nad has been researched along with Aging in 437 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 97 (22.20) | 18.7374 |
| 1990's | 33 (7.55) | 18.2507 |
| 2000's | 63 (14.42) | 29.6817 |
| 2010's | 138 (31.58) | 24.3611 |
| 2020's | 106 (24.26) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, WQ; Lu, K; Wen, DT; Zheng, L | 1 |
| Chai, H; Chen, Y; Cheng, Y; Liu, X; Wei, Z | 1 |
| Diab, J; Ferrario, E; Strømland, Ø; Sverkeli, LJ; Ziegler, M | 1 |
| Okumura, K; Takeda, K | 1 |
| Benfdil, M; Bouchard, J; Bourdeau, V; Ferbeyre, G; Fernandez-Ruiz, A; Fouillen, A; Gagnon, E; Guillon, J; Hulea, L; Huot, G; Igelmann, S; Kalegari, P; Kenner, L; Lessard, F; Lopes-Paciencia, S; Mignacca, L; Moriggl, R; Nanci, A; Omichinski, JG; Papadopoli, D; Pencik, J; Pollak, MN; Ponce, KJ; Quenneville, J; Rowell, MC; Topisirovic, I; Uchenunu, O; Vuong, N; Wahba, HM | 1 |
| Baur, JA; Bhat, YR; Botolin, P; Chellappa, K; Chen, L; Chiles, E; Chu, Q; Descamps, HC; Doke, T; Hayat, F; Jankowski, C; Lingala, SR; Lu, W; McReynolds, MR; Migaud, ME; Mukherjee, S; Rabinowitz, JD; Shen, Y; Su, X; Susztak, K; Thaiss, CA | 1 |
| Ho, WJ; Kordowitzki, P; Listijono, DR | 1 |
| Cheng, DY; Peng, F; Shen, Q; Xue, YP; Xue, YZ; Zhang, SJ; Zheng, YG | 1 |
| Chu, X; Raju, RP | 1 |
| Abdellatif, M; Kroemer, G; Sedej, S | 1 |
| Damgaard, MV; Mori, MAS; Peluso, A; Treebak, JT | 1 |
| Conlon, N; Ford, D | 1 |
| Arnold, KR; Barter, TT; Beasley, HK; Garza-Lopez, E; Hinton, A; Marshall, AG; McReynolds, MR; Morton, DJ; Phillips, MA; Vue, Z | 1 |
| Bertoldo, MJ; Campbell, JM; Gilchrist, RB; Goldys, EM; Goss, DM; Habibalahi, A; Ledger, WL; Mahbub, SB; Wu, LE | 1 |
| Pei, Z; Wang, F; Wang, K; Wang, L | 1 |
| Chini, CCS; Chini, EN; Cohen, RL; Kolumam, G; Liang Wong, Y; Mazdeh, DZ; Peclat, TR; Tarragó, MG; Thompson, KL; Warner, GM; Zavala-Solorio, J; Zhang, C | 1 |
| Chen, HZ; Dong, ZJ; Gao, L; Gu, HM; Hu, Z; Jiang, W; Ju, Z; Li, L; Liu, C; Ma, XR; Meng, Z; Peng, C; Shu, Y; Wang, DX; Wang, F; Wu, Y; Xiao, Y; Yang, C; Yao, K; Yin, Y; Zhang, Y; Zhao, JW; Zheng, SS; Zhu, X | 1 |
| Brotto, M; Manickam, R; Tipparaju, SM; Wagner, S | 1 |
| Lalam, SK; Soma, M | 1 |
| Li, J; Lu, J; Nadeeshani, H; Ying, T; Zhang, B | 1 |
| Chen, H; Chini, CCS; Chini, EN; Lopez, SA; Meyer, RG; Meyer-Ficca, ML; Swanson, CA; Thompson, KL; Tucker, AG; Wandersee, MK; Warner, GM; Zwerdling, AE | 1 |
| Cesanelli, L; Degens, H; Swaminathan, A; Venckunas, T | 1 |
| Kothari, D; Li, Y; Liang, J; Niu, K; Ru, M; Wang, R; Wang, W; Wu, X; Zhai, Z | 1 |
| Adams, TS; Antony, VB; Banerjee, S; Cui, H; Dey, T; Gomez, JL; Kaminski, N; Liu, G; Liu, RM; Sanders, YY; Thannickal, VJ; Xie, N | 1 |
| Anugula, S; Clark, P; Guimera, AM; Rasmussen, LJ; Shanley, DP; Wordsworth, J | 1 |
| Hoeks, J; Houtkooper, RH; Janssens, GE | 1 |
| Crane, ED; Crane, JD; Day, TA; Green, AE; Li, J; Menzies, KJ; Wong, W; Zhang, H | 1 |
| Gold, DA; Sinclair, DA | 1 |
| Canto, C; Cercillieux, A; Ciarlo, E; Giroud-Gerbetant, J; Jacot, G; Joffraud, M; Métairon, S; Ratajczak, J; Rumpler, M; Sambeat, A; Sanchez-Garcia, JL; Valera-Alberni, M; Zollinger, A | 1 |
| Conlon, NJ | 1 |
| Liu, B; Sun, S; Wang, M; Xia, X | 1 |
| An, Y; Chang, X; Fang, K; Liu, S; Zhang, N; Zhou, H; Zong, J | 1 |
| Kageyama, M; Kanou, M; Matsuyama, R; Nakajima, R; Omata, T; Yamana, K | 1 |
| Braidy, N; Helman, T | 1 |
| Chubanava, S; Treebak, JT | 1 |
| Kataura, T; Korolchuk, VI; Sarkar, S; Sedlackova, L | 1 |
| Feuz, MB; Meyer, RG; Meyer-Ficca, ML | 1 |
| Fukamizu, Y; Igarashi, M; Kadowaki, T; Kashiwabara, K; Miura, M; Nakagawa, T; Nakagawa-Nagahama, Y; Sakurai, T; Sato, T; Yaku, K; Yamauchi, T | 1 |
| Guan, M; Kuang, Z; Li, N; Li, X; Liu, C; Qian, Z; Shen, J; Tang, Y; Yang, L; Yang, Y; Zhan, Y | 1 |
| Araki, SI; Kitada, M; Koya, D | 1 |
| Bohr, VA; Chu, X; Claybourne, Q; Croteau, DL; Dan, X; Figueroa, DM; Gray, S; McDevitt, RA; Yang, B; Zhang, Y | 1 |
| Musi, N | 1 |
| Chakraborty, SS; Coen, PM; DeLany, JP; DeNicola, GM; Dutta, T; Falzone, A; Gardell, SJ; Kapoor, N; Mathew, M; Prieto-Farigua, N; Smith, SR; Ward, NP | 1 |
| Craighead, DH; Freeberg, KA; Martens, CR; Seals, DR; Udovich, CC | 1 |
| de Vogel-van den Bosch, J; Geurts, JMW; Grevendonk, L; Hoeks, J; Houtkooper, RH; Janssens, GE; Perez, RZ; Schomakers, BV; Schrauwen, P; van Weeghel, M | 1 |
| Baur, JA; de Cabo, R; Espinoza, SE; Khosla, S; Musi, N | 1 |
| Gong, JS; Liu, Y; Marshall, G; Shi, JS; Su, C; Xu, ZH | 1 |
| Baur, JA; Bhasin, S; Migaud, M; Musi, N; Seals, D | 1 |
| Blacher, E; Iweka, CA; Kara, N | 1 |
| Kang, S; Rathmann, A; Sauve, AA; Wang, Q; Yang, Y; Zhang, N | 1 |
| Arakawa, T; Ichikawa, K; Iitani, K; Iwasaki, Y; Mitsubayashi, K; Mori, H; Toma, K | 1 |
| Lu, HC; Park, JH; Yang, S | 1 |
| Andrys, C; Borska, L; Borsky, P; Byma, S; Fiala, Z; Holmannova, D; Kremlacek, J; Kucera, O; Parova, H; Rehacek, V; Svadlakova, T | 1 |
| Liu, S; Zhang, W | 1 |
| Hyeon, J; Kim, E; Kim, KP; Lee, HM; Lee, J; Lee, YI; Nam, CH; Park, HS; Shin, J | 1 |
| Chen, L; Chen, M; Hou, Y; Hu, M; Liu, R; Luan, J; Wang, P; Yu, Q | 1 |
| Dijk, F; Goddijn, M; Hamer, G; Houtkooper, RH; Janssens, GE; Mastenbroek, S; Schomakers, BV; Smits, MAJ; van Weeghel, M; Wever, EJM; Wüst, RCI | 1 |
| Chen, F; Chen, Y; Chen, YE; Chui, D; Cui, H; Dong, E; Du, J; Gao, Y; Ge, X; Guo, X; He, Q; Hu, G; Huang, Y; Ji, L; Li, K; Li, W; Liao, S; Liu, X; Meng, X; Pan, B; Shan, W; Shi, M; Sun, Z; Tian, D; Wang, Y; Xu, J; Xu, W; Xu, Y; Xue, J; Yang, J; Yao, C; Yu, W; Yu, Y; Zhan, R; Zhang, Q; Zhao, M; Zhao, X; Zheng, L; Zhou, B; Zhu, Y | 1 |
| Bu, T; Su, L; Sun, X; Zhang, Y | 1 |
| Akerman, I; Brenner, C; Burley, CV; Cartwright, DM; Doig, CL; Elhassan, YS; Fletcher, RS; Garten, A; Jenkinson, N; Kluckova, K; Lai, YC; Lavery, GG; Lucas, SJE; Manolopoulos, KN; Nightingale, P; Oakey, L; Philp, A; Schmidt, MS; Seabright, A; Tennant, DA; Wallis, GA; Wilson, M | 1 |
| Gulshan, M; Nakagawa, T; Okabe, K; Okamoto, H; Takatsu, K; Yaku, K | 1 |
| Fang, EF; Lautrup, S; Mattson, MP; Sinclair, DA | 1 |
| Hunt, M; Payne, BAI | 1 |
| Antoun, E; Barton, SJ; Charpagne, A; Civiletto, G; Cooper, C; Descombes, P; Fang Tan, P; Feige, JN; Feng, L; Forrester, T; Francis-Emmanuel, P; Garratt, ES; Giner, MP; Godfrey, KM; Green, CO; Karaz, S; Karnani, N; Kothandaraman, N; Leow, MK; Lillycrop, KA; Marquis, J; McFarlane, C; Metairon, S; Migliavacca, E; Ming Sim, C; Moco, S; Nelson, G; Ngo, S; Patel, HP; Pleasants, T; Raymond, F; Sayer, AA; Seng Chong, Y; Sheppard, A; Slater-Jefferies, J; Sonntag, T; Syddall, HE; Tay, SKH; Titcombe, P; Vaz, C; Westbury, LD; Wong, G; Yonghui, W | 1 |
| Braidy, N; Liu, Y | 1 |
| Aman, Y; Bergersen, LH; Brenner, C; Fang, EF; Frank, J; Gilmour, BC; Gudmundsrud, R; Holmøy, T; Hov, A; Lautrup, S; Nilsen, H; Omland, T; Røsjø, H; Storm-Mathisen, J; Søraas, A; Tysnes, OB; Tzoulis, C; Ziegler, M | 1 |
| Castro-Portuguez, R; Sutphin, GL | 1 |
| Araki, T; Bertoldo, MJ; Bustamante, S; Campbell, JM; Gilchrist, RB; Goldys, E; Goss, DM; Habibalahi, A; Ho, WJ; Homer, HA; Jin, XL; Kim, LJ; Lau, L; Le Couteur, DG; Li, C; Listijono, DR; Loh, WN; Mahbub, S; Maniam, J; Marinova, MB; Mikolaizak, AS; Morris, MJ; O'Neill, C; Richani, D; Riepsamen, AH; Selesniemi, K; Sinclair, DA; Turner, N; Walters, KA; Wong, ASA; Wu, LE; Wu, RM; Youngson, NA; Zhao, Y | 1 |
| Ramanathan, A; Sharma, R | 1 |
| Han, WH; Lemieux, H; Matthew, R; Sauvé, Y; Schneider, J | 1 |
| Bressac, L; Guerreiro, S; Privat, AL; Toulorge, D | 1 |
| Korolchuk, VI; Sedlackova, L | 1 |
| Kim, MS; Roh, E | 1 |
| Chen, W; Chen, X; Hu, Q; Huang, L; Ju, Z; Li, F; Li, T; Liu, R; Loscalzo, J; Qian, Y; Shi, M; Wang, A; Wang, C; Wang, H; Wang, Q; Yang, Y; Yao, J; Yue, X; Zhang, Y; Zhang, Z; Zhao, Y; Zhou, Y; Zhu, L; Zhu, X; Zou, Y; Zuo, F | 1 |
| Braidy, N; Bustamante, S; Caplan, GA; Clement, J; Jayasena, T; Sachdev, PS; Welschinger, R | 1 |
| Boriek, AM; Pardo, PS | 1 |
| Affinati, AH; Bass, J; Braun, R; Brenner, C; Cedernaes, J; Hong, H; Lee, C; Levine, DC; Omura, C; Peek, CB; Ramsey, KM; Schmidt, MS; Weidemann, BJ | 1 |
| Cong, L; Dai, S; Hsueh, AJ; Jin, H; Li, H; Luo, X; Shi, S; Sun, Y; Wang, H; Wang, Y; Yang, Q; Yao, G; Zhu, J | 1 |
| Berger, NA; Kincaid, JW | 1 |
| Denu, JM; Klein, MA | 1 |
| Almaliki, MS; Omran, HM | 1 |
| Allison, SJ; Griffiths, HBS; King, SJ; Williams, C | 1 |
| Choi, JY; Kang, BE; Ryu, D; Stein, S | 1 |
| Gentile, C; Lauria, A; Martorana, A | 1 |
| Mattson, MP | 1 |
| Fan, Y; Gong, X; He, S; Hu, Z; Jia, L; Li, Y; Liang, X; Lin, X; Liu, X; Shi, Y; Tang, H; Wang, H; Yang, L; Yang, Y; Zeng, S | 1 |
| Cui, Z; Gao, Q; Miao, Y; Rui, R; Xiong, B | 1 |
| Miller, R; Richards, GA; Wentzel, AR | 1 |
| Gao, W; Huang, C; Huber, PE; Li, C; Shen, G; Xie, N; Zhang, L; Zhou, X; Zou, B | 1 |
| McCully, KS | 3 |
| Basisty, N; Ben-Sahra, I; Brenner, C; Campisi, J; Covarrubias, AJ; Gibbs, E; Heckenbach, I; Ishihara, K; Iyer, SS; Kale, A; Kasler, HG; Kim, IJ; Kwok, R; Lee, YM; Lopez-Dominguez, JA; Newman, J; Ott, M; Perrone, R; Pisco, AO; Quake, SR; Riley, R; Scheibye-Knudsen, M; Schilling, B; Schmidt, MS; Shin, KO; Silva, E; Verdin, E; Vitangcol, K; Wiley, CD; Wong, HS; Wu, Q | 1 |
| Agorrody, G; Baker, DJ; Baur, JA; Chellappa, K; Childs, BG; Chini, CCS; Chini, EN; Clarke, S; Dang, K; De Cecco, M; de Oliveira, GC; Espindola-Netto, JM; Gomez, LS; Hogan, KA; Jankowski, C; Kanamori, KS; Kashyap, S; Kirkland, AL; Kirkland, JL; McReynolds, MR; Peclat, TR; Puranik, AS; Rabinowitz, JD; Sedivy, JM; Tarragó, MG; Tchkonia, T; Thompson, KL; van Deursen, JM; van Schooten, W; Vidal, P; Warner, GM; Witte, MA | 1 |
| Covarrubias, AJ; Grozio, A; Perrone, R; Verdin, E | 1 |
| Bartling, B; Pliquett, RU; Schwarzmann, L; Simm, A | 1 |
| Bae, SJ; Dao, T; Gariani, K; Green, AE; Ha, KT; Kim, YA; Lee, MR; Menzies, KJ; Ryu, D | 1 |
| Kovač, V; Milisav, I; Poljsak, B | 1 |
| Auwerx, J; de Lima, TI; Li, H; Oh, CM; Romani, M; Shong, M; Sorrentino, V; Zhang, H | 1 |
| Khodorkovskiy, M; Kropotov, A; Kulikova, V; Migaud, ME; Nerinovski, K; Nikiforov, A; Solovjeva, L; Sudnitsyna, J; Svetlova, M; Yakimov, A; Ziegler, M | 1 |
| Blanc, J; Burkin, D; Coletti, D; Deloux, R; Karoui, A; Lavery, G; Li, Z; Mericskay, M; Mougenot, N; Tannous, C | 1 |
| Chen, Z; Liang, Y; Tanzi, RE; Wang, C; Wey, HY; Xu, Y; Zhang, C | 1 |
| Bessho, Y; Khaidizar, FD; Nakahata, Y | 1 |
| Seibert, D; Wysocki, K | 1 |
| Cao, B; Chen, X; Das Gupta, K; Deshpande, N; Fulton, M; Hatwell-Humble, J; Heazlewood, CK; Heazlewood, SY; Kapetanovic, R; Kraus, F; Li, J; Naval-Sanchez, M; Nefzger, CM; Nguyen, Q; Nilsson, SK; Parton, RG; Pham, T; Polo, JM; Rae, J; Ryan, MT; Schröder, J; Sun, X; Sun, YBY; Sweet, MJ; Williams, B; Yari, H | 1 |
| Baden, P; Deleidi, M; Pérez, MJ | 1 |
| Allen, SP; Allsop, J; Gerou, M; Hall, B; Kolb, SJ; Meyer, K; Shaw, PJ; Woof, R | 1 |
| Cen, Y; Curry, A; White, D | 1 |
| Ji, LL; Yeo, D | 1 |
| Chen, D; Montllor-Albalate, C; Song, Z | 1 |
| Li, C; Wu, LE | 1 |
| Aravind, L; Bonkowski, MS; Gorbunova, V; Hubbard, BP; Li, J; Ling, AJ; Lou, Z; Moniot, S; Qin, B; Rajman, LA; Sinclair, DA; Steegborn, C; Zhang, D | 1 |
| Chaturvedi, P; Tyagi, SC | 1 |
| Larrick, JW; Mendelsohn, AR | 3 |
| Cho, YS; Chung, KS; Kim, JY; Kwon, Y; Mun, SJ; Ryu, JS; Son, MJ | 1 |
| Fischer, F; Jaspers, S; Mellem, D; Pagel-Wolff, S; Rübhausen, MA; Sattler, M; Wenck, H | 1 |
| Osborne, B; Samsudeen, AF; Sultani, G; Turner, N | 1 |
| Poljsak, B | 1 |
| Hoek, JB; Rottenberg, H | 1 |
| Fan, X; Gao, Y; Gaur, U; Li, D; Lian, T; Sun, B; Tu, J; Yang, D; Yang, M | 1 |
| Djouder, N; Garrido, A | 1 |
| Bee, L; Benitah, SA; Brenner, C; Masri, S; Peixoto, FO; Sassone-Corsi, P; Sato, S; Schmidt, MS; Solanas, G; Symeonidi, A | 1 |
| Bohr, VA; Croteau, DL; Demarest, TG; Fang, EF; Hou, Y; Lautrup, S; Mattson, MP | 1 |
| Braidy, N; Grant, R; Sachdev, PS | 1 |
| Baur, JA; Imai, SI; Yoshino, J | 1 |
| Ying, W; Zhang, M | 1 |
| Nakagawa, T; Okabe, K; Yaku, K | 2 |
| Chini, CCS; Chini, EN; de Oliveira, GC; Espindola Netto, JM; van Schooten, W | 1 |
| Goody, MF; Henry, CA | 1 |
| Arany, Z; Bonkowski, MS; Das, A; Guarente, L; Huang, GX; Hung, TT; Igarashi, M; Joshi, S; Kang, MJ; Kim, LJ; Lee, B; Li, C; Longchamp, A; Lu, Y; Mitchell, JR; Osborne, B; Schultz, MB; Sinclair, DA; Treviño-Villarreal, JH; Turner, N; Williams, EO; Wu, LE | 1 |
| Cui, J; Fan, R; Huang, Y; Qian, X; Ren, F; Wang, Q; Wei, L; Xiong, X; Zhao, B | 1 |
| Milisav, I; Poljsak, B | 1 |
| Bartoli, M; Fuller, J; Jadeja, RN; Jones, MA; Joseph, E; Martin, PM; Powell, FL; Thounaojam, MC | 1 |
| Admed, B; Ansah, TA; Lai, CQ; LeRoith, T; Li, J; Liu, D; Ordovás, JM; Parnell, LD; Si, H; Wang, X; Zhang, L | 1 |
| Braidy, N; Clement, J; Poljak, A; Sachdev, P; Wong, M | 1 |
| Kane, AE; Sinclair, DA | 1 |
| Andreasson, KI; Bernstein, D; Contrepois, K; Coronado, M; Dove, C; Joshi, AU; Lee, BA; Liu, L; Majeti, R; Mhatre, S; Migaud, M; Minhas, PS; Mochly-Rosen, D; Moon, PK; Rabinowitz, JD; Snyder, MP; Wang, Q | 1 |
| de Medina, P | 1 |
| Gou, B; He, C; Li, Y; Song, M; Wang, Y | 1 |
| Brewer, GJ; Digman, MA; Dong, Y | 1 |
| Badalzadeh, R; Hosseini, L; Mahmoudi, J; Vafaee, MS | 1 |
| Balasubramanian, P; Baur, JA; Csiszar, A; Farkas, E; Kiss, T; Tarantini, S; Ungvari, Z; Yabluchanskiy, A | 1 |
| Guarente, L; Igarashi, M; Jaksch, F; Kadowaki, T; Miura, M; Williams, E; Yamauchi, T | 1 |
