nafamostat has been researched along with Cerebral Ischemia in 5 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the effect of nafamostat mesilate (NM), a synthetic serine protease inhibitor, on BBB disruption following cerebral ischemia is unknown." | 7.83 | Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection. ( Chen, T; Fang, Y; Li, C; Liao, H; Pang, T; Shi, X; Wang, J; Zhang, L, 2016) |
| "The authors retrospectively identified the patients who received nafamostat mesilate and who suffered symptomatic ischemic stroke within 30 postoperative days." | 7.78 | Nafamostat mesilate, as a treatment for heparin resistance, is not associated with perioperative ischemic stroke in patients undergoing cardiac surgery with cardiopulmonary bypass. ( Hiraiwa, T; Kikura, M; Tanaka, K, 2012) |
| "The preventive effect of the serine protease inhibitor FUT-175 (nafamostat mesilate), a potent inhibitor of the complement system, against vasospasm was evaluated in 34 high risk patients with thick and diffuse subarachnoid hemorrhage (SAH) demonstrated by computed tomography corresponding to Fisher group 3." | 5.08 | Combination of serine protease inhibitor FUT-175 and thromboxane synthetase inhibitor OKY-046 decreases cerebral vasospasm in patients with subarachnoid hemorrhage. ( Kaminogo, M; Onizuka, M; Shibata, S; Yasunaga, A; Yonekura, M, 1998) |
| " However, the effect of nafamostat mesilate (NM), a synthetic serine protease inhibitor, on BBB disruption following cerebral ischemia is unknown." | 3.83 | Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection. ( Chen, T; Fang, Y; Li, C; Liao, H; Pang, T; Shi, X; Wang, J; Zhang, L, 2016) |
| "The authors retrospectively identified the patients who received nafamostat mesilate and who suffered symptomatic ischemic stroke within 30 postoperative days." | 3.78 | Nafamostat mesilate, as a treatment for heparin resistance, is not associated with perioperative ischemic stroke in patients undergoing cardiac surgery with cardiopulmonary bypass. ( Hiraiwa, T; Kikura, M; Tanaka, K, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, T | 2 |
| Wang, J | 2 |
| Li, C | 2 |
| Zhang, W | 1 |
| Zhang, L | 2 |
| An, L | 1 |
| Pang, T | 2 |
| Shi, X | 2 |
| Liao, H | 2 |
| Fang, Y | 1 |
| Kikura, M | 1 |
| Tanaka, K | 2 |
| Hiraiwa, T | 1 |
| Kaminogo, M | 1 |
| Yonekura, M | 1 |
| Onizuka, M | 1 |
| Yasunaga, A | 1 |
| Shibata, S | 1 |
1 trial available for nafamostat and Cerebral Ischemia
| Article | Year |
|---|---|
Combination of serine protease inhibitor FUT-175 and thromboxane synthetase inhibitor OKY-046 decreases cerebral vasospasm in patients with subarachnoid hemorrhage.
Topics: Aged; Aneurysm, Ruptured; Benzamidines; Brain Damage, Chronic; Brain Ischemia; Drug Evaluation; Drug | 1998 |
4 other studies available for nafamostat and Cerebral Ischemia
| Article | Year |
|---|---|
Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition.
Topics: Animals; Antithrombins; Benzamidines; Brain Ischemia; Dose-Response Relationship, Drug; Fibrinolysin | 2014 |
Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection.
Topics: Animals; Astrocytes; Benzamidines; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Endothelial Cel | 2016 |
Nafamostat mesilate, as a treatment for heparin resistance, is not associated with perioperative ischemic stroke in patients undergoing cardiac surgery with cardiopulmonary bypass.
Topics: Aged; Benzamidines; Brain Ischemia; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cohort Stud | 2012 |
Protease inhibitors for delayed cerebral ischemia after subarachnoid haemorrhage?
Topics: Benzamidines; Brain Ischemia; Guanidines; Humans; Serine Proteinase Inhibitors; Subarachnoid Hemorrh | 1992 |