or subchronic (25 days) treatment with delta 9-tetrahydrocannabinol (THC), the major psychoactive constituent of marihuana, on plasma norepinephrine (NE), epinephrine (E), corticosterone, beta-endorphin (beta-end), and splenic natural killer (NK) cell activity of the rat was studied. Groups of animals received subcutaneously, either THC in corn oil + saline (3 mg THC/kg); oil + saline; or THC + naloxone (2 mg naloxone/kg and 3 mg THC/kg). Acute injection of THC with or without naloxone did not significantly change plasma levels of NE, E corticosterone, beta-end, or the NK cell activity. However, subchronic treatment with THC significantly reduced plasma levels of NE, E, corticosterone, and NK cell activity, compared to controls. The plasma beta-end levels were significantly elevated in the THC-treated animals. In the THC + naloxone group of animals, the plasma hormone levels (corticosterone and beta-end) were similar to control levels and the NK cell activity was significantly higher than in THC-treated animals. These results indicate that subchronic exposure to THC results in suppression of splenic NK cell activity. The interaction of THC with the endogenous opiate system appears to be a contributing factor leading to the NK cell suppression in rats. A direct suppressive action of THC or its metabolites on the NK cell is not ruled out by this study.

    Topics: Animals; beta-Endorphin; Catecholamines; Corticosterone; Dronabinol; Endorphins; Immunologic Deficiency Syndromes; Injections, Subcutaneous; Killer Cells, Natural; Male; Naloxone; Rats; Rats, Inbred Strains; Spleen

1985