| Chini, C; Chini, E; Hogan, KA; Kirkland, JL; Peclat, TR; Tarragó, MG; Tchkonia, T; Warner, GM | 1 |
| Savitz, J | 1 |
| Agerholm, M; Brandauer, J; Consitt, LA; de Guia, RM; Helge, JW; Houmard, JA; Larsen, S; Nielsen, TS; Søgaard, D; Treebak, JT | 1 |
| Brewer, GJ; Dong, Y | 1 |
| Brewer, GJ; Digman, MA; Dong, Y; Sameni, S | 1 |
| Guarente, L; Herskovits, AZ | 1 |
| Chen, D; Fang, N; Li, H; Li, L; Yao, Y; Zhou, C | 1 |
| Auwerx, J; Cantó, C; Guarente, L; Houtkooper, RH; Jo, YS; Katsyuba, E; Mottis, A; Mouchiroud, L; Moullan, N; Ryu, D; Schoonjans, K; Viswanathan, M | 1 |
| Brasili, E; Capuani, G; Finamore, A; Marini, F; Mengheri, E; Miccheli, A; Roselli, M; Sciubba, F; Tomassini, A | 1 |
| Brewer, GJ; Ghosh, D; LeVault, KR | 1 |
| Imai, S; Yoshino, J | 1 |
| Della-Morte, D; Ricordi, C; Rundek, T | 1 |
| Agadzhanyan, ZS; Dmitriev, LF; Doroshchuk, AD; Shiryaeva, YK | 1 |
| Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Jayasena, T; Mansour, H; Poljak, A; Sachdev, P; Smythe, G | 1 |
| Bell, EL; de Cabo, R; Gomes, AP; Hubbard, BP; Ling, AJ; Mercken, EM; Montgomery, MK; Moslehi, JJ; Palmeira, CM; Price, NL; Rajman, L; Rolo, AP; Sinclair, DA; Teodoro, JS; Turner, N; White, JP; Wrann, CD | 1 |
| Verdin, E | 2 |
| Harrington, M | 1 |
| Croft, KD; Grant, R; Guest, J; Mori, TA | 1 |
| Denu, JM; Prolla, TA | 1 |
| Alarcón, T; Joven, J; Menendez, JA | 1 |
| Christian, BE; Shadel, GS | 1 |
| Laszki-Szcząchor, K; Polak-Jonkisz, D; Rehan, L; Sobieszczańska, M | 1 |
| Lucia, A; Pareja-Galeano, H; Sanchis-Gomar, F | 1 |
| Guarente, L; Imai, S | 1 |
| Oblong, JE | 1 |
| Michan, S | 1 |
| Hur, JH; Stork, DA; Walker, DW | 1 |
| Guarente, L; Nakagawa, T | 1 |
| Galeffi, F; Sadgrove, MP; Shetty, PK; Turner, DA | 1 |
| Sobol, RW | 1 |
| Chen, W; Lee, BY; Lu, M; Ugurbil, K; Zhu, XH | 1 |
| Ahlqvist, KJ; Hämäläinen, RH; Suomalainen, A | 1 |
| Gaignard, P; Guennoun, R; Liere, P; Pianos, A; Savouroux, S; Schumacher, M; Slama, A; Thérond, P | 1 |
| Chery, A; Durand, S; Enot, DP; Galluzzi, L; Kroemer, G; Madeo, F; Niso-Santano, M; Pietrocola, F; Vacchelli, E | 1 |
| Auwerx, J; Cantó, C; Menzies, KJ | 1 |
| Beal, MF; Clark-Matott, J; Dai, Y; Ma, X; Safdar, A; Saleem, A; Shurubor, Y; Simon, DK; Tarnopolsky, M | 1 |
| Bramlett, HM; Brand, FJ; de Rivero Vaccari, JP; Patel, HH; Perez-Pinzon, MA; Raval, AP | 1 |
| Caspary, DM; Choi, HW; Llano, DA; Ravindra, A; Stebbings, KA; Turner, JG | 1 |
| Szukiewicz, D; Wątroba, M | 1 |
| Yamaguchi, S; Yoshino, J | 1 |
| Li, WL; Miao, CY; Wang, SN; Xu, TY | 1 |
| Fan, MB; Guan, YF; Hua, X; Li, GQ; Li, ZY; Liu, J; Miao, CY; Song, J; Wang, P; Xu, TY; Yang, X; Zhou, CC | 1 |
| Ido, Y | 1 |
| Baar, EL; Denu, JM; Dhillon, RS; Eliceiri, KW; Fernandez, LA; Gregg, T; Kimple, ME; Lamming, DW; Merrins, MJ; Poudel, C; Rogers, JD; Schmidt, BA; Sdao, SM; Truchan, NA | 1 |
| Schultz, MB; Sinclair, DA | 1 |
| Campisi, J; Wiley, CD | 1 |
| Camacho-Pereira, J; Chini, CCS; Chini, EN; Escande, C; Galina, A; Nin, V; Puranik, AS; Reid, JM; Schoon, RA; Tarragó, MG; Warner, GM | 1 |
| Cho, YS; Kwon, Y; Son, MJ; Son, T | 1 |
| Feng, Y; Ni, L; Wang, H; Wen, DT; Zhang, M; Zheng, L | 1 |
| Baur, JA; Chellappa, K; Davila, A; Davis, JG; Dellinger, RW; Frederick, DW; Gosai, SJ; Gregory, BD; Khurana, TS; Liu, L; Loro, E; Migaud, ME; Mourkioti, F; Nakamaru-Ogiso, E; Quinn, WJ; Rabinowitz, JD; Redpath, P; Silverman, IM; Tichy, ED | 1 |
| Bonkowski, MS; Sinclair, DA | 1 |
| Andersson, U; Buler, M; Hakkola, J | 1 |
| Kawamura, T; Mori, N; Shibata, K | 1 |
| Guarente, L | 3 |
| Chini, CCS; Chini, EN; Tarragó, MG | 1 |
| Haigis, MC; Santos, D; van de Ven, RAH | 1 |
| Hekimi, S; Lapointe, J | 1 |
| Olgun, A | 1 |
| Hagopian, K; Ramsey, JJ; Weindruch, R | 1 |
| Imai, S | 7 |
| Chen, S; Gali, RR; Ghosh, S; Grosu, P; Hanover, JA; Shi, Y; Whetstine, JR | 1 |
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| Braidy, N; Grant, R; Guillemin, GJ; Massudi, H | 1 |
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| Mayevsky, A; Yoles, E; Zarchin, N; Zurovsky, Y | 1 |
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127 review(s) available for nad and Aging
| Article | Year |
|---|---|
Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?
Topics: Aging; Dietary Supplements; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide | 2021 |
The balance between NAD
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Armadillo Domain Proteins; Cognitive Dysfunction; Cytoskeletal Proteins; Drug Discovery; Humans; Metabolic Diseases; NAD; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Signal Transduction; Sirtuins | 2021 |
Biological synthesis of nicotinamide mononucleotide.
Topics: Adenosine; Adenosine Triphosphate; Aging; Cytokines; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Nucleotides; Ribose; Xylose | 2021 |
Regulation of NAD
Topics: Aging; Animals; Cardiovascular Diseases; Diabetes Mellitus; Humans; Mitochondria; NAD; Signal Transduction | 2022 |
Age-Dependent Decline of NAD
Topics: Aged; Aging; Animals; Gene Expression Regulation; Humans; NAD; Species Specificity | 2021 |
A systems-approach to NAD+ restoration.
Topics: Aging; Humans; NAD; Niacinamide; Reproducibility of Results | 2022 |
NAD
Topics: Aging; Animals; Epigenesis, Genetic; Mice; Muscle, Skeletal; Muscular Diseases; NAD; Poly(ADP-ribose) Polymerases | 2022 |
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.
Topics: Aging; Animals; Chronic Disease; Humans; Longevity; Mice; NAD; Nicotinamide Mononucleotide | 2022 |
Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.
Topics: Aged; Aging; Cognitive Dysfunction; Humans; Longevity; NAD; Nicotinamide Mononucleotide | 2022 |
Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing.
Topics: Aging; AMP-Activated Protein Kinases; Genomic Instability; Humans; Inflammation; Mitochondria; NAD; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Sirtuin 1 | 2022 |
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders.
Topics: Aging; Dietary Supplements; Humans; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide | 2023 |
Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content.
Topics: Aged; Aging; Exercise; Humans; Muscle, Skeletal; NAD; Oxidation-Reduction | 2023 |
Beyond Pellagra-Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease.
Topics: Aging; Clinical Relevance; Humans; NAD; Neoplasms; Pellagra | 2023 |
The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research.
Topics: ADP-ribosyl Cyclase 1; Aging; Humans; Inflammation; Metabolic Diseases; NAD | 2023 |
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.
Topics: Aged; Aging; Dietary Supplements; Humans; NAD; Nicotinamide Mononucleotide; Obesity | 2023 |
Technology and functional insights into the nicotinamide mononucleotide for human health.
Topics: Aging; Humans; NAD; Nicotinamide Mononucleotide; Technology | 2023 |
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.
Topics: Aged; Aging; Biology; Fatty Liver; Humans; NAD; Neurodegenerative Diseases | 2023 |
Chrono-Gerontology: Integrating Circadian Rhythms and Aging in Stroke Research.
Topics: Aged; Aging; Circadian Rhythm; Humans; Ischemia; NAD; Stroke | 2023 |
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases.
Topics: Aging; Animals; Axons; Energy Metabolism; Glucose; Humans; NAD; Neurodegenerative Diseases | 2023 |
NAD
Topics: Aging; Eye; Humans; Macular Degeneration; NAD; Quality of Life | 2023 |
Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.
Topics: Aging; Exercise; Humans; Muscle, Skeletal; NAD; Nicotinamide Phosphoribosyltransferase | 2023 |
NAD
Topics: Aging; Animals; Brain; Cell Line; Humans; Mice; NAD; Neurodegenerative Diseases; Neurons; Rats | 2019 |
Mitochondria and ageing with HIV.
Topics: Aged; Aged, 80 and over; Aging; Anti-HIV Agents; Biomarkers; Chronic Disease; DNA, Mitochondrial; Flow Cytometry; Frailty; HIV Infections; Humans; Magnetic Resonance Spectroscopy; Mitochondria; NAD; Oxidative Phosphorylation; Reactive Oxygen Species; Reverse Transcriptase Inhibitors; Spectroscopy, Near-Infrared | 2020 |
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
Topics: Aging; Animals; Humans; Inflammation; Mice; NAD; Neurodegenerative Diseases; Niacinamide; Nicotinamide Mononucleotide; Oxidative Stress; Pyridinium Compounds; Rats; Risk Assessment | 2020 |
Targeting NAD
Topics: Aging; Humans; NAD; Translational Research, Biomedical | 2020 |
Kynurenine pathway, NAD
Topics: Aging; Animals; Brain; Humans; Kynurenine; Longevity; Metabolic Networks and Pathways; Mice; Mitochondria; Mitophagy; NAD; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Tryptophan | 2020 |
The Aging Metabolome-Biomarkers to Hub Metabolites.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Biomarkers; Citric Acid Cycle; DNA Damage; Epigenesis, Genetic; Humans; Ketoglutaric Acids; Metabolic Networks and Pathways; Metabolome; Metabolomics; NAD; NADP | 2020 |
CD38 in Neurodegeneration and Neuroinflammation.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Astrocytes; Brain; Humans; Membrane Glycoproteins; Mice; Mice, Knockout; Microglia; NAD; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents | 2020 |
The crosstalk of NAD, ROS and autophagy in cellular health and ageing.
Topics: Aging; Autophagy; Humans; NAD; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2020 |
Hypothalamic NAD
Topics: Aged; Aging; Chronobiology Disorders; Circadian Rhythm; Energy Metabolism; Humans; Hypothalamus; NAD; Obesity; Sirtuins | 2020 |
SIRT1 Regulation in Ageing and Obesity.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; DNA Damage; Exercise; Gene Expression Regulation; Humans; Hypoxia; Inflammation; Insulin Resistance; Metabolic Syndrome; Mice; NAD; Obesity; Oxidative Stress; Protein Domains; Protein Processing, Post-Translational; Risk; Sirtuin 1; Stress, Mechanical | 2020 |
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
Topics: Aging; Amino Acid Substitution; Animals; Catalysis; Chromatin; DNA Repair; Homeostasis; Humans; Longevity; NAD; Neoplasms; Protein Conformation; Sirtuins; Small Molecule Libraries | 2020 |
Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis.
Topics: Aging; Autoimmune Diseases; Betacoronavirus; Coronavirus Infections; COVID-19; Cytokines; Humans; NAD; Pandemics; Pneumonia, Viral; Poly (ADP-Ribose) Polymerase-1; SARS-CoV-2; Telomere Shortening | 2020 |
Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target.
Topics: Aging; Animals; Catalysis; Cytokines; Gene Expression Profiling; Glycolysis; Humans; Lactate Dehydrogenase 5; Mitochondria; NAD; Neoplasms; Nicotinamide Phosphoribosyltransferase; Oxidation-Reduction; Poly (ADP-Ribose) Polymerase-1; Signal Transduction; Sirtuins; Tumor Microenvironment | 2020 |
Implications of NAD
Topics: ADP-ribosyl Cyclase; Aging; Animals; Biosynthetic Pathways; Carboxy-Lyases; Clinical Trials as Topic; Enzyme Inhibitors; Gastrointestinal Microbiome; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Probiotics; Pyridinium Compounds; Sirtuins; Translational Research, Biomedical | 2020 |
Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching.
Topics: Aging; Alzheimer Disease; Animals; Diet, Ketogenic; Fasting; GABAergic Neurons; Humans; Interneurons; Ketones; NAD; Nerve Net | 2020 |
NAD
Topics: Aging; Cyclic ADP-Ribose; Humans; Metabolic Diseases; NAD; NADP; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction | 2020 |
Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
Topics: Aging; Animals; Arteriosclerosis; Cholesterol; Diterpenes; Homocysteine; Humans; Mitochondria; NAD; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Phosphorylation; Permeability; Squalene; Tocotrienols; Vitamin B 12 | 2020 |
NAD
Topics: Aging; Animals; Cell Physiological Phenomena; Energy Metabolism; Humans; Metabolic Networks and Pathways; Mitochondria; NAD | 2021 |
Sarcopenia and Muscle Aging: A Brief Overview.
Topics: Aged; Aging; Animals; Coumarins; Gastrointestinal Microbiome; Humans; Mitochondria; Mitophagy; Muscle, Skeletal; NAD; Sarcopenia | 2020 |
Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD
Topics: Aging; Animals; Caloric Restriction; Circadian Rhythm; Cold Temperature; Cytokines; DNA Repair; Fasting; Healthy Lifestyle; Heat-Shock Response; Humans; Inflammation; Life Style; NAD; Nicotinamide Phosphoribosyltransferase; Signal Transduction; Sirtuins; Sleep | 2020 |
Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process.
Topics: Aging; Animals; Humans; NAD; Nicotinamide Phosphoribosyltransferase | 2021 |
Risks and rewards of targeting NAD
Topics: Aging; Animals; Biosynthetic Pathways; Humans; Molecular Targeted Therapy; NAD; Nervous System Diseases; Risk Assessment | 2021 |
NAD
Topics: Aging; Animals; Antioxidants; Heart; Humans; Mice; Mitochondria; Muscle, Skeletal; Muscular Dystrophies; Myocytes, Cardiac; NAD; Oxidation-Reduction | 2018 |
NAD
Topics: Aging; Animals; Homeostasis; Humans; NAD; Neoplasms; Neurodegenerative Diseases | 2017 |
NAMPT-Mediated NAD Biosynthesis as the Internal Timing Mechanism: In NAD+ World, Time Is Running in Its Own Way.
Topics: Aging; Animals; Biological Clocks; Cell Cycle; Circadian Rhythm; Cytokines; Humans; Mice; NAD; Nicotinamide Phosphoribosyltransferase; Rats; Signal Transduction; Sirtuin 1 | 2018 |
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore.
