nafamostat has been researched along with Hemorrhagic Shock in 7 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
| Excerpt | Relevance | Reference |
|---|---|---|
| " "In vivo" generation of neutrophil-activating factors by gut proteases may be a cause of multiorgan failure after hemorrhagic shock, and can be prevented with the serine protease inhibitor nafamostat mesilate (Futhan)." | 7.72 | Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. ( Coimbra, R; Doucet, JJ; Hoyt, DB; Hugli, TE; Junger, WG; Loomis, WH; Paul L, W; Schmid-Schönbein, GW, 2004) |
| "A model of hemorrhagic shock that simulates the clinical course of injured patients was created in anesthetized dogs." | 5.30 | Nafamostat mesilate, a synthetic protease inhibitor, attenuated hypercoagulability in a canine model of hemorrhagic shock. ( Kato, K; Koido, Y; Shichinohe, K; Shimizu-Suganuma, M, 1997) |
| "Male rats were subjected to trauma-hemorrhagic shock (T/HS) or trauma sham-shock (T/SS) and resuscitated with RL, HTS, nafamostat, or the combination of HTS and nafamostat." | 3.73 | Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition. ( Berezina, TL; Deitch, EA; Feketeova, E; Homma, H; Lu, Q; Machiedo, GW; Xu, DZ; Zaets, SB, 2005) |
| " "In vivo" generation of neutrophil-activating factors by gut proteases may be a cause of multiorgan failure after hemorrhagic shock, and can be prevented with the serine protease inhibitor nafamostat mesilate (Futhan)." | 3.72 | Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock. ( Coimbra, R; Doucet, JJ; Hoyt, DB; Hugli, TE; Junger, WG; Loomis, WH; Paul L, W; Schmid-Schönbein, GW, 2004) |
| "Intestinal and lung injury was assessed at 3 h after resuscitation with Ringer's lactate solution." | 1.32 | Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury. ( Deitch, EA; Feketeova, E; Lu, Q; Shi, HP; Xu, DZ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, HD | 1 |
| Malinoski, DJ | 1 |
| Borazjani, B | 1 |
| Patel, MS | 1 |
| Chen, J | 1 |
| Slone, J | 1 |
| Nguyen, XM | 1 |
| Steward, E | 1 |
| Schmid-Schonbein, GW | 3 |
| Hoyt, DB | 2 |
| Altshuler, AE | 1 |
| Penn, AH | 1 |
| Yang, JA | 1 |
| Kim, GR | 1 |
| Deitch, EA | 2 |
| Shi, HP | 2 |
| Lu, Q | 2 |
| Feketeova, E | 2 |
| Xu, DZ | 2 |
| Doucet, JJ | 1 |
| Coimbra, R | 1 |
| Junger, WG | 1 |
| Paul L, W | 1 |
| Loomis, WH | 1 |
| Hugli, TE | 1 |
| Wen, Y | 1 |
| Zhang, C | 1 |
| Xue, Q | 1 |
| Lei, ST | 1 |
| Homma, H | 1 |
| Berezina, TL | 1 |
| Zaets, SB | 1 |
| Machiedo, GW | 1 |
| Koido, Y | 1 |
| Kato, K | 1 |
| Shimizu-Suganuma, M | 1 |
| Shichinohe, K | 1 |
7 other studies available for nafamostat and Hemorrhagic Shock
| Article | Year |
|---|---|
Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine.
Topics: Analysis of Variance; Animals; Benzamidines; Disease Models, Animal; Drug Evaluation, Preclinical; D | 2010 |
Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats.
Topics: Animals; Ascitic Fluid; Benzamidines; Body Fluids; Brain; Guanidines; Immunoblotting; Liver; Lung; M | 2012 |
Serine proteases are involved in the pathogenesis of trauma-hemorrhagic shock-induced gut and lung injury.
Topics: Animals; Benzamidines; Cell Adhesion Molecules; Disease Models, Animal; Guanidines; Ileum; Intestina | 2003 |
Inhibition of enteral enzymes by enteroclysis with nafamostat mesilate reduces neutrophil activation and transfusion requirements after hemorrhagic shock.
Topics: Animals; Benzamidines; Blood Transfusion; Electrolytes; Enema; Guanidines; Intestinal Mucosa; Intest | 2004 |
[Role of pancreatic enzymes in gut injury secondary to trauma/hemorrhagic shock in rats].
Topics: Animals; Benzamidines; Guanidines; Intestines; Male; Pancreas; Rats; Rats, Sprague-Dawley; Shock, He | 2004 |
Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition.
Topics: Animals; Benzamidines; Coloring Agents; Drug Therapy, Combination; Erythrocyte Deformability; Evans | 2005 |
Nafamostat mesilate, a synthetic protease inhibitor, attenuated hypercoagulability in a canine model of hemorrhagic shock.
Topics: Animals; Benzamidines; Blood Coagulation; Dogs; Guanidines; Partial Thromboplastin Time; Platelet Ag | 1997 |