nabam and Papilloma

Mancozeb, a polymeric complex of ethylene bis (dithiocarbamate) manganese with zinc salt is a protective fungicide. In the present study complete carcinogenic activity of mancozeb, has been observed following topical application on dorsal mouse skin. Female Swiss albino mice were exposed to mancozeb at a dose of 100 mg/kg body weight dissolved in 100 microliters dimethyl sulfoxide 3 times per week. Development of tumours was observed after 31 weeks (217 days) of mancozeb application. A high rate of mortality was observed after 54 weeks (378 days) of mancozeb application due to its toxicity and the study was terminated after 60 weeks. On histological examination, these tumours were found mostly to be benign in nature, e.g., squamous cell papillomas and keratoacanthomas.

Topics: Administration, Topical; Animals; Body Weight; Fungicides, Industrial; Maneb; Mice; Papilloma; Skin Neoplasms; Survival Analysis; Zineb

Mancozeb is a protectant fungicide and is a polymeric complex of ethylene bis(dithiocarbamate)manganese (i.e. Maneb) with zinc salt. In this study, the tumour initiating ability of mancozeb has been observed by a 2-stage initiation-promotion protocol in mouse skin.

Topics: Animals; Carcinogens; Female; Maneb; Mice; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thiocarbamates; Zineb