nafamostat has been researched along with Subarachnoid Hemorrhage in 9 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the management of subarachnoid hemorrhage (SAH)." | 8.12 | Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice. ( Egashira, Y; Enomoto, Y; Hara, H; Imai, T; Iwama, T; Matsubara, H; Nakamura, S; Nakayama, N; Oka, N; Shimazawa, M; Tsuji, S, 2022) |
| "The preventive effect of the serine protease inhibitor FUT-175 (nafamostat mesilate), a potent inhibitor of the complement system, against vasospasm was evaluated in 34 high risk patients with thick and diffuse subarachnoid hemorrhage (SAH) demonstrated by computed tomography corresponding to Fisher group 3." | 5.08 | Combination of serine protease inhibitor FUT-175 and thromboxane synthetase inhibitor OKY-046 decreases cerebral vasospasm in patients with subarachnoid hemorrhage. ( Kaminogo, M; Onizuka, M; Shibata, S; Yasunaga, A; Yonekura, M, 1998) |
| "This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the management of subarachnoid hemorrhage (SAH)." | 4.12 | Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice. ( Egashira, Y; Enomoto, Y; Hara, H; Imai, T; Iwama, T; Matsubara, H; Nakamura, S; Nakayama, N; Oka, N; Shimazawa, M; Tsuji, S, 2022) |
| "To evaluate the development of cerebral vasospasm, the caliber of the basilar artery was measured on x-ray film before and at 2 days after SAH." | 1.31 | Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. ( Kikuchi, H; Nagata, I; Sakai, H; Sakai, N; Xue, JH; Yanamoto, H; Zhang, Z, 2001) |
| " The dural sinus thrombosis was thought to be caused by a long term use of metenolone acetate, and it was discontinued." | 1.30 | [Superior sagittal sinus thrombosis presenting with subarachnoid hemorrhage in a patient with aplastic anemia]. ( Hashimoto, M; Kinoshita, Y; Ohta, H; Urasaki, E; Yamada, H; Yokota, A, 1998) |
| "During subarachnoid hemorrhage (SAH), coagulated blood in the subarachnoid space may be regarded as foreign by the immune system." | 1.29 | Cerebral vasospasm caused by cisternal injection of polystyrene latex beads in rabbits is inhibited by a serine protease inhibitor. ( Kikuchi, H; Nozaki, K; Okamoto, S; Yanamoto, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Matsubara, H | 1 |
| Imai, T | 1 |
| Tsuji, S | 1 |
| Oka, N | 1 |
| Egashira, Y | 1 |
| Enomoto, Y | 1 |
| Nakayama, N | 1 |
| Nakamura, S | 1 |
| Shimazawa, M | 1 |
| Iwama, T | 1 |
| Hara, H | 1 |
| Yanamoto, H | 5 |
| Kikuchi, H | 5 |
| Okamoto, S | 4 |
| Nozaki, K | 2 |
| Ohta, H | 1 |
| Kinoshita, Y | 1 |
| Hashimoto, M | 1 |
| Yamada, H | 1 |
| Urasaki, E | 1 |
| Yokota, A | 1 |
| Kaminogo, M | 1 |
| Yonekura, M | 1 |
| Onizuka, M | 1 |
| Yasunaga, A | 1 |
| Shibata, S | 1 |
| Zhang, Z | 1 |
| Nagata, I | 1 |
| Xue, JH | 1 |
| Sakai, N | 1 |
| Sakai, H | 1 |
| Sato, M | 1 |
| Shimizu, Y | 1 |
| Yoneda, S | 1 |
2 trials available for nafamostat and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Combination of serine protease inhibitor FUT-175 and thromboxane synthetase inhibitor OKY-046 decreases cerebral vasospasm in patients with subarachnoid hemorrhage.
Topics: Aged; Aneurysm, Ruptured; Benzamidines; Brain Damage, Chronic; Brain Ischemia; Drug Evaluation; Drug | 1998 |
Therapeutic trial of cerebral vasospasm with the serine protease inhibitor, FUT-175, administered in the acute stage after subarachnoid hemorrhage.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Benzamidines; Cerebral Angiogra | 1992 |
7 other studies available for nafamostat and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice.
Topics: Animals; Benzamidines; Brain; Brain Injuries; Cells, Cultured; Cerebrovascular Circulation; Disease | 2022 |
Cerebral vasospasm caused by cisternal injection of polystyrene latex beads in rabbits is inhibited by a serine protease inhibitor.
Topics: Animals; Benzamidines; Cerebral Angiography; Cisterna Magna; Guanidines; Injections; Ischemic Attack | 1994 |
Effects of protease inhibitor and immunosuppressant on cerebral vasospasm after subarachnoid hemorrhage in rabbits.
Topics: Animals; Benzamidines; Betamethasone; Cyclosporine; Drug Administration Schedule; Gabexate; Guanidin | 1994 |
[Superior sagittal sinus thrombosis presenting with subarachnoid hemorrhage in a patient with aplastic anemia].
Topics: Anemia, Aplastic; Anticoagulants; Benzamidines; Female; Guanidines; Humans; Magnetic Resonance Imagi | 1998 |
Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB.
Topics: Animals; Antithrombins; Arginine; Becaplermin; Benzamidines; Cerebral Arteries; Cisterna Magna; Guan | 2001 |
Protease inhibitors for delayed cerebral ischemia after subarachnoid haemorrhage?
Topics: Benzamidines; Brain Ischemia; Guanidines; Humans; Serine Proteinase Inhibitors; Subarachnoid Hemorrh | 1992 |
Preventive effect of synthetic serine protease inhibitor, FUT-175, on cerebral vasospasm in rabbits.
Topics: Animals; Benzamidines; Cerebral Angiography; Cerebral Arteries; Complement Activation; Drug Evaluati | 1992 |