nafronyl has been researched along with Dementia in 25 studies
Nafronyl: A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a single-blind study, 12 men (mean age 63 years) with senile dementia were given nafronyl in a dosage of 100 mg eight times daily for a week, followed by 100 mg four times daily for 12 weeks." | 7.66 | Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia. ( Berger, PA; Hollister, LE; Tinklenberg, JR; Yesavage, JA, 1982) |
| " It covers firstly the general problems of stroke, dementia and 'common symptoms' of the elderly, and then looks in detail at those compounds which have to date attracted most attention (ergot derivatives, cinnarizine, flunarizine, vincamine, eburnamonine, naftidrofuryl, oxpentifylline, piracetam and citicoline), as well as those which are currently considered investigational (choline and lecithin)." | 6.15 | 'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders. ( Spagnoli, A; Tognoni, G, 1983) |
| "In a single-blind study, 12 men (mean age 63 years) with senile dementia were given nafronyl in a dosage of 100 mg eight times daily for a week, followed by 100 mg four times daily for 12 weeks." | 3.66 | Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia. ( Berger, PA; Hollister, LE; Tinklenberg, JR; Yesavage, JA, 1982) |
| "Dementia is a cerebral disorder resulting in a progressive deterioration of intellectual function that compromises the patient's ability to function." | 2.69 | Efficacy of naftidrofuryl in patients with vascular or mixed dementia: results of a multicenter, double-blind trial. ( Emeriau, JP; Lehert, P; Mosnier, M, 2000) |
| "Dementia is a brain disorder characterized by the permanent loss of higher cognitive functions." | 2.47 | Naftidrofuryl for dementia. ( Hao, Z; Lu, D; McCleery, J; Song, H; Wu, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, D | 1 |
| Song, H | 1 |
| Hao, Z | 1 |
| Wu, T | 1 |
| McCleery, J | 1 |
| Yesavage, JA | 2 |
| Tinklenberg, JR | 2 |
| Hollister, LE | 3 |
| Berger, PA | 2 |
| Castleden, CM | 1 |
| Spagnoli, A | 1 |
| Tognoni, G | 1 |
| Branconnier, RJ | 3 |
| Knox, J | 1 |
| Hindmarch, I | 1 |
| Wallace, M | 1 |
| Cook, P | 1 |
| James, I | 1 |
| Naess, K | 1 |
| Gottschalk, LA | 1 |
| Eckardt, MJ | 1 |
| Cohn, JB | 1 |
| Terman, SA | 1 |
| Wolf, RJ | 1 |
| Emeriau, JP | 1 |
| Lehert, P | 1 |
| Mosnier, M | 1 |
| Gold, M | 1 |
| Brodie, NH | 1 |
| Cole, JO | 2 |
| Yesavage, J | 1 |
| Judge, TG | 2 |
| Saldmann, F | 1 |
| Funel, A | 1 |
| Jacquet, P | 1 |
| Grossmann, WM | 1 |
| Standl, A | 1 |
| May, U | 1 |
| van Laak, HH | 1 |
| Hirche, H | 1 |
| Klawans, HL | 1 |
| Genovese, N | 1 |
| Cucinotta, D | 1 |
| Dall'Asta, D | 1 |
| Benaglia, F | 1 |
| Ciotti, G | 1 |
| Nicora, M | 1 |
| Passeri, M | 1 |
7 reviews available for nafronyl and Dementia
| Article | Year |
|---|---|
Naftidrofuryl for dementia.
Topics: Aged; Aged, 80 and over; Dementia; Female; Humans; Male; Nafronyl; Nootropic Agents; Psychotropic Dr | 2011 |
Therapeutic possibilities in patients with senile dementia.
Topics: Acetylcholine; Aged; Dementia; Dihydroergotoxine; Furans; Humans; Kinetics; Mesylates; Nafronyl; Par | 1984 |
'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders.
Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Cytidine Diphosphate | 1983 |
The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia.
Topics: Aged; Brain; Dementia; Dihydroergotoxine; Humans; Meclofenoxate; Nafronyl; Piracetam; Pyrithioxin; V | 1983 |
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Pharmacology of dementia.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System | 1986 |
Naftidrofuryl (Praxilene).
