nabumetone and Ulcer
nabumetone has been researched along with Ulcer in 3 studies
Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nabumetone proved to be an effective anti-inflammatory agent that was devoid of gastrointestinal irritancy." | 1.29 | Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac. ( Blower, PR; Gentry, C; Melarange, R; Spangler, R; Toseland, CD, 1994) |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Melarange, R | 1 |
| Gentry, C | 1 |
| Blower, PR | 1 |
| Toseland, CD | 1 |
| Spangler, R | 1 |
| Somasundaram, S | 2 |
| Rafi, S | 2 |
| Hayllar, J | 1 |
| Sigthorsson, G | 1 |
| Jacob, M | 1 |
| Price, AB | 1 |
| Macpherson, A | 1 |
| Mahmod, T | 1 |
| Scott, D | 1 |
| Wrigglesworth, JM | 1 |
| Bjarnason, I | 2 |
| Simpson, R | 1 |
| Shergill, JK | 1 |
| Wrigglesworth, J | 1 |
Other Studies
3 other studies available for nabumetone and Ulcer
| Article | Year |
|---|---|
Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carr | 1994 |
Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile | 1997 |
2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cell Membrane Permeability; Electron Sp | 2002 |