Topics: Aging; Animals; Calcium; Caloric Restriction; Cyclophilins; Gene Expression Regulation; Humans; Ischemic Preconditioning; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; NAD; Neurodegenerative Diseases; Oxidation-Reduction; Reactive Oxygen Species; Reperfusion Injury | 2017 |
NAD
Topics: Aging; Humans; Incidence; Life Expectancy; Longevity; NAD; Neoplasms; Niacinamide; Nicotinamide Mononucleotide; Vitamin B Complex | 2017 |
NAD
Topics: Aging; Alzheimer Disease; Animals; Cardiovascular Diseases; Energy Metabolism; Humans; Muscular Atrophy; NAD; Parkinson Disease | 2017 |
Nicotinamide adenine dinucleotide and its related precursors for the treatment of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Brain; Central Nervous System; Dietary Supplements; Humans; Memory; NAD; Neuroprotective Agents; Oxidative Stress | 2018 |
NAD
Topics: Aging; Animals; Humans; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds | 2018 |
NAD
Topics: Aging; Animals; Brain Ischemia; Diabetes Mellitus; Humans; Myocardial Ischemia; NAD; Signal Transduction | 2019 |
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Antibodies; Humans; Molecular Targeted Therapy; NAD; NAD+ Nucleosidase; Neoplasms; Small Molecule Libraries | 2018 |
A need for NAD+ in muscle development, homeostasis, and aging.
Topics: Aging; Animals; Homeostasis; Humans; Intracellular Space; Muscle Development; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pyridinium Compounds; Regeneration; Signal Transduction | 2018 |
NAD metabolism: Implications in aging and longevity.
Topics: Aging; Animals; Humans; Longevity; NAD; Neoplasms; Neurodegenerative Diseases | 2018 |
Sirtuins and NAD
Topics: Age Factors; Aging; Animals; Cardiovascular Diseases; Cardiovascular System; Enzyme Activation; Enzyme Activators; Humans; Metabolic Diseases; NAD; Sirtuins; Up-Regulation | 2018 |
Topics: Aging; Animals; Atherosclerosis; Calcium; Cellular Senescence; Dementia; Homocysteine; Humans; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; NAD; Nitric Oxide; Oxidative Phosphorylation; Telomere | 2018 |
Mitochondrial regulation of cardiac aging.
Topics: Aging; Animals; DNA, Mitochondrial; Heart; Heart Diseases; Humans; Mitochondria, Heart; Mitophagy; Mutation; Myocardium; NAD; Reactive Oxygen Species; Sirtuins; Unfolded Protein Response | 2019 |
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions.
Topics: Aging; Drug Discovery; Humans; Ischemia; Mitochondria; NAD; Niacinamide; Nicotinamide Mononucleotide; Pyridinium Compounds | 2019 |
Role of endothelial NAD
Topics: Age Factors; Aging; Animals; Cellular Senescence; Endothelium, Vascular; Energy Metabolism; Humans; NAD; Oxidative Stress; Signal Transduction; Vascular Diseases | 2019 |
The kynurenine pathway: a finger in every pie.
Topics: Aging; Animals; Energy Metabolism; Humans; Kynurenine; Mental Disorders; NAD; Neurodegenerative Diseases; Signal Transduction; Tryptophan | 2020 |
Interacting NAD
Topics: Aging; Animals; Cellular Senescence; Humans; Inflammation; NAD | 2019 |
Sirtuin deacetylases in neurodegenerative diseases of aging.
Topics: Aging; Caloric Restriction; Energy Metabolism; Histone Deacetylases; Humans; NAD; Neurodegenerative Diseases; Sirtuins | 2013 |
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing.
Topics: Aging; Animals; Humans; Insulin; Insulin Resistance; Insulin Secretion; Metabolism; NAD; Nicotinamide Phosphoribosyltransferase; Nutritional Status; Sirtuin 1 | 2013 |
Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels.
Topics: Aging; Animals; Cell Nucleus; Humans; Mitochondria; Models, Biological; Muscle, Skeletal; NAD | 2014 |
SIRT1 and NAD as regulators of ageing.
Topics: Aging; Animals; Circadian Rhythm; Histone Deacetylases; Humans; Metabolic Networks and Pathways; Models, Biological; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1 | 2014 |
NAD+ and sirtuins in aging and disease.
Topics: Aging; Animals; Circadian Rhythm; Disease; Humans; Mitochondria; NAD; Sirtuins | 2014 |
The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging.
Topics: Aging; Energy Metabolism; Glycolysis; Humans; Metabolome; NAD; Niacinamide; Oxidative Phosphorylation; Oxidative Stress; Skin; Ultraviolet Rays | 2014 |
Calorie restriction and NAD⁺/sirtuin counteract the hallmarks of aging.
Topics: Aging; Caloric Restriction; Epigenesis, Genetic; Genomic Instability; Humans; Models, Genetic; NAD; Signal Transduction; Sirtuins; Telomere Shortening | 2014 |
Complex-I-ty in aging.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drosophila melanogaster; Drosophila Proteins; Electron Transport Complex I; Humans; Mitochondria; Mitochondrial Proteins; NAD | 2014 |
Stem cells, mitochondria and aging.
Topics: Aging; Animals; Homeostasis; Humans; Mitochondria; NAD; Reactive Oxygen Species; Sirtuin 3; Stem Cells | 2015 |
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.
Topics: Aging; Animals; Cell Nucleus; Energy Metabolism; Homeostasis; Humans; Metabolic Diseases; Mitochondria; Molecular Targeted Therapy; NAD; Neoplasms; Neurodegenerative Diseases; Poly(ADP-ribose) Polymerases; Sirtuins | 2015 |
The role of sirtuins in aging and age-related diseases.
Topics: Aging; Animals; Disease; Humans; Models, Biological; NAD; Sirtuins | 2016 |
[The pathophysiological importance and therapeutic potential of NAD+ biosynthesis in age-related diseases].
Topics: Aging; Animals; Feedback, Physiological; Humans; Metabolic Diseases; NAD; Neoplasms | 2015 |
NAD⁺ in aging, metabolism, and neurodegeneration.
Topics: Aging; Biosynthetic Pathways; Diabetes Mellitus, Type 2; DNA Damage; Fatty Liver; Humans; Mitochondria; NAD; Neurodegenerative Diseases; Obesity; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Sirtuins | 2015 |
Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.
Topics: Aging; Animals; Humans; NAD; Nervous System Diseases; Neurogenesis; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase | 2016 |
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
Topics: Aging; AMP-Activated Protein Kinases; Animals; C-Peptide; Diabetes Complications; Diabetic Angiopathies; Disease Models, Animal; Epigenesis, Genetic; Feedback, Physiological; Forkhead Box Protein O3; Humans; Hypoxia; Insulin Resistance; NAD; Oxidation-Reduction; Oxidative Stress; Signal Transduction; Sirtuin 1 | 2016 |
From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.
Topics: Aging; Animals; Autophagy; Cellular Senescence; Humans; Mitochondria; NAD; Signal Transduction | 2016 |
Slowing ageing by design: the rise of NAD
Topics: Aging; Allosteric Regulation; Animals; Clinical Trials as Topic; Enzyme Activators; Humans; NAD; Resveratrol; Sirtuins; Stilbenes | 2016 |
Who watches the watchmen? Regulation of the expression and activity of sirtuins.
Topics: Aging; Animals; Humans; MicroRNAs; NAD; Oxidative Stress; Protein Processing, Post-Translational; Sirtuins | 2016 |
NAD and the aging process: Role in life, death and everything in between.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Armadillo Domain Proteins; Caloric Restriction; Cyclic ADP-Ribose; Cytoskeletal Proteins; Humans; Membrane Glycoproteins; Mitochondria; NAD; NADP; Oxidation-Reduction; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Signal Transduction; Sirtuins | 2017 |
Mitochondrial Sirtuins and Molecular Mechanisms of Aging.
Topics: Aging; Animals; Hearing Loss; Humans; Mitochondria; NAD; Neurodegenerative Diseases; Protein Interaction Maps; Sirtuins; Stress, Physiological | 2017 |
The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance.
Topics: Aging; Animals; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuins | 2009 |
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.
Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1; Sirtuins | 2009 |
From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian Sirt1 and systemic NAD biosynthesis.
Topics: Aging; Animals; Cellular Senescence; Gene Expression Regulation; Heterochromatin; Humans; Models, Biological; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1 | 2009 |
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty.
Topics: Aging; Animals; Caloric Restriction; Energy Metabolism; Humans; Longevity; Mice; Models, Animal; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1; Sirtuins | 2009 |
Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.
Topics: Aging; Animals; Caloric Restriction; Gene Expression; Humans; Longevity; Models, Biological; NAD; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Stress, Physiological; Telomere | 2010 |
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging.
Topics: Aging; Animals; ARNTL Transcription Factors; Circadian Rhythm; CLOCK Proteins; Feedback, Physiological; Humans; Models, Biological; NAD; Signal Transduction; Sirtuins | 2010 |
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis.
Topics: Aging; Animals; Drug Design; Enzyme Activation; Flavonoids; Humans; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Phenols; Polyphenols; Sirtuins; Small Molecule Libraries | 2010 |
CYB5R3: a key player in aerobic metabolism and aging?
Topics: Aging; Animals; Cytochrome-B(5) Reductase; Energy Metabolism; Humans; NAD; Sirtuins | 2009 |
Vitamin B3, the nicotinamide adenine dinucleotides and aging.
Topics: ADP Ribose Transferases; Aging; Animals; Apoptosis; Cell Cycle; Cell Physiological Phenomena; DNA Damage; Energy Metabolism; Humans; NAD; Niacinamide; Oxidation-Reduction; Signal Transduction; Sirtuins | 2010 |
Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation.
Topics: Aging; Gene Expression Regulation; Humans; Mitochondria; NAD; Reactive Oxygen Species | 2010 |
Sirtuin family: a link to metabolic signaling and senescence.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Humans; NAD; Resveratrol; Signal Transduction; Sirtuins; Stilbenes | 2010 |
Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world.
Topics: Aging; Cytokines; Energy Metabolism; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1 | 2010 |
Mitochondrial complex I: a central regulator of the aging process.
Topics: Aging; Animals; DNA Damage; Drosophila melanogaster; Electron Transport Complex I; Mitochondria; NAD; Reactive Oxygen Species | 2011 |
NMNAT expression and its relation to NAD metabolism.
Topics: Aging; Amino Acid Sequence; Animals; Disease; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; NAD; Nicotinamide-Nucleotide Adenylyltransferase | 2011 |
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis.
Topics: Aging; Animals; Humans; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1 | 2011 |
NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns.
Topics: Aging; Animals; Cell Death; Cell Membrane; DNA Repair; Energy Metabolism; Enzyme Activation; Humans; Kynurenine; Mammals; NAD; Neurodegenerative Diseases; Oxidative Stress; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sirtuins | 2012 |
Sirtuins as regulators of metabolism and healthspan.
Topics: Aging; Animals; Energy Metabolism; Glucose; Histones; Homeostasis; Humans; Insulin; Insulin Secretion; Lipid Metabolism; Longevity; Multigene Family; NAD; Phylogeny; Protein Processing, Post-Translational; Resveratrol; Sirtuins; Stilbenes | 2012 |
Glial hemichannels and their involvement in aging and neurodegenerative diseases.
Topics: Adenosine Triphosphate; Aging; Astrocytes; Calcium; Cannabinoids; Central Nervous System; Connexin 43; Connexins; Dinoprostone; Glucose; Glutamic Acid; Humans; Inflammation; Interleukin-1beta; Ion Channels; NAD; Nerve Degeneration; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurons; Oligodendroglia; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
Overview of pyridine nucleotides review series.
Topics: Aging; Animals; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Humans; NAD; NADP; Oxidative Stress | 2012 |
SIRT1 in metabolic syndrome: where to target matters.
Topics: Aging; Animals; Cardiovascular Diseases; Exercise; Glucose; Humans; Lipid Metabolism; Metabolic Syndrome; Muscle, Skeletal; NAD; Organ Specificity; Protein Structure, Tertiary; Sirtuin 1 | 2012 |
Mitochondrial metabolism, sirtuins, and aging.
Topics: Aging; Animals; Humans; Mitochondria; Mitochondrial Proteins; NAD; Sirtuins | 2012 |
Towards elucidating the role of SirT1 in osteoarthritis.
Topics: Aged; Aggrecans; Aging; Animals; Biomechanical Phenomena; Cartilage, Articular; Cell Survival; Chondrocytes; Cytokines; Epigenesis, Genetic; Extracellular Matrix; Female; Histones; Humans; Male; Middle Aged; NAD; Nicotinamide Phosphoribosyltransferase; Osteoarthritis; Sirtuin 1 | 2013 |
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.
Topics: Aging; Animals; Eukaryotic Cells; Genes, Regulator; Humans; Longevity; Metabolic Diseases; NAD; Sirtuins | 2003 |
THE BIOLOGICAL ROLE OF ENZYME CHANGES IN THE AGING OF THE ORGANISM.
Topics: Acid Phosphatase; Aging; Alkaline Phosphatase; Enzymes; Erythrocytes; Geriatrics; Metabolism; Methemoglobinemia; NAD; Nucleotides; Pyrophosphatases; Research | 1964 |
THE CATALYTIC ENVIRONMENT AND ITS BIOLOGICAL IMPLICATIONS.
Topics: Adaptation, Physiological; Aging; Catalysis; Enzymes; Growth; Humans; Metabolism; NAD; NADP; Nutritional Physiological Phenomena; Nutritional Sciences; Proteins; Regeneration | 1964 |
Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide.
Topics: Aging; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Caspases; Cell Survival; Endothelial Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Mitochondria; NAD; Neurons; Niacinamide; Phosphatidylserines; Poly(ADP-ribose) Polymerases; Proteins; Tumor Necrosis Factor-alpha | 2004 |
[FOXO: the regulator of metabolism, longevity, and aging].
Topics: Acetylation; Aging; Animals; Caloric Restriction; Drosophila Proteins; Forkhead Transcription Factors; Gluconeogenesis; Histone Deacetylases; Humans; Insulin; Insulin-Like Growth Factor I; Longevity; Metabolism; NAD; Phosphorylation; Signal Transduction; Sirtuins; Transcription Factors; Transcription, Genetic; Ubiquitin | 2005 |
Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; DNA-Binding Proteins; Forkhead Box Protein O1; Forkhead Transcription Factors; Hepatocyte Nuclear Factor 3-gamma; Histone Deacetylases; Humans; NAD; Nuclear Proteins; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors; Transcription, Genetic | 2005 |
[Chemistry and biology of NAD-dependent deacetylases].
Topics: Acetylation; Aging; Animals; Chemical Phenomena; Chemistry; Chromatin; Gene Silencing; Genetics; Histone Deacetylase Inhibitors; Humans; NAD; Naphthalenes; Neoplasms; Pyrones; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirtuin 2; Sirtuins | 2005 |
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal.
Topics: Aging; Animals; Cell Death; Cell Nucleus; Chromatin; DNA Damage; DNA Repair; Genomic Instability; Glycoside Hydrolases; Humans; Inflammation; NAD; Neoplasms; Neurons; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Signal Transduction; Spindle Apparatus; Transcription, Genetic | 2005 |
The biochemistry of sirtuins.
Topics: ADP Ribose Transferases; Aging; Amino Acid Sequence; Animals; Caloric Restriction; Humans; Molecular Sequence Data; Molecular Structure; Multigene Family; NAD; O-Acetyl-ADP-Ribose; Protein Conformation; Protein Isoforms; Sequence Alignment; Sirtuins | 2006 |
Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?
Topics: Aging; Animals; Caloric Restriction; Longevity; Mammals; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Pentosyltransferases; Saccharomyces cerevisiae; Sirtuins | 2006 |
Sirtuins in aging and age-related disease.
Topics: ADP Ribose Transferases; Aging; Animals; Diabetes Mellitus; Eukaryotic Cells; Histone Deacetylases; Humans; Models, Biological; NAD; Neoplasms; Neurodegenerative Diseases; Sirtuins | 2006 |
NAD+ and NADH in brain functions, brain diseases and brain aging.
Topics: Aging; Biological Transport; Brain; Brain Diseases; Humans; NAD | 2007 |
NAD+ metabolism in health and disease.
Topics: ADP Ribose Transferases; ADP-ribosyl Cyclase; Aging; Animals; Candida glabrata; Candidiasis; Humans; Lipids; NAD; Neurodegenerative Diseases; Niacinamide; Poly(ADP-ribose) Polymerases; Sirtuins | 2007 |
Cross-talk between aging and cancer: the epigenetic language.
Topics: Aging; Animals; Cell Proliferation; CpG Islands; Diet; DNA Methylation; Epigenesis, Genetic; Homeostasis; Humans; Models, Biological; Mutation; NAD; Neoplasms; Risk; Sirtuins | 2007 |
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
Topics: Acrylamides; Adenosine Diphosphate Ribose; Aging; Animals; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials, Phase II as Topic; Cyclic ADP-Ribose; DNA Damage; Drug Design; Enzyme Inhibitors; Humans; Kynurenine; Mice; NAD; Neoplasms; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Poly Adenosine Diphosphate Ribose; Signal Transduction; Sirtuins; Tryptophan | 2007 |
Shortage of lipid-radical cycles in membranes as a possible prime cause of energetic failure in aging and Alzheimer disease.
Topics: Adenosine Diphosphate; Aging; Aldehydes; alpha-Tocopherol; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Cell Membrane; Energy Metabolism; Fatty Acids, Unsaturated; Humans; Lipid Peroxidation; Mitochondria; Mitochondrial ADP, ATP Translocases; Molecular Structure; NAD; Oxidation-Reduction; Reactive Oxygen Species | 2007 |
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs.
Topics: Acetylation; Aging; Diabetes Mellitus; Histone Deacetylases; Histones; Humans; Lysine; NAD; Neoplasms; Sirtuins | 2007 |
Age-related effects in enzyme catalysis.
Topics: Adenine Nucleotides; Aging; Amino Acids; Animals; Catalysis; Glyceraldehyde-3-Phosphate Dehydrogenases; Muscles; NAD; Protein Binding; Rabbits; Rats; Spectrum Analysis | 1984 |
The universality of bioenergetic disease: the role of mitochondrial mutation and the putative inter-relationship between mitochondria and plasma membrane NADH oxidoreductase.
Topics: Adenosine Triphosphate; Aging; Antioxidants; Apoptosis; Cell Membrane; DNA, Mitochondrial; Electron Transport Complex I; Energy Metabolism; Ferricyanides; Humans; Immunosuppressive Agents; Mitochondria; Mitochondrial Myopathies; Models, Biological; Mutation; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction | 1994 |
An updating of the biochemical function of coenzyme Q in mitochondria.
