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nafronyl and Dementia

nafronyl has been researched along with Dementia in 25 studies

Nafronyl: A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"In a single-blind study, 12 men (mean age 63 years) with senile dementia were given nafronyl in a dosage of 100 mg eight times daily for a week, followed by 100 mg four times daily for 12 weeks."7.66Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia. ( Berger, PA; Hollister, LE; Tinklenberg, JR; Yesavage, JA, 1982)
" It covers firstly the general problems of stroke, dementia and 'common symptoms' of the elderly, and then looks in detail at those compounds which have to date attracted most attention (ergot derivatives, cinnarizine, flunarizine, vincamine, eburnamonine, naftidrofuryl, oxpentifylline, piracetam and citicoline), as well as those which are currently considered investigational (choline and lecithin)."6.15'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders. ( Spagnoli, A; Tognoni, G, 1983)
"In a single-blind study, 12 men (mean age 63 years) with senile dementia were given nafronyl in a dosage of 100 mg eight times daily for a week, followed by 100 mg four times daily for 12 weeks."3.66Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia. ( Berger, PA; Hollister, LE; Tinklenberg, JR; Yesavage, JA, 1982)
"Dementia is a cerebral disorder resulting in a progressive deterioration of intellectual function that compromises the patient's ability to function."2.69Efficacy of naftidrofuryl in patients with vascular or mixed dementia: results of a multicenter, double-blind trial. ( Emeriau, JP; Lehert, P; Mosnier, M, 2000)
"Dementia is a brain disorder characterized by the permanent loss of higher cognitive functions."2.47Naftidrofuryl for dementia. ( Hao, Z; Lu, D; McCleery, J; Song, H; Wu, T, 2011)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-199020 (80.00)18.7374
1990's2 (8.00)18.2507
2000's2 (8.00)29.6817
2010's1 (4.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lu, D1
Song, H1
Hao, Z1
Wu, T1
McCleery, J1
Yesavage, JA2
Tinklenberg, JR2
Hollister, LE3
Berger, PA2
Castleden, CM1
Spagnoli, A1
Tognoni, G1
Branconnier, RJ3
Knox, J1
Hindmarch, I1
Wallace, M1
Cook, P1
James, I1
Naess, K1
Gottschalk, LA1
Eckardt, MJ1
Cohn, JB1
Terman, SA1
Wolf, RJ1
Emeriau, JP1
Lehert, P1
Mosnier, M1
Gold, M1
Brodie, NH1
Cole, JO2
Yesavage, J1
Judge, TG2
Saldmann, F1
Funel, A1
Jacquet, P1
Grossmann, WM1
Standl, A1
May, U1
van Laak, HH1
Hirche, H1
Klawans, HL1
Genovese, N1
Cucinotta, D1
Dall'Asta, D1
Benaglia, F1
Ciotti, G1
Nicora, M1
Passeri, M1

Reviews

7 reviews available for nafronyl and Dementia

ArticleYear
Naftidrofuryl for dementia.
    The Cochrane database of systematic reviews, 2011, Dec-07, Issue:12

    Topics: Aged; Aged, 80 and over; Dementia; Female; Humans; Male; Nafronyl; Nootropic Agents; Psychotropic Dr

2011
Therapeutic possibilities in patients with senile dementia.
    Journal of the Royal College of Physicians of London, 1984, Volume: 18, Issue:1

    Topics: Acetylcholine; Aged; Dementia; Dihydroergotoxine; Furans; Humans; Kinetics; Mesylates; Nafronyl; Par

1984
'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders.
    Drugs, 1983, Volume: 26, Issue:1

    Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Cytidine Diphosphate

1983
The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia.
    Psychopharmacology bulletin, 1983,Spring, Volume: 19, Issue:2

    Topics: Aged; Brain; Dementia; Dihydroergotoxine; Humans; Meclofenoxate; Nafronyl; Piracetam; Pyrithioxin; V

1983
Drug therapy: cerebral vasodilators (first of two parts).
    The New England journal of medicine, 1981, Dec-17, Volume: 305, Issue:25

    Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla

1981
Pharmacology of dementia.
    Neurologic clinics, 1986, Volume: 4, Issue:2

    Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System

1986
Naftidrofuryl (Praxilene).
    Drug and therapeutics bulletin, 1988, Apr-05, Volume: 26, Issue:7

    Topics: Acute Disease; Cerebrovascular Disorders; Dementia; Furans; Humans; Nafronyl

1988

Trials

11 trials available for nafronyl and Dementia

ArticleYear
'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders.
    Drugs, 1983, Volume: 26, Issue:1

    Topics: Adult; Aged; Cerebrovascular Disorders; Cinnarizine; Clinical Trials as Topic; Cytidine Diphosphate

1983
Effects of twice standard dosage of neuroactive drugs in dementia. A preliminary report.
    The British journal of clinical practice, 1984, Volume: 38, Issue:9

    Topics: Aged; Dementia; Dihydroergotoxine; Drug Administration Schedule; Female; Furans; Humans; Male; Nafro

1984
Drug therapy: cerebral vasodilators (first of two parts).
    The New England journal of medicine, 1981, Dec-17, Volume: 305, Issue:25

