nafamostat has been researched along with Acute Necrotizing Pancreatitis in 8 studies
nafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplastic
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continuous regional arterial infusion (CRAI) of protease inhibitor nafamostat mesilate (NM) is used in the context of predicted severe acute pancreatitis (SAP) to prevent the development of pancreatic necrosis." | 9.34 | Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial. ( Gabata, T; Haradome, H; Hirota, M; Ikeda, K; Isaji, S; Ishida, E; Ito, T; Iwasaki, E; Kataoka, K; Kayaba, C; Kimura, K; Kitamura, K; Kozaka, K; Maguchi, H; Masamune, A; Mayumi, T; Mitoro, A; Miura, S; Nakai, Y; Nakamura, R; Sanuki, T; Sawano, H; Shimosegawa, T; Takeda, K; Takenaka, M; Takeyama, Y; Yamagiwa, K, 2020) |
| "Continuous regional arterial infusion (CRAI) of protease inhibitor nafamostat mesilate (NM) is used in the context of predicted severe acute pancreatitis (SAP) to prevent the development of pancreatic necrosis." | 5.34 | Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial. ( Gabata, T; Haradome, H; Hirota, M; Ikeda, K; Isaji, S; Ishida, E; Ito, T; Iwasaki, E; Kataoka, K; Kayaba, C; Kimura, K; Kitamura, K; Kozaka, K; Maguchi, H; Masamune, A; Mayumi, T; Mitoro, A; Miura, S; Nakai, Y; Nakamura, R; Sanuki, T; Sawano, H; Shimosegawa, T; Takeda, K; Takenaka, M; Takeyama, Y; Yamagiwa, K, 2020) |
| "This paper reviewed our experience with the nonsurgical management of acute necrotizing pancreatitis (ANP) by continuous regional arterial infusion (CRAI) of protease inhibitor (nafamostat mesilate, 240 mg/day) and antibiotic (imipenem, 0." | 5.09 | Role of early continuous regional arterial infusion of protease inhibitor and antibiotic in nonsurgical treatment of acute necrotizing pancreatitis. ( Kobari, M; Matsuno, S; Shibuya, K; Sunamura, M; Takeda, K, 1999) |
| "We divided 84 patients with acute necrotizing pancreatitis into two groups, CRAI (-) and CRAI (+), and compared the outcome." | 1.34 | Treatment strategy against infection: clinical outcome of continuous regional arterial infusion, enteral nutrition, and surgery in severe acute pancreatitis. ( Ajiki, T; Fujino, Y; Fujita, T; Kuroda, Y; Matsumoto, I; Nakajima, T; Sakai, T; Sawa, H; Shinzeki, M; Takeyama, Y; Ueda, T; Yasuda, T, 2007) |
| "Nafamostat has maximal effects on the pancreas and peritoneal capillary leakage when delivered by way of local intra-arterial infusion, and shows a greater reduction of lung leukocyte infiltration and capillary leakage by the intravenous route." | 1.31 | Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis. ( Antoniu, BA; Balcom, JH; Fernández-del Castillo, CF; Keck, T; Lewandrowski, K; Warshaw, AL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hirota, M | 2 |
| Shimosegawa, T | 1 |
| Kitamura, K | 1 |
| Takeda, K | 5 |
| Takeyama, Y | 2 |
| Mayumi, T | 1 |
| Ito, T | 2 |
| Takenaka, M | 1 |
| Iwasaki, E | 1 |
| Sawano, H | 1 |
| Ishida, E | 1 |
| Miura, S | 1 |
| Masamune, A | 1 |
| Nakai, Y | 1 |
| Mitoro, A | 1 |
| Maguchi, H | 1 |
| Kimura, K | 1 |
| Sanuki, T | 1 |
| Haradome, H | 1 |
| Kozaka, K | 1 |
| Gabata, T | 1 |
| Kataoka, K | 1 |
| Isaji, S | 1 |
| Nakamura, R | 1 |
| Yamagiwa, K | 1 |
| Kayaba, C | 1 |
| Ikeda, K | 1 |
| Keck, T | 2 |
| Yamauchi, J | 2 |
| Shibuya, K | 3 |
| Sunamura, M | 3 |
| Matsuno, S | 3 |
| Mikami, Y | 1 |
| Yasuda, T | 1 |
| Ueda, T | 1 |
| Shinzeki, M | 1 |
| Sawa, H | 1 |
| Nakajima, T | 1 |
| Matsumoto, I | 1 |
| Fujita, T | 1 |
| Sakai, T | 1 |
| Ajiki, T | 1 |
| Fujino, Y | 1 |
| Kuroda, Y | 1 |
| Kobari, M | 1 |
| Balcom, JH | 1 |
| Antoniu, BA | 1 |
| Lewandrowski, K | 1 |
| Warshaw, AL | 1 |
| Fernández-del Castillo, CF | 1 |
2 reviews available for nafamostat and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Site-specific therapeutic effects of protease inhibitors: effect of route of administration in experimental pancreatitis.
Topics: Animals; Benzamidines; Disease Models, Animal; Guanidines; Infusions, Intravenous; Pancreatitis, Acu | 2001 |
[Continuous regional arterial infusion of protease inhibitor and antibiotic for severe acute pancreatitis].
Topics: Acute Disease; Angiography; Anti-Bacterial Agents; Benzamidines; Clinical Trials as Topic; Guanidine | 2004 |
3 trials available for nafamostat and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial.
Topics: Administration, Intravenous; Adult; Aged; Benzamidines; Female; Guanidines; Humans; Infusions, Intra | 2020 |
Benefit of continuous regional arterial infusion of protease inhibitor and antibiotic in the management of acute necrotizing pancreatitis.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Angiography; Anti-Bacterial Agents; APACHE; Benzamidines; C | 2001 |
Role of early continuous regional arterial infusion of protease inhibitor and antibiotic in nonsurgical treatment of acute necrotizing pancreatitis.
Topics: Adult; Aged; Benzamidines; Drug Therapy, Combination; Female; Guanidines; Humans; Imipenem; Infusion | 1999 |
3 other studies available for nafamostat and Acute Necrotizing Pancreatitis
| Article | Year |
|---|---|
Continuous regional application of protease inhibitor in the treatment of acute pancreatitis. An experimental study using closed duodenal obstruction model in dogs.
Topics: Animals; Benzamidines; Disease Models, Animal; Dogs; Duodenal Obstruction; Guanidines; Infusions, In | 2001 |
Treatment strategy against infection: clinical outcome of continuous regional arterial infusion, enteral nutrition, and surgery in severe acute pancreatitis.
Topics: Anti-Bacterial Agents; Bacterial Infections; Benzamidines; Biopsy, Fine-Needle; Drug Therapy, Combin | 2007 |
Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis.
Topics: Animals; Benzamidines; Capillary Permeability; Complement Inactivator Proteins; Evans Blue; Gabexate | 2001 |