Topics: Aging; Animals; Cattle; Cricetinae; Dietary Fats; Doxorubicin; Electron Transport; Energy Metabolism; Kinetics; Lipid Peroxidation; Mitochondria; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxidative Stress; Rats; Ubiquinone | 1994 |
Sir2 links chromatin silencing, metabolism, and aging.
Topics: Aging; Animals; Chromatin; Gene Expression Regulation; Histone Deacetylases; Humans; Metabolism; NAD; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Trans-Activators | 2000 |
An analysis of the role of coenzyme Q in free radical generation and as an antioxidant.
Topics: Aging; Animals; Antioxidants; Doxorubicin; Electron Transport; Free Radicals; Humans; Lipid Peroxidation; Mitochondria; NAD; NADP; Oxidative Phosphorylation; Oxygen; Superoxides; Ubiquinone | 1992 |
ADP-ribosylation: approach to molecular basis of aging.
Topics: Aging; Animals; Epithelium; Homeostasis; Lens, Crystalline; NAD; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases | 1991 |
3 trial(s) available for nad and Aging
| Article | Year |
|---|---|
Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men.
Topics: Aged; Aging; Animals; Hearing; Humans; Male; NAD; Niacin; Regression Analysis | 2023 |
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD
Topics: Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; Cross-Sectional Studies; Cytokines; Double-Blind Method; Humans; Male; Metabolome; Muscle, Skeletal; NAD; Niacinamide; Pyridinium Compounds; Transcriptome | 2019 |
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; Homeostasis; Humans; Magnetic Resonance Imaging; Male; Middle Aged; NAD; Oxidation-Reduction; Radiography | 2015 |
307 other study(ies) available for nad and Aging
| Article | Year |
|---|---|
Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila.
Topics: Aging; Animals; Cardiomyopathies; Drosophila; Drosophila Proteins; NAD | 2021 |
Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice.
Topics: Aging; Animals; Killer Cells, Natural; Mice; Mice, Inbred BALB C; NAD; Nicotinamide Mononucleotide | 2021 |
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Topics: Aging; Animals; Cell Line, Tumor; Cellular Senescence; Cytosol; Glucose; Humans; Hydrogen; Malate Dehydrogenase; Male; Mice; Mice, Inbred NOD; Mice, Transgenic; NAD; Oxidation-Reduction; Pyruvate Carboxylase; Pyruvic Acid | 2021 |
NAD
Topics: Aging; Animals; Caloric Restriction; Mice; NAD; Niacinamide | 2021 |
Nicotinamide Adenine Nucleotide-The Fountain of Youth to Prevent Oocyte Aging?
Topics: Aging; Female; Fertility Preservation; Humans; NAD; Oocytes; Pregnancy; Reproduction; Reproductive Techniques, Assisted | 2021 |
NAD
Topics: Aging; Animals; Heart Diseases; Heart Failure; Humans; Hydrolases; Myocytes, Cardiac; NAD | 2021 |
Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved
Topics: Aging; Animals; Carbohydrate Metabolism; Citric Acid Cycle; Directed Molecular Evolution; Drosophila melanogaster; Genomics; Longevity; Metabolomics; Mitochondria; Multifactorial Inheritance; NAD; Polymorphism, Single Nucleotide | 2022 |
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes.
Topics: Aging; Animals; Female; Fertility; Mice; NAD; Nicotinamide Mononucleotide; Oocytes | 2022 |
Nicotinamide Adenine Dinucleotide in the Development and Treatment of Cardiac Remodeling and Aging.
Topics: Aging; Animals; Antioxidants; Heart; Humans; Mice; NAD; Niacinamide; Ventricular Remodeling | 2022 |
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Longevity; Mice; NAD; NAD+ Nucleosidase | 2022 |
Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing.
Topics: Aging; Animals; Cell Differentiation; Cells, Cultured; Mice; Myelin Sheath; NAD; Oligodendrocyte Precursor Cells; Oligodendroglia; Remyelination; Sirtuin 2 | 2022 |
Low NAD
Topics: Aging; Animals; Male; Mice; Mice, Transgenic; NAD; Niacin; Spermatogenesis | 2022 |
Impact of methionine restriction on muscle aerobic metabolism and hypertrophy in young and old mice on an obesogenic diet.
Topics: Aging; Animals; Diet, High-Fat; Hypertrophy; Inflammation; Male; Methionine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; NAD; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A | 2022 |
Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells.
Topics: Aging; Animals; Antioxidants; Cellular Senescence; Claudin-1; Dietary Supplements; Galactose; Mice; NAD; Nicotinamide Mononucleotide; Occludin; RNA, Messenger; Sirtuins | 2022 |
CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging.
Topics: Aging; Alveolar Epithelial Cells; Animals; Bleomycin; Cellular Senescence; Humans; Idiopathic Pulmonary Fibrosis; Lung; Mice; NAD | 2022 |
NAD
Topics: Aging; Health Status; Humans; NAD | 2022 |
Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD
Topics: Aging; Animals; Homeostasis; Mice; Mice, Inbred C57BL; NAD; PPAR gamma; Stem Cells; Tumor Suppressor Protein p53 | 2022 |
Sirtuin Evolution at the Dawn of Animal Life.
Topics: Aging; Animals; Humans; Longevity; NAD; Sirtuins; Vertebrates | 2022 |
Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Insulin-Secreting Cells; Mice; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds | 2022 |
The Role of NAD+ in Regenerative Medicine.
Topics: Aging; Humans; NAD; Regenerative Medicine | 2022 |
Investigating Physiopathological Roles for Sirtuins in a Mouse Model.
Topics: Aging; Animals; Energy Metabolism; Epigenesis, Genetic; Mice; NAD; Sirtuins | 2023 |
Downregulation of Sirt6 by CD38 promotes cell senescence and aging.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Cell Line; Cellular Senescence; Down-Regulation; Membrane Glycoproteins; Mice; NAD; Rats; RNA, Small Interfering; Sirtuins | 2022 |
Stabilization and quantitative measurement of nicotinamide adenine dinucleotide in human whole blood using dried blood spot sampling.
Topics: Aging; Humans; NAD | 2023 |
Metabolic function of autophagy is essential for cell survival.
Topics: Aging; Autophagy; Cell Survival; Humans; Mitochondria; NAD; Poly(ADP-ribose) Polymerases | 2023 |
Nicotine rebalances NAD
Topics: Aging; Animals; Cytokines; Energy Metabolism; Homeostasis; Male; Mice; NAD; Nicotine | 2023 |
Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.
Topics: Aging; Animals; DNA Damage; Humans; Inflammation; Mice; Mice, Inbred C57BL; NAD; Olfaction Disorders; Olfactory Bulb; Smell | 2023 |
NAD-elevating Interventions for Cardiometabolic Disease.
Topics: Aged; Aging; Cardiovascular Diseases; Humans; Middle Aged; NAD; Obesity; Overweight | 2023 |
Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans.
Topics: Aging; Animals; Cells, Cultured; Cytokines; Humans; Mice; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase | 2023 |
Healthy aging and muscle function are positively associated with NAD
Topics: Aged; Aging; Cross-Sectional Studies; Healthy Aging; Humans; Muscle, Skeletal; NAD | 2022 |
Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.
Topics: Aging; Humans; Metformin; NAD; National Institute on Aging (U.S.); Senotherapeutics; United States | 2023 |
Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD
Topics: Aging; Animals; Biological Transport; Humans; Mice; NAD; Nicotinamide Mononucleotide | 2023 |
Gas-Phase Biosensors (Bio-Sniffers) for Measurement of 2-Nonenal, the Causative Volatile Molecule of Human Aging-Related Body Odor.
Topics: Aging; Aldehydes; Biosensing Techniques; Body Odor; Humans; NAD | 2023 |
Evaluation of potential aging biomarkers in healthy individuals: telomerase, AGEs, GDF11/15, sirtuin 1, NAD+, NLRP3, DNA/RNA damage, and klotho.
Topics: Aged; Aging; Biomarkers; Bone Morphogenetic Proteins; DNA; Female; Glycation End Products, Advanced; Growth Differentiation Factors; Health Status; Humans; Male; NAD; NLR Family, Pyrin Domain-Containing 3 Protein; Sirtuin 1; Telomerase | 2023 |
Vutiglabridin exerts anti-ageing effects in aged mice through alleviating age-related metabolic dysfunctions.
Topics: Aging; Animals; Inflammation; Insulin Resistance; Mice; NAD; Reactive Oxygen Species | 2023 |
Fingerstick blood assay maps real-world NAD
Topics: Aging; Female; Humans; Male; NAD; Nicotinamide Mononucleotide; Pyridinium Compounds | 2023 |
Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction.
Topics: Aging; Female; Humans; Male; Mitochondria; NAD; Oocytes; Oxidative Stress | 2023 |
NAD
Topics: Aging; Animals; Blood-Brain Barrier; Brain; Connexin 43; Humans; Mice; NAD; Poly (ADP-Ribose) Polymerase-1 | 2023 |
Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD).
Topics: Aging; Animals; Guanine Nucleotides; Guanosine Triphosphate; Inosine Triphosphate; Mice; NAD; Poly(ADP-ribose) Polymerases; Sirtuins | 2019 |
Mitochondrial oxidative capacity and NAD
Topics: Aged; Aged, 80 and over; Aging; Biopsy; Case-Control Studies; Energy Metabolism; Humans; Jamaica; Male; Middle Aged; Mitochondria; Muscle, Skeletal; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Proteostasis; Sarcopenia; Singapore; United Kingdom | 2019 |
NAD
Topics: Aging; Animals; Female; Fertility; Mice; Mice, Transgenic; NAD | 2020 |
Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat.
Topics: Aging; Animals; Blood Glucose; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; Diet; Electron Transport Complex IV; Fasting; Fatty Acids; Female; Male; Mitochondria, Heart; Murinae; NAD; Oxidation-Reduction; Phenotype; Sex Characteristics | 2020 |
Illuminating NAD
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aging; Animals; Biosensing Techniques; Fluorescence; HEK293 Cells; Humans; Luminescent Proteins; Macrophages; Male; Mice; Middle Aged; NAD; Young Adult; Zebrafish | 2020 |
Clinical Assessment of the NADome as Biomarkers for Healthy Aging.
Topics: Aging; Biomarkers; Blood Platelets; Cells, Cultured; Cerebrospinal Fluid; Chromatography, Liquid; Evaluation Studies as Topic; Healthy Aging; Humans; Inflammation; Leukocytes, Mononuclear; NAD; Oxidative Stress; Tandem Mass Spectrometry; Urine | 2020 |
NAD
Topics: Age Factors; Aging; Animals; ARNTL Transcription Factors; Circadian Clocks; Circadian Rhythm; CLOCK Proteins; Cytokines; Female; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; NAD; Period Circadian Proteins; Sirtuin 1; Sirtuins | 2020 |
Increasing ovarian NAD
Topics: Aging; Animals; Energy Metabolism; Female; Mice; Mitochondria; NAD; Niacinamide; Reactive Oxygen Species | 2020 |
NAD metabolism in aging and cancer.
Topics: Aging; Animals; Humans; NAD; Neoplasms; Neurodegenerative Diseases; Oxidation-Reduction; Poly Adenosine Diphosphate Ribose | 2020 |
In Silico Insights into the SARS CoV-2 Main Protease Suggest NADH Endogenous Defences in the Control of the Pandemic Coronavirus Infection.
Topics: Aging; Antiviral Agents; Betacoronavirus; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; DNA Damage; Drug Repositioning; HIV Protease Inhibitors; Humans; Models, Molecular; Molecular Docking Simulation; NAD; Oxidation-Reduction; Pandemics; Pneumonia, Viral; Protease Inhibitors; SARS-CoV-2; Viral Nonstructural Proteins | 2020 |
Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD
Topics: Aging; Animals; DNA, Mitochondrial; Female; Humans; Mice; Mutation; NAD; Reproduction | 2020 |
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
Topics: Aging; Animals; Apoptosis; Cellular Senescence; Chromosomes, Mammalian; Cytoplasmic Granules; Dietary Supplements; DNA Damage; Embryonic Development; Female; Fertilization; Kinetochores; Male; Meiosis; Metalloproteases; Mice, Inbred ICR; Microtubules; Mitochondria; NAD; Nicotinamide Mononucleotide; Oocytes; Reactive Oxygen Species; Spermatozoa; Spindle Apparatus; Transcriptome | 2020 |
COVID-19: NAD
Topics: ADAM17 Protein; ADP-ribosyl Cyclase 1; Age Factors; Aged; Aging; COVID-19; Diabetes Mellitus, Type 2; Disease Progression; Disease Susceptibility; Humans; Inflammation; Membrane Glycoproteins; NAD; Obesity; Oxidative Stress; Protein Binding; Sirtuin 1; Virus Replication; Zinc | 2020 |
Senescent cells promote tissue NAD
Topics: Adipose Tissue, White; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Aging; Animals; Antigens, CD; Cellular Senescence; Cytokines; Female; Gene Expression; Glycolysis; GPI-Linked Proteins; Humans; Liver; Macrophage Activation; Male; Membrane Glycoproteins; Metabolome; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; NAD+ Nucleosidase | 2020 |
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD
Topics: Adipocytes, White; Adipose Tissue, White; ADP-ribosyl Cyclase 1; Aging; Animals; Bone Marrow Transplantation; Cellular Senescence; HEK293 Cells; Humans; Inflammation; Liver; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NAD; Nicotinamide Mononucleotide; Phenotype | 2020 |
Sex-related differences in human plasma NAD+/NADH levels depend on age.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Middle Aged; NAD; Sex Factors; Young Adult | 2021 |
NAD
Topics: Aging; Amyloidosis; Animals; Caenorhabditis elegans; Homeostasis; Humans; Mice; Muscle, Skeletal; NAD | 2021 |
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells.
Topics: Aging; Cytosol; Equilibrative Nucleoside Transport Proteins; HEK293 Cells; Humans; Magnetic Resonance Spectroscopy; Membrane Transport Proteins; Metabolomics; NAD; Niacinamide; Nicotinamide Mononucleotide; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Recombinant Proteins; Ribonucleosides | 2021 |
NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.
Topics: Aging; Animals; Cardiomegaly; Cardiomyopathy, Dilated; Cytosol; Disease Models, Animal; Electrocardiography; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Laminin; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Up-Regulation; Ventricular Remodeling | 2021 |
Molecular imaging of NAD
Topics: Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Molecular Imaging; NAD; Positron-Emission Tomography; Sirtuin 1 | 2021 |
Genomics of aging: The role of sirtuin and metabolic health.
Topics: Aging; Diabetes Mellitus, Type 2; Genomics; Humans; NAD; Sirtuins | 2021 |
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells.
Topics: Age Factors; Aging; Animals; Bone Marrow Cells; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Hematopoietic Stem Cells; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Models, Biological; NAD; Niacinamide; Oxidative Phosphorylation; Pyridinium Compounds | 2021 |
Progresses in both basic research and clinical trials of NAD+ in Parkinson's disease.
Topics: Aging; Animals; Clinical Trials as Topic; Energy Metabolism; Humans; NAD; Parkinson Disease | 2021 |
Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.
Topics: Adult; Aged; Aging; Amyotrophic Lateral Sclerosis; Citric Acid Cycle; Disease Progression; Energy Metabolism; Female; Fibroblasts; Glycogen; Glycolysis; Humans; Inosine; Ketoglutaric Acids; Male; Middle Aged; NAD | 2021 |
Small Molecule Regulators Targeting NAD
Topics: Aging; Energy Metabolism; Humans; Metabolic Networks and Pathways; NAD; Oxidation-Reduction | 2022 |
NAD
Topics: Acetylation; Aging; Animals; Homeostasis; Humans; Models, Biological; Muscle Proteins; Muscle, Skeletal; NAD | 2021 |
The therapeutic promises of NAD
Topics: Aging; Female; Humans; Insulin Resistance; Muscles; NAD; Prediabetic State | 2021 |
A conserved NAD
Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Conserved Sequence; DNA Damage; DNA Repair; Fibroblasts; HEK293 Cells; Humans; Mice; Models, Molecular; NAD; Neoplasms; Paraquat; Poly (ADP-Ribose) Polymerase-1; Protein Interaction Domains and Motifs; Radiation Tolerance; RNA, Small Interfering; Sequence Homology, Nucleic Acid | 2017 |
The NAD+/PARP1/SIRT1 Axis in Aging.
Topics: Aging; Animals; DNA Damage; Humans; Mice; NAD; Poly(ADP-ribose) Polymerases; Signal Transduction; Sirtuin 1 | 2017 |
Upregulation of mitochondrial NAD
Topics: Aging; Animals; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Colony-Forming Units Assay; Glioblastoma; Humans; Lactic Acid; Lewis X Antigen; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; NAD; NADP Transhydrogenases; Neoplastic Stem Cells; Oxygen Consumption; RNA, Small Interfering; Sirtuin 3; Xenograft Model Antitumor Assays | 2017 |
Fragmentation of the mitochondrial network in skin in vivo.
Topics: Aged; Aging; Humans; Keratinocytes; Microscopy, Fluorescence, Multiphoton; Mitochondria; NAD; Skin; Young Adult | 2017 |
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa.
Topics: Aging; Animals; Evolution, Molecular; Helminths; Humans; Mice; NAD; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Selection, Genetic; Signal Transduction; Sirtuins | 2017 |
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.
Topics: Acetyl Coenzyme A; Acetylation; Aging; Animals; Caloric Restriction; Circadian Rhythm; Histones; Liver; Metabolic Networks and Pathways; Mice; NAD; Proteins; Sirtuin 1; Stem Cells; Transcriptome | 2017 |
Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry.
Topics: Aging; Animals; Chromatography, Liquid; Kidney; Linear Models; Liver; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Muscles; NAD; Organ Specificity; Reproducibility of Results; Tandem Mass Spectrometry | 2018 |
Impairment of an Endothelial NAD
Topics: Aging; Animals; Endothelial Cells; Humans; Hydrogen Sulfide; Mice; Mice, Knockout; Microvessels; Mitochondria; Muscle, Skeletal; NAD; Neovascularization, Physiologic; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Receptors, Notch; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Vascular Endothelial Growth Factor A | 2018 |
Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance.
Topics: Aging; Animals; Diet, High-Fat; Fatty Liver; HEK293 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; NIH 3T3 Cells; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Triglycerides | 2018 |
Restoring NAD(+) Levels with NAD(+) Intermediates, the Second Law of Thermodynamics, and Aging Delay.
Topics: Aging; Homeostasis; Humans; Metabolic Networks and Pathways; Mitochondria; NAD; Thermodynamics | 2018 |
Loss of NAMPT in aging retinal pigment epithelium reduces NAD
Topics: Acrylamides; Aging; Animals; Cells, Cultured; Cytokines; Epithelial Cells; Gene Expression Regulation; Humans; Male; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Piperidines; Retinal Pigment Epithelium; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice.
