nabumetone has been researched along with Granuloma in 3 studies
Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nabumetone itself was found only in very low concentrations at the inflamed site and was not found in plasma." | 1.27 | Penetration of nabumetone into inflammatory exudates in the rat. ( Haddock, RE; Jeffery, DJ; Mangan, FR; Pardon, IS, 1983) |
| "Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs." | 1.26 | Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent. ( Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goudie, AC | 1 |
| Gaster, LM | 1 |
| Lake, AW | 1 |
| Rose, CJ | 1 |
| Freeman, PC | 2 |
| Hughes, BO | 1 |
| Miller, D | 1 |
| Boyle, EA | 1 |
| Mangan, FR | 2 |
| Thomson, MJ | 1 |
| Haddock, RE | 1 |
| Jeffery, DJ | 1 |
| Pardon, IS | 1 |
3 other studies available for nabumetone and Granuloma
| Article | Year |
|---|---|
4-(6-Methoxy-2-naphthyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds.
Topics: Animals; Anti-Inflammatory Agents; Female; Gossypium; Granuloma; Naphthalenes; Rats; Structure-Activ | 1978 |
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; F | 1982 |
Penetration of nabumetone into inflammatory exudates in the rat.
Topics: Animals; Anti-Inflammatory Agents; Autoradiography; Butanones; Exudates and Transudates; Female; Gos | 1983 |