nalorphine and Apnea

The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen, with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea. Pethidine caused an increase in the period of primary apnoea and a decrease in the duration and rate of gasping. When nalorphine was combined with pethidine the period of primary apnoea was still increased although the duration and number of gasps were restored to control values. Naloxone, in contrast, acted as a mild respiratory stimulant, shown as a longer phase of dyspnoea. Also it completely abolished the respiratory depression produced by pethidine. Naloxone may be preferable to nalorphine as a drug to reverse the effects of pethidine immediately after birth.

Topics: Animals; Apnea; Dyspnea; Humans; Hypoxia; Infant, Newborn; Meperidine; Morphine; Nalorphine; Naloxone; Nitrogen; Rabbits; Respiration

Topics: Apnea; Atropine; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Isonipecotic Acids; Male; Motion Sickness; Nalorphine; Respiratory Insufficiency

Topics: Antidotes; Apnea; Child, Preschool; Female; Humans; Isonipecotic Acids; Nalorphine; Poisoning

Topics: Animals; Animals, Newborn; Apnea; Asphyxia Neonatorum; Dyspnea; Humans; Hypoxia; Infant, Newborn; Levallorphan; Meperidine; Morphine; Nalorphine; Rabbits; Respiration

Topics: Animals; Apnea; Blood Circulation; Bradycardia; Central Nervous System; Cerebral Decortication; Decerebrate State; Dogs; Female; Hypotension; Male; Nalorphine; Respiration

Topics: Adjuvants, Anesthesia; Adult; Aged; Analgesia; Apnea; Female; Humans; Male; Middle Aged; Muscles; Nalorphine; Phenoperidine; Preanesthetic Medication; Thoracic Surgery; Thorax

Topics: Animals; Animals, Newborn; Apnea; Body Weight; Dyspnea; Hypoxia; Levallorphan; Meperidine; Morphine; Nalorphine; Rabbits; Respiratory Function Tests

Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone; Mice; Morphine; Nalorphine; Pain; Pharmacology; Proadifen; Research; Seizures; Toxicology

Topics: Analgesics; Anesthesia; Apnea; Central Nervous System Agents; Depression; Dextromoramide; Humans; Meperidine; Methadone; Morphine; Nalorphine

Topics: Apnea; Humans; Morphine; Nalorphine; Narcotic Antagonists; Narcotics