nadp has been researched along with Chemical and Drug Induced Liver Injury in 53 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 33 (62.26) | 18.7374 |
1990's | 6 (11.32) | 18.2507 |
2000's | 7 (13.21) | 29.6817 |
2010's | 7 (13.21) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Chen, X; Kaleri, NA; Li, J; Li, X; Sun, K; Wang, L; Zhang, W | 1 |
Jin, T; Liu, J; Shi, JS; Tao, N; Wu, Q; Zhang, D; Zhu, QN | 1 |
Guelfi, M; Maioli, MA; Medeiros, HC; Mingatto, FE; Moreira, PR; Pereira, FT | 1 |
Choi, JM; Jeon, JS; Kim, SK; Kim, YM; Lee, JY; Lee, K; Oh, SJ; Ryu, CS | 1 |
Horie, T; Ito, K; Sekine, S; Shirakawa, M; Tanaka, A | 1 |
Hashizume, T; Komuro, S; Mise, M; Usui, T; Yabuki, M | 1 |
Hu, Z; Li, S; Liao, M; Ma, H; Wang, Q; Wang, Y; Wu, C; Yang, B; Yuan, Y; Zheng, Z | 1 |
Adamska, T; Baer-Dubowska, W; Ignatowicz, E; Krajka-Kuźniak, V; Szaefer, H | 1 |
Andrés, D; Bautista, M; Cascales, M; Sánchez-Reus, I | 1 |
DINMAN, BD; FOX, CF; FRAJOLA, WJ; HAMDI, EA | 1 |
SLATER, TF | 2 |
Pashkov, AN; Popov, SS; Rakhmanova, TI; Semenikhina, AV | 1 |
Devaki, T; Raghavendran, HB; Sathivel, A | 1 |
Ikeda, T | 1 |
Dalvie, D; Deese, A; Kang, P; Smith, E; Zhou, S | 1 |
Macneil, DJ; Menetski, J; Mumick, S; Nizner, P; Qian, S; Reitman, ML; Tota, MR | 1 |
Kloss, MW; Rauckman, EJ; Rosen, GM | 1 |
Boroujerdi, M; Carlo, JR; Rosenbaum, SE | 1 |
Cavagnaro, J; Rauckman, EJ; Rosen, GM | 1 |
Chan, CH; James, JL; Moody, DE; Smuckler, EA | 1 |
Willis, RJ | 1 |
Atkinson, A; Meeks, RG; Roy, D | 1 |
Hamrick, ME; Harris, SR | 1 |
Dhawan, D; Goel, A | 1 |
Corcoran, GB; Mitchell, JR; Nelson, SD; Snodgrass, WR; Timbrell, JA | 1 |
Fujisawa, K; Kojima, M; Kurihara, N | 1 |
Cascales, F; Cascales, M; Cerdán, S; Chacón, P; Santos-Ruiz, A | 1 |
Khan, S; Lauriault, VV; O'Brien, PJ | 1 |
DeGray, JA; Mason, RP; Rao, DN | 1 |
Hartmann, HJ; Miesel, R; Weser, U | 1 |
Delaforge, M; Jaouen, M; Jollès, P; Mansuy, D; Migliore-Samour, D | 1 |
Kärki, NT; Keinänen, K; Saarni, HU; Sotaniemi, EA; Stenbäck, F; Stengård, JH | 1 |
Jatoe, SD; Lauriault, V; McGirr, LG; O'Brien, PJ | 1 |
Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC | 1 |
Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
Faeder, E; Fowler, BA; Hook, GE; Lucier, GW; McDaniel, OS; Sonawane, BR | 1 |
Carlson, GP; Fausto, N; Fuller, GC | 1 |
Sawyer, BC; Slater, TF; Sträuli, UD | 2 |
Apostolesco, I; Dobreanu-Enesco, V; Popesco, I; Velican, D; Zamfiresco-Gheorghiu, M | 1 |
Sawyer, BC; Slater, TF | 2 |
Leevy, CM | 1 |
Brody, TM; Gibb, JW | 1 |
Glende, EA; Recknagel, RO | 1 |
Khaĭkina, BI; Pavlova, II | 1 |
DeCarli, LM; Lieber, CS | 1 |
Brodie, BB; Cho, AK; Gillette, JR; Krishna, G; Reid, WD; Sipes, G | 1 |
Taketa, K; Watanabe, A | 1 |
Brodie, BB; Cho, AK; Krishna, G; Reid, WD | 1 |
Chopra, P; Nayak, NC; Ramalingaswami, V; Roy, S | 1 |
Gerdes, H; Littmann, KP; Spuck, W | 1 |
3 review(s) available for nadp and Chemical and Drug Induced Liver Injury
Article | Year |
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[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP2E1; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Predisposition to Disease; Humans; Hypoglycemic Agents; Imines; NADP; Pharmacogenetics; Thiazolidinediones; Troglitazone | 2006 |
Cocaine-mediated hepatotoxicity. A critical review.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cocaine; Enzymes; Glutathione; Humans; Liver; NADP; Oxidation-Reduction | 1984 |
[Hepatotoxicity of alcohol based on its metabolism].
