nafamostat has been researched along with Brain Edema in 3 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the effect of nafamostat mesilate (NM), a synthetic serine protease inhibitor, on BBB disruption following cerebral ischemia is unknown." | 7.83 | Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection. ( Chen, T; Fang, Y; Li, C; Liao, H; Pang, T; Shi, X; Wang, J; Zhang, L, 2016) |
| " However, the effect of nafamostat mesilate (NM), a synthetic serine protease inhibitor, on BBB disruption following cerebral ischemia is unknown." | 3.83 | Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection. ( Chen, T; Fang, Y; Li, C; Liao, H; Pang, T; Shi, X; Wang, J; Zhang, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kwon, SK | 1 |
| Ahn, M | 1 |
| Song, HJ | 1 |
| Kang, SK | 1 |
| Jung, SB | 1 |
| Harsha, N | 1 |
| Jee, S | 1 |
| Moon, JY | 1 |
| Suh, KS | 1 |
| Lee, SD | 1 |
| Jeon, BH | 1 |
| Kim, DW | 1 |
| Kim, CS | 1 |
| Wang, J | 1 |
| Li, C | 1 |
| Chen, T | 1 |
| Fang, Y | 1 |
| Shi, X | 1 |
| Pang, T | 1 |
| Zhang, L | 1 |
| Liao, H | 1 |
| Nakamura, T | 1 |
| Kuroda, Y | 1 |
| Hosomi, N | 1 |
| Okabe, N | 1 |
| Kawai, N | 1 |
| Tamiya, T | 1 |
| Xi, G | 1 |
| Keep, RF | 1 |
| Itano, T | 1 |
3 other studies available for nafamostat and Brain Edema
| Article | Year |
|---|---|
Nafamostat mesilate attenuates transient focal ischemia/reperfusion-induced brain injury via the inhibition of endoplasmic reticulum stress.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Benzamidines; Br | 2015 |
Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection.
Topics: Animals; Astrocytes; Benzamidines; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Endothelial Cel | 2016 |
Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Basal Ganglia; Benzamidines; Brain Edema; Brain Injuries; Cere | 2010 |