nalorphine and Acute-Disease

Naloxone or physiological solution were injected in different doses to 11 baboons (Papio hamadryas) weighing 7-8 kg after bloodletting in a volume of 40% of the total amount of the blood. Naloxone effectively raised (in all the doses) the arterial blood pressure which dropped after bloodletting. The action of naloxone injected in small doses was more pronounced and had unique time parameters. Besides, the respiratory rate was also increased. Injection of nalorphine in a dose of 1 mg/kg produced a similar but a more demonstrable action as compared with naloxone in a dose of 1 mg/kg. A conclusion is made about the possibility of using the antagonists of opioid peptides on a clinical basis for the treatment of shock conditions. An assumption of an inconclusive role played by the subtypes of opiate receptors in the formation of shock conditions is also confirmed.

Topics: Acute Disease; Animals; Blood Pressure; Hemorrhage; Hypotension; Male; Nalorphine; Naloxone; Papio; Respiration

Topics: Acute Disease; Adult; Aged; Droperidol; Drug Synergism; Female; Fentanyl; Humans; Male; Middle Aged; Myocardial Infarction; Nalorphine; Neuroleptanalgesia

Topics: Acute Disease; Animals; Antidotes; Atropine; Chelating Agents; Dimercaprol; Edetic Acid; Humans; Levallorphan; Metals; Morphine; Nalorphine; Oximes; Parathion; Physostigmine; Poisoning; Pralidoxime Compounds

Topics: Acute Disease; Administration, Oral; Adult; Coma; Female; Furosemide; Heroin; Humans; Hydrocortisone; Injections, Intravenous; Intubation, Intratracheal; Methadone; Nalorphine; Oxygen Inhalation Therapy; Penicillin G; Pulmonary Edema; Radiography; Substance-Related Disorders; Time Factors