Topics: Aging; Animals; Catechin; Diabetes Mellitus, Experimental; Diet; Male; Metabolomics; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Muscular Atrophy; NAD; Peroxisome Proliferator-Activated Receptors; Survival Rate | 2019 |
The Plasma NAD
Topics: Aged; Aging; Body Mass Index; Female; Humans; Least-Squares Analysis; Male; Metabolome; Middle Aged; NAD; Regression Analysis; Young Adult | 2019 |
Macrophage de novo NAD
Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; Oxidative Phosphorylation; Pentosyltransferases; Phagocytosis; Signal Transduction; Tryptophan | 2019 |
Deciphering the metabolic secret of longevity through the analysis of metabolic response to stress on long-lived species.
Topics: Aging; Animals; Homeostasis; Humans; Longevity; Metabolomics; Mice; Models, Theoretical; Mole Rats; NAD; Neoplasms; Oxidative Stress; Rats; Resveratrol; Species Specificity; Spermidine; Stress, Physiological | 2019 |
Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Genotype; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Mitochondria; NAD; Neurons; Optical Imaging; Oxidation-Reduction; Oxidative Phosphorylation; Sex Characteristics; tau Proteins | 2019 |
NAD
Topics: Adult Stem Cells; Aging; Animals; Carbazoles; Cell Proliferation; Cells, Cultured; Dextran Sulfate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Pyridinium Compounds; Rejuvenation; Sirolimus | 2019 |
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Cells, Cultured; Cellular Senescence; Endothelial Cells; Female; Human Umbilical Vein Endothelial Cells; Humans; Macrophages; Mice, Inbred C57BL; Middle Aged; NAD | 2019 |
Aerobic and resistance exercise training reverses age-dependent decline in NAD
Topics: Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthropometry; Blood Glucose; Cytokines; Exercise Therapy; Female; Humans; Insulin; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle, Skeletal; NAD; Nicotinamide Phosphoribosyltransferase; Nicotinamide-Nucleotide Adenylyltransferase; Phosphotransferases (Alcohol Group Acceptor); Resistance Training; Young Adult | 2019 |
NAD
Topics: Aging; Animals; Humans; NAD; Signal Transduction | 2019 |
Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites.
Topics: Aging; Alzheimer Disease; Animals; Brain; Caenorhabditis elegans Proteins; Carrier Proteins; Citric Acid Cycle; Disease Models, Animal; Energy Metabolism; Female; Hippocampus; Male; Metabolome; Mice; Mice, Transgenic; NAD; NADP; Oxidation-Reduction | 2019 |
Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts.
Topics: Aging; Alzheimer Disease; Animals; Cell Nucleus; Cells, Cultured; Cellular Senescence; Cysteine; Cystine; Cytoplasm; Disease Models, Animal; Energy Metabolism; Female; Hippocampus; Humans; Intravital Microscopy; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mitochondria; NAD; Neurons; Oxidation-Reduction; Oxidative Stress; Primary Cell Culture | 2019 |
Failure to protect against myocardial ischemia-reperfusion injury with sevoflurane postconditioning in old rats in vivo.
Topics: Aging; Anesthetics, Inhalation; Animals; Blotting, Western; Enzyme Activation; Ischemic Postconditioning; MAP Kinase Signaling System; Methyl Ethers; Mitochondria; Mitogen-Activated Protein Kinases; Myocardial Reperfusion Injury; Myocardium; NAD; Permeability; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sevoflurane; Ventricular Function, Left | 2013 |
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Forkhead Transcription Factors; Hepatocytes; Longevity; Mice; Mitochondria; NAD; Poly(ADP-ribose) Polymerase Inhibitors; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors; Unfolded Protein Response | 2013 |
Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice.
Topics: Age Factors; Aging; Animals; Bifidobacterium; Feces; Homocysteine; Intestines; Lactobacillus acidophilus; Magnetic Resonance Spectroscopy; Male; Metabolic Networks and Pathways; Metabolome; Mice; Mice, Inbred BALB C; NAD; Niacin; Niacinamide; Pentanoic Acids; Phenylacetates; Probiotics; Sarcosine; Xylose | 2013 |
Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Glutamate-Cysteine Ligase; Glutathione; Glycyrrhetinic Acid; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; NAD; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Niacinamide; Oxidation-Reduction; Reactive Oxygen Species | 2014 |
The fountain of youth: role of sirtuins in aging and regenerative medicine.
Topics: Aging; Animals; Caloric Restriction; Clinical Trials as Topic; Humans; Mice; Motor Activity; NAD; Regenerative Medicine; Signal Transduction; Sirtuins; Stem Cells | 2013 |
Role of cytochrome b5 and α-tocopherol to microsomal and mitochondrial oxidation.
Topics: Adenosine Triphosphate; Aging; alpha-Tocopherol; Animals; Antioxidants; Benzene Derivatives; Carrier Proteins; Cell Membrane; Heme-Binding Proteins; Hemeproteins; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Mitochondria; NAD; Oxidation-Reduction; Rats; Rats, Wistar; Reactive Oxygen Species | 2013 |
Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Aging; Animals; Brain; DNA Damage; Electron Transport; Female; Gene Knockdown Techniques; Lipid Peroxidation; Membrane Glycoproteins; Mitochondria; NAD; Oxidative Stress; Poly(ADP-ribose) Polymerases; Protein Carbonylation; Rats; Rats, Wistar; RNA, Small Interfering; Sirtuin 1; Tissue Distribution | 2014 |
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Cell Nucleus; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mitochondria; Muscle, Skeletal; NAD; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Sirtuin 1; Transcription Factors | 2013 |
The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan.
Topics: Aging; Humans; Longevity; Models, Biological; NAD; Sirtuins | 2014 |
Cell communication feeds the fountain of youth.
Topics: Aging; Animals; Cell Nucleus; Energy Metabolism; Enzyme Precursors; Mice; Mice, Knockout; Mitochondria; NAD; Signal Transduction; Sirtuin 1 | 2014 |
Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid.
Topics: Adult; Aged; Aging; Alcohol Drinking; Biomarkers; Humans; Inflammation; Life Style; Male; Middle Aged; NAD; Oxidative Stress; Sex Characteristics; Young Adult | 2014 |
NAD+ deficiency in age-related mitochondrial dysfunction.
Topics: Aging; Animals; Cell Nucleus; Mitochondria; NAD; Oxidative Phosphorylation | 2014 |
Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.
Topics: Aging; Cell Hypoxia; Cellular Reprogramming; Epigenesis, Genetic; Fumarate Hydratase; Fumarates; Glutarates; Humans; Hypoxia-Inducible Factor 1; Isocitrate Dehydrogenase; Mitochondria; Mutation; NAD; Neoplasms; Proto-Oncogene Proteins c-myc; Succinate Dehydrogenase; Succinates | 2014 |
Aging: it's SIRTainly possible to restore mitochondrial dysfunction.
Topics: Aging; Animals; Cell Nucleus; Mitochondria; NAD; Oxidative Phosphorylation | 2014 |
p16INK4a, NAD(+) , and sestrins: new targets for combating aging-related chronic illness?
Topics: Aging; Animals; Biomarkers; Chronic Disease; Cyclin-Dependent Kinase Inhibitor p16; Heat-Shock Proteins; Humans; Molecular Targeted Therapy; Muscles; NAD | 2014 |
SnapShot: sirtuins, NAD, and aging.
Topics: Aging; Caloric Restriction; Histones; Humans; NAD; Sirtuins | 2014 |
Age-related metabolic fatigue during low glucose conditions in rat hippocampus.
Topics: Aging; Animals; CA1 Region, Hippocampal; Glucose; Glycogen; Hypoglycemia; In Vitro Techniques; Lactic Acid; Mitochondria; NAD; Neurons; Oxidation-Reduction; Oxygen Consumption; Rats, Inbred F344 | 2015 |
Preface. NAD metabolism and signaling: Critical pathways in bacteria, yeast and mammals influencing genome stability, cell survival and disease.
Topics: Aging; Animals; Bacteria; Cell Survival; Congresses as Topic; DNA Repair; Genomic Instability; Humans; Mammals; NAD; Signal Transduction; Sirtuins; Yeasts | 2014 |
The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia.
Topics: Adenosine Triphosphate; Aging; Caloric Restriction; Catalytic Domain; Dementia; Humans; Hyperhomocysteinemia; NAD; Oxidative Phosphorylation; Sirtuins | 2015 |
Effect of Sex Differences on Brain Mitochondrial Function and Its Suppression by Ovariectomy and in Aged Mice.
Topics: Aging; Animals; Brain; Cell Respiration; Estradiol; Female; Flavin-Adenine Dinucleotide; Male; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Ovariectomy; Oxidative Stress; Sex Characteristics | 2015 |
Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.
Topics: Aging; Amino Acids; Animals; Autophagy; Female; Liver; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myocardium; NAD; Oleic Acid; Palmitates; Phosphatidylinositol 3-Kinases; Principal Component Analysis; Signal Transduction; Spermidine; Spermine | 2015 |
Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Aspartic Acid; Brain; Carnitine; DNA Damage; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Female; Glutamates; Male; Metabolomics; Mice; Mutation; NAD; Neurotransmitter Agents; Physical Conditioning, Animal; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases | 2015 |
Estrogen receptor beta signaling alters cellular inflammasomes activity after global cerebral ischemia in reproductively senescence female rats.
Topics: Aging; Animals; Apoptosis Regulatory Proteins; Brain Ischemia; CARD Signaling Adaptor Proteins; Caspase 1; Cytokines; Disease Models, Animal; Estrogen Receptor beta; Female; Hippocampus; Immunity, Innate; Inflammasomes; NAD; Neurons; Oligodeoxyribonucleotides, Antisense; Ovariectomy; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Ageing-related changes in GABAergic inhibition in mouse auditory cortex, measured using in vitro flavoprotein autofluorescence imaging.
Topics: Aging; Animals; Auditory Cortex; Flavin-Adenine Dinucleotide; GABA Antagonists; Mice; NAD; Oxidative Stress | 2016 |
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Topics: Aging; Animals; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; NAD; Non-alcoholic Fatty Liver Disease | 2016 |
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.
Topics: Adenosine Triphosphate; Aging; Animals; Calcium; Electrophysiology; Glucose; Humans; In Vitro Techniques; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mitochondria; NAD; NADP; Potassium Channels | 2016 |
Why NAD(+) Declines during Aging: It's Destroyed.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Mice; Mitochondria; Models, Biological; NAD | 2016 |
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Topics: ADP-ribosyl Cyclase 1; Aging; Animals; Diet, High-Fat; Mammals; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NAD; NAD+ Nucleosidase; Niacinamide; Organ Specificity; Pyridinium Compounds; RNA, Messenger; Sirtuin 3 | 2016 |
Restoration of Mitochondrial NAD
Topics: Aging; Animals; Cell Lineage; Cellular Reprogramming; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Gene Knockdown Techniques; Humans; Mesenchymal Stem Cells; Mice, Knockout; Mitochondria; NAD; NADP Transhydrogenases; Nicotinamide-Nucleotide Adenylyltransferase; Sirtuin 3; Stem Cells | 2016 |
The expression of CG9940 affects the adaptation of cardiac function, mobility, and lifespan to exercise in aging Drosophila.
Topics: Adaptation, Physiological; Aging; Animals; Cardiovascular Physiological Phenomena; Drosophila; Drosophila Proteins; Female; Glutaminase; Mitochondria; NAD; Physical Conditioning, Animal; Physical Endurance | 2016 |
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.
Topics: Administration, Oral; Aging; Animals; Biological Availability; Energy Metabolism; Glucose; Homeostasis; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Muscle Strength; Muscle, Skeletal; NAD; Necrosis; Niacinamide; Nicotinamide Phosphoribosyltransferase; Organ Size; Physical Conditioning, Animal; Pyridinium Compounds; Transcription, Genetic | 2016 |
β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats.
Topics: Aging; Animals; Injections, Intraperitoneal; Longevity; Male; NAD; Niacinamide; Nicotinamide Mononucleotide; Rats; Rats, Wistar | 2016 |
Overcoming ATM Deficiency by Activating the NAD
Topics: Aging; Animals; Mice; NAD; Sirtuin 1 | 2016 |
Early mitochondrial dysfunction in long-lived Mclk1+/- mice.
Topics: Adenosine Triphosphate; Aging; Animals; Gene Expression Regulation; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Proteins; Mixed Function Oxygenases; Models, Biological; NAD; Oxidative Stress; Oxygen Consumption; Phenotype; Tricarboxylic Acids | 2008 |
Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging.
Topics: Aging; Animals; Dihydroorotate Dehydrogenase; DNA Damage; DNA, Mitochondrial; Humans; Mice; Mitochondria; Mitochondrial Proteins; NAD; NADP Transhydrogenases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plant Proteins; Ubiquinone | 2009 |
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver.
Topics: Age Factors; Aging; Aldehyde Reductase; Animals; Caloric Restriction; Fructose; Glucose; L-Iditol 2-Dehydrogenase; Lactic Acid; Liver; Malates; Male; Mice; Mice, Inbred C57BL; NAD; NADP; Oxidation-Reduction; Pyruvic Acid; Sorbitol | 2009 |
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Forkhead Transcription Factors; Insulin; Insulin-Like Growth Factor I; Longevity; NAD; Repressor Proteins; RNA Interference; Signal Transduction; Sirtuins; Transcription Factors; Triglycerides | 2009 |
Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.
Topics: Aging; Animals; Antioxidants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Life Expectancy; Longevity; NAD; Sirtuins; Transcription Factors | 2010 |
Cell biology. Hypoxic hookup.
Topics: Acetylation; Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cells, Cultured; Erythropoietin; Gene Expression; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Mice; NAD; Neoplasms; Oxidation-Reduction; Sirtuin 1; Sirtuins | 2009 |
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats.
Topics: Age Factors; Aging; Animals; Cytokines; DNA Damage; DNA Glycosylases; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Muscle Contraction; Muscle, Skeletal; NAD; Nicotinamide Phosphoribosyltransferase; Oxidation-Reduction; Oxidative Stress; Physical Exertion; Protein Carbonylation; Rats; Rats, Wistar; Sirtuin 1; Vascular Endothelial Growth Factor A | 2010 |
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
Topics: Adaptor Proteins, Signal Transducing; Aging; Animals; Cell Nucleus; Dietary Fats; Fatty Liver; Humans; Liver; Longevity; Mice; NAD; NAD+ Nucleosidase; Sirtuin 1 | 2010 |
Expression of myosin heavy chain isoforms in the postnatal mouse masseter muscle.
Topics: Aging; Animals; Animals, Newborn; Male; Masseter Muscle; Mice; Mice, Inbred Strains; Myosin Heavy Chains; NAD; Nonmuscle Myosin Type IIA; Nonmuscle Myosin Type IIB; Protein Isoforms | 2009 |
NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?
Topics: Aging; Animals; Caenorhabditis elegans; Carnosine; Cell Survival; Gene Expression Regulation; Glycation End Products, Advanced; Mitochondria; NAD; Neurons; Proteins; Pyruvaldehyde; Reactive Oxygen Species | 2010 |
Age-associated differences in activation of Akt/GSK-3beta signaling pathways and inhibition of mitochondrial permeability transition pore opening in the rat heart.
Topics: Aging; Anesthetics, Inhalation; Animals; Cardiotonic Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart Ventricles; Hemodynamics; Ischemic Preconditioning, Myocardial; Isoflurane; Male; Microscopy, Electron; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NAD; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Signal Transduction | 2010 |
Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats.
Topics: Acetylation; Aging; Amyloid beta-Protein Precursor; Animals; Cerebellum; Male; Muscle Strength; NAD; Neuropsychological Tests; Nicotinamide Phosphoribosyltransferase; Physical Conditioning, Animal; Psychomotor Performance; Rats; Sirtuin 1; Tubulin | 2010 |
Viral genome silencing by neuronal sirtuin 1.
Topics: Adenoviridae; Adenoviridae Infections; Aging; Animals; Blotting, Western; Cell Culture Techniques; Embryo, Mammalian; Enzyme Inhibitors; Fluorescence; Ganglia, Spinal; Gene Expression Regulation, Viral; Gene Silencing; Genome, Viral; Histones; Humans; Male; Mice; NAD; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sensory Receptor Cells; Sirtuin 1; Transduction, Genetic; Virus Activation | 2011 |
Cardioprotection of the aged rat heart by GSK-3beta inhibitor is attenuated: age-related changes in mitochondrial permeability transition pore modulation.
Topics: Aging; Animals; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; Indoles; Male; Maleimides; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; NAD; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2011 |
Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
Topics: Aging; Animals; Caloric Restriction; Fatty Liver; Liver; Mice; Mitochondria; NAD; Obesity; Phenotype; Sirtuin 3 | 2011 |
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats.
Topics: Acetylation; Aging; Aldehydes; Animals; Antioxidants; Biomarkers; Brain; DNA Damage; Electron Transport; Enzyme Activation; Female; Intracellular Space; Lipid Peroxidation; Mitochondria; NAD; Organ Specificity; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Protein Carbonylation; Rats; Rats, Wistar; Sirtuin 1; Tumor Suppressor Protein p53 | 2011 |
Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals.
Topics: Adipocytes; Adipogenesis; Aging; Animals; Bone Marrow Cells; Carbazoles; Cell Line; Cell Lineage; Culture Media; Cytokines; Humans; Intracellular Space; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Osteogenesis; Sirtuin 1; Stromal Cells | 2011 |
Age-associated differences in the inhibition of mitochondrial permeability transition pore opening by cyclosporine A.
Topics: Aging; Animals; Cardiotonic Agents; Cell Separation; Cyclosporine; Hemodynamics; Image Processing, Computer-Assisted; Immunosuppressive Agents; In Vitro Techniques; Male; Microscopy, Confocal; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; NAD; Permeability; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2011 |
Substrate stereoselectivity of mammalian D-aspartyl endopeptidase.
Topics: Adenosine Triphosphate; Aging; Animals; Aspartic Acid Endopeptidases; Chromatography, High Pressure Liquid; Crystallins; D-Aspartic Acid; Humans; Liver; Mice; Mitochondrial Membranes; NAD; Peptides; Stereoisomerism; Substrate Specificity | 2011 |
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Topics: Aging; Animals; Circadian Rhythm; Cytokines; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Glucose; Hypoglycemic Agents; Insulin; Lipid Metabolism; Mice; NAD; Nicotinamide Mononucleotide; Nicotinamide Phosphoribosyltransferase; Oxidative Stress; Sirtuin 1 | 2011 |
Reduced mitochondrial Ca2+ loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts.
Topics: Aging; Animals; Calcium; Cardiotonic Agents; Coronary Circulation; Cytosol; Digoxin; Dopamine; Guinea Pigs; Mitochondria; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NAD; Recovery of Function | 2012 |
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue, White; Aging; AMP-Activated Protein Kinase Kinases; Animals; Caloric Restriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Diet; Glucose Intolerance; Guanine Nucleotide Exchange Factors; Mice; Models, Molecular; Muscle, Skeletal; NAD; Obesity; Protein Kinases; Resveratrol; Rolipram; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Sirtuin 1; Stilbenes | 2012 |
A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons.
