nalorphine and Fever

Topics: Amines; Analgesics; Animals; Atropine; Autonomic Nervous System; Bacteria; Body Temperature; Body Temperature Regulation; Calorimetry; Central Nervous System; Depression, Chemical; Dinitrophenols; Environment; Feedback; Fever; Hibernation; Hormones; Humans; Hypothalamus; Hypothermia; Lysergic Acid Diethylamide; Mental Processes; Morphine; Nalorphine; Neurotransmitter Agents; Parasympathomimetics; Pharmacology; Physiology, Comparative; Pyrogens; Stimulation, Chemical; Thermography; Thermosensing; Toxins, Biological; Tranquilizing Agents; Viruses

Topics: Animals; Arrhythmias, Cardiac; Bradycardia; Cerebral Aqueduct; Cerebral Ventricles; Fever; Humans; Injections, Spinal; Medulla Oblongata; Morphine; Morphine Dependence; Nalorphine; Pons; Rabbits; Seizures; Substance Withdrawal Syndrome

Topics: Alphaprodine; Amines; Analgesics; Animals; Azepines; Codeine; Dextropropoxyphene; Dose-Response Relationship, Drug; Drug Interactions; Female; Fever; Isonipecotic Acids; Levallorphan; Levorphanol; Male; Methadone; Monoamine Oxidase Inhibitors; Nalorphine; Rabbits; Time Factors

1. In rats, a subcutaneous injection of morphine (2.5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0.1 mg/kg), but not of neostigmine (0.08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine.2. It is concluded that the hyperthermia is a specific response to morphine, central in origin, and the result of diminished acetylcholine (ACh) release from central cholinergic neurones.

Topics: Acetylcholine; Animals; Body Temperature; Central Nervous System; Female; Fever; Injections, Intraperitoneal; Injections, Subcutaneous; Morphine; Nalorphine; Neostigmine; Neurons; Physostigmine; Rats

Topics: Amphetamine; Amphetamines; Animals; Chlorpromazine; Cocaine; Cyanides; Fever; Insulin; Iproniazid; Lysergic Acid Diethylamide; Mice; Morphine; Nalorphine; Pharmacology; Pilocarpine; Research; Reserpine; Tripelennamine; Tubocurarine

Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Body Temperature; Fever; Gastric Juice; Hot Temperature; Indomethacin; Lipopolysaccharides; Morphine; Nalorphine; Pharmacology; Pyrogens; Rats; Research; Toxicology

Topics: Amphetamine; Amphetamines; Animals; Body Temperature; Fever; Hallucinogens; Lagomorpha; Nalorphine; Pharmacology; Rabbits; Research