Page last updated: 2024-10-31

nabumetone and Granuloma

nabumetone has been researched along with Granuloma in 3 studies

Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.

Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.

Research Excerpts

ExcerptRelevanceReference
"Nabumetone itself was found only in very low concentrations at the inflamed site and was not found in plasma."1.27Penetration of nabumetone into inflammatory exudates in the rat. ( Haddock, RE; Jeffery, DJ; Mangan, FR; Pardon, IS, 1983)
"Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs."1.26Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent. ( Boyle, EA; Freeman, PC; Mangan, FR; Thomson, MJ, 1982)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goudie, AC1
Gaster, LM1
Lake, AW1
Rose, CJ1
Freeman, PC2
Hughes, BO1
Miller, D1
Boyle, EA1
Mangan, FR2
Thomson, MJ1
Haddock, RE1
Jeffery, DJ1
Pardon, IS1

Other Studies

3 other studies available for nabumetone and Granuloma

ArticleYear
4-(6-Methoxy-2-naphthyl)butan-2-one and related analogues, a novel structural class of antiinflammatory compounds.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Female; Gossypium; Granuloma; Naphthalenes; Rats; Structure-Activ

1978
Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Butanones; F

1982
Penetration of nabumetone into inflammatory exudates in the rat.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Autoradiography; Butanones; Exudates and Transudates; Female; Gos

1983