Topics: Adenine Nucleotides; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Cytochromes c; Disease Models, Animal; Glutathione; Hippocampus; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; NAD; Neurons; Niacinamide; Oxidants; Oxidation-Reduction; Presenilin-1; Reactive Oxygen Species; tau Proteins; Vitamin B Complex | 2012 |
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.
Topics: Adolescent; Adult; Aged; Aging; Biomarkers; DNA Damage; Female; Humans; Infant, Newborn; Lipid Peroxidation; Male; Middle Aged; NAD; Oxidative Stress; Poly(ADP-ribose) Polymerases; Sex Characteristics; Sirtuin 1; Young Adult | 2012 |
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.
Topics: Aging; Animals; Aspartic Acid; Astrocytes; Brain; Cell Separation; Cells, Cultured; Cellular Senescence; Cytoplasm; Energy Metabolism; Female; Glutamic Acid; Lactic Acid; Male; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Membrane Transport Proteins; NAD; Nerve Tissue Proteins; Neurons; Oxidation-Reduction; Primary Cell Culture; Pyruvic Acid; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases.
Topics: Acrylamides; Aging; Animals; Brain Diseases; Cerebellum; Corpus Striatum; Female; Hippocampus; Mice; NAD; Neurons; Nicotinamide Phosphoribosyltransferase; Piperidines; Rats | 2012 |
Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Caloric Restriction; Cognition; Dietary Supplements; Energy Metabolism; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mitochondria; Muscle, Skeletal; NAD; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones | 2012 |
Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus.
Topics: Aging; Animals; Blotting, Western; Catalase; Citrate (si)-Synthase; Eating; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Hippocampus; Mice; NAD; Oxidation-Reduction; Physical Conditioning, Animal; Sirtuin 1; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2012 |
Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Aging; Animals; Biomarkers, Tumor; Collagen; Cyclohexenes; Disease Progression; Elastin; Female; Image Interpretation, Computer-Assisted; Linear Models; Lipofuscin; Mice; Microscopy, Fluorescence, Multiphoton; NAD; Ovarian Neoplasms; Ovary; Vinyl Compounds | 2013 |
Changes in actomyosin ATP consumption rate in rat diaphragm muscle fibers during postnatal development.
Topics: Actomyosin; Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Algorithms; Animals; Body Weight; Diaphragm; Isomerism; Kinetics; L-Lactate Dehydrogenase; Male; Muscle Fatigue; Muscle Fibers, Skeletal; Myosin Heavy Chains; NAD; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2003 |
Hungering for simplicity.
Topics: Aging; Caloric Restriction; Histone Deacetylases; NAD; Niacinamide; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins | 2003 |
[Research on the relation between vitamin coenzymes and corresponding enzymes in relation to the age of the animal and under the influence of certain substances proper to the organism].
Topics: Acetylesterase; Adenine Nucleotides; Aging; Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Coenzymes; Cysteine; D-Alanine Transaminase; Folic Acid; Humans; NAD; Niacin; Niacinamide; Pantothenic Acid; Pyridoxine; Riboflavin; Thiamine; Thiamine Pyrophosphate; Vitamins | 1963 |
Enzyme changes in flight muscle correlated with aging and flight ability in the male housefly.
Topics: Adenosine Triphosphatases; Aging; Animals; Glucosephosphate Dehydrogenase; Glycerolphosphate Dehydrogenase; Houseflies; Male; Mitochondria, Muscle; Muscles; NAD; Wings, Animal | 1963 |
DEVELOPMENTAL HISTOCHEMISTRY OF THE RAT EYE.
Topics: Aging; Animals, Newborn; Dihydrolipoamide Dehydrogenase; Electron Transport Complex II; Embryology; Eye; Histocytochemistry; L-Lactate Dehydrogenase; Malate Dehydrogenase; NAD; NADP; Rats; Research; Rosaniline Dyes; Succinate Dehydrogenase | 1964 |
NEUROCHEMICAL STUDIES ON THE INHERITED RETINAL DEGENERATION OF THE RAT. I. LACTATE DEHYDROGENASE IN THE DEVELOPING RETINA.
Topics: Aging; Chemical Phenomena; Chemistry; Electrophoresis; Genetics; L-Lactate Dehydrogenase; NAD; Pathology; Rats; Research; Retina; Retinal Degeneration | 1963 |
RELATIONSHIP BETWEEN AGE AND ENZYMATIC ACTIVITIES IN HUMAN ERYTHROCYTES FROM NORMAL AND FAVA BEAN-SENSITIVE SUBJECTS.
Topics: Aged; Aging; Aldehyde-Lyases; Anemia; Anemia, Hemolytic; Biomedical Research; Erythrocytes; Favism; Glucosephosphate Dehydrogenase; Glutathione; Hemoglobinometry; Humans; Hypersensitivity; Metabolism; Methemoglobin; NAD; NADP; Osmosis; Oxidoreductases; Phenylhydrazines; Plants, Edible; Spectrophotometry; Vegetables; Vicia faba | 1964 |
EFFECT OF THYROXINE ADMINISTRATION ON THE 11-BETA-HYDROXYSTEROID DEHYDROGENASES IN RAT LIVER AND KIDNEY.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenal Cortex Hormones; Adrenalectomy; Aging; Cortisone; Hydrocortisone; Hydrogen-Ion Concentration; Hydroxysteroid Dehydrogenases; Isocitrate Dehydrogenase; Kidney; Liver; Metabolism; NAD; NADP; Pharmacology; Rats; Research; Thyroidectomy; Thyroxine | 1964 |
CONTROL OF GLUTAMATE DEHYDROGENASE IN THE BASIDIOMYCETE SCHIZOPHYLLUM COMMUNE.
Topics: Aging; Amino Acids; Asparagine; Basidiomycota; Glutamate Dehydrogenase; Metabolism; NAD; Research; Schizophyllum | 1965 |
LOCALIZATION OF THE ENZYMES THAT CATALYZE HYDROGEN AND ELECTRON TRANSPORT IN HEMOPHILUS PARAINFLUENZAE AND THE NATURE OF THE RESPIRATORY CHAIN SYSTEM.
Topics: Aging; Catalysis; Cytochromes; Cytoplasm; Electron Transport; Enzyme Inhibitors; Haemophilus; Haemophilus Infections; Haemophilus parainfluenzae; Hydrogen; Metabolism; NAD; Oxidative Phosphorylation; Oxidoreductases; Pigments, Biological; Research; Spectrophotometry | 1964 |
CONTENT AND SYNTHESIS OF HEPATIC PYRIDINE NUCLEOTIDES IN FETAL AND NEONATAL RABBITS.
Topics: Aging; Animals; DNA; Female; Fetus; Humans; Liver; Maternal-Fetal Exchange; Metabolism; NAD; NADP; Niacinamide; Nitrogen; Placenta; Plasma; Pregnancy; Pregnancy, Animal; Rabbits; Research; Umbilical Cord; Uterus; Water | 1965 |
Glutamate-induced differential mitochondrial response in young and adult rats.
Topics: Adenosine Triphosphate; Aging; Animals; Calcium; Calcium Signaling; Cell Survival; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamic Acid; Intracellular Membranes; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Mitochondria; NAD; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2004 |
Specificity of coenzyme Q inhibition of an aging-related cell surface NADH oxidase (ECTO-NOX) that generates superoxide.
Topics: Aging; Cytochromes c; Disulfides; Enzyme Inhibitors; Humans; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Proteins; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Ubiquinone | 2003 |
Scientific community. Aging research's family feud.
Topics: Aging; Animals; Australia; Biotechnology; Caloric Restriction; Histone Deacetylases; History, 20th Century; History, 21st Century; Humans; Longevity; NAD; Niacinamide; Nicotinamidase; Resveratrol; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Stilbenes; United States | 2004 |
Beneficial effects of mild lifelong dietary restriction on skeletal muscle: prevention of age-related mitochondrial damage, morphological changes, and vulnerability to a chemical toxin.
Topics: Aging; Animals; Catalase; Crystallins; Diet; Food Deprivation; Glutathione Peroxidase; Guanine; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunohistochemistry; Male; Mercury; Mitochondria, Muscle; Muscle, Skeletal; NAD; Rats; Rats, Wistar; Superoxide Dismutase; Tissue Distribution | 2004 |
Age-related alteration of brain function during cerebral ischemia.
Topics: Aging; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Hemodynamics; Male; NAD; Rats; Regional Blood Flow; Reperfusion | 2003 |
Treatment with reduced nicotinamide adenine dinucleotide (NADH) improves water maze performance in old Wistar rats.
Topics: Aging; Analysis of Variance; Animals; Brain; Cognition; Dose-Response Relationship, Drug; Energy Metabolism; Injections, Intraperitoneal; Male; Maze Learning; Motor Skills; NAD; Posture; Rats; Rats, Wistar; Rotarod Performance Test | 2004 |
A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance.
Topics: Adult; Aged; Aging; Animals; Flavin-Adenine Dinucleotide; Humans; Insulin Resistance; Lipid Metabolism; Middle Aged; Mitochondria, Muscle; Models, Animal; Muscle, Skeletal; Myofibrils; NAD; Oxygen Consumption; Rats; Risk Factors; Sarcolemma | 2004 |
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart.
Topics: Aging; Amino Acid Sequence; Animals; Citrate (si)-Synthase; Coenzyme A; Enzyme Activation; Esters; Isoenzymes; Male; Mitochondria; Molecular Sequence Data; Myocardium; NAD; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex; Rats; Rats, Inbred F344; Swine | 2004 |
Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster.
Topics: Aging; Animals; Cell Respiration; Citrate (si)-Synthase; Drosophila melanogaster; Electron Transport; Electron Transport Complex IV; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Male; Mitochondria; NAD; Oxidative Stress; Oxygen Consumption; Substrate Specificity | 2005 |
Misregulation of poly(ADP-ribose) polymerase-1 activity and cell type-specific loss of poly(ADP-ribose) synthesis in the cerebellum of aged rats.
Topics: Aging; Animals; Blotting, Western; Brain; Brain Chemistry; Cell Nucleus; Immunohistochemistry; Male; NAD; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 2005 |
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Aging; Animals; Animals, Newborn; Brain; Cyclic ADP-Ribose; Guanine Nucleotides; Hydrogen-Ion Concentration; Kinetics; Mice; Mice, Knockout; NAD; Synaptosomes; Zinc | 2006 |
Unlocking the secrets of longevity genes.
Topics: Aging; Animals; Diet; DNA, Ribosomal; Energy Intake; Energy Metabolism; Humans; Insulin; Insulin-Like Growth Factor I; Longevity; Mutation; NAD; Repetitive Sequences, Nucleic Acid; Resveratrol; Saccharomyces cerevisiae; Sirtuins; Stilbenes; Stress, Physiological | 2006 |
Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38.
Topics: Acetylation; ADP-ribosyl Cyclase 1; Aging; Animals; Calcium; Cell Nucleus; Gene Expression Regulation; Homeostasis; Liver; Mice; Mice, Knockout; NAD; Nuclear Envelope; Recombinant Proteins; Sirtuin 1; Sirtuins | 2006 |
NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia.
Topics: Aging; Animals; Calcium Signaling; Cell Hypoxia; Cell Survival; Disease Susceptibility; Excitatory Postsynaptic Potentials; Hippocampus; Hypoxia, Brain; NAD; Organ Culture Techniques; Oxidation-Reduction; Rats; Rats, Inbred F344 | 2008 |
Sirt1 regulates aging and resistance to oxidative stress in the heart.
Topics: Adenosine Triphosphate; Aging; Animals; Apoptosis; Cells, Cultured; Echocardiography; Forkhead Box Protein O1; Forkhead Transcription Factors; Mice; Mice, Transgenic; Myocardium; NAD; Oxidative Stress; Rats; Rats, Wistar; Sirtuin 1; Sirtuins; Ventricular Function, Left | 2007 |
Vitamins and aging: pathways to NAD+ synthesis.
Topics: Aging; Animals; Histone Deacetylases; Humans; Longevity; NAD; Niacinamide; Pyridinium Compounds; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Vitamins | 2007 |
Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?
Topics: Aging; Animals; Caloric Restriction; Energy Metabolism; NAD; Proteins; Sirtuins | 2008 |
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.
Topics: Aging; Animals; Female; Glucose; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channels; Islets of Langerhans; Male; Mice; Mice, Transgenic; Mitochondrial Proteins; NAD; Nicotinamide Mononucleotide; Sirtuin 1; Sirtuins; Uncoupling Protein 2 | 2008 |
Hippocampal mitochondrial dysfunction in rat aging.
Topics: Aging; Animals; Electron Transport Complex I; Electron Transport Complex III; Electron Transport Complex IV; Energy Metabolism; Hippocampus; Male; Mitochondria; Mitochondrial Diseases; NAD; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2008 |
Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy.
Topics: Acetylcholinesterase; Aging; Animals; Brain Chemistry; Choline; Chronic Disease; Disease Models, Animal; Energy Metabolism; Glucosephosphate Dehydrogenase; Isocitrate Dehydrogenase; Manganese Poisoning; NAD; Nervous System Diseases; Neurotransmitter Agents; Rats; Synaptosomes | 1984 |
Changes in NAD levels in human lymphocytes and fibroblasts during aging and in premature aging syndromes.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Child; Child, Preschool; Diabetes Mellitus; Down Syndrome; Fibroblasts; Humans; Lymphocytes; Middle Aged; NAD; Progeria; Syndrome; Werner Syndrome | 1983 |
The role of old age in the effects of glucose on insulin secretion, pentosephosphate shunt activity, pyridine nucleotides and glutathione of rat pancreatic islets.
Topics: Aging; Animals; DNA; Female; Glucose; Glucose Tolerance Test; Glutathione; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NAD; NADP; Oxidation-Reduction; Pentosephosphates; Rats; Rats, Inbred Strains; Theophylline | 1984 |
Influence of aging on cerebral derangement by acute severe hypoxia during hypovolemic hypotension.
Topics: Adenine Nucleotides; Aging; Animals; Cerebral Cortex; Cytochromes; Dogs; Energy Metabolism; Female; Hypotension; Hypoxia, Brain; NAD; Oxygen Consumption; Synaptosomes | 1984 |
Effects of aging and hypoxia on energy transduction at synaptosomal level.
Topics: Adenine Nucleotides; Aging; Animals; Dogs; Energy Metabolism; Female; Mitochondria; Motor Cortex; NAD; Oxygen; Oxygen Consumption; Synaptosomes | 1984 |
The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.
Topics: Aging; Aldehyde Reductase; Animals; Cataract; Diabetes Complications; Diabetes Mellitus; Fructose; Humans; Kinetics; Lens, Crystalline; Molecular Weight; NAD; NADP; Sugar Alcohol Dehydrogenases; Xylitol | 1981 |
[Microsomal oxidation system in the course of development and aging].
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Electron Transport; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats | 1980 |
Age-related changes in rat adipose tissue in response to fasting: protein, lactate and pyruvate levels.
Topics: Adipose Tissue; Aging; Animals; Fasting; Lactates; Lactic Acid; Male; NAD; Proteins; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains | 1983 |
The role of ATP/ADP ratio in the control of hepatic gluconeogenesis during the early neonatal period.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Gluconeogenesis; Kinetics; Liver; NAD; Oxidation-Reduction; Phosphoenolpyruvate Carboxykinase (GTP); Rats | 1983 |
Effect of adrenalectomy, hydrocortisone & actinomycin D on activity of NAD- & NAD-linked isocitrate dehydrogenase of liver of rats of various ages.
Topics: Adrenalectomy; Aging; Animals; Dactinomycin; Hydrocortisone; Isocitrate Dehydrogenase; Liver; Male; NAD; NADP; Rats | 1980 |
[Correlation between [NAD+]:[NADH] and the "phosphate potential" in liver cytoplasm of developing chicken embryos].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aging; Animals; Chick Embryo; Chickens; Kinetics; Liver; NAD; Oxidation-Reduction; Phosphates | 1981 |
Location of age-related modifications in rat muscle glyceraldehyde-3-phosphate dehydrogenase.
Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Muscle Development; Muscles; NAD; Rats; Rats, Inbred Strains | 1981 |
Comparison between developmental and senescent changes in enzyme activities linked to energy metabolism in rat heart.
Topics: Aging; Animals; Citrate (si)-Synthase; Cytoplasm; Energy Metabolism; Female; Heart; Isocitrate Dehydrogenase; Malate Dehydrogenase; Male; Mitochondria, Heart; NAD; NADP; Pyruvate Kinase; Rats; Succinate Dehydrogenase | 1981 |
The effects of age on the metabolic and electrical responses to decapitation in the awake and the anesthetized rat brain.
Topics: Aging; Anesthesia; Animals; Brain; Brain Ischemia; Electroencephalography; Electrophysiology; Fluorometry; Male; NAD; Oxidation-Reduction; Rats; Wakefulness | 1981 |
Oxidation of hypotaurine in vitro by mouse liver and brain tissues.
Topics: Aging; Animals; Brain; Cations, Divalent; Female; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Liver; Male; Mice; NAD; NADP; Oxidation-Reduction; Subcellular Fractions; Taurine; Temperature | 1981 |
Age-related effects in coenzyme binding patterns of rat muscle glyceraldehyde-3-phosphate dehydrogenase.
Topics: Aging; Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Muscle Development; Muscles; NAD; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
Age-dependent changes in glutamate oxidation by non-synaptic and synaptic mitochondria from rat brain.
Topics: Aging; Animals; Aspartate Aminotransferases; Brain; Glutamate Dehydrogenase; Glutamates; Ketoglutaric Acids; Male; Mitochondria; NAD; Oxidation-Reduction; Rats; Synapses | 1980 |
Factors affecting the development of hyperbaric oxygen toxicity in the awake rat brain.
Topics: Aging; Animals; Brain; Diazepam; Electroencephalography; Hyperbaric Oxygenation; Male; NAD; Pentobarbital; Rats; Seizures; Wakefulness | 1980 |
Effect of galactosamine on adenine and uracil nucleotide levels in isolated hepatocytes of young and old rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Aging; Animals; Cells, Cultured; Galactosamine; Liver; Male; NAD; Rats; Rats, Wistar; Uracil Nucleotides; Uridine Diphosphate Glucuronic Acid; Uridine Diphosphate Sugars; Uridine Triphosphate | 1994 |
Regulation of NPY/NPY Y1 receptor/G protein system in rat brain cortex.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Colforsin; Female; GTP-Binding Proteins; Homeostasis; Inositol Phosphates; Kinetics; Male; NAD; Neuropeptide Y; Norepinephrine; Pertussis Toxin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neuropeptide Y; Sex Characteristics; Species Specificity; Virulence Factors, Bordetella | 1995 |
Age and GSH metabolism in rat cerebral cortex, as related to oxidative and energy parameters.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aging; Animals; Cerebral Cortex; Energy Metabolism; Glutathione; Male; NAD; NADP; Oxidation-Reduction; Rats; Rats, Wistar | 1993 |
Structure, innervation, and age-associated changes of mouse forearm muscles.
