nalorphine has been researched along with Hyperesthesia* in 4 studies
4 other study(ies) available for nalorphine and Hyperesthesia
| Article | Year |
|---|---|
II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists.
Morphine, enkephalins, nalorphine, naloxone and pentazocine are shown to have a peripheral analgesic effect. In our modification of the Randall-Selitto test these substances were 50--100 times more potent than a standard local anaesthetic, lidocaine. At this peripheral site, naloxone did not antagonize the effect of morphine. Morphine had a marked analgesic effect on the hyperalgesia induced by PGE2 and PGI2, BaCl2, Ca2+ ionophore A23187, isoprenaline but not on that induced by dibutyryl cyclic AMP. It was suggested that the peripheral analgesic effect of morphine is due to an inhibition of adenylate-cyclase activity. Topics: Analgesics; Animals; Barium; Bucladesine; Endorphins; Enkephalins; Hyperalgesia; Hyperesthesia; Ionophores; Isoproterenol; Lidocaine; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats | 1979 |
III - Prostaglandin hyperalgesia: relevance of the peripheral effect for the analgesic action of opioid-antagonists.
Morphine injected into the rat cerebral ventricles had a marked analgesic effect, while no effect was observed with pentazocine and naloxone or nalorphine caused a strong hyperalgesia. Administered systemically (IP) naloxone and nalorphine caused a transitory analgesia followed by a long lasting hyperalgesic effect; morphine and pentazocine showed only an analgesic effect. It was concluded that the site of analgesic action of opioid-antagonists is peripheral rather than central. The peptidase-resistant enkephalin-analog, BW 180c, which does not cross the blood brain barrier, caused a marked analgesia by IP administration to paws made hyperalgesic by PGE2 or carrageenin. It is suggested that agents derived from morphine, morphine-antagonists, enkephalins or cGMP devoid of central effect but having a strong peripheral effect may constitute a new class of safer analgesics. Topics: Analgesics; Animals; Carrageenan; Enkephalins; Hyperalgesia; Hyperesthesia; Injections, Intraperitoneal; Injections, Intraventricular; Morphine; Nalorphine; Naloxone; Narcotic Antagonists; Nociceptors; Pentazocine; Prostaglandins E; Rats | 1979 |
Morphine-induced hyperalgesia in rats tested on the hot plate.
Topics: Analysis of Variance; Animals; Hot Temperature; Hyperesthesia; Male; Morphine; Nalorphine; Rats; Stress, Physiological; Time Factors | 1971 |
Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; Cyclazocine; Dextropropoxyphene; Edema; Hyperesthesia; Indomethacin; Irritants; Morphine; Nalorphine; Narcotic Antagonists; Pentazocine; Rats | 1965 |