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nabumetone and Aging

nabumetone has been researched along with Aging in 4 studies

Nabumetone: A butanone non-steroidal anti-inflammatory drug and cyclooxygenase-2 (COX2) inhibitor that is used in the management of pain associated with OSTEOARTHRITIS and RHEUMATOID ARTHRITIS.
nabumetone : A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses."6.67Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992)
" The most common adverse effects that occurred were related to the gastrointestinal tract, nervous system, skin, and special senses."2.67Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis. ( Fleischmann, RM, 1992)
"Nabumetone is a new, nonacidic, nonsteroidal antiinflammatory drug."2.38An overview of the clinical pharmacokinetics of nabumetone. ( Hyneck, ML, 1992)
"We have performed a detailed pharmacokinetic study of the plasma concentrations of the major active metabolite of nabumetone, 6-methoxy-2-naphthylacetic acid (6 MNA), attained after a single dose and during chronic administration comparing the results of a group of young healthy volunteers with those of a group of elderly arthritic patients."1.28A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients. ( Chellingsworth, MC; Jubb, R; Kendall, MJ; Kill, DC; Thawley, AR; Undre, NA, 1989)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hyneck, ML1
Aronoff, GR1
Fleischmann, RM1
Kendall, MJ1
Chellingsworth, MC1
Jubb, R1
Thawley, AR1
Undre, NA1
Kill, DC1

Reviews

2 reviews available for nabumetone and Aging

ArticleYear
An overview of the clinical pharmacokinetics of nabumetone.
    The Journal of rheumatology. Supplement, 1992, Volume: 36

    Topics: Adult; Aged; Aging; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Eating; Humans; Ki

1992
Therapeutic implications associated with renal studies of nabumetone.
    The Journal of rheumatology. Supplement, 1992, Volume: 36

    Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials as Topic; Double-Blind Me

1992

Trials

1 trial available for nabumetone and Aging

ArticleYear
Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis.
    The Journal of rheumatology. Supplement, 1992, Volume: 36

    Topics: Adult; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Butanon

1992

Other Studies

1 other study available for nabumetone and Aging

ArticleYear
A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents, Non-Steroidal; Arthriti

1989