Page last updated: 2024-10-31

nabumetone and Ulcer

nabumetone has been researched along with Ulcer in 3 studies

Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"Nabumetone proved to be an effective anti-inflammatory agent that was devoid of gastrointestinal irritancy."1.29Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac. ( Blower, PR; Gentry, C; Melarange, R; Spangler, R; Toseland, CD, 1994)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Melarange, R1
Gentry, C1
Blower, PR1
Toseland, CD1
Spangler, R1
Somasundaram, S2
Rafi, S2
Hayllar, J1
Sigthorsson, G1
Jacob, M1
Price, AB1
Macpherson, A1
Mahmod, T1
Scott, D1
Wrigglesworth, JM1
Bjarnason, I2
Simpson, R1
Shergill, JK1
Wrigglesworth, J1

Other Studies

3 other studies available for nabumetone and Ulcer

ArticleYear
Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac.
    European journal of rheumatology and inflammation, 1994, Volume: 14, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carr

1994
Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.
    Gut, 1997, Volume: 41, Issue:3

    Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile

1997
2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum.
    BMC gastroenterology, 2002, Apr-18, Volume: 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cell Membrane Permeability; Electron Sp

2002