Topics: Acute Disease; Cerebrovascular Disorders; Dementia; Furans; Humans; Nafronyl | 1988 |
11 trials available for nafronyl and Dementia
| Article | Year |
|---|---|
'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders.
Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Cytidine Diphosphate | 1983 |
Effects of twice standard dosage of neuroactive drugs in dementia. A preliminary report.
Topics: Aged; Dementia; Dihydroergotoxine; Drug Administration Schedule; Female; Furans; Humans; Male; Nafro | 1984 |
Drug therapy: cerebral vasodilators (first of two parts).
Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla | 1981 |
Efficacy of naftidrofuryl in patients with vascular or mixed dementia: results of a multicenter, double-blind trial.
Topics: Aged; Aged, 80 and over; Dementia; Dementia, Vascular; Double-Blind Method; Female; Humans; Male; Na | 2000 |
A double-blind trial of naftidrofuryl in treating confused elderly patients in general practice.
Topics: Aged; Clinical Trials as Topic; Dementia; Family Practice; Female; Furans; Humans; Male; Nafronyl | 1977 |
A memory assessment technique for use in geriatric psychopharmacology: drug efficacy trial with naftidrofuryl.
Topics: Aged; Clinical Trials as Topic; Dementia; Drug Evaluation; Female; Furans; Humans; Male; Memory, Sho | 1977 |
The impairment index as a symptom-independent parameter of drug efficacy in geriatric psychopharmacology.
Topics: Aged; Clinical Trials as Topic; Dementia; Female; Furans; Humans; Male; Memory; Middle Aged; Nafrony | 1978 |
Efficacy of naftidrofuryl in patients with moderate senile dementia.
Topics: Activities of Daily Living; Administration, Oral; Aged; Dementia; Double-Blind Method; Female; Geria | 1991 |
Naftidrofuryl in the treatment of mild senile dementia. A double-blind study.
Topics: Age Factors; Aged; Alzheimer Disease; Dementia; Dementia, Vascular; Double-Blind Method; Electroence | 1990 |
Pharmacology of dementia.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System | 1986 |
[Efficacy and tolerance of long-term naftidrofuryl treatment of patients with senile dementia. Controlled study versus placebo].
Topics: Aged; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Tolerance; Female; Furans; Human | 1987 |
10 other studies available for nafronyl and Dementia
| Article | Year |
|---|---|
Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Dementia; Furans; Glucose; Homovanillic Acid; Humans; Hydroxyi | 1982 |
[Naftidrofuryl. (Pralixene)].
Topics: Dementia; Furans; Humans; Nafronyl | 1980 |
A cognitive impairment scale applicable to verbal samples and its possible use in clinical trials in patients with dementia [proceedings].
Topics: Adult; Aged; Cognition Disorders; Dementia; Double-Blind Method; Drug Evaluation; Female; Humans; Ma | 1980 |
The efficacy of naftidrofuryl in patients with vascular or mixed dementia.
Topics: Dementia; Humans; Intelligence Tests; Nafronyl; Parasympatholytics; Severity of Illness Index | 2000 |
Vasodilators in senile dementias: a review of the literature.
Topics: Aged; Cinnarizine; Cyclandelate; Dementia; Dihydroergotoxine; Drug Evaluation; Humans; Isoxsuprine; | 1979 |
Vasodilators in senile dementia.
Topics: Aged; Dementia; Dihydroergotoxine; Humans; Nafronyl; Vasodilator Agents | 1979 |
The therapeutic uses of naftidrofuryl (Praxilene)--cerebrovascular disease.
Topics: Aged; Animals; Cerebrovascular Disorders; Dementia; Furans; Humans; Nafronyl | 1978 |
Drugs and dementia.
Topics: Aged; Cyclandelate; Dementia; Dihydroergotoxine; Female; Humans; Male; Nafronyl | 1976 |
Drugs for dementia.
Topics: Aged; Cyclandelate; Dementia; Dihydroergotoxine; Female; Humans; Isoxsuprine; Male; Meclofenoxate; M | 1975 |
Alzheimer's disease. Is it worth treating?
Topics: Aged; Alzheimer Disease; Dementia; Dihydroergotoxine; Humans; Nafronyl; Papaverine; Pentoxifylline; | 1985 |