nalorphine and Hypoxia

The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping. When nalorphine was combined with pethidine the period of primary apnoea was still increased although the duration and number of gasps were restored to control values. Naloxone, in contrast, acted as a mild respiratory stimulant, shown as a longer phase of dyspnoea. Also it completely abolished the respiratory depression produced by pethidine. Naloxone may be preferable to nalorphine as a drug to reverse the effects of pethidine immediately after birth.

Topics: Animals; Apnea; Dyspnea; Humans; Hypoxia; Infant, Newborn; Meperidine; Morphine; Nalorphine; Naloxone; Nitrogen; Rabbits; Respiration

Topics: Animals; Atropine; Central Nervous System Stimulants; Diaphragm; Female; Hypercapnia; Hypoxia; Male; Methylphenidate; Morphine; Muscles; Nalorphine; Neostigmine; Pneumothorax, Artificial; Rabbits; Stomach; Time Factors; Trachea

Topics: Adolescent; Atrial Fibrillation; Blood Gas Analysis; Blood Pressure; Female; Heroin; Humans; Hypoxia; Intubation, Intratracheal; Levallorphan; Male; Nalorphine; Naloxone; Pneumonia, Aspiration; Positive-Pressure Respiration; Pulmonary Edema; Pupil; Respiration; Substance-Related Disorders

Topics: Adolescent; Adult; Brain; Brain Chemistry; Dextropropoxyphene; Female; Humans; Hypoxia; Kidney; Liver; Lung; Male; Nalorphine; Organ Size; Pulmonary Edema; Seizures; Stomach; Suicide

Topics: Asphyxia; Asphyxia Neonatorum; Delivery, Obstetric; Female; Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Methods; Nalorphine; Pregnancy; Pulse; Respiration, Artificial; Resuscitation

Topics: Adolescent; Adult; Anti-Bacterial Agents; Arrhythmias, Cardiac; Black or African American; Body Temperature; Coma; Drug Combinations; Ethnicity; Female; Heroin; Humans; Hypoxia; Male; Nalorphine; New York City; Pneumonia; Puerto Rico; Pulmonary Edema; Retrospective Studies; Substance-Related Disorders

Topics: Animals; Animals, Newborn; Apnea; Asphyxia Neonatorum; Dyspnea; Humans; Hypoxia; Infant, Newborn; Levallorphan; Meperidine; Morphine; Nalorphine; Rabbits; Respiration

Topics: Animals; Animals, Newborn; Apnea; Body Weight; Dyspnea; Hypoxia; Levallorphan; Meperidine; Morphine; Nalorphine; Rabbits; Respiratory Function Tests