nafamostat has been researched along with Acute Respiratory Distress Syndrome in 6 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
| Excerpt | Relevance | Reference |
|---|---|---|
| "Male rats were subjected to trauma-hemorrhagic shock (T/HS) or trauma sham-shock (T/SS) and resuscitated with RL, HTS, nafamostat, or the combination of HTS and nafamostat." | 3.73 | Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition. ( Berezina, TL; Deitch, EA; Feketeova, E; Homma, H; Lu, Q; Machiedo, GW; Xu, DZ; Zaets, SB, 2005) |
| "We treated two patients with severe respiratory failure due to coronavirus disease 2019 (COVID-19)." | 2.66 | High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review : High levels of anti-SSA/Ro antibodies in COVID-19. ( Fujii, H; Hiraoka, N; Horiguchi, M; Matsuyama, A; Omura, A; Ono, S; Shiotsu, S; Suga, Y; Takumi, C; Tanaka, S; Tsuji, T; Yuba, T, 2020) |
| "5 days later he developed adult respiratory distress syndrome (ARDS)." | 2.39 | [A case of adult onset Still's disease complicated with adult respiratory distress syndrome and disseminated intravascular coagulation]. ( Akizuki, M; Fujii, T; Ichikawa, Y; Mimori, T; Shinozawa, T; Suwa, A; Tojo, T; Yokoyama, M, 1995) |
| " We investigated the ideal dosage and efficacy of nafamostat mesilate for use with ECMO in patients with acute cardiac or respiratory failure." | 1.37 | Use of nafamostat mesilate as an anticoagulant during extracorporeal membrane oxygenation. ( Han, SJ; Hong, KS; Kim, HS; Kim, KI; Lee, SH; Lee, WK; Whang, SM, 2011) |
| "Nafamostat mesilate (NM) is a broad-range synthetic protease inhibitor with some anti-inflammatory action." | 1.34 | Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. ( Hagiwara, S; Iwasaka, H; Noguchi, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, H | 1 |
| Tsuji, T | 1 |
| Yuba, T | 1 |
| Tanaka, S | 1 |
| Suga, Y | 1 |
| Matsuyama, A | 1 |
| Omura, A | 1 |
| Shiotsu, S | 1 |
| Takumi, C | 1 |
| Ono, S | 1 |
| Horiguchi, M | 1 |
| Hiraoka, N | 1 |
| Han, SJ | 1 |
| Kim, HS | 1 |
| Kim, KI | 1 |
| Whang, SM | 1 |
| Hong, KS | 1 |
| Lee, WK | 1 |
| Lee, SH | 1 |
| Homma, H | 1 |
| Deitch, EA | 1 |
| Feketeova, E | 1 |
| Lu, Q | 1 |
| Berezina, TL | 1 |
| Zaets, SB | 1 |
| Machiedo, GW | 1 |
| Xu, DZ | 1 |
| Hagiwara, S | 1 |
| Iwasaka, H | 1 |
| Noguchi, T | 1 |
| Yokoyama, M | 1 |
| Suwa, A | 1 |
| Shinozawa, T | 1 |
| Fujii, T | 1 |
| Mimori, T | 1 |
| Akizuki, M | 1 |
| Ichikawa, Y | 1 |
| Tojo, T | 1 |
| Porcel, JM | 1 |
2 reviews available for nafamostat and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review : High levels of anti-SSA/Ro antibodies in COVID-19.
Topics: Aged; Amides; Antibodies, Antinuclear; Antiviral Agents; Benzamidines; Betacoronavirus; Coronavirus | 2020 |
[A case of adult onset Still's disease complicated with adult respiratory distress syndrome and disseminated intravascular coagulation].
Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzamidines; Disseminated | 1995 |
4 other studies available for nafamostat and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Use of nafamostat mesilate as an anticoagulant during extracorporeal membrane oxygenation.
Topics: Acute Disease; Anticoagulants; Benzamidines; Dose-Response Relationship, Drug; Extracorporeal Membra | 2011 |
Small volume resuscitation with hypertonic saline is more effective in ameliorating trauma-hemorrhagic shock-induced lung injury, neutrophil activation and red blood cell dysfunction than pancreatitic protease inhibition.
Topics: Animals; Benzamidines; Coloring Agents; Drug Therapy, Combination; Erythrocyte Deformability; Evans | 2005 |
Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamidines; Disease Models, Animal; Guanidines; | 2007 |
[Complement inhibition: a new therapeutic modality?].
Topics: Adult; Animals; Antigens, CD; Benzamidines; Blood Proteins; Carrier Proteins; CD55 Antigens; CD59 An | 1995 |