nafamostat has been researched along with MODS in 10 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male rats were subjected to trauma-hemorrhagic shock (T/HS) or trauma sham-shock (T/SS) and resuscitated with RL, HTS, nafamostat, or the combination of HTS and nafamostat." | 3.73 | Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition. ( Berezina, TL; Deitch, EA; Feketeova, E; Homma, H; Lu, Q; Machiedo, GW; Xu, DZ; Zaets, SB, 2005) |
| "Six patients undergoing CHDF for multiple organ dysfunction syndrome (MODS) were chosen as subjects." | 2.71 | Pharmacokinetics of nafamostat mesilate during continuous hemodiafiltration with a polyacrylonitrile membrane. ( Nakae, H; Tajimi, K, 2003) |
| "However, she died of multiple organ failure and systemic cytomegalovirus infection in the chronic stage." | 1.32 | [Fulminant myocarditis treated with percutaneous cardiopulmonary support and long-term complications: three case reports]. ( Kusaba, T; Matsumuro, A; Nakahara, Y; Nakamura, T; Sawada, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, HD | 1 |
| Malinoski, DJ | 1 |
| Borazjani, B | 1 |
| Patel, MS | 1 |
| Chen, J | 1 |
| Slone, J | 1 |
| Nguyen, XM | 1 |
| Steward, E | 1 |
| Schmid-Schonbein, GW | 3 |
| Hoyt, DB | 1 |
| Nakae, H | 1 |
| Tajimi, K | 1 |
| Kusaba, T | 1 |
| Nakahara, Y | 1 |
| Matsumuro, A | 1 |
| Nakamura, T | 1 |
| Sawada, S | 1 |
| Ishimaru, K | 1 |
| Mitsuoka, H | 2 |
| Unno, N | 1 |
| Inuzuka, K | 1 |
| Nakamura, S | 1 |
| Homma, H | 1 |
| Deitch, EA | 1 |
| Feketeova, E | 1 |
| Lu, Q | 1 |
| Berezina, TL | 1 |
| Zaets, SB | 1 |
| Machiedo, GW | 1 |
| Xu, DZ | 1 |
| Morishita, K | 1 |
| Inoue, S | 1 |
| Baba, T | 1 |
| Sakata, J | 1 |
| Kazui, T | 1 |
| Abe, T | 1 |
| Kashima, K | 1 |
| Kataoka, K | 1 |
| Umehara, K | 1 |
| Yoshida, K | 1 |
| Toki, F | 1 |
| Takeuchi, T | 1 |
| Hirasawa, H | 1 |
| Sugai, T | 1 |
| Ohtake, Y | 1 |
| Oda, S | 1 |
2 trials available for nafamostat and MODS
| Article | Year |
|---|---|
Pharmacokinetics of nafamostat mesilate during continuous hemodiafiltration with a polyacrylonitrile membrane.
Topics: Acrylic Resins; Aged; Anticoagulants; Benzamidines; Catecholamines; Drug Interactions; Female; Guani | 2003 |
Our distal aortic perfusion system in descending thoracic and thoracoabdominal aortic aneurysm repairs.
Topics: Analysis of Variance; Anticoagulants; Antithrombins; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Th | 1997 |
8 other studies available for nafamostat and MODS
| Article | Year |
|---|---|
Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine.
Topics: Analysis of Variance; Animals; Benzamidines; Disease Models, Animal; Drug Evaluation, Preclinical; D | 2010 |
[Fulminant myocarditis treated with percutaneous cardiopulmonary support and long-term complications: three case reports].
Topics: Acute Disease; Adolescent; Adult; Aged; Anticoagulants; Benzamidines; Cardiopulmonary Bypass; Fatal | 2004 |
Pancreatic proteases and inflammatory mediators in peritoneal fluid during splanchnic arterial occlusion and reperfusion.
Topics: Animals; Arteries; Benzamidines; Blood Pressure; Cardiovascular System; Endopeptidases; Enzyme Inhib | 2004 |
Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition.
Topics: Animals; Benzamidines; Coloring Agents; Drug Therapy, Combination; Erythrocyte Deformability; Evans | 2005 |
Mechanisms for blockade of in vivo activator production in the ischemic intestine and multi-organ failure.
Topics: Allopurinol; Animals; Benzamidines; Bile; Blood Pressure; Duodenum; Guanidines; Intestinal Mucosa; I | 2000 |
[Treatment of acute pancreatitis].
Topics: Acute Disease; Benzamidines; Disseminated Intravascular Coagulation; Drainage; Gabexate; Glycoprotei | 1992 |
[Antienzyme preparations in the treatment of acute pancreatitis].
Topics: Acute Disease; Adult; Aprotinin; Benzamidines; Cytidine Diphosphate Choline; Disseminated Intravascu | 1990 |
[Continuous hemodiafiltration].
Topics: Animals; Benzamidines; Creatinine; Dialysis Solutions; Guanidines; Hemofiltration; Humans; Kidney Di | 1991 |