Page last updated: 2024-10-31

nafamostat and Asthma

nafamostat has been researched along with Asthma in 5 studies

nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Nafamostat was administered in a mouse model for asthma based on sensitization by house dust mite (HDM) extract, followed by the assessment of effects on airway hyperreactivity, inflammatory parameters and gene expression."8.31Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity. ( Akula, S; Allam, VSRR; Pejler, G; Taha, S; Waern, I; Wernersson, S, 2023)
"To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma."7.74Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. ( Inagaki, N; Ishizaki, M; Kajiwara, D; Nagai, H; Tanaka, H; Toyohara, T; Wakahara, K, 2008)
"We sought to investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic asthma."7.73Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. ( Chen, CL; Kao, ST; Lin, KJ; Tani, T; Wang, JY; Wang, SD; Yu, CK; Zeng, ZY, 2006)
"Nafamostat was administered in a mouse model for asthma based on sensitization by house dust mite (HDM) extract, followed by the assessment of effects on airway hyperreactivity, inflammatory parameters and gene expression."4.31Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity. ( Akula, S; Allam, VSRR; Pejler, G; Taha, S; Waern, I; Wernersson, S, 2023)
" However, the effects of the serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on a long-term challenged mouse model of chronic asthma are unclear."3.80The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model. ( Chao, YP; Chiang, CJ; Kao, ST; Lin, CC; Lin, J; Lin, LJ; Wang, SD, 2014)
"To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma."3.74Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. ( Inagaki, N; Ishizaki, M; Kajiwara, D; Nagai, H; Tanaka, H; Toyohara, T; Wakahara, K, 2008)
"We sought to investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic asthma."3.73Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. ( Chen, CL; Kao, ST; Lin, KJ; Tani, T; Wang, JY; Wang, SD; Yu, CK; Zeng, ZY, 2006)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Allam, VSRR1
Waern, I1
Taha, S1
Akula, S1
Wernersson, S1
Pejler, G1
Lin, CC1
Lin, LJ1
Wang, SD2
Chiang, CJ1
Chao, YP1
Lin, J1
Kao, ST2
Ishizaki, M1
Tanaka, H1
Kajiwara, D1
Toyohara, T1
Wakahara, K1
Inagaki, N1
Nagai, H1
Chen, CL1
Zeng, ZY1
Lin, KJ1
Tani, T1
Yu, CK1
Wang, JY1
Abe, M1
Shibata, K1
Akatsu, H1
Shimizu, N1
Sakata, N1
Katsuragi, T1
Okada, H1

Other Studies

5 other studies available for nafamostat and Asthma

ArticleYear
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Eosinophilia; Eosinophils; Gene Expression; Human

2023
The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model.
    Mediators of inflammation, 2014, Volume: 2014

    Topics: Allergens; Animals; Asthma; Benzamidines; Disease Models, Animal; Gabexate; Glycoproteins; Guanidine

2014
Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.
    Journal of pharmacological sciences, 2008, Volume: 108, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Benzamidines; Bronchoalveolar Lavage Fluid

2008
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
    The Journal of allergy and clinical immunology, 2006, Volume: 118, Issue:1

    Topics: Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Benzamidines; Chemokines; Cysteine

2006
Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Oct-15, Volume: 167, Issue:8

    Topics: Airway Resistance; Animals; Antigens; Antigens, CD; Asthma; Benzamidines; Bronchi; Bronchoalveolar L

2001