Topics: Aging; Animals; Atrophy; Cytoplasmic Granules; Denervation; Female; Forelimb; Glycolysis; Histocytochemistry; Lysosomes; Mice; Mice, Inbred C57BL; Mitochondria; Muscles; NAD; Time Factors; Ulnar Nerve | 1993 |
Multiple isoforms of 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase in mouse tissues: male-specific isoforms are expressed in the gonads and liver.
Topics: Aging; Animals; Base Sequence; Blotting, Northern; Female; Gene Expression; Isoenzymes; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Molecular Sequence Data; Multienzyme Complexes; NAD; Organ Specificity; Ovary; Progesterone Reductase; Sex Characteristics; Sexual Maturation; Steroid Isomerases; Testis | 1993 |
Hypotonic fragility of outer membrane and activation of external pathway of NADH oxidation in rat liver mitochondria are increased with age.
Topics: Aging; Animals; Female; Hypotonic Solutions; Intracellular Membranes; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Wistar; Rotenone; Sex Characteristics | 1993 |
Function of NAD glycohydrolase in ADP-ribose uptake from NAD by human erythrocytes.
Topics: Adenosine Diphosphate Ribose; Adult; Aging; Biological Transport; Erythrocytes; Humans; In Vitro Techniques; Infant, Newborn; NAD; NAD+ Nucleosidase | 1993 |
Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: I. thymus.
Topics: Adjuvants, Immunologic; Aging; Animals; Chickens; Epithelial Cells; Epithelium; Immunohistochemistry; L-Lactate Dehydrogenase; Lymphatic System; NAD; NADP; Succinate Dehydrogenase; Thymus Extracts; Thymus Gland | 1995 |
Detoxification of reactive aldehydes in mitochondria: effects of age and dietary restriction.
Topics: Aging; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehydes; Animals; Diet; Enzyme Activation; Glutathione; Glutathione Transferase; Inactivation, Metabolic; Liver; Male; Mitochondria; NAD; Rats; Rats, Inbred F344 | 1996 |
Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats.
Topics: Aging; Animals; Cerebral Cortex; DNA, Mitochondrial; Enzyme Inhibitors; Male; Mitochondria; Multienzyme Complexes; NAD; NAD(P)H Dehydrogenase (Quinone); NADH, NADPH Oxidoreductases; Neuroglia; Neurons; Rats; Rats, Wistar; Rotenone; Synapses | 1997 |
Vagal nuclei in the medulla oblongata: structure and activity are maintained in aged rats.
Topics: Aging; Animals; Autonomic Nervous System; Capillaries; Cell Count; Cerebrovascular Circulation; Electron Transport Complex IV; Male; Medulla Oblongata; NAD; Rats; Rats, Wistar; Solitary Nucleus; Vagus Nerve | 1997 |
Rat liver mitochondrial respiratory capacities in the transition from weaning to adulthood.
Topics: Aging; Animals; Cell Respiration; Flavin-Adenine Dinucleotide; Lipid Metabolism; Male; Mitochondria, Liver; NAD; Rats; Rats, Wistar; Substrate Specificity; Succinate Dehydrogenase | 1998 |
Differences in nucleotide metabolism and mechanical recovery after cardioplegic arrest of the heart at different age.
Topics: Adenosine Triphosphate; Aging; Animals; Guanosine Triphosphate; Heart; Heart Arrest, Induced; Male; Myocardium; NAD; Rats; Rats, Sprague-Dawley; Ribonucleotides | 1998 |
Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase.
Topics: Aging; Animals; Cell Respiration; Ketoglutarate Dehydrogenase Complex; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; NAD; Rats; Rats, Inbred F344 | 1999 |
Effect of the oxidative stress induced by adriamycin on rat hepatocyte bioenergetics during ageing.
Topics: Adenosine Triphosphate; Aging; Animals; Doxorubicin; Energy Metabolism; Hydrolysis; In Vitro Techniques; Liver; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species | 2000 |
Cell biology. New clue to age control in yeast.
Topics: Acetylation; Adenosine Diphosphate Ribose; Aging; Animals; DNA-Binding Proteins; Energy Intake; Gene Silencing; Histone Deacetylases; Histones; NAD; Poly(ADP-ribose) Polymerases; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Trans-Activators; Yeasts | 2000 |
Age-dependent changes in glycosaminoglycan content in the skin of fasted rats. A possible mechanism.
Topics: Aging; Animals; Blood Glucose; Fasting; Glycosaminoglycans; Lactic Acid; Male; NAD; Pyruvic Acid; Rats; Rats, Wistar; Skin; Uronic Acids | 2000 |
Age dependence of heat stress mediated cardioprotection.
Topics: Aging; Animals; Heart; Heat-Shock Response; HSP70 Heat-Shock Proteins; Male; NAD; NADP; Rats; Rats, Sprague-Dawley | 2000 |
Aging, chromatin, and food restriction--connecting the dots.
Topics: Aging; Animals; Cell Division; Chromatin; DNA Repair; DNA Replication; DNA, Circular; DNA, Fungal; DNA, Ribosomal; Energy Intake; Gene Silencing; Glucose; Histone Deacetylases; Histones; Longevity; Mutation; NAD; Reactive Oxygen Species; Recombination, Genetic; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Trans-Activators | 2000 |
Metabolic and ionic responses to global brain ischemia in the newborn dog in vivo: II. Post-natal age aspects.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Ischemia; Calcium; Dogs; Hypoxia, Brain; Ischemic Attack, Transient; NAD; Potassium | 2000 |
Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats.
Topics: Aging; Animals; Aorta; Blood Pressure; Cells, Cultured; Desoxycorticosterone; Ditiocarb; Enzyme Inhibitors; Hypertension; Multienzyme Complexes; Muscle, Smooth, Vascular; NAD; NADH, NADPH Oxidoreductases; Onium Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Sodium Chloride; Superoxide Dismutase; Superoxides; Systole | 2001 |
Alcohol dehydrogenase activities in the human gastric mucosa: effects of Helicobacter pylori infection, sex, age, and the part of the stomach.
Topics: Adult; Aged; Aging; Alcohol Dehydrogenase; Cytosol; Female; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Isoenzymes; Male; Middle Aged; NAD; Oxidation-Reduction; Sex Characteristics | 2001 |
N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitro.
Topics: Aging; Animals; Antioxidants; Behavior, Animal; Cell Line; Cellular Senescence; Culture Media; Cysteine Endopeptidases; Eating; Growth Substances; Humans; Hydroxylamines; Male; Mitochondria; Multienzyme Complexes; NAD; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344 | 2001 |
Light-dependent gene expression for proteins in the respiratory chain of potato leaves.
Topics: Aging; Blotting, Western; Circadian Rhythm; Darkness; Electron Transport; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Light; Mitochondria; NAD; NADH Dehydrogenase; NADP; Oxidation-Reduction; Plant Leaves; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Plant; Rotenone; Solanum tuberosum | 2001 |
Molecular clocks in reptiles: life history influences rate of molecular evolution.
Topics: Aging; Animals; Body Constitution; Cytochrome b Group; Environment; Evolution, Molecular; Litter Size; Models, Genetic; Mutagenesis; NAD; Phylogeny; Proto-Oncogene Proteins c-mos; Reptiles; Sexual Maturation; Species Specificity; Time Factors | 2002 |
Scientists uncover new clues about ageing.
Topics: Aging; Animals; Energy Metabolism; Histone Deacetylases; Humans; Longevity; NAD; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Sirtuin 2; Sirtuins; Trans-Activators; Yeasts | 2000 |
Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging.
Topics: Age Factors; Aging; Animals; Electron Transport Complex I; Electron Transport Complex III; Energy Metabolism; Enzyme Inhibitors; Male; Mitochondria, Liver; NAD; NADH, NADPH Oxidoreductases; Oxidative Phosphorylation; Oxidoreductases; Oxygen Consumption; Rats; Rats, Wistar; Rotenone | 2002 |
Effect of aging on brain energy-metabolism.
Topics: Aging; Animals; Brain; Cerebrovascular Circulation; Energy Metabolism; Hypoxia; Mitochondria; NAD; Oxygen; Rats; Time Factors | 2002 |
Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Ascorbic Acid; Child; Child, Preschool; Electron Spin Resonance Spectroscopy; Humans; Hydrogen Peroxide; Infant; Light; Lipid Peroxidation; Lipid Peroxides; Lipofuscin; Melanosomes; Middle Aged; NAD; Oxygen Consumption; Pigment Epithelium of Eye; Reactive Oxygen Species | 2002 |
Changes in the acid-soluble nucleotide composition of red cells of cattle at various ages.
Topics: Adenine Nucleotides; Aging; Animals; Cattle; Erythrocytes; Female; Guanosine Triphosphate; NAD; NADP; Ribonucleotides; Solubility; Trichloroacetic Acid; Uracil Nucleotides; Uric Acid; Uridine Diphosphate Glucose; Uridine Diphosphate N-Acetylglucosamine | 1976 |
Prostaglandin metabolism in the kidneys of spontaneously hypertensive rats.
Topics: Aging; Aniline Compounds; Animals; Epinephrine; Glutathione; Hydrogen-Ion Concentration; Hydroquinones; Hydroxyprostaglandin Dehydrogenases; Hypertension; Kidney; Male; NAD; NADP; Phenols; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Sulfhydryl Compounds; Tetrahydrofolates | 1977 |
Activity of enzymes associated with the biosynthesis of testosterone by gonads of the old mouse.
Topics: Aging; Algestone; Androstenedione; Animals; Body Weight; Desoxycorticosterone; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Male; Mice; Mice, Inbred C57BL; NAD; NADP; Organ Size; Progesterone; Steroid Hydroxylases; Testis; Testosterone | 1977 |
[Differentiation of muscle fibers of various types during postnatal development of the ventral serrate muscle in a rat].
Topics: Abdominal Muscles; Aging; Animals; L-Lactate Dehydrogenase; Lactates; Muscle Development; NAD; NADH, NADPH Oxidoreductases; NADP; Rats; Succinate Dehydrogenase; Succinates | 1979 |
Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats.
Topics: Aging; Alcohol Oxidoreductases; Animals; Carbohydrate Dehydrogenases; Diabetes Mellitus, Experimental; Glucuronates; Liver; Male; Mice; NAD; NADP; Pentoses; Rats; Xylulose | 1979 |
Biochemical and histochemical changes in energy supply enzyme pattern of muscles of the rat during old age.
Topics: Adenosine Triphosphatases; Aerobiosis; Aging; Animals; Citrate (si)-Synthase; Diaphragm; Energy Metabolism; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycerolphosphate Dehydrogenase; Glycolysis; Hexokinase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Mitochondria, Muscle; Muscles; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Rats; Succinate Dehydrogenase | 1975 |
Age-related changes in the flight muscle mitochondria from the blowfly Sarcophaga bullata.
Topics: Aging; Animals; Cytochromes; Diptera; Energy Metabolism; Female; Glycerophosphates; Hydrogen Peroxide; Male; Mitochondria, Muscle; Mitochondrial Swelling; NAD; Oxygen Consumption; Proline; Pyruvates | 1976 |
Metabolite concentrations in the liver of the adult and developing guinea pig and the control of glycolysis in vivo.
Topics: Adenine Nucleotides; Aging; Animals; Citric Acid Cycle; Female; Gestational Age; Glucose; Glycogen; Glycolysis; Guinea Pigs; Hexosephosphates; Liver; Male; NAD; Potassium; Pregnancy; Sodium; Trioses | 1976 |
The contribution of tryptophan to the regulation of the NAD+ level in mouse liver.
Topics: Aging; Animals; Liver; Mice; NAD; Niacinamide; Nicotinic Acids; Organ Specificity; Tryptophan | 1975 |
Suppression and stimulation of DNA synthesis by ADP-ribosylation of nuclear proteins from adult hen and chick embryo liver.
Topics: Aging; Animals; Cell Nucleus; Chick Embryo; Chickens; DNA; Female; Liver; NAD; Niacinamide; Nucleoside Diphosphate Sugars; Poly Adenosine Diphosphate Ribose; Proteins; Templates, Genetic | 1978 |
Age-dependent changes in the activities of ATPase and some pyridine nucleotide-linked enzymes in the chick testis.
Topics: Adenosine Triphosphatases; Aging; Animals; Body Weight; Chickens; Female; Isocitrate Dehydrogenase; Male; NAD; Organ Size; Succinate Dehydrogenase; Testis | 1977 |
Effects of age on brain oxidative metabolism in vivo.
Topics: Aging; Animals; Brain; Cerebral Cortex; Cerebrovascular Circulation; Cortical Spreading Depression; Cytochromes; Electric Stimulation; Energy Metabolism; Evoked Potentials; Male; Mitochondria; NAD; Oxidation-Reduction; Oxygen; Rats | 1979 |
Consequences dietary ethanol on permeability and respiration of mitochondria and liver ADH in young and aged rats.
Topics: Adenosine Triphosphate; Aging; Alcohol Oxidoreductases; Animals; Cell Membrane Permeability; Diet; Ethanol; Glutamates; Malates; Male; Mitochondria, Liver; Mitochondrial Swelling; NAD; Oxidative Phosphorylation; Rats; Succinates | 1979 |
Neuroglia of the optic nerve in the course of myelination.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Aging; Alkaline Phosphatase; Animals; Isocitrate Dehydrogenase; Myelin Sheath; NAD; Nerve Fibers, Myelinated; Neuroglia; Optic Nerve; Rabbits; Thiamine Pyrophosphatase | 1979 |
Cysteine oxidase activity in rat retina during development.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Cysteine; Female; Male; Mitochondria; NAD; NADP; Rats; Retina; Sulfinic Acids; Taurine | 1975 |
Pyrophosphate in synovial fluid and urine and its relationship to urinary risk factors for stone disease.
Topics: Adolescent; Adult; Aged; Aging; Analysis of Variance; Child; Child, Preschool; Dihydroxyacetone Phosphate; Diphosphates; Female; Fructosephosphates; Humans; Hypophosphatasia; Kidney Calculi; Knee Joint; Male; Middle Aged; NAD; Oxidation-Reduction; Phosphorylation; Risk Factors; Sex Factors; Synovial Fluid | 1992 |
Quantitative determination of pertussis toxin-sensitive G proteins using [32P]ADP-ribosylation in human platelet membranes: negative correlation with ages.
Topics: Adenosine Diphosphate; Adult; Aging; Autoradiography; Blood Platelets; Cell Membrane; Female; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Macromolecular Substances; Magnesium Chloride; Male; Membrane Proteins; Middle Aged; Molecular Weight; NAD; Pertussis Toxin; Phosphorus Radioisotopes; Ribose; Sensitivity and Specificity; Virulence Factors, Bordetella | 1992 |
Decrease of phosphorylating oxidation and increase of heat producing NADH oxidation in rat liver mitochondria during life-span prolongation of rats by calorie-restricted diet.
Topics: Aging; Animals; Body Temperature Regulation; Energy Metabolism; Food Deprivation; Longevity; Male; Mitochondria, Liver; NAD; Oxidation-Reduction; Oxidative Phosphorylation; Rats; Rats, Inbred Strains | 1992 |
Effect of age and gender on in vivo ethanol elimination, hepatic alcohol dehydrogenase activity, and NAD+ availability in F344 rats.
Topics: Aging; Alcohol Dehydrogenase; Animals; Body Weight; Ethanol; Female; Liver; Male; Mitochondria, Liver; NAD; Organ Size; Oxidation-Reduction; Rats; Rats, Inbred F344; Sex Factors | 1992 |
Effect of aging on kinetic parameters of 3 alpha(beta)-hydroxysteroid oxidoreductases in epithelium and stroma of human normal and hyperplastic prostate.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cell Membrane; Epithelium; Humans; Kinetics; Male; Middle Aged; NAD; NADP; Prostate; Prostatic Hyperplasia | 1990 |
Recovery of lung pyridine nucleotides following acute exposure of adult and aged rats to ozone.
Topics: Aging; Animals; Lung; Male; NAD; NADP; Oxidation-Reduction; Ozone; Rats; Rats, Inbred F344; Specific Pathogen-Free Organisms | 1991 |
Reduction of mono(ADP-ribosyl)ation of 20 kDa protein with maturation in rat testis: involvement of guanine nucleotides.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Aging; Animals; Cell Nucleus; Guanine Nucleotides; Male; Molecular Weight; NAD; Nuclear Proteins; Organ Specificity; Rats; Rats, Inbred Strains; Subcellular Fractions; Testis | 1991 |
Cellular models and tissue equivalent systems for evaluating the structures and significance of age-modified proteins.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Aging; Animals; Cells, Cultured; Chickens; Child, Preschool; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; In Vitro Techniques; Lymphocytes; Middle Aged; Models, Biological; NAD; Progeria; Proteins; Triose-Phosphate Isomerase; Werner Syndrome | 1991 |
Maturational development of drug-metabolizing enzymes in dogs.
Topics: Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dogs; Female; Male; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH-Ferrihemoprotein Reductase; Sex Factors; Time Factors | 1990 |
Effect of age on superoxide dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster.
Topics: Aging; Animals; Catalase; Drosophila melanogaster; Free Radicals; Glutathione; Glutathione Reductase; NAD; NADP; Oxygen; Peroxides; Superoxide Dismutase | 1990 |
Age dependent changes of a biochemical rhythm--the glycolytic oscillator of the blowfly Phormia terraenovae.
Topics: Aging; Animals; Biological Clocks; Circadian Rhythm; Diptera; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Male; NAD; Phosphofructokinase-1; Pyruvate Kinase | 1990 |
H2O2-dependent NADH oxidation activity in senile cataractous human lens: its relation to glutathione redox cycle.
Topics: Aged; Aged, 80 and over; Aging; Cataract; Crystallins; Glutathione; Humans; Hydrogen Peroxide; Lens, Crystalline; Middle Aged; NAD; Oxidation-Reduction | 1990 |
Maturational development of drug-metabolizing enzymes in sheep.
Topics: Age Factors; Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Male; Microsomes, Liver; NAD; NADP; Sheep | 1990 |
Influence of aging and drug treatment on the bioenergetics of hypoxic brain.
Topics: Adenosine Triphosphate; Aging; Animals; Brain; Diencephalon; Electron Transport; Energy Metabolism; Hypoxia; Male; Mitochondria; NAD; Oxidation-Reduction; Phosphorylation; Rats; Rats, Inbred Strains; Synaptosomes; Telencephalon; Thermodynamics | 1990 |
The levels of adenine nucleotides and pyridine coenzymes in red blood cells from the newborn, determined simultaneously by HPLC.
Topics: Adenine Nucleotides; Adult; Aging; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Infant, Newborn; NAD; NADP | 1990 |
Cellular, biochemical, and molecular basis of T-cell senescence.