    Topics: Aged; Aging; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as Topic; Cycla

1981
Efficacy of naftidrofuryl in patients with vascular or mixed dementia: results of a multicenter, double-blind trial.
    Clinical therapeutics, 2000, Volume: 22, Issue:7

    Topics: Aged; Aged, 80 and over; Dementia; Dementia, Vascular; Double-Blind Method; Female; Humans; Male; Na

2000
A double-blind trial of naftidrofuryl in treating confused elderly patients in general practice.
    The Practitioner, 1977, Volume: 218, Issue:1304

    Topics: Aged; Clinical Trials as Topic; Dementia; Family Practice; Female; Furans; Humans; Male; Nafronyl

1977
A memory assessment technique for use in geriatric psychopharmacology: drug efficacy trial with naftidrofuryl.
    Journal of the American Geriatrics Society, 1977, Volume: 25, Issue:4

    Topics: Aged; Clinical Trials as Topic; Dementia; Drug Evaluation; Female; Furans; Humans; Male; Memory, Sho

1977
The impairment index as a symptom-independent parameter of drug efficacy in geriatric psychopharmacology.
    Journal of gerontology, 1978, Volume: 33, Issue:2

    Topics: Aged; Clinical Trials as Topic; Dementia; Female; Furans; Humans; Male; Memory; Middle Aged; Nafrony

1978
Efficacy of naftidrofuryl in patients with moderate senile dementia.
    Current medical research and opinion, 1991, Volume: 12, Issue:6

    Topics: Activities of Daily Living; Administration, Oral; Aged; Dementia; Double-Blind Method; Female; Geria

1991
Naftidrofuryl in the treatment of mild senile dementia. A double-blind study.
    Pharmacopsychiatry, 1990, Volume: 23, Issue:6

    Topics: Age Factors; Aged; Alzheimer Disease; Dementia; Dementia, Vascular; Double-Blind Method; Electroence

1990
Pharmacology of dementia.
    Neurologic clinics, 1986, Volume: 4, Issue:2

    Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Aged; Aminopyridines; Central Nervous System

1986
[Efficacy and tolerance of long-term naftidrofuryl treatment of patients with senile dementia. Controlled study versus placebo].
    Giornale di clinica medica, 1987, Volume: 68, Issue:4

    Topics: Aged; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Tolerance; Female; Furans; Human

1987

Other Studies

10 other studies available for nafronyl and Dementia

ArticleYear
Effect of nafronyl on lactate and pyruvate in the cerebrospinal fluid of patients with senile dementia.
    Journal of the American Geriatrics Society, 1982, Volume: 30, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Dementia; Furans; Glucose; Homovanillic Acid; Humans; Hydroxyi

1982
[Naftidrofuryl. (Pralixene)].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1980, Mar-20, Volume: 100, Issue:8-9

    Topics: Dementia; Furans; Humans; Nafronyl

1980
A cognitive impairment scale applicable to verbal samples and its possible use in clinical trials in patients with dementia [proceedings].
    Psychopharmacology bulletin, 1980, Volume: 16, Issue:4

    Topics: Adult; Aged; Cognition Disorders; Dementia; Double-Blind Method; Drug Evaluation; Female; Humans; Ma

1980
The efficacy of naftidrofuryl in patients with vascular or mixed dementia.
    Clinical therapeutics, 2000, Volume: 22, Issue:10

    Topics: Dementia; Humans; Intelligence Tests; Nafronyl; Parasympatholytics; Severity of Illness Index

2000
Vasodilators in senile dementias: a review of the literature.
    Archives of general psychiatry, 1979, Volume: 36, Issue:2

    Topics: Aged; Cinnarizine; Cyclandelate; Dementia; Dihydroergotoxine; Drug Evaluation; Humans; Isoxsuprine;

1979
Vasodilators in senile dementia.
    British medical journal, 1979, Nov-10, Volume: 2, Issue:6199

    Topics: Aged; Dementia; Dihydroergotoxine; Humans; Nafronyl; Vasodilator Agents

1979
The therapeutic uses of naftidrofuryl (Praxilene)--cerebrovascular disease.
    Scottish medical journal, 1978, Volume: 23, Issue:1

    Topics: Aged; Animals; Cerebrovascular Disorders; Dementia; Furans; Humans; Nafronyl

1978
Drugs and dementia.
    British journal of clinical pharmacology, 1976, Volume: 3, Issue:1 Suppl 1

    Topics: Aged; Cyclandelate; Dementia; Dihydroergotoxine; Female; Humans; Male; Nafronyl

1976
Drugs for dementia.
    Drug and therapeutics bulletin, 1975, Oct-24, Volume: 13, Issue:22

    Topics: Aged; Cyclandelate; Dementia; Dihydroergotoxine; Female; Humans; Isoxsuprine; Male; Meclofenoxate; M

1975
Alzheimer's disease. Is it worth treating?
    Drugs, 1985, Volume: 29, Issue:6

    Topics: Aged; Alzheimer Disease; Dementia; Dihydroergotoxine; Humans; Nafronyl; Papaverine; Pentoxifylline;

1985