nalorphine and Hyperplasia

nalorphine has been researched along with Hyperplasia* in 1 studies

Other Studies

1 other study(ies) available for nalorphine and Hyperplasia

ArticleYear
Is methylnalorphinium the prototype of an ideal peripheral analgesic?
    European journal of pharmacology, 1984, Mar-16, Volume: 99, Issue:1

    Oral methylnalorphine ( methylnalorphinium ) caused a dose-dependent selective inhibition of inflammatory hyperalgesia (measured in the rat by a modified version of the Randall- Selitto test) without affecting the oedema. When subcutaneously injected, repeated doses of morphine for 5 days caused progressive analgesic tolerance. Tolerance was not observed after similar treatment with methylnalorphinium or methylmorphinium . Animals displaying analgesic tolerance to systemic morphine did not exhibit tolerance to the local ( intraplantar ) injection of morphine, methylnalorphinium or methylmorphinium . In contrast with nalorphine and other opiates, methylnalorphinium did not reduce intestinal transit in mice. Methylnalorphinium , a mixed opiate agonist-antagonist devoid of central effects, might be considered the prototype of an ideal peripheral analgesic since it was orally active, did not affect intestinal transit and did not cause analgesic tolerance.

    Topics: Analgesics; Animals; Carrageenan; Drug Evaluation, Preclinical; Drug Tolerance; Gastrointestinal Motility; Hyperplasia; Male; Mice; Morphine Derivatives; Nalorphine; Peripheral Nerves; Rats; Rats, Inbred Strains

1984