Topics: Aging; Cell Count; Cell Membrane; Cell Nucleus; Cytoplasm; Humans; Immunity, Cellular; Ion Channels; NAD; T-Lymphocytes; Transcription Factors | 1987 |
Keratan sulphate: a functional substitute for chondroitin sulphate in O2 deficient tissues?
Topics: Aging; Cartilage; Chondroitin; Chondroitin Sulfates; Cornea; Glycerolphosphate Dehydrogenase; Glycosaminoglycans; Humans; Intervertebral Disc; Keratan Sulfate; Mitochondria; NAD; Oxygen | 1989 |
Characterization of age-related malondialdehyde oxidation: the effect of modulation by food restriction.
Topics: Aging; Animals; Disulfiram; Food Deprivation; Liver; Male; Malonates; Malondialdehyde; Mitochondria, Liver; NAD; Oxidation-Reduction; Rats; Rats, Inbred F344; Subcellular Fractions | 1989 |
Mechanism of aging of rat muscle glyceraldehyde-3-phosphate dehydrogenase studied by selective enzyme-oxidation.
Topics: Aging; Animals; Fluorescent Dyes; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; NAD; Naphthalenesulfonates; Oxidation-Reduction; Oxygen; Protein Conformation; Rats; Spectrometry, Fluorescence; Sulfhydryl Reagents; Superoxides | 1987 |
Alterations of fasting glucose and fat metabolism in intrauterine growth-retarded newborn dogs.
Topics: Aging; Alanine; Animals; Animals, Newborn; Blood Glucose; Disease Models, Animal; Dogs; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Female; Fetal Growth Retardation; Glucose; Ketone Bodies; Lactates; Liver; Liver Glycogen; NAD; Pregnancy; Reference Values; Triglycerides | 1989 |
Regulation of corticosterone metabolism in liver cell fractions in young and adult rats: cofactor requirements, effects of stress and phenobarbital treatment.
Topics: Aging; Animals; Chemical Fractionation; Coenzymes; Corticosterone; Liver; Male; NAD; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stress, Physiological; Tissue Distribution | 1987 |
Monosaccharide autoxidation in health and disease.
Topics: Aging; Carbohydrate Metabolism; Disease; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Kinetics; Mitosis; Monosaccharides; NAD; NADP; Oxidation-Reduction; Oxygen Consumption | 1985 |
Alpha 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aging; Animals; Cerebral Cortex; Clonidine; Colforsin; Epinephrine; Female; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Male; Membranes; NAD; Pertussis Toxin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1986 |
Evidence for age-related changes in pyridine nucleotide content of isolated rat islets.
Topics: Aging; Animals; Glycerolphosphate Dehydrogenase; In Vitro Techniques; Islets of Langerhans; Male; Mitochondria; NAD; Rats; Rats, Inbred Strains | 1988 |
Kinetic analysis of adrenal 3 beta-hydroxysteroid dehydrogenase activity during human development.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adolescent; Adrenal Glands; Adult; Aging; Child; Dehydroepiandrosterone; Female; Humans; Infant; Kinetics; Male; Microsomes; Middle Aged; NAD; Pregnenolone | 1985 |
Isocitrate dehydrogenase activity and its regulation by estradiol in tissues of rats of various ages.
Topics: Aging; Animals; Brain; Estradiol; Female; Isocitrate Dehydrogenase; Kidney Cortex; Liver; NAD; NADP; Ovariectomy; Rats | 1988 |
Influence of age, hexobarbital, and aniline on NADPH/NADH dependent hydrogen peroxide production in rat hepatic microsomes.
Topics: Aging; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Hexobarbital; Hydrogen Peroxide; In Vitro Techniques; Male; Microsomes, Liver; NAD; NADP; Rats; Rats, Inbred Strains | 1986 |
Changes of synaptosomal energy metabolism induced by hypoxia during aging.
Topics: Adenine Nucleotides; Aging; Animals; Dogs; Energy Metabolism; Female; Hypoxia, Brain; Mitochondria; Motor Cortex; NAD; Oxidation-Reduction; Oxygen Consumption; Phosphocreatine | 1987 |
Selenite-induced NAD(P)H oxidation and calcium release in isolated mitochondria: relationship to in vivo toxicity.
Topics: Aging; Animals; Animals, Newborn; Calcium; Guinea Pigs; Kidney; Kinetics; Liver; Mitochondria; Mitochondria, Liver; NAD; NADP; Oxidation-Reduction; Selenious Acid; Selenium | 1987 |
Age-related changes in the redox status of the housefly, Musca domestica.
Topics: Aging; Animals; Free Radicals; Glutathione; Houseflies; Hydrogen Peroxide; Male; NAD; NADP; Oxidation-Reduction | 1987 |
Effect of age and sex on allyl alcohol hepatotoxicity in rats: role of liver alcohol and aldehyde dehydrogenase activities.
Topics: 1-Propanol; Aging; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Cytosol; Female; Kinetics; Lactates; Liver; Male; Mitochondria, Liver; NAD; Propanols; Pyruvates; Rats; Rats, Inbred F344; Sex Factors; Subcellular Fractions | 1987 |
Arrhenius plots of membrane-bound enzymes of mitochondria and microsomes in the brain cortex of developing and old rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Hydroxybutyrate Dehydrogenase; Intracellular Membranes; Male; Mathematics; Microsomes; Mitochondria; NAD; NADH Dehydrogenase; Rats; Rats, Inbred Strains | 1986 |
Age-related changes in the redox status of rat muscle cells and their role in enzyme-aging.
Topics: Aging; Animals; Glutathione; Glutathione Reductase; Glyceraldehyde-3-Phosphate Dehydrogenases; Muscles; NAD; NADP; Oxidation-Reduction; Rats; Rats, Inbred WF | 1985 |
Changes in brain phosphorus metabolites during the post-natal development of the rat.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Brain; Female; Guinea Pigs; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Muscles; NAD; Phosphocreatine; Phosphorus; Rats; Rats, Inbred Strains; Skin | 1985 |
Localization and properties of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity in the rat kidney.
Topics: Aging; Animals; Hydroxyprostaglandin Dehydrogenases; Kidney; Kinetics; Male; NAD; Nephrons; Proteins; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution | 1985 |
Nucleotides and nucleic acids.
Topics: Age Factors; Aging; Animals; Aorta; Arteries; Arteriosclerosis; Carotid Arteries; Cattle; Coronary Vessels; DNA; Guinea Pigs; Humans; Mesenteric Arteries; NAD; NADP; Nucleotides; Polynucleotides; Rabbits; Rats; RNA; Uridine Diphosphate Sugars | 1974 |
Biosynthesis of fatty acids in vitro by homogenate of developing rat brain: desaturation and chain-elongation.
Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Chromatography, Gas; Chromatography, Thin Layer; Coenzyme A; Fatty Acid Desaturases; Fatty Acids, Nonesterified; Female; Fetus; Male; Malonates; NAD; NADP; Oleic Acids; Oxidation-Reduction; Palmitic Acids; Pregnancy; Rats; Stearic Acids; Time Factors | 1974 |
Studies on the electron transfer system. LXVI. Effect of diphosphopyridine nucleotide deficiency on respiration, respiratory control, and phosphorylation in mitochondria.
Topics: Aging; Animals; Cattle; In Vitro Techniques; Malates; Mitochondria; Myocardium; NAD; Oxidative Phosphorylation; Polarography; Pyruvates | 1966 |
Histoenzymatic studies of vessels in hypertensive rats.
Topics: Aging; Animals; Aorta; Aorta, Thoracic; Arteries; Diet; Dihydrolipoamide Dehydrogenase; Histocytochemistry; Hypertension; Hypertension, Renal; NAD; Phosphoric Monoester Hydrolases; Rats; Sodium Chloride | 1967 |
Histochemical studies on the diencephalon of senescent rats.
Topics: Aging; Animals; Copper; Diencephalon; Electron Transport Complex IV; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; L-Lactate Dehydrogenase; Male; NAD; Nucleic Acids; Rats; Succinate Dehydrogenase | 1966 |
[Characteristics of NAD metabolism in the brain--with reference to a comparison with the liver].
Topics: Aging; Animals; Brain; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Male; NAD; Niacinamide; Nicotinic Acids; Rats; Reserpine | 1966 |
Sex-dependent vascular changes in young, adult, aged, and hypertensive rats.
Topics: Adenosine Triphosphatases; Aging; Alkaline Phosphatase; Animals; Aorta; Arteries; Arteriosclerosis; Collagen; Female; Histocytochemistry; Hypertension; Male; NAD; Nucleotidases; Proline; Rats; Sex Factors; Tritium | 1968 |
Alterations in lactate dehydrogenase of the brain, heart, skeletal muscle, and liver of rats of various ages.
Topics: Aging; Animals; Brain; Female; Kinetics; L-Lactate Dehydrogenase; Liver; Muscles; Myocardium; NAD; Oxalates; Rats | 1968 |
The biosynthesis and degradation of nicotinamide-adenine dinucleotide during cick embryonic development.
Topics: Aging; Animals; Carbon Isotopes; Chick Embryo; N-Glycosyl Hydrolases; NAD; Niacinamide; Nicotinic Acids; Phosphoric Monoester Hydrolases; Tryptophan | 1969 |
Studies on myo-inositol metabolism in galactosemia.
Topics: Adenosine Triphosphate; Aging; Alcohols; Alkaline Phosphatase; Animals; Brain; Carbon Isotopes; Dietary Carbohydrates; Galactose; Galactosemias; Glucose; Glucosephosphate Dehydrogenase; Hexokinase; Hexosephosphates; Inositol; Microsomes; NAD; Phosphoric Monoester Hydrolases; Rats; Time Factors | 1969 |
Activity of the phenylalanine hydroxylating system in liver of newborn, suckling and adult rats.
Topics: Aging; Aldehydes; Animals; Animals, Newborn; Body Weight; Carbon Isotopes; Female; Kinetics; Liver; Male; Mixed Function Oxygenases; NAD; Organ Size; Phenylalanine; Proteins; Rats; Tyrosine | 1969 |
Composition of cellular membranes in the pancreas of the guinea pig. 3. Enzymatic activities.
Topics: Adenosine Triphosphatases; Aging; Amidohydrolases; Animals; Cell Membrane; Cold Temperature; Cytochromes; Electron Transport; Electron Transport Complex IV; Endoplasmic Reticulum; Enzyme Precursors; Esterases; Golgi Apparatus; Guinea Pigs; Histocytochemistry; Magnesium; Male; Microsomes; NAD; Nucleotidases; Oxidoreductases; Pancreas; Phosphoric Monoester Hydrolases | 1971 |
Induction of a specific enzyme inadequacy in infant rats by the use of a homologue of riboflavin.
Topics: Aging; Animals; Body Weight; Electron Transport; Female; Flavin-Adenine Dinucleotide; Flavins; Heart; Kidney; Liver; Myocardium; NAD; Oxidoreductases; Pregnancy; Rats; Riboflavin; Succinate Dehydrogenase | 1971 |
[Structural and functional changes in reactivating cells of Nitrobacter winogradskyi Buch].
Topics: Adenosine Triphosphatases; Aging; Carbon; Carbon Dioxide; Cell Membrane; Cytochromes; Cytoplasmic Granules; DNA, Bacterial; Flavin-Adenine Dinucleotide; Freeze Etching; Hydrogen-Ion Concentration; Ligases; Microscopy, Electron; NAD; Nitrites; Nitrobacter; Oxidation-Reduction; Oxygen Consumption; Phosphates; Time Factors; Ultrasonics | 1971 |
The regulatory function of potato pyruvate dehydrogenase.
Topics: Acetaldehyde; Adenine Nucleotides; Adenosine Triphosphate; Aerobiosis; Aging; Anaerobiosis; Buffers; Coenzyme A; Glyoxylates; Kinetics; L-Lactate Dehydrogenase; Magnesium; Mathematics; Mitochondria; NAD; Oxidation-Reduction; Oxidoreductases; Phosphates; Plant Cells; Plants; Pyruvates; Sulfites; Vibration | 1971 |
Nicotinamide adenine dinucleotide in developing chick embryo.
Topics: Aging; Alcohol Oxidoreductases; Animals; Chick Embryo; Egg White; Egg Yolk; Female; Hydrogen-Ion Concentration; Liver; NAD; Niacinamide; Nicotinic Acids; Ovalbumin; Pyridines; Tryptophan | 1971 |
Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala.
Topics: Aging; Animals; Cytochromes; Diptera; Flight, Animal; Glycerophosphates; Leucine; Malates; Microscopy, Electron; Mitochondria, Muscle; Muscle Proteins; Myofibrils; NAD; Oxidative Phosphorylation; Pyruvates; Tritium | 1972 |
Enzymes of glycerol metabolism in developing rat liver and kidney.
Topics: Aging; Animals; Body Weight; Brain; Dietary Fats; Female; Flavin-Adenine Dinucleotide; Fructosephosphates; Glycerol; Glycerolphosphate Dehydrogenase; Glycerophosphates; Kidney; Kidney Cortex; Kidney Medulla; Liver; Male; NAD; Phosphotransferases; Pregnancy; Rats; Spectrometry, Fluorescence | 1974 |
Modulation of malate dehydrogenase of young and old rats by various effectors.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Binding, Competitive; Brain; Citrates; Enzyme Repression; Glucosephosphates; In Vitro Techniques; Isoenzymes; Kinetics; Malate Dehydrogenase; Muscles; NAD; Oxaloacetates; Rats; Spectrophotometry | 1974 |
Nuclear poly (ADPR) and mono (ADPR) residues in tissues with different growth rates.
Topics: Adenosine Diphosphate; Aging; Alkaline Phosphatase; Animals; Animals, Newborn; Carcinoma, Ehrlich Tumor; Cell Division; Cell Nucleus; Chromatography, DEAE-Cellulose; Chromatography, Paper; Hydroxylamines; Liver; Male; Mice; Mice, Inbred BALB C; NAD; Nucleoside Diphosphate Sugars; Phosphoric Diester Hydrolases; Polynucleotides; Rats; Ribose; Snakes; Time Factors; Tritium; Venoms | 1974 |
Enzyme changes during ageing.
Topics: Acid Phosphatase; Aging; Alkaline Phosphatase; Animals; Cattle; Dihydrolipoamide Dehydrogenase; DNA; Electron Transport Complex IV; Enzymes; Female; Glucosephosphate Dehydrogenase; Glucuronidase; Humans; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; NAD; Organ Size; Proteins; Rats; Sex Factors; Succinate Dehydrogenase | 1973 |
Decline or respiratory activity of myocardial mitochondria in senescence.
Topics: Aging; Animals; Ascorbic Acid; Glutamates; Malates; Mitochondria, Muscle; Myocardium; NAD; Oxidation-Reduction; Oxygen Consumption; Palmitates; Pyruvates; Rats; Rats, Inbred F344; Structure-Activity Relationship; Succinates | 1973 |
The oxidative enzyme pattern in developing and adult mice and adult rabbits.
Topics: Aging; Alcohol Oxidoreductases; Animals; Animals, Newborn; Bronchi; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Female; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycerolphosphate Dehydrogenase; Glycolysis; Histocytochemistry; Hydroxybutyrate Dehydrogenase; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Lung; Macrophages; Malate Dehydrogenase; Male; Mice; NAD; NADP; Oxidoreductases; Pregnancy; Pulmonary Alveoli; Rabbits; Vitamin K | 1967 |
Effect of benzimidazole and kinetin on the nicotinamide nucleotide content of senescing wheat leaves.
Topics: Adenine Nucleotides; Aging; Benzimidazoles; Chlorophyll; Chloroplasts; Darkness; Light; NAD; NADP; Oxidation-Reduction; Plant Growth Regulators; Plant Proteins; Triticum | 1968 |
Heterogeneity of rough-surfaced liver microsomal membranes of adult, phenobarbital-treated, and newborn rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Centrifugation, Density Gradient; Electron Transport Complex IV; Fasting; Glucose-6-Phosphatase; Glycerol; Leucine; Liver; Membranes; Microscopy, Electron; Microsomes; NAD; NADP; Osmosis; Phenobarbital; Proteins; Rats; Tritium | 1968 |
[Research on the biochemistry of crystallin. 3. Studies of the variations of the levels of free nucleotides as a function of age of crystallin cells].
Topics: Aging; Animals; Cattle; Chromatography; Crystallins; NAD; NADP; Nucleotides; Rabbits; Rats | 1968 |
Changes in fungi with age. IV. Role of coenzymes in the respiratory decreases in Rhizoctonia solani and Sclerotium bataticola.
Topics: Adenosine Triphosphate; Aging; Cell-Free System; Coenzymes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Fungi; Iron; NAD; NADP; Oxygen Consumption; Trace Elements | 1968 |
Microsomal enzymes in porcine lens.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Aging; Alkaline Phosphatase; Animals; Cholinesterases; Electron Transport Complex IV; Female; Glucose-6-Phosphatase; Lens, Crystalline; Male; Microsomes; NAD; NADP; Oxidoreductases; Spectrophotometry; Sulfatases; Swine | 1968 |
[The organization of biologic membranes].
Topics: Aging; Animals; Biological Transport; Cell Membrane; Endoplasmic Reticulum; Female; Lipids; Liver; Membranes; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Models, Structural; NAD; NADP; Pregnancy; Proteins; Rats | 1970 |
Lipid peroxide formation in rat brain.
Topics: Aging; Animals; Ascorbic Acid; Brain; Brain Chemistry; Cell Nucleus; Edetic Acid; Encephalomyelitis, Autoimmune, Experimental; Hot Temperature; Hydrogen-Ion Concentration; Iron; Lipid Metabolism; Lipids; Metals; Microsomes; Mitochondria; Myelin Sheath; NAD; NADP; Peroxides; Proteins; Rats; Sulfhydryl Compounds; Surface-Active Agents; Synaptic Vesicles | 1971 |
Electron transport in sarcoplasmic reticulum of fast and slow muscles.
Topics: Aging; Animals; Animals, Newborn; Chickens; Chlorine; Cytochromes; Electron Transport; Endoplasmic Reticulum; Ferricyanides; Indophenol; Microsomes; Muscles; NAD; NADP; Oxidoreductases; Polarography; Rabbits; Rats; Rotenone; Spectrophotometry | 1971 |
The energy metabolism of myocardium and its regulation in animals of various age.
Topics: Adaptation, Physiological; Adenosine Triphosphate; Aging; Animals; Electron Transport Complex IV; Fructose-Bisphosphate Aldolase; Glycogen; Glycolysis; Hexokinase; Homeostasis; Lactates; Mitochondria, Muscle; Myocardium; Myoglobin; NAD; NADP; Oxidative Phosphorylation; Oxygen Consumption; Phosphocreatine; Phosphofructokinase-1; Phosphorus Isotopes; Phosphorylases; Rats; Succinate Dehydrogenase | 1968 |