nafamostat has been researched along with Asthma in 5 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nafamostat was administered in a mouse model for asthma based on sensitization by house dust mite (HDM) extract, followed by the assessment of effects on airway hyperreactivity, inflammatory parameters and gene expression." | 8.31 | Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity. ( Akula, S; Allam, VSRR; Pejler, G; Taha, S; Waern, I; Wernersson, S, 2023) |
| "To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma." | 7.74 | Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. ( Inagaki, N; Ishizaki, M; Kajiwara, D; Nagai, H; Tanaka, H; Toyohara, T; Wakahara, K, 2008) |
| "We sought to investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic asthma." | 7.73 | Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. ( Chen, CL; Kao, ST; Lin, KJ; Tani, T; Wang, JY; Wang, SD; Yu, CK; Zeng, ZY, 2006) |
| "Nafamostat was administered in a mouse model for asthma based on sensitization by house dust mite (HDM) extract, followed by the assessment of effects on airway hyperreactivity, inflammatory parameters and gene expression." | 4.31 | Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity. ( Akula, S; Allam, VSRR; Pejler, G; Taha, S; Waern, I; Wernersson, S, 2023) |
| " However, the effects of the serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on a long-term challenged mouse model of chronic asthma are unclear." | 3.80 | The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model. ( Chao, YP; Chiang, CJ; Kao, ST; Lin, CC; Lin, J; Lin, LJ; Wang, SD, 2014) |
| "To clarify the involvement of serine proteases in the development of allergic airway inflammation, we investigated the effect of nafamostat mesilate, a serine protease inhibitor, in a murine model of allergic asthma." | 3.74 | Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma. ( Inagaki, N; Ishizaki, M; Kajiwara, D; Nagai, H; Tanaka, H; Toyohara, T; Wakahara, K, 2008) |
| "We sought to investigate the effects of serine protease inhibitors nafamostat mesilate (FUT), gabexate mesilate (FOY), and ulinastatin (UTI) on airway inflammation in a mouse model of allergic asthma." | 3.73 | Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. ( Chen, CL; Kao, ST; Lin, KJ; Tani, T; Wang, JY; Wang, SD; Yu, CK; Zeng, ZY, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allam, VSRR | 1 |
| Waern, I | 1 |
| Taha, S | 1 |
| Akula, S | 1 |
| Wernersson, S | 1 |
| Pejler, G | 1 |
| Lin, CC | 1 |
| Lin, LJ | 1 |
| Wang, SD | 2 |
| Chiang, CJ | 1 |
| Chao, YP | 1 |
| Lin, J | 1 |
| Kao, ST | 2 |
| Ishizaki, M | 1 |
| Tanaka, H | 1 |
| Kajiwara, D | 1 |
| Toyohara, T | 1 |
| Wakahara, K | 1 |
| Inagaki, N | 1 |
| Nagai, H | 1 |
| Chen, CL | 1 |
| Zeng, ZY | 1 |
| Lin, KJ | 1 |
| Tani, T | 1 |
| Yu, CK | 1 |
| Wang, JY | 1 |
| Abe, M | 1 |
| Shibata, K | 1 |
| Akatsu, H | 1 |
| Shimizu, N | 1 |
| Sakata, N | 1 |
| Katsuragi, T | 1 |
| Okada, H | 1 |
5 other studies available for nafamostat and Asthma
| Article | Year |
|---|---|
Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Cytokines; Eosinophilia; Eosinophils; Gene Expression; Human | 2023 |
The effect of serine protease inhibitors on airway inflammation in a chronic allergen-induced asthma mouse model.
Topics: Allergens; Animals; Asthma; Benzamidines; Disease Models, Animal; Gabexate; Glycoproteins; Guanidine | 2014 |
Nafamostat mesilate, a potent serine protease inhibitor, inhibits airway eosinophilic inflammation and airway epithelial remodeling in a murine model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Benzamidines; Bronchoalveolar Lavage Fluid | 2008 |
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Benzamidines; Chemokines; Cysteine | 2006 |
Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats.
Topics: Airway Resistance; Animals; Antigens; Antigens, CD; Asthma; Benzamidines; Bronchi; Bronchoalveolar L | 2001 |