Topics: Alcohol Oxidoreductases; Animals; Chemical and Drug Induced Liver Injury; Dietary Proteins; Ethanol; Fatty Liver; Humans; Liver; Mitochondria, Liver; NAD; NADP; Rats | 1976 |
50 other study(ies) available for nadp and Chemical and Drug Induced Liver Injury
Article | Year |
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Dietary Copper Reduces the Hepatotoxicity of (-)-Epigallocatechin-3-Gallate in Mice.
Topics: Animals; Antioxidants; Catechin; Ceruloplasmin; Chemical and Drug Induced Liver Injury; Copper; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Malondialdehyde; Mice, Inbred ICR; NADP; Oxidation-Reduction; Tea | 2017 |
Induction of Nrf2 and metallothionein as a common mechanism of hepatoprotective medicinal herbs.
Topics: Acetaminophen; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Galactosamine; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Liver; Male; Metallothionein; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; NAD(P)H Dehydrogenase (Quinone); NADP; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Piper; Plant Extracts | 2014 |
Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Bixaceae; Carbon Tetrachloride; Carotenoids; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Reductase; Lipid Peroxidation; Liver; Male; Malondialdehyde; NADP; Oxidative Stress; Plant Extracts; Rats, Wistar; Reactive Oxygen Species; Transaminases | 2014 |
Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes.
Topics: Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Hep G2 Cells; Humans; Liver; Microsomes, Liver; NADP | 2015 |
Metabolic activation of hepatotoxic drug (benzbromarone) induced mitochondrial membrane permeability transition.
Topics: Activation, Metabolic; Animals; Benzbromarone; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Membrane Potential, Mitochondrial; Microsomes, Liver; Mitochondria, Liver; Mitochondrial Swelling; NADP; Rats, Sprague-Dawley | 2015 |
Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Glucuronic Acid; Glucuronosyltransferase; Glutathione; Hepatocytes; Humans; Liver; Metabolomics; Microsomes, Liver; NADP; Protein Binding; Reproducibility of Results; Risk Assessment; Risk Factors | 2009 |
Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]-1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats.
Topics: Amino Acids; Animals; Apoptosis; Blood Proteins; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Female; Histocytochemistry; In Situ Nick-End Labeling; Liver; Mass Spectrometry; Mesylates; NADP; Proteome; Proteomics; Pyrroles; Rats; Rats, Wistar; Reactive Oxygen Species | 2010 |
Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats.
Topics: Alkylating Agents; Animals; Beta vulgaris; Beverages; Blotting, Western; Chemical and Drug Induced Liver Injury; Comet Assay; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytosol; Diethylnitrosamine; DNA Damage; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Male; Microsomes, Liver; NADP; Proteins; Rats; Rats, Wistar | 2012 |
Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity. Expression of metallothionein and HSP70.
Topics: Animals; Anti-Inflammatory Agents; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Interactions; Gadolinium; Gene Expression; HSP70 Heat-Shock Proteins; Kupffer Cells; Male; Metallothionein; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidative Stress; Rats; Rats, Wistar; Thioacetamide | 2003 |
CCI4 TOXICITY. III. HEPATO-STRUCTURAL AND ENZYMATIC CHANGE.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Hepatitis; Liver; Microscopy; NADP; Oxidoreductases; Rabbits; Research | 1963 |
A NOTE ON THE RELATIVE TOXIC ACTIVITIES OF TETRACHLOROMETHANE AND TRICHLORO-FLUORO-METHANE ON THE RAT.
Topics: Blood; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry, Physical; Chloroform; Fluorides; Glucuronidase; Hepatitis; Methane; NADP; Necrosis; Rats; Research; Solvents; Toxicology | 1965 |
Glutathione system and activity of NADPH-generating enzymes in the liver of intact rats and animals with toxic hepatitis receiving melatonin.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Isocitrate Dehydrogenase; Liver; Male; Melatonin; NADP; Oxidation-Reduction; Rats | 2005 |
Defensive nature of Sargassum polycystum (Brown alga) against acetaminophen-induced toxic hepatitis in rats: role of drug metabolizing microsomal enzyme system, tumor necrosis factor-alpha and fate of liver cell structural integrity.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Endoplasmic Reticulum; Imines; Inactivation, Metabolic; Liver; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron; Microsomes, Liver; Mitochondria; NADP; NADPH-Ferrihemoprotein Reductase; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Sargassum; Tumor Necrosis Factor-alpha | 2006 |
Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Topics: Androgen Antagonists; Antineoplastic Agents, Hormonal; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Flutamide; Glutathione; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; NADP; Recombinant Proteins; Tandem Mass Spectrometry | 2007 |
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
Topics: Acetaminophen; Analgesics; Animals; Chemical and Drug Induced Liver Injury; Cytosol; Genotype; Glutathione; Liver; Malate Dehydrogenase; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NADP | 2008 |
Protective action of 2(3)-tert-butyl-4-hydroxyanisole (BHA) on acetaminophen-induced liver necrosis in male A/J mice.
Topics: Acetaminophen; Animals; Anisoles; Butylated Hydroxyanisole; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Liver Diseases; Male; Mice; Mice, Inbred A; Microsomes, Liver; NADP; Necrosis; Protein Binding | 1984 |
Norcocaine nitroxide. A potential hepatotoxic metabolite of cocaine.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cocaine; In Vitro Techniques; Kinetics; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Rats; Rats, Inbred F344 | 1982 |
The phospholipids of the hepatic endoplasmic reticulum. Structural change in liver injury.
Topics: Adenosine Diphosphate; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorides; Endoplasmic Reticulum; Ferric Compounds; Liver; Liver Diseases; Male; Microsomes, Liver; NADP; Phosphatidic Acids; Rats; Rats, Inbred Strains | 1982 |
Possible role of endogenous toxigenic lipids in the carbon tetrachloride poisoned hepatocyte.
Topics: Biotransformation; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Free Radicals; Membrane Lipids; Microsomes, Liver; NADP; Peroxides | 1980 |
Increased oxidative stress in the liver of mice treated with trichloroethylene.
Topics: Animals; Chemical and Drug Induced Liver Injury; Clofibrate; Liver; Male; Malondialdehyde; Mice; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen Consumption; Trichloroacetic Acid; Trichloroethylene | 1993 |
Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors.
Topics: Acetaminophen; Animals; Calcium; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diltiazem; DNA; Homeostasis; Male; Mice; Mitochondria, Liver; NADP; Oxidation-Reduction; Phospholipases A; Phospholipases A2 | 1993 |
Further evidence for zinc as a hepatoprotective agent in rat liver toxicity.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Mixed Function Oxygenases; NADP; Rats; Zinc | 1995 |
Isoniazid and iproniazid: activation of metabolites to toxic intermediates in man and rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Hydrazines; Iproniazid; Isoniazid; Microsomes, Liver; NADP; Rats; Structure-Activity Relationship | 1976 |
Hepatotoxic effect of thioacetamide (TAM) on NADP-linked enzymes, aminotransferases and glutamate dehydrogenase.
Topics: Acetamides; Alanine Transaminase; Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutamate Dehydrogenase; Male; NADP; Rats; Thioacetamide; Transaminases | 1978 |
Hepatocyte cytotoxicity induced by various hepatotoxins mediated by cytochrome P-450IIE1: protection with diethyldithiocarbamate administration.
Topics: Animals; Carbon Disulfide; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Disulfiram; Ditiocarb; Liver Diseases; Male; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating; Pyrazoles; Rats; Rats, Inbred Strains | 1992 |
Reduction of paraquat and related bipyridylium compounds to free radical metabolites by rat hepatocytes.
Topics: Animals; Benzyl Viologen; Cations; Chemical and Drug Induced Liver Injury; Cobalt; Cytochrome P-450 Enzyme System; Diquat; Electron Spin Resonance Spectroscopy; Free Radicals; Liver; Male; Metyrapone; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Paraquat; Pentetic Acid; Pyridinium Compounds; Rats | 1991 |
Antiinflammatory reactivity of copper(I)-thionein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Chemical and Drug Induced Liver Injury; Ficusin; Free Radicals; Inflammation; Injections, Intraperitoneal; L-Iditol 2-Dehydrogenase; Male; Metallothionein; Mice; NADP; Neutrophils; Oxygen; Phagocytosis; Singlet Oxygen; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1990 |
In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity.
Topics: Acetaminophen; Adjuvants, Immunologic; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Lipid Peroxidation; Liver Diseases; Mice; Microsomes, Liver; NADP; Oligopeptides; Pimelic Acids | 1989 |
Medroxyprogesterone acetate and phenobarbital induce NADPH producing enzyme activities in rats with a chemical liver injury.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Dimethylnitrosamine; Enzyme Induction; Glucose-6-Phosphatase; Isocitrate Dehydrogenase; Malate Dehydrogenase; Male; Medroxyprogesterone; Medroxyprogesterone Acetate; NADP; Phenobarbital; Phosphogluconate Dehydrogenase; Rats; Rats, Inbred Strains | 1985 |
The toxicity of disulphides to isolated hepatocytes and mitochondria.
Topics: Adenosine Triphosphate; Animals; Calcium; Chemical and Drug Induced Liver Injury; Cystamine; Disulfides; Dithiothreitol; In Vitro Techniques; Liver; Male; Membrane Potentials; Mitochondria; Mitochondria, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1988 |
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Metabolism; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Pyridines; Rats; Rats, Inbred Strains; Triiodothyronine | 1988 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
TCDD-induced changes in rat liver microsomal enzymes.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzopyrenes; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dioxins; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Glucuronidase; Glucuronosyltransferase; Hydroxylation; Liver; Male; Microsomes, Liver; Mitochondria, Liver; NADP; Oxidative Phosphorylation; Proteins; Rats | 1973 |
Effects of spironolactone on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Aldehydes; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Glucose-6-Phosphatase; Male; Malonates; Microsomes, Liver; NADP; Rats; Spironolactone | 1974 |
Changes in liver nucleotide concentrations in experimental liver injury. 1. Carbon tetrachloride poisoning.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver; NAD; NADP; Necrosis; Paraffin; Promethazine; Rats | 1964 |
Changes in liver nucleotide concentrations in experimental liver injury. 2. Acute ethanol poisoning.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethanol; Fatty Liver; Liver; NAD; NADP; Rats | 1964 |
Contributions to the study of certain energy-producing intracellular enzymes during chronic experimental hepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Histocytochemistry; NAD; NADP; Oxidoreductases; Rabbits | 1966 |
Liver nucleotides in acute experimental liver injury induced by dimethylnitrosamine and by thioacetamide.
Topics: Amides; Animals; Chemical and Drug Induced Liver Injury; Female; Liver; NAD; NADP; Nitrosamines; Rats; Sulfhydryl Compounds | 1966 |
Nicotinamide-adenine dinucleotides in acute liver injury induced by ethionine, and a comparison with the effects of salicylate.
Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Ethionine; Female; Liver; NAD; NADP; Rats; Sodium Salicylate | 1966 |
Clinical diagnosis, evaluation and treatment of liver disease in in alcoholics.
Topics: Alcoholism; Blood Glucose; Chemical and Drug Induced Liver Injury; Ethanol; Fatty Liver; Humans; Lactates; Liver Diseases; NAD; NADP; Organ Size | 1967 |
The protective effect of nicotinamide on carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antidotes; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Liver; Mitochondria, Liver; NAD; NADP; Niacinamide; Rats; Temperature | 1967 |
The inhibitory effects in vitro of phenothiazines and other drugs on lipid-peroxidation systems in rat liver microsomes, and their relationship to the liver necrosis produced by carbon tetrachloride.
Topics: Adenine Nucleotides; Animals; Animals, Newborn; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chickens; Depression, Chemical; Female; Iron; Lipid Metabolism; Liver; Microsomes; NADP; Oxygen Consumption; Peroxides; Phenols; Phenothiazines; Promethazine; Rats; Stimulation, Chemical; Succinates; Sulfites; Temperature; Trifluoperazine | 1968 |
Biochemical basis for the in vitro pro-oxidant action of carbon tetrachloride.
Topics: Aldehydes; Animals; Antimetabolites; Benzene; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochromes; Edetic Acid; Electron Transport; Ferricyanides; Glutathione; Lipid Metabolism; Male; Malonates; Methane; Microsomes, Liver; NADP; Oxidation-Reduction; Rats | 1969 |
[Distribution characteristics of nicotinamide coenzymes (NAD and NADP) in the cellular structures of the liver and brain following administration of DDT].
Topics: Animals; Brain; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cytoplasm; DDT; Fluorometry; Liver; Male; Mitochondria; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Rats | 1970 |
Reduced nicotinamide-adenine dinucleotide phosphate oxidase: activity enhanced by ethanol consumption.
Topics: Alcohol Drinking; Animals; Catalase; Chemical and Drug Induced Liver Injury; Ethanol; Female; Hydrogen Peroxide; Male; Microsomes, Liver; NADP; Oxidoreductases; Rats; Stimulation, Chemical | 1970 |
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Topics: Animals; Autoradiography; Benzene Derivatives; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Drug Synergism; Glutathione; Hydrocarbons, Halogenated; Liver; Liver Diseases; Male; Microsomes, Liver; NADP; Naphthalenes; Necrosis; Phenobarbital; Rats | 1971 |
Interconvertible microheterogeneity of glucose-6-phosphate dehydrogenase in rat liver.
Topics: Acrylates; Animals; Carbon Tetrachloride Poisoning; Cattle; Centrifugation, Density Gradient; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlorides; Drug Stability; Electrophoresis, Disc; Glucosephosphate Dehydrogenase; Hemoglobins; Kidney; Liver; Male; Mercaptoethanol; Mercury; Molecular Weight; Muscles; NADP; Rats; Solubility; Spectrophotometry; Time Factors | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlorine; Chromatography, Paper; Ethers, Cyclic; Glutathione; Hydrocarbons, Halogenated; Iodine; Liver; Male; Mice; Microsomes, Liver; Models, Biological; NADP; Necrosis; Phenobarbital; Rats; Sheep; Sulfur Isotopes | 1971 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Electron Transport; Endoplasmic Reticulum; Ethionine; Fatty Liver; Glucose-6-Phosphatase; Histocytochemistry; Liver; Macaca; Male; Microsomes, Liver; NADP; Necrosis; Oxidoreductases; Phenazines; Phenobarbital; Proadifen; Protein Deficiency; Rats; Rats, Inbred Strains | 1972 |
[Effect of experimental liver damage on the reduction of testosterone and 4-androstene-3,17-dione].
Topics: 17-Ketosteroids; Androstanes; Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Ethanol; In Vitro Techniques; Liver Diseases; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Inbred Strains; Testosterone | 1972 |