naloxone has been researched along with Cell-Transformation--Neoplastic* in 3 studies
3 other study(ies) available for naloxone and Cell-Transformation--Neoplastic
Article | Year |
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Effect of synthetic beta-endorphin-like peptide immunorphin on human T lymphocytes.
Beta-endorphin and the synthetic beta-endorphin-like decapeptide Ser-Leu-Thr-Cys-Leu-Val-Lys-Gly-Phe-Tyr (referred to as immunorphin), corresponding to the sequence 364-373 of the CH3 domain of human immunoglobulin G heavy chain, were shown to stimulate concanavalin A-induced proliferation of T lymphocytes from the blood of healthy donors. [Met(5)]Enkephalin and the antagonist of opioid receptors naloxone examined in parallel were inactive. The stimulating effect of beta-endorphin and immunorphin on T lymphocyte proliferation is not inhibited by naloxone. Studies on receptor binding of (125)I-labeled immunorphin to T lymphocytes revealed that it binds with high affinity to naloxone-insensitive receptors (K(d) = 7.0 +/- 0.3 nM). Unlabeled immunorphin completely inhibits (125)I-labeled beta-endorphin specific binding to naloxone-insensitive receptors on T lymphocytes (K(i) = 0.6 +/- 0.1 nM). Thus, beta-endorphin and immunorphin interact with common naloxone-insensitive receptors on T lymphocytes. Topics: beta-Endorphin; Binding, Competitive; Cell Division; Cell Transformation, Neoplastic; Concanavalin A; Enkephalin, Methionine; Humans; Immunoglobulin Constant Regions; Immunoglobulin G; Immunoglobulin gamma-Chains; Immunoglobulin Heavy Chains; Iodine Radioisotopes; Lymphocyte Activation; Naloxone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Receptors, Opioid; T-Lymphocytes | 2002 |
Opioids alter tumor cell growth and differentiation in vitro.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Heroin; Mice; Mitosis; Naloxone; Neuroblastoma | 1984 |
The effect of heroin and naloxone on the growth of neuroblastoma tumors in mice.
Topics: Animals; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Heroin; Male; Mice; Mice, Inbred A; Naloxone; Neuroblastoma; Time